Xiaoyuan Guo

Xiaoyuan Guo, Judy Wawira Gichoya, Saptarshi Purkayastha et al.

Detecting out-of-distribution (OOD) samples in medical imaging plays an important role for downstream medical diagnosis. However, existing OOD detectors are demonstrated on natural images composed of inter-classes and have difficulty generalizing to medical images. The key issue is the granularity of OOD data in the medical domain, where intra-class OOD samples are predominant. We focus on the generalizability of OOD detection for medical images and propose a self-supervised Cascade Variational autoencoder-based Anomaly Detector (CVAD). We use a variational autoencoders' cascade architecture, which combines latent representation at multiple scales, before being fed to a discriminator to distinguish the OOD data from the in-distribution (ID) data. Finally, both the reconstruction error and the OOD probability predicted by the binary discriminator are used to determine the anomalies. We compare the performance with the state-of-the-art deep learning models to demonstrate our model's efficacy on various open-access medical imaging datasets for both intra- and inter-class OOD. Further extensive results on datasets including common natural datasets show our model's effectiveness and generalizability. The code is available at https://github.com/XiaoyuanGuo/CVAD.

Xiaoyuan Guo, Hanyi Yu, Blair Rossetti et al.

Highly clumped nuclei clusters captured in fluorescence in situ hybridization microscopy images are common histology entities under investigations in a wide spectrum of tissue-related biomedical investigations. Due to their large scale in presence, computer based image analysis is used to facilitate such analysis with improved analysis efficiency and reproducibility. To ensure the quality of downstream biomedical analyses, it is essential to segment clustered nuclei with high quality. However, this presents a technical challenge commonly encountered in a large number of biomedical research, as nuclei are often overlapped due to a high cell density. In this paper, we propose an segmentation algorithm that identifies point pair connection candidates and evaluates adjacent point connections with a formulated ellipse fitting quality indicator. After connection relationships are determined, we recover the resulting dividing paths by following points with specific eigenvalues from Hessian in a constrained searching space. We validate our algorithm with 560 image patches from two classes of tumor regions of seven brain tumor patients. Both qualitative and quantitative experimental results suggest that our algorithm is promising for dividing overlapped nuclei in fluorescence in situ hybridization microscopy images widely used in various biomedical research.

Jiali Duan, Shuai Zhou, Jun Wan et al.

Recently, the popularity of depth-sensors such as Kinect has made depth videos easily available while its advantages have not been fully exploited. This paper investigates, for gesture recognition, to explore the spatial and temporal information complementarily embedded in RGB and depth sequences. We propose a convolutional twostream consensus voting network (2SCVN) which explicitly models both the short-term and long-term structure of the RGB sequences. To alleviate distractions from background, a 3d depth-saliency ConvNet stream (3DDSN) is aggregated in parallel to identify subtle motion characteristics. These two components in an unified framework significantly improve the recognition accuracy. On the challenging Chalearn IsoGD benchmark, our proposed method outperforms the first place on the leader-board by a large margin (10.29%) while also achieving the best result on RGBD-HuDaAct dataset (96.74%). Both quantitative experiments and qualitative analysis shows the effectiveness of our proposed framework and codes will be released to facilitate future research.