Minghui Zhang

Minghui Zhang, Yangqian Wu, Hanxiao Zhang et al. · harvard

Open international challenges are becoming the de facto standard for assessing computer vision and image analysis algorithms. In recent years, new methods have extended the reach of pulmonary airway segmentation that is closer to the limit of image resolution. Since EXACT'09 pulmonary airway segmentation, limited effort has been directed to quantitative comparison of newly emerged algorithms driven by the maturity of deep learning based approaches and clinical drive for resolving finer details of distal airways for early intervention of pulmonary diseases. Thus far, public annotated datasets are extremely limited, hindering the development of data-driven methods and detailed performance evaluation of new algorithms. To provide a benchmark for the medical imaging community, we organized the Multi-site, Multi-domain Airway Tree Modeling (ATM'22), which was held as an official challenge event during the MICCAI 2022 conference. ATM'22 provides large-scale CT scans with detailed pulmonary airway annotation, including 500 CT scans (300 for training, 50 for validation, and 150 for testing). The dataset was collected from different sites and it further included a portion of noisy COVID-19 CTs with ground-glass opacity and consolidation. Twenty-three teams participated in the entire phase of the challenge and the algorithms for the top ten teams are reviewed in this paper. Quantitative and qualitative results revealed that deep learning models embedded with the topological continuity enhancement achieved superior performance in general. ATM'22 challenge holds as an open-call design, the training data and the gold standard evaluation are available upon successful registration via its homepage.

Tao Yu, Yujia Yang, Shenghua Chai et al.

Video misinformation increasingly operates at the semantic and evidential level: authentic footage may be selectively edited, temporally reordered, spliced across sources, or augmented with AI-generated content to construct false narratives. Such evidence-dependent manipulations cannot be reliably verified from the input video alone, because the missing, reordered, replaced, or recontextualized evidence lies outside the video itself. We introduce \textbf{EVID-Bench}, a benchmark for search-grounded video misinformation detection, where a system must search the open web for related videos and identify what information is false through cross-video comparison. EVID-Bench comprises 222 videos spanning 9 manipulation types across 3 categories: AI generation, single-source editing, and multi-source editing. All samples are verified to be undetectable by frontier models through visual inspection alone. We evaluate nine frontier multimodal models using a retrieval-augmented verification baseline. The best system achieves only 61.43\% point-level accuracy and 43.24\% video-level accuracy, while AI-generated manipulations remain especially challenging. Error analysis reveals recurring challenges: models fixate on irrelevant anchors, misattribute synthetic content to editorial splicing, and terminate search prematurely before fully explaining the manipulation.

Zhongying Deng, Cheng Tang, Ziyan Huang et al. · pku

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

Hanxiao Zhang, Xiao Gu, Minghui Zhang et al. · oxford

The LIDC-IDRI database is the most popular benchmark for lung cancer prediction. However, with subjective assessment from radiologists, nodules in LIDC may have entirely different malignancy annotations from the pathological ground truth, introducing label assignment errors and subsequent supervision bias during training. The LIDC database thus requires more objective labels for learning-based cancer prediction. Based on an extra small dataset containing 180 nodules diagnosed by pathological examination, we propose to re-label LIDC data to mitigate the effect of original annotation bias verified on this robust benchmark. We demonstrate in this paper that providing new labels by similar nodule retrieval based on metric learning would be an effective re-labeling strategy. Training on these re-labeled LIDC nodules leads to improved model performance, which is enhanced when new labels of uncertain nodules are added. We further infer that re-labeling LIDC is current an expedient way for robust lung cancer prediction while building a large pathological-proven nodule database provides the long-term solution.

Reuben Dorent, Roya Khajavi, Tagwa Idris et al.

Accurate assessment of lymph node size in 3D CT scans is crucial for cancer staging, therapeutic management, and monitoring treatment response. Existing state-of-the-art segmentation frameworks in medical imaging often rely on fully annotated datasets. However, for lymph node segmentation, these datasets are typically small due to the extensive time and expertise required to annotate the numerous lymph nodes in 3D CT scans. Weakly-supervised learning, which leverages incomplete or noisy annotations, has recently gained interest in the medical imaging community as a potential solution. Despite the variety of weakly-supervised techniques proposed, most have been validated only on private datasets or small publicly available datasets. To address this limitation, the Mediastinal Lymph Node Quantification (LNQ) challenge was organized in conjunction with the 26th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2023). This challenge aimed to advance weakly-supervised segmentation methods by providing a new, partially annotated dataset and a robust evaluation framework. A total of 16 teams from 5 countries submitted predictions to the validation leaderboard, and 6 teams from 3 countries participated in the evaluation phase. The results highlighted both the potential and the current limitations of weakly-supervised approaches. On one hand, weakly-supervised approaches obtained relatively good performance with a median Dice score of $61.0\%$. On the other hand, top-ranked teams, with a median Dice score exceeding $70\%$, boosted their performance by leveraging smaller but fully annotated datasets to combine weak supervision and full supervision. This highlights both the promise of weakly-supervised methods and the ongoing need for high-quality, fully annotated data to achieve higher segmentation performance.

Bing Guan, Cailian Yang, Liu Zhang et al.

The radiation dose in computed tomography (CT) examinations is harmful for patients but can be significantly reduced by intuitively decreasing the number of projection views. Reducing projection views usually leads to severe aliasing artifacts in reconstructed images. Previous deep learning (DL) techniques with sparse-view data require sparse-view/full-view CT image pairs to train the network with supervised manners. When the number of projection view changes, the DL network should be retrained with updated sparse-view/full-view CT image pairs. To relieve this limitation, we present a fully unsupervised score-based generative model in sinogram domain for sparse-view CT reconstruction. Specifically, we first train a score-based generative model on full-view sinogram data and use multi-channel strategy to form highdimensional tensor as the network input to capture their prior distribution. Then, at the inference stage, the stochastic differential equation (SDE) solver and data-consistency step were performed iteratively to achieve fullview projection. Filtered back-projection (FBP) algorithm was used to achieve the final image reconstruction. Qualitative and quantitative studies were implemented to evaluate the presented method with several CT data. Experimental results demonstrated that our method achieved comparable or better performance than the supervised learning counterparts.

Zhigen Li, Jianxiang Peng, Yanmeng Wang et al.

Dialogue agents powered by Large Language Models (LLMs) show superior performance in various tasks. Despite the better user understanding and human-like responses, their lack of controllability remains a key challenge, often leading to unfocused conversations or task failure. To address this, we introduce Standard Operating Procedure (SOP) to regulate dialogue flow. Specifically, we propose ChatSOP, a novel SOP-guided Monte Carlo Tree Search (MCTS) planning framework designed to enhance the controllability of LLM-driven dialogue agents. To enable this, we curate a dataset comprising SOP-annotated multi-scenario dialogues, generated using a semi-automated role-playing system with GPT-4o and validated through strict manual quality control. Additionally, we propose a novel method that integrates Chain of Thought reasoning with supervised fine-tuning for SOP prediction and utilizes SOP-guided Monte Carlo Tree Search for optimal action planning during dialogues. Experimental results demonstrate the effectiveness of our method, such as achieving a 27.95% improvement in action accuracy compared to baseline models based on GPT-3.5 and also showing notable gains for open-source models. Dataset and codes are publicly available.

Minghui Zhang, Alex Sokolov, Weixin Cai et al. · microsoft-research

Natural language generation (NLG) is one of the most impactful fields in NLP, and recent years have witnessed its evolution brought about by large language models (LLMs). As the key instrument for writing assistance applications, they are generally prone to replicating or extending offensive content provided in the input. In low-resource data regime, they can also lead to repetitive outputs. Usually, offensive content and repetitions are mitigated with post-hoc methods, including n-gram level blocklists, top-k and nucleus sampling. In this paper, we apply non-exact repetition suppression using token and sequence level unlikelihood loss, and further explore the framework of unlikelihood training objective in order to jointly endow the model with abilities to avoid generating offensive words and phrases from the beginning. Finally, with comprehensive experiments, we demonstrate that our proposed methods work exceptionally in controlling the repetition and content quality of LLM outputs.

Zongjiang Tu, Die Liu, Xiaoqing Wang et al.

Deep learning based parallel imaging (PI) has made great progresses in recent years to accelerate magnetic resonance imaging (MRI). Nevertheless, it still has some limitations, such as the robustness and flexibility of existing methods have great deficiency. In this work, we propose a method to explore the k-space domain learning via robust generative modeling for flexible calibration-less PI reconstruction, coined weight-k-space generative model (WKGM). Specifically, WKGM is a generalized k-space domain model, where the k-space weighting technology and high-dimensional space augmentation design are efficiently incorporated for score-based generative model training, resulting in good and robust reconstructions. In addition, WKGM is flexible and thus can be synergistically combined with various traditional k-space PI models, which can make full use of the correlation between multi-coil data and realizecalibration-less PI. Even though our model was trained on only 500 images, experimental results with varying sampling patterns and acceleration factors demonstrate that WKGM can attain state-of-the-art reconstruction results with the well-learned k-space generative prior.

Hong Peng, Chen Jiang, Jing Cheng et al.

Magnetic resonance imaging serves as an essential tool for clinical diagnosis. However, it suffers from a long acquisition time. The utilization of deep learning, especially the deep generative models, offers aggressive acceleration and better reconstruction in magnetic resonance imaging. Nevertheless, learning the data distribution as prior knowledge and reconstructing the image from limited data remains challenging. In this work, we propose a novel Hankel-k-space generative model (HKGM), which can generate samples from a training set of as little as one k-space data. At the prior learning stage, we first construct a large Hankel matrix from k-space data, then extract multiple structured k-space patches from the large Hankel matrix to capture the internal distribution among different patches. Extracting patches from a Hankel matrix enables the generative model to be learned from redundant and low-rank data space. At the iterative reconstruction stage, it is observed that the desired solution obeys the learned prior knowledge. The intermediate reconstruction solution is updated by taking it as the input of the generative model. The updated result is then alternatively operated by imposing low-rank penalty on its Hankel matrix and data consistency con-strain on the measurement data. Experimental results confirmed that the internal statistics of patches within a single k-space data carry enough information for learning a powerful generative model and provide state-of-the-art reconstruction.

Tao Yu, Haopeng Jin, Hao Wang et al.

In recent years, large language models (LLMs) have made rapid progress in information retrieval, yet existing research has mainly focused on text or static multimodal settings. Open-domain video shot retrieval, which involves richer temporal structure and more complex semantics, still lacks systematic benchmarks and analysis. To fill this gap, we introduce ShotFinder, a benchmark that formalizes editing requirements as keyframe-oriented shot descriptions and introduces five types of controllable single-factor constraints: Temporal order, Color, Visual style, Audio, and Resolution. We curate 1,210 high-quality samples from YouTube across 20 thematic categories, using large models for generation with human verification. Based on the benchmark, we propose ShotFinder, a text-driven three-stage retrieval and localization pipeline: (1) query expansion via video imagination, (2) candidate video retrieval with a search engine, and (3) description-guided temporal localization. Experiments on multiple closed-source and open-source models reveal a significant gap to human performance, with clear imbalance across constraints: temporal localization is relatively tractable, while color and visual style remain major challenges. These results reveal that open-domain video shot retrieval is still a critical capability that multimodal large models have yet to overcome.

Puyang Wang, Dazhou Guo, Dandan Zheng et al.

Intrathoracic airway segmentation in computed tomography (CT) is a prerequisite for various respiratory disease analyses such as chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Unlike other organs with simpler shapes or topology, the airway's complex tree structure imposes an unbearable burden to generate the "ground truth" label (up to 7 or 3 hours of manual or semi-automatic annotation on each case). Most of the existing airway datasets are incompletely labeled/annotated, thus limiting the completeness of computer-segmented airway. In this paper, we propose a new anatomy-aware multi-class airway segmentation method enhanced by topology-guided iterative self-learning. Based on the natural airway anatomy, we formulate a simple yet highly effective anatomy-aware multi-class segmentation task to intuitively handle the severe intra-class imbalance of the airway. To solve the incomplete labeling issue, we propose a tailored self-iterative learning scheme to segment toward the complete airway tree. For generating pseudo-labels to achieve higher sensitivity , we introduce a novel breakage attention map and design a topology-guided pseudo-label refinement method by iteratively connecting breaking branches commonly existed from initial pseudo-labels. Extensive experiments have been conducted on four datasets including two public challenges. The proposed method ranked 1st in both EXACT'09 challenge using average score and ATM'22 challenge on weighted average score. In a public BAS dataset and a private lung cancer dataset, our method significantly improves previous leading approaches by extracting at least (absolute) 7.5% more detected tree length and 4.0% more tree branches, while maintaining similar precision.

Minghui Zhang, Xiaobin Li, Jie Chen et al.

In modern nuclear physics experiments, identifying events of interest is challenging for nuclear reaction studies with the active target Time Projection Chamber (TPC). In this work, machine learning techniques are employed to analyze the complex data of the 12C + 12C fusion reaction from a TPC named MATE (multi-purpose active-target time projection chamber for nuclear experiments). Specifically, we successfully applied Residual Neural Network (ResNet-50, ResNet-34 and ResNet-18) and Visual Geometry Group (VGG-19) to classify elastic scattering and fusion reaction events from the 12C + 12C reaction. The classification results of the four models are nearly identical, with accuracies of approximately 97% for the simulated data and 90% for the experimental data. Moreover, these approaches successfully identify some events that are misclassified by traditional methods. These models are also applied to classify events from different fusion reaction channels, with classification accuracies of approximately 95% on simulated data. In addition, a Convolutional Neural Network (CNN) model is developed to reconstruct the reaction vertex, providing an alternative strategy for vertex reconstruction. These results indicate that machine learning techniques can effectively classify reaction events from different channels and reconstruct the reaction vertex, thereby paving the way for future analyses of complex nuclear reaction data.

Marawan Elbatel, Mohamed Ghonim, Jiaji Mao et al.

Automated segmentation of liver lesions on non-contrast computed tomography (NCCT) is clinically important but fundamentally challenging, particularly in low-resource settings across Africa and Asia where contrast agents are frequently unavailable. Progress has been limited by the absence of annotated NCCT benchmarks. Here we describe the TriALS challenge for automated liver lesion segmentation under contrast-limited conditions, supported by a multi-centre dataset of 150 cases with four-phase CT acquisitions (600 volumes) from Egyptian and Chinese institutions. Algorithms were evaluated on 70 cases from three institutions, including an independent external cohort. The top-performing method achieved a mean venous-phase Dice of 0.754, consistent with human-level performance, yet dropped to 0.57 on NCCT. On external validation, the leading method outperformed off-the-shelf models by up to 28% in Dice on NCCT. Algorithm performance was most strongly predicted by training data scale and pre-training strategy. A cross-year comparison exposed a persistent perceptual barrier on NCCT that scaling pre-training alone cannot overcome. Data, annotations, and code are available at https://github.com/xmed-lab/TriALS.

Minghui Zhang, Guang-Zhong Yang, Yun Gu

Detailed pulmonary airway segmentation is a clinically important task for endobronchial intervention and treatment of peripheral located lung cancer lesions. Convolutional Neural Networks (CNNs) are promising tools for medical image analysis but have been performing poorly for cases when existing a significant imbalanced feature distribution, which is true for the airway data as the trachea and principal bronchi dominate most of the voxels whereas the lobar bronchi and distal segmental bronchi occupy a small proportion. In this paper, we propose a Differentiable Topology-Preserved Distance Transform (DTPDT) framework to improve the performance of airway segmentation. A Topology-Preserved Surrogate (TPS) learning strategy is first proposed to balance the training progress within-class distribution. Furthermore, a Convolutional Distance Transform (CDT) is designed to identify the breakage phenomenon with superior sensitivity and minimize the variation of the distance map between the predictionand ground-truth. The proposed method is validated with the publically available reference airway segmentation datasets. The detected rate of branch and length on public EXACT'09 and BAS datasets are 82.1%/79.6% and 96.5%/91.5% respectively, demonstrating the reliability and efficiency of the method in terms of improving the topology completeness of the segmentation performance while maintaining the overall topology accuracy.

Wei Zhang, Zengwei Xiao, Hui Tao et al.

Although recent deep learning methods, especially generative models, have shown good performance in fast magnetic resonance imaging, there is still much room for improvement in high-dimensional generation. Considering that internal dimensions in score-based generative models have a critical impact on estimating the gradient of the data distribution, we present a new idea, low-rank tensor assisted k-space generative model (LR-KGM), for parallel imaging reconstruction. This means that we transform original prior information into high-dimensional prior information for learning. More specifically, the multi-channel data is constructed into a large Hankel matrix and the matrix is subsequently folded into tensor for prior learning. In the testing phase, the low-rank rotation strategy is utilized to impose low-rank constraints on tensor output of the generative network. Furthermore, we alternately use traditional generative iterations and low-rank high-dimensional tensor iterations for reconstruction. Experimental comparisons with the state-of-the-arts demonstrated that the proposed LR-KGM method achieved better performance.

Tao Yu, yiming ding, Shenghua Chai et al.

Current omni-modal benchmarks mainly evaluate models under settings where multiple modalities are provided simultaneously, while the ability to start from audio alone and actively search for cross-modal evidence remains underexplored. In this paper, we introduce \textbf{Omni-DeepSearch}, a benchmark for audio-driven omni-modal deep search. Given one or more audio clips and a related question, models must infer useful clues from audio, invoke text, image, and video search tools, and perform multi-hop reasoning to produce a short, objective, and verifiable answer. Omni-DeepSearch contains 640 samples across 15 fine-grained categories, covering four retrieval target modalities and four audio content types. A multi-stage filtering pipeline ensures audio dependence, retrieval necessity, visual modality necessity, and answer uniqueness. Experiments on recent closed-source and open-source omni-modal models show that this task remains highly challenging: the strongest evaluated model, Gemini-3-Pro, achieves only 43.44\% average accuracy. Further analyses illustrate key bottlenecks in audio entity inference, query formulation, tool-use reliability, multi-hop retrieval, and cross-modal verification. These results highlight audio-driven omni-modal deep search as an important and underexplored direction for future multimodal agents.

Xin You, Yixin Lou, Minghui Zhang et al.

Automatic and precise multi-class vertebrae segmentation from CT images is crucial for various clinical applications. However, due to similar appearances between adjacent vertebrae and the existence of various pathologies, existing single-stage and multi-stage methods suffer from imprecise vertebrae segmentation. Essentially, these methods fail to explicitly impose both contour precision and intra-vertebrae voxel consistency constraints synchronously, resulting in the intra-vertebrae segmentation inconsistency, which refers to multiple label predictions inside a singular vertebra. In this work, we intend to label complete binary masks with sequential indices to address that challenge. Specifically, a contour generation network is proposed based on Structural Low-Rank Descriptors for shape consistency, termed SLoRD. For a structural representation of vertebral contours, we adopt the spherical coordinate system and devise the spherical centroid to calculate contour descriptors. Due to vertebrae's similar appearances, basic contour descriptors can be acquired offline to restore original contours. Therefore, SLoRD leverages these contour priors and explicit shape constraints to facilitate regressed contour points close to vertebral surfaces. Quantitative and qualitative evaluations on VerSe 2019 and 2020 demonstrate the superior performance of our framework over other single-stage and multi-stage state-of-the-art (SOTA) methods. Further, SLoRD is a plug-and-play framework to refine the segmentation inconsistency existing in coarse predictions from other approaches. Source codes are available.

Yaoyu Liu, Minghui Zhang, Xin You et al.

Modeling medical vessel-like anatomy is challenging due to its intricate topology and sensitivity to dataset shifts. Consequently, task-specific models often suffer from topological inconsistencies, including artificial disconnections and spurious merges. Motivated by the promise of multimodal large language models (MLLMs) for zero-shot generalization, we propose TubeMLLM, a unified foundation model that couples structured understanding with controllable generation for medical vessel-like anatomy. By integrating topological priors through explicit natural language prompting and aligning them with visual representations in a shared-attention architecture, TubeMLLM significantly enhances topology-aware perception. Furthermore, we construct TubeMData, a pionner multimodal benchmark comprising comprehensive topology-centric tasks, and introduce an adaptive loss weighting strategy to emphasize topology-critical regions during training. Extensive experiments on fifteen diverse datasets demonstrate our superiority. Quantitatively, TubeMLLM achieves state-of-the-art out-of-distribution performance, substantially reducing global topological discrepancies on color fundus photography (decreasing the $β_{0}$ number error from 37.42 to 8.58 compared to baselines). Notably, TubeMLLM exhibits exceptional zero-shot cross-modality transferring ability on unseen X-ray angiography, achieving a Dice score of 67.50% while significantly reducing the $β_{0}$ error to 1.21. TubeMLLM also maintains robustness against degradations such as blur, noise, and low resolution. Furthermore, in topology-aware understanding tasks, the model achieves 97.38% accuracy in evaluating mask topological quality, significantly outperforming standard vision-language baselines.

Muhammad Imran, Jonathan R. Krebs, Vishal Balaji Sivaraman et al.

Multi-class segmentation of the aorta in computed tomography angiography (CTA) scans is essential for diagnosing and planning complex endovascular treatments for patients with aortic dissections. However, existing methods reduce aortic segmentation to a binary problem, limiting their ability to measure diameters across different branches and zones. Furthermore, no open-source dataset is currently available to support the development of multi-class aortic segmentation methods. To address this gap, we organized the AortaSeg24 MICCAI Challenge, introducing the first dataset of 100 CTA volumes annotated for 23 clinically relevant aortic branches and zones. This dataset was designed to facilitate both model development and validation. The challenge attracted 121 teams worldwide, with participants leveraging state-of-the-art frameworks such as nnU-Net and exploring novel techniques, including cascaded models, data augmentation strategies, and custom loss functions. We evaluated the submitted algorithms using the Dice Similarity Coefficient (DSC) and Normalized Surface Distance (NSD), highlighting the approaches adopted by the top five performing teams. This paper presents the challenge design, dataset details, evaluation metrics, and an in-depth analysis of the top-performing algorithms. The annotated dataset, evaluation code, and implementations of the leading methods are publicly available to support further research. All resources can be accessed at https://aortaseg24.grand-challenge.org.

Yaoyu Liu, Minghui Zhang, Junjun He et al.

Automatic extraction of vessel skeletons is crucial for many clinical applications. However, achieving topologically faithful delineation of thin vessel skeletons remains highly challenging, primarily due to frequent discontinuities and the presence of spurious skeleton segments. To address these difficulties, we propose TopoVST, a topology-fidelitious vessel skeleton tracker. TopoVST constructs multi-scale sphere graphs to sample the input image and employs graph neural networks to jointly estimate tracking directions and vessel radii. The utilization of multi-scale representations is enhanced through a gating-based feature fusion mechanism, while the issue of class imbalance during training is mitigated by embedding a geometry-aware weighting scheme into the directional loss. In addition, we design a wave-propagation-based skeleton tracking algorithm that explicitly mitigates the generation of spurious skeletons through space-occupancy filtering. We evaluate TopoVST on two vessel datasets with different geometries. Extensive comparisons with state-of-the-art baselines demonstrate that TopoVST achieves competitive performance in both overlapping and topological metrics. Our source code is available at: https://github.com/EndoluminalSurgicalVision-IMR/TopoVST.

Minghui Zhang, Yaoyu Liu, Junyang Wu et al.

Medical tubular anatomical structures are inherently three-dimensional conduits with lumens, enclosing walls, and complex branching topologies. Accurate reconstruction of their geometry and topology is crucial for applications such as bronchoscopic navigation and cerebral arterial connectivity assessment. Existing methods often rely on voxel-wise overlap measures, which fail to capture topological correctness and completeness. Although topology-aware losses and persistent homology constraints have shown promise, they are usually applied patch-wise and cannot guarantee global preservation or correct geometric errors at inference. To address these limitations, we propose a novel TopoSculpt, a framework for topological refinement of 3D fine-grained tubular structures. TopoSculpt (i) adopts a holistic whole-region modeling strategy to capture full spatial context, (ii) first introduces a Topological Integrity Betti (TIB) constraint that jointly enforces Betti number priors and global integrity, and (iii) employs a curriculum refinement scheme with persistent homology to progressively correct errors from coarse to fine scales. Extensive experiments on challenging pulmonary airway and Circle of Willis datasets demonstrate substantial improvements in both geometry and topology. For instance, $β_{0}$ errors are reduced from 69.00 to 3.40 on the airway dataset and from 1.65 to 0.30 on the CoW dataset, with Tree length detected and branch detected rates improving by nearly 10\%. These results highlight the effectiveness of TopoSculpt in correcting critical topological errors and advancing the high-fidelity modeling of complex 3D tubular anatomy. The project homepage is available at: https://github.com/Puzzled-Hui/TopoSculpt.

Tao Yu, Hao Wang, Changyu Li et al.

Large language model (LLM) agents are increasingly expected to operate in enterprise environments, where work is distributed across specialized roles, permission-controlled systems, and cross-departmental procedures. However, existing enterprise benchmarks largely evaluate single agents with broad tool access, while existing multi-agent benchmarks rarely capture realistic enterprise constraints such as role specialization, access control, stateful business systems, and policy-based approvals. We introduce \textsc{EntCollabBench}, a benchmark for evaluating enterprise multi-agent collaboration. \textsc{EntCollabBench} simulates a permission-isolated organization with 11 role-specialized agents across six departments and contains two evaluation subsets: a Workflow subset, where agents collaboratively modify enterprise system states, and an Approval subset, where agents make policy-grounded decisions. Evaluation is based on execution traces, database state verification, and deterministic policy adjudication rather than natural-language response judging. Experiments with representative LLM agents show that current models still struggle with end-to-end enterprise collaboration, especially in delegation, context transfer, parameter grounding, workflow closure, and decision commitment. \textsc{EntCollabBench} provides a reproducible testbed for measuring and improving agent systems intended for realistic organizational environments.

Tao Yu, Minghui Zhang, Zhiqing Cui et al.

Transforming scientific papers into multimodal presentation content is essential for research dissemination but remains labor intensive. Existing automated solutions typically treat each format as an isolated downstream task, leading to redundant processing and semantic inconsistency. We introduce PaperX, a unified framework that models academic presentation generation as a structural transformation and rendering process. Central to our approach is the Scholar DAG, an intermediate representation that decouples the paper's logical structure from its final presentation syntax. By applying adaptive graph traversal strategies, PaperX generates diverse, high quality outputs from a single source. Comprehensive evaluations demonstrate that our framework achieves the state of the art performance in content fidelity and aesthetic quality while significantly improving cost efficiency compared to specialized single task agents.

Kaiyuan Yang, Fabio Musio, Yihui Ma et al.

The Circle of Willis (CoW) is an important network of arteries connecting major circulations of the brain. Its vascular architecture is believed to affect the risk, severity, and clinical outcome of serious neurovascular diseases. However, characterizing the highly variable CoW anatomy is still a manual and time-consuming expert task. The CoW is usually imaged by two non-invasive angiographic imaging modalities, magnetic resonance angiography (MRA) and computed tomography angiography (CTA), but there exist limited datasets with annotations on CoW anatomy, especially for CTA. Therefore, we organized the TopCoW challenge with the release of an annotated CoW dataset. The TopCoW dataset is the first public dataset with voxel-level annotations for 13 CoW vessel components, enabled by virtual reality technology. It is also the first large dataset using 200 pairs of MRA and CTA from the same patients. As part of the benchmark, we invited submissions worldwide and attracted over 250 registered participants from six continents. The submissions were evaluated on both internal and external test datasets of 226 scans from over five centers. The top performing teams achieved over 90% Dice scores at segmenting the CoW components, over 80% F1 scores at detecting key CoW components, and over 70% balanced accuracy at classifying CoW variants for nearly all test sets. The best algorithms also showed clinical potential in classifying fetal-type posterior cerebral artery and locating aneurysms with CoW anatomy. TopCoW demonstrated the utility and versatility of CoW segmentation algorithms for a wide range of downstream clinical applications with explainability. The annotated datasets and best performing algorithms have been released as public Zenodo records to foster further methodological development and clinical tool building.

Adrian de Wynter, Ishaan Watts, Tua Wongsangaroonsri et al. · cmu, deepmind

Large language models (LLMs) and small language models (SLMs) are being adopted at remarkable speed, although their safety still remains a serious concern. With the advent of multilingual S/LLMs, the question now becomes a matter of scale: can we expand multilingual safety evaluations of these models with the same velocity at which they are deployed? To this end, we introduce RTP-LX, a human-transcreated and human-annotated corpus of toxic prompts and outputs in 28 languages. RTP-LX follows participatory design practices, and a portion of the corpus is especially designed to detect culturally-specific toxic language. We evaluate 10 S/LLMs on their ability to detect toxic content in a culturally-sensitive, multilingual scenario. We find that, although they typically score acceptably in terms of accuracy, they have low agreement with human judges when scoring holistically the toxicity of a prompt; and have difficulty discerning harm in context-dependent scenarios, particularly with subtle-yet-harmful content (e.g. microaggressions, bias). We release this dataset to contribute to further reduce harmful uses of these models and improve their safe deployment.

Yang Nan, Xiaodan Xing, Shiyi Wang et al.

Airway-related quantitative imaging biomarkers are crucial for examination, diagnosis, and prognosis in pulmonary diseases. However, the manual delineation of airway trees remains prohibitively time-consuming. While significant efforts have been made towards enhancing airway modelling, current public-available datasets concentrate on lung diseases with moderate morphological variations. The intricate honeycombing patterns present in the lung tissues of fibrotic lung disease patients exacerbate the challenges, often leading to various prediction errors. To address this issue, the 'Airway-Informed Quantitative CT Imaging Biomarker for Fibrotic Lung Disease 2023' (AIIB23) competition was organized in conjunction with the official 2023 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI). The airway structures were meticulously annotated by three experienced radiologists. Competitors were encouraged to develop automatic airway segmentation models with high robustness and generalization abilities, followed by exploring the most correlated QIB of mortality prediction. A training set of 120 high-resolution computerised tomography (HRCT) scans were publicly released with expert annotations and mortality status. The online validation set incorporated 52 HRCT scans from patients with fibrotic lung disease and the offline test set included 140 cases from fibrosis and COVID-19 patients. The results have shown that the capacity of extracting airway trees from patients with fibrotic lung disease could be enhanced by introducing voxel-wise weighted general union loss and continuity loss. In addition to the competitive image biomarkers for prognosis, a strong airway-derived biomarker (Hazard ratio>1.5, p<0.0001) was revealed for survival prognostication compared with existing clinical measurements, clinician assessment and AI-based biomarkers.

Xin You, Ming Ding, Minghui Zhang et al.

Precise boundary segmentation of volumetric images is a critical task for image-guided diagnosis and computer-assisted intervention, especially for boundary confusion in clinical practice. However, U-shape networks cannot effectively resolve this challenge due to the lack of boundary shape constraints. Besides, existing methods of refining boundaries overemphasize the slender structure, which results in the overfitting phenomenon due to networks' limited abilities to model tiny objects. In this paper, we reconceptualize the mechanism of boundary generation by encompassing the interaction dynamics with adjacent regions. Moreover, we propose a unified network termed PnPNet to model shape characteristics of the confused boundary region. Core ingredients of PnPNet contain the pushing and pulling branches. Specifically, based on diffusion theory, we devise the semantic difference module (SDM) from the pushing branch to squeeze the boundary region. Explicit and implicit differential information inside SDM significantly boost representation abilities for inter-class boundaries. Additionally, motivated by the K-means algorithm, the class clustering module (CCM) from the pulling branch is introduced to stretch the intersected boundary region. Thus, pushing and pulling branches will shrink and enlarge the boundary uncertainty respectively. They furnish two adversarial forces to promote models to output a more precise delineation of boundaries. We carry out experiments on three challenging public datasets and one in-house dataset, containing three types of boundary confusion in model predictions. Experimental results demonstrate the superiority of PnPNet over other segmentation networks, especially on evaluation metrics of HD and ASSD. Besides, pushing and pulling branches can serve as plug-and-play modules to enhance classic U-shape baseline models. Codes are available.

Xin You, Minghui Zhang, Hanxiao Zhang et al.

Temporal modeling on regular respiration-induced motions is crucial to image-guided clinical applications. Existing methods cannot simulate temporal motions unless high-dose imaging scans including starting and ending frames exist simultaneously. However, in the preoperative data acquisition stage, the slight movement of patients may result in dynamic backgrounds between the first and last frames in a respiratory period. This additional deviation can hardly be removed by image registration, thus affecting the temporal modeling. To address that limitation, we pioneeringly simulate the regular motion process via the image-to-video (I2V) synthesis framework, which animates with the first frame to forecast future frames of a given length. Besides, to promote the temporal consistency of animated videos, we devise the Temporal Differential Diffusion Model to generate temporal differential fields, which measure the relative differential representations between adjacent frames. The prompt attention layer is devised for fine-grained differential fields, and the field augmented layer is adopted to better interact these fields with the I2V framework, promoting more accurate temporal variation of synthesized videos. Extensive results on ACDC cardiac and 4D Lung datasets reveal that our approach simulates 4D videos along the intrinsic motion trajectory, rivaling other competitive methods on perceptual similarity and temporal consistency. Codes will be available soon.

Minghui Zhang, Chenyu Li, Fangfang Xie et al.

Accurate anatomical labeling and analysis of the pulmonary structure and its surrounding anatomy from thoracic CT is getting increasingly important for understanding the etilogy of abnormalities or supporting targetted therapy and early interventions. Whilst lung and airway cell atlases have been attempted, there is a lack of fine-grained morphological atlases that are clinically deployable. In this work, we introduce AirMorph, a robust, end-to-end deep learning pipeline enabling fully automatic and comprehensive airway anatomical labeling at lobar, segmental, and subsegmental resolutions that can be used to create digital atlases of the lung. Evaluated across large-scale multi-center datasets comprising diverse pulmonary conditions, the AirMorph consistently outperformed existing segmentation and labeling methods in terms of accuracy, topological consistency, and completeness. To simplify clinical interpretation, we further introduce a compact anatomical signature quantifying critical morphological airway features, including stenosis, ectasia, tortuosity, divergence, length, and complexity. When applied to various pulmonary diseases such as pulmonary fibrosis, emphysema, atelectasis, consolidation, and reticular opacities, it demonstrates strong discriminative power, revealing disease-specific morphological patterns with high interpretability and explainability. Additionally, AirMorph supports efficient automated branching pattern analysis, potentially enhancing bronchoscopic navigation planning and procedural safety, offering a valuable clinical tool for improved diagnosis, targeted treatment, and personalized patient care.

Chenyu Li, Minghui Zhang, Chuyan Zhang et al.

Accurate airway anatomical labeling is crucial for clinicians to identify and navigate complex bronchial structures during bronchoscopy. Automatic airway anatomical labeling is challenging due to significant individual variability and anatomical variations. Previous methods are prone to generate inconsistent predictions, which is harmful for preoperative planning and intraoperative navigation. This paper aims to address these challenges by proposing a novel method that enhances topological consistency and improves the detection of abnormal airway branches. We propose a novel approach incorporating two modules: the Soft Subtree Consistency (SSC) and the Abnormal Branch Saliency (ABS). The SSC module constructs a soft subtree to capture clinically relevant topological relationships, allowing for flexible feature aggregation within and across subtrees. The ABS module facilitates the interaction between node features and prototypes to distinguish abnormal branches, preventing the erroneous aggregation of features between normal and abnormal nodes. Evaluated on a challenging dataset characterized by severe airway distortion and atrophy, our method achieves superior performance compared to state-of-the-art approaches. Specifically, it attains a 91.4% accuracy at the segmental level and an 83.7% accuracy at the subsegmental level, representing a 1.4% increase in subsegmental accuracy and a 3.1% increase in topological consistency. Notably, the method demonstrates reliable performance in cases with disease-induced airway deformities, ensuring consistent and accurate labeling.

Minghui Zhang, Xin You, Hanxiao Zhang et al.

The Circle of Willis (CoW) vessels is critical to connecting major circulations of the brain. The topology of the vascular structure is clinical significance to evaluate the risk, severity of the neuro-vascular diseases. The CoW has two representative angiographic imaging modalities, computed tomography angiography (CTA) and magnetic resonance angiography (MRA). TopCow24 provided 125 paired CTA-MRA dataset for the analysis of CoW. To explore both CTA and MRA images in a unified framework to learn the inherent topology of Cow, we construct the universal dataset via independent intensity preprocess, followed by joint resampling and normarlization. Then, we utilize the topology-aware loss to enhance the topology completeness of the CoW and the discrimination between different classes. A complementary topology-aware refinement is further conducted to enhance the connectivity within the same class. Our method was evaluated on all the three tasks and two modalities, achieving competitive results. In the final test phase of TopCow24 Challenge, we achieved the second place in the CTA-Seg-Task, the third palce in the CTA-Box-Task, the first place in the CTA-Edg-Task, the second place in the MRA-Seg-Task, the third palce in the MRA-Box-Task, the second place in the MRA-Edg-Task.

Minghui Zhang, Hao Zheng, Yawen Huang et al. · tsinghua

Shape modeling of volumetric medical images is crucial for quantitative analysis and surgical planning in computer-aided diagnosis. To alleviate the burden of expert clinicians, reconstructed shapes are typically obtained from deep learning models, such as Convolutional Neural Networks (CNNs) or transformer-based architectures, followed by the marching cube algorithm. However, automatic shape reconstruction often falls short of perfection due to the limited resolution of images and the absence of shape prior constraints. To overcome these limitations, we propose the Reliable Shape Interaction with Implicit Template (ReShapeIT) network, which models anatomical structures in continuous space rather than discrete voxel grids. ReShapeIT represents an anatomical structure with an implicit template field shared within the same category, complemented by a deformation field. It ensures the implicit template field generates valid templates by strengthening the constraint of the correspondence between the instance shape and the template shape. The valid template shape can then be utilized for implicit generalization. A Template Interaction Module (TIM) is introduced to reconstruct unseen shapes by interacting the valid template shapes with the instance-wise latent codes. Experimental results on three datasets demonstrate the superiority of our approach in anatomical structure reconstruction. The Chamfer Distance/Earth Mover's Distance achieved by ReShapeIT are 0.225/0.318 on Liver, 0.125/0.067 on Pancreas, and 0.414/0.098 on Lung Lobe.

Junyang Wu, Mingyi Luo, Fangfang Xie et al.

Accurate intraoperative navigation is essential for robot-assisted endoluminal intervention, but remains difficult because of limited endoscopic field of view and dynamic artifacts. Existing navigation platforms often rely on external localization technologies, such as electromagnetic tracking or shape sensing, which increase hardware complexity and remain vulnerable to intraoperative anatomical mismatch. We present a vision-only autonomy framework that performs long-horizon bronchoscopic navigation using preoperative CT-derived virtual targets and live endoscopic video, without external tracking during navigation. The framework uses hierarchical long-short agents: a short-term reactive agent for continuous low-latency motion control, and a long-term strategic agent for decision support at anatomically ambiguous points. When their recommendations conflict, a world-model critic predicts future visual states for candidate actions and selects the action whose predicted state best matches the target view. We evaluated the system in a high-fidelity airway phantom, three ex vivo porcine lungs, and a live porcine model. The system reached all planned segmental targets in the phantom, maintained 80\% success to the eighth generation ex vivo, and achieved in vivo navigation performance comparable to the expert bronchoscopist. These results support the preclinical feasibility of sensor-free autonomous bronchoscopic navigation.

Minghui Zhang, Yaoyu Liu, Xin You et al.

Accurate multi-class tubular modeling is critical for precise lesion localization and optimal treatment planning. Deep learning methods enable automated shape modeling by prioritizing volumetric overlap accuracy. However, the inherent complexity of fine-grained semantic tubular shapes is not fully emphasized by overlap accuracy, resulting in reduced topological preservation. To address this, we propose the Shapeaware Sampling (SAS), which optimizes patchsize allocation for online sampling and extracts a topology-preserved skeletal representation for the objective function. Fractal Dimension-based Patchsize (FDPS) is first introduced to quantify semantic tubular shape complexity through axis-specific fractal dimension analysis. Axes with higher fractal complexity are then sampled with smaller patchsizes to capture fine-grained features and resolve structural intricacies. In addition, Minimum Path-Cost Skeletonization (MPC-Skel) is employed to sample topologically consistent skeletal representations of semantic tubular shapes for skeleton-weighted objective functions. MPC-Skel reduces artifacts from conventional skeletonization methods and directs the focus to critical topological regions, enhancing tubular topology preservation. SAS is computationally efficient and easily integrable into optimization pipelines. Evaluation on two semantic tubular datasets showed consistent improvements in both volumetric overlap and topological integrity metrics.

Pengfei Yu, Bin Huang, Minghui Zhang et al.

Score-based diffusion models have shown significant promise in the field of sparse-view CT reconstruction. However, the projection dataset is large and riddled with redundancy. Consequently, applying the diffusion model to unprocessed data results in lower learning effectiveness and higher learning difficulty, frequently leading to reconstructed images that lack fine details. To address these issues, we propose the ordered-subsets multi-diffusion model (OSMM) for sparse-view CT reconstruction. The OSMM innovatively divides the CT projection data into equal subsets and employs multi-subsets diffusion model (MSDM) to learn from each subset independently. This targeted learning approach reduces complexity and enhances the reconstruction of fine details. Furthermore, the integration of one-whole diffusion model (OWDM) with complete sinogram data acts as a global information constraint, which can reduce the possibility of generating erroneous or inconsistent sinogram information. Moreover, the OSMM's unsupervised learning framework provides strong robustness and generalizability, adapting seamlessly to varying sparsity levels of CT sinograms. This ensures consistent and reliable performance across different clinical scenarios. Experimental results demonstrate that OSMM outperforms traditional diffusion models in terms of image quality and noise resilience, offering a powerful and versatile solution for advanced CT imaging in sparse-view scenarios.

Hanxiao Zhang, Liang Chen, Xiao Gu et al.

Recent evolution in deep learning has proven its value for CT-based lung nodule classification. Most current techniques are intrinsically black-box systems, suffering from two generalizability issues in clinical practice. First, benign-malignant discrimination is often assessed by human observers without pathologic diagnoses at the nodule level. We termed these data as "unsure data". Second, a classifier does not necessarily acquire reliable nodule features for stable learning and robust prediction with patch-level labels during learning. In this study, we construct a sure dataset with pathologically-confirmed labels and propose a collaborative learning framework to facilitate sure nodule classification by integrating unsure data knowledge through nodule segmentation and malignancy score regression. A loss function is designed to learn reliable features by introducing interpretability constraints regulated with nodule segmentation maps. Furthermore, based on model inference results that reflect the understanding from both machine and experts, we explore a new nodule analysis method for similar historical nodule retrieval and interpretable diagnosis. Detailed experimental results demonstrate that our approach is beneficial for achieving improved performance coupled with faithful model reasoning for lung cancer prediction. Extensive cross-evaluation results further illustrate the effect of unsure data for deep-learning-based methods in lung nodule classification.

Yangqian Wu, Minghui Zhang, Weihao Yu et al.

Purpose: Bronchoscopic intervention is a widely-used clinical technique for pulmonary diseases, which requires an accurate and topological complete airway map for its localization and guidance. The airway map could be extracted from chest computed tomography (CT) scans automatically by airway segmentation methods. Due to the complex tree-like structure of the airway, preserving its topology completeness while maintaining the segmentation accuracy is a challenging task. Methods: In this paper, a long-term slice propagation (LTSP) method is proposed for accurate airway segmentation from pathological CT scans. We also design a two-stage end-to-end segmentation framework utilizing the LTSP method in the decoding process. Stage 1 is used to generate a coarse feature map by an encoder-decoder architecture. Stage 2 is to adopt the proposed LTSP method for exploiting the continuity information and enhancing the weak airway features in the coarse feature map. The final segmentation result is predicted from the refined feature map. Results: Extensive experiments were conducted to evaluate the performance of the proposed method on 70 clinical CT scans. The results demonstrate the considerable improvements of the proposed method compared to some state-of-the-art methods as most breakages are eliminated and more tiny bronchi are detected. The ablation studies further confirm the effectiveness of the constituents of the proposed method. Conclusion: Slice continuity information is beneficial to accurate airway segmentation. Furthermore, by propagating the long-term slice feature, the airway topology connectivity is preserved with overall segmentation accuracy maintained.

Weihao Yu, Hao Zheng, Minghui Zhang et al.

Airway segmentation is critical for virtual bronchoscopy and computer-aided pulmonary disease analysis. In recent years, convolutional neural networks (CNNs) have been widely used to delineate the bronchial tree. However, the segmentation results of the CNN-based methods usually include many discontinuous branches, which need manual repair in clinical use. A major reason for the breakages is that the appearance of the airway wall can be affected by the lung disease as well as the adjacency of the vessels, while the network tends to overfit to these special patterns in the training set. To learn robust features for these areas, we design a multi-branch framework that adopts the geodesic distance transform to capture the intensity changes between airway lumen and wall. Another reason for the breakages is the intra-class imbalance. Since the volume of the peripheral bronchi may be much smaller than the large branches in an input patch, the common segmentation loss is not sensitive to the breakages among the distal branches. Therefore, in this paper, a breakage-sensitive regularization term is designed and can be easily combined with other loss functions. Extensive experiments are conducted on publicly available datasets. Compared with state-of-the-art methods, our framework can detect more branches while maintaining competitive segmentation performance.

Wanqing Zhu, Bing Guan, Shanshan Wang et al.

The integration of compressed sensing and parallel imaging (CS-PI) provides a robust mechanism for accelerating MRI acquisitions. However, most such strategies require the explicit formation of either coil sensitivity profiles or a cross-coil correlation operator, and as a result reconstruction corresponds to solving a challenging bilinear optimization problem. In this work, we present an unsupervised deep learning framework for calibration-free parallel MRI, coined universal generative modeling for parallel imaging (UGM-PI). More precisely, we make use of the merits of both wavelet transform and the adaptive iteration strategy in a unified framework. We train a powerful noise conditional score network by forming wavelet tensor as the network input at the training phase. Experimental results on both physical phantom and in vivo datasets implied that the proposed method is comparable and even superior to state-of-the-art CS-PI reconstruction approaches.

Cailian Yang, Xianghao Liao, Yuhao Wang et al.

Magnetic resonance imaging (MRI) is a widely used medical imaging modality. However, due to the limitations in hardware, scan time, and throughput, it is often clinically challenging to obtain high-quality MR images. In this article, we propose a method of using artificial intelligence to expand the channel to achieve the goal of generating the virtual coils. The main characteristic of our work is utilizing dummy variable technology to expand/extrapolate the receive coils in both image and k-space domains. The high-dimensional information formed by channel expansion is used as the prior information to improve the reconstruction effect of parallel imaging. Two main components are incorporated into the network design, namely variable augmentation technology and sum of squares (SOS) objective function. Variable augmentation provides the network with more high-dimensional prior information, which is helpful for the network to extract the deep feature information of the data. The SOS objective function is employed to solve the deficiency of k-space data training while speeding up convergence. Experimental results demonstrated its great potentials in super-resolution of MR images and accelerated parallel imaging reconstruction.

Minghui Zhang, Xin Yu, Hanxiao Zhang et al.

3D Convolutional Neural Networks (CNNs) have been widely adopted for airway segmentation. The performance of 3D CNNs is greatly influenced by the dataset while the public airway datasets are mainly clean CT scans with coarse annotation, thus difficult to be generalized to noisy CT scans (e.g. COVID-19 CT scans). In this work, we proposed a new dual-stream network to address the variability between the clean domain and noisy domain, which utilizes the clean CT scans and a small amount of labeled noisy CT scans for airway segmentation. We designed two different encoders to extract the transferable clean features and the unique noisy features separately, followed by two independent decoders. Further on, the transferable features are refined by the channel-wise feature recalibration and Signed Distance Map (SDM) regression. The feature recalibration module emphasizes critical features and the SDM pays more attention to the bronchi, which is beneficial to extracting the transferable topological features robust to the coarse labels. Extensive experimental results demonstrated the obvious improvement brought by our proposed method. Compared to other state-of-the-art transfer learning methods, our method accurately segmented more bronchi in the noisy CT scans.

Kai Hong, Chunhua Wu, Cailian Yang et al.

This work presents an unsupervised deep learning scheme that exploiting high-dimensional assisted score-based generative model for color image restoration tasks. Considering that the sample number and internal dimension in score-based generative model have key influence on estimating the gradients of data distribution, two different high-dimensional ways are proposed: The channel-copy transformation increases the sample number and the pixel-scale transformation decreases feasible space dimension. Subsequently, a set of high-dimensional tensors represented by these transformations are used to train the network through denoising score matching. Then, sampling is performed by annealing Langevin dynamics and alternative data-consistency update. Furthermore, to alleviate the difficulty of learning high-dimensional representation, a progressive strategy is proposed to leverage the performance. The proposed unsupervised learning and iterative restoration algo-rithm, which involves a pre-trained generative network to obtain prior, has transparent and clear interpretation compared to other data-driven approaches. Experimental results on demosaicking and inpainting conveyed the remarkable performance and diversity of our proposed method.

Kai Hong, Jin Li, Wanyun Li et al.

This paper proposes an iterative generative model for solving the automatic colorization problem. Although previous researches have shown the capability to generate plausible color, the edge color overflow and the requirement of the reference images still exist. The starting point of the unsupervised learning in this study is the observation that the gradient map possesses latent information of the image. Therefore, the inference process of the generative modeling is conducted in joint intensity-gradient domain. Specifically, a set of intensity-gradient formed high-dimensional tensors, as the network input, are used to train a powerful noise conditional score network at the training phase. Furthermore, the joint intensity-gradient constraint in data-fidelity term is proposed to limit the degree of freedom within generative model at the iterative colorization stage, and it is conducive to edge-preserving. Extensive experiments demonstrated that the system outperformed state-of-the-art methods whether in quantitative comparisons or user study.

Yiling Liu, Qiegen Liu, Minghui Zhang et al.

To improve the compressive sensing MRI (CS-MRI) approaches in terms of fine structure loss under high acceleration factors, we have proposed an iterative feature refinement model (IFR-CS), equipped with fixed transforms, to restore the meaningful structures and details. Nevertheless, the proposed IFR-CS still has some limitations, such as the selection of hyper-parameters, a lengthy reconstruction time, and the fixed sparsifying transform. To alleviate these issues, we unroll the iterative feature refinement procedures in IFR-CS to a supervised model-driven network, dubbed IFR-Net. Equipped with training data pairs, both regularization parameter and the utmost feature refinement operator in IFR-CS become trainable. Additionally, inspired by the powerful representation capability of convolutional neural network (CNN), CNN-based inversion blocks are explored in the sparsity-promoting denoising module to generalize the sparsity-enforcing operator. Extensive experiments on both simulated and in vivo MR datasets have shown that the proposed network possesses a strong capability to capture image details and preserve well the structural information with fast reconstruction speed.

Siyuan Wang, Junjie Lv, Yuanyuan Hu et al.

Compressive sensing is an impressive approach for fast MRI. It aims at reconstructing MR image using only a few under-sampled data in k-space, enhancing the efficiency of the data acquisition. In this study, we propose to learn priors based on undecimated wavelet transform and an iterative image reconstruction algorithm. At the stage of prior learning, transformed feature images obtained by undecimated wavelet transform are stacked as an input of denoising autoencoder network (DAE). The highly redundant and multi-scale input enables the correlation of feature images at different channels, which allows a robust network-driven prior. At the iterative reconstruction, the transformed DAE prior is incorporated into the classical iterative procedure by the means of proximal gradient algorithm. Experimental comparisons on different sampling trajectories and ratios validated the great potential of the presented algorithm.