Shanshan Wang

Weijian Huang, Cheng Li, Hong-Yu Zhou et al.

Recently, multi-modal vision-language foundation models have gained significant attention in the medical field. While these models offer great opportunities, they still face crucial challenges, such as the requirement for fine-grained knowledge understanding in computer-aided diagnosis and the capability of utilizing very limited or even no task-specific labeled data in real-world clinical applications. In this study, we present MaCo, a masked contrastive chest X-ray foundation model that tackles these challenges. MaCo explores masked contrastive learning to simultaneously achieve fine-grained image understanding and zero-shot learning for a variety of medical imaging tasks. It designs a correlation weighting mechanism to adjust the correlation between masked chest X-ray image patches and their corresponding reports, thereby enhancing the model's representation learning capabilities. To evaluate the performance of MaCo, we conducted extensive experiments using 6 well-known open-source X-ray datasets. The experimental results demonstrate the superiority of MaCo over 10 state-of-the-art approaches across tasks such as classification, segmentation, detection, and phrase grounding. These findings highlight the significant potential of MaCo in advancing a wide range of medical image analysis tasks.

Weijian Huang, Hao Yang, Cheng Li et al.

Multi-modal representation methods have achieved advanced performance in medical applications by extracting more robust features from multi-domain data. However, existing methods usually need to train additional branches for downstream tasks, which may increase the model complexities in clinical applications as well as introduce additional human inductive bias. Besides, very few studies exploit the rich clinical knowledge embedded in clinical daily reports. To this end, we propose a novel medical generalist agent, MGA, that can address three kinds of common clinical tasks via clinical reports knowledge transformation. Unlike the existing methods, MGA can easily adapt to different tasks without specific downstream branches when their corresponding annotations are missing. More importantly, we are the first attempt to use medical professional language guidance as a transmission medium to guide the agent's behavior. The proposed method is implemented on four well-known X-ray open-source datasets, MIMIC-CXR, CheXpert, MIMIC-CXR-JPG, and MIMIC-CXR-MS. Promising results are obtained, which validate the effectiveness of our proposed MGA. Code is available at: https://github.com/SZUHvern/MGA

Haojia Lin, Xiawu Zheng, Lijiang Li et al.

Recent advances in 3D point cloud analysis bring a diverse set of network architectures to the field. However, the lack of a unified framework to interpret those networks makes any systematic comparison, contrast, or analysis challenging, and practically limits healthy development of the field. In this paper, we take the initiative to explore and propose a unified framework called PointMeta, to which the popular 3D point cloud analysis approaches could fit. This brings three benefits. First, it allows us to compare different approaches in a fair manner, and use quick experiments to verify any empirical observations or assumptions summarized from the comparison. Second, the big picture brought by PointMeta enables us to think across different components, and revisit common beliefs and key design decisions made by the popular approaches. Third, based on the learnings from the previous two analyses, by doing simple tweaks on the existing approaches, we are able to derive a basic building block, termed PointMetaBase. It shows very strong performance in efficiency and effectiveness through extensive experiments on challenging benchmarks, and thus verifies the necessity and benefits of high-level interpretation, contrast, and comparison like PointMeta. In particular, PointMetaBase surpasses the previous state-of-the-art method by 0.7%/1.4/%2.1% mIoU with only 2%/11%/13% of the computation cost on the S3DIS datasets.

Shanshan Wang, ALuSi, Xun Yang et al.

Domain generalization (DG) task aims to learn a robust model from source domains that could handle the out-of-distribution (OOD) issue. In order to improve the generalization ability of the model in unseen domains, increasing the diversity of training samples is an effective solution. However, existing augmentation approaches always have some limitations. On the one hand, the augmentation manner in most DG methods is not enough as the model may not see the perturbed features in approximate the worst case due to the randomness, thus the transferability in features could not be fully explored. On the other hand, the causality in discriminative features is not involved in these methods, which harms the generalization ability of model due to the spurious correlations. To address these issues, we propose a Dual-stream Feature Augmentation~(DFA) method by constructing some hard features from two perspectives. Firstly, to improve the transferability, we construct some targeted features with domain related augmentation manner. Through the guidance of uncertainty, some hard cross-domain fictitious features are generated to simulate domain shift. Secondly, to take the causality into consideration, the spurious correlated non-causal information is disentangled by an adversarial mask, then the more discriminative features can be extracted through these hard causal related information. Different from previous fixed synthesizing strategy, the two augmentations are integrated into a unified learnable feature disentangle model. Based on these hard features, contrastive learning is employed to keep the semantic consistency and improve the robustness of the model. Extensive experiments on several datasets demonstrated that our approach could achieve state-of-the-art performance for domain generalization. Our code is available at: https://github.com/alusi123/DFA.

Weijian Huang, Cheng Li, Wenxin Fan et al.

Recovering high-quality images from undersampled measurements is critical for accelerated MRI reconstruction. Recently, various supervised deep learning-based MRI reconstruction methods have been developed. Despite the achieved promising performances, these methods require fully sampled reference data, the acquisition of which is resource-intensive and time-consuming. Self-supervised learning has emerged as a promising solution to alleviate the reliance on fully sampled datasets. However, existing self-supervised methods suffer from reconstruction errors due to the insufficient constraint enforced on the non-sampled data points and the error accumulation happened alongside the iterative image reconstruction process for model-driven deep learning reconstrutions. To address these challenges, we propose K2Calibrate, a K-space adaptation strategy for self-supervised model-driven MR reconstruction optimization. By iteratively calibrating the learned measurements, K2Calibrate can reduce the network's reconstruction deterioration caused by statistically dependent noise. Extensive experiments have been conducted on the open-source dataset FastMRI, and K2Calibrate achieves better results than five state-of-the-art methods. The proposed K2Calibrate is plug-and-play and can be easily integrated with different model-driven deep learning reconstruction methods.

Zhongying Deng, Cheng Tang, Ziyan Huang et al. · pku

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

Hao Yang, Weijian Huang, Jiarun Liu et al.

The ability to incrementally learn new classes from limited samples is crucial to the development of artificial intelligence systems for real clinical application. Although existing incremental learning techniques have attempted to address this issue, they still struggle with only few labeled data, particularly when the samples are from varied domains. In this paper, we explore the cross-domain few-shot incremental learning (CDFSCIL) problem. CDFSCIL requires models to learn new classes from very few labeled samples incrementally, and the new classes may be vastly different from the target space. To counteract this difficulty, we propose a cross-domain enhancement constraint and cross-domain data augmentation method. Experiments on MedMNIST show that the classification performance of this method is better than other similar incremental learning methods.

Zongjiang Tu, Chen Jiang, Yu Guan et al.

Decreasing magnetic resonance (MR) image acquisition times can potentially make MR examinations more accessible. Prior arts including the deep learning models have been devoted to solving the problem of long MRI imaging time. Recently, deep generative models have exhibited great potentials in algorithm robustness and usage flexibility. Nevertheless, none of existing schemes can be learned or employed to the k-space measurement directly. Furthermore, how do the deep generative models work well in hybrid domain is also worth being investigated. In this work, by taking advantage of the deep energy-based models, we propose a k-space and image domain collaborative generative model to comprehensively estimate the MR data from under-sampled measurement. Experimental comparisons with the state-of-the-arts demonstrated that the proposed hybrid method has less error in reconstruction accuracy and is more stable under different acceleration factors

Shanshan Wang, Zhumin Chen, Zhaochun Ren et al.

Pre-trained language models (PLM) have demonstrated their effectiveness for a broad range of information retrieval and natural language processing tasks. As the core part of PLM, multi-head self-attention is appealing for its ability to jointly attend to information from different positions. However, researchers have found that PLM always exhibits fixed attention patterns regardless of the input (e.g., excessively paying attention to [CLS] or [SEP]), which we argue might neglect important information in the other positions. In this work, we propose a simple yet effective attention guiding mechanism to improve the performance of PLM by encouraging attention towards the established goals. Specifically, we propose two kinds of attention guiding methods, i.e., map discrimination guiding (MDG) and attention pattern decorrelation guiding (PDG). The former definitely encourages the diversity among multiple self-attention heads to jointly attend to information from different representation subspaces, while the latter encourages self-attention to attend to as many different positions of the input as possible. We conduct experiments with multiple general pre-trained models (i.e., BERT, ALBERT, and Roberta) and domain-specific pre-trained models (i.e., BioBERT, ClinicalBERT, BlueBert, and SciBERT) on three benchmark datasets (i.e., MultiNLI, MedNLI, and Cross-genre-IR). Extensive experimental results demonstrate that our proposed MDG and PDG bring stable performance improvements on all datasets with high efficiency and low cost.

Zongjiang Tu, Die Liu, Xiaoqing Wang et al.

Deep learning based parallel imaging (PI) has made great progresses in recent years to accelerate magnetic resonance imaging (MRI). Nevertheless, it still has some limitations, such as the robustness and flexibility of existing methods have great deficiency. In this work, we propose a method to explore the k-space domain learning via robust generative modeling for flexible calibration-less PI reconstruction, coined weight-k-space generative model (WKGM). Specifically, WKGM is a generalized k-space domain model, where the k-space weighting technology and high-dimensional space augmentation design are efficiently incorporated for score-based generative model training, resulting in good and robust reconstructions. In addition, WKGM is flexible and thus can be synergistically combined with various traditional k-space PI models, which can make full use of the correlation between multi-coil data and realizecalibration-less PI. Even though our model was trained on only 500 images, experimental results with varying sampling patterns and acceleration factors demonstrate that WKGM can attain state-of-the-art reconstruction results with the well-learned k-space generative prior.

Shanshan Wang, Sugumar Murugesan, Junshan Zhang

We consider a cognitive radio network with multiple primary users (PUs) and one secondary user (SU), where a spectrum server is utilized for spectrum sensing and scheduling the SU to transmit over one of the PU channels opportunistically. One practical yet challenging scenario is when \textit{both} the PU occupancy and the channel fading vary over time and exhibit temporal correlations. Little work has been done for exploiting such temporal memory in the channel fading and the PU occupancy simultaneously for opportunistic spectrum scheduling. A main goal of this work is to understand the intricate tradeoffs resulting from the interactions of the two sets of system states - the channel fading and the PU occupancy, by casting the problem as a partially observable Markov decision process. We first show that a simple greedy policy is optimal in some special cases. To build a clear understanding of the tradeoffs, we then introduce a full-observation genie-aided system, where the spectrum server collects channel fading states from all PU channels. The genie-aided system is used to decompose the tradeoffs in the original system into multiple tiers, which are examined progressively. Numerical examples indicate that the optimal scheduler in the original system, with observation on the scheduled channel only, achieves a performance very close to the genie-aided system. Further, as expected, the optimal policy in the original system significantly outperforms randomized scheduling, pointing to the merit of exploiting the temporal correlation structure in both channel fading and PU occupancy.

Hong Peng, Chen Jiang, Jing Cheng et al.

Magnetic resonance imaging serves as an essential tool for clinical diagnosis. However, it suffers from a long acquisition time. The utilization of deep learning, especially the deep generative models, offers aggressive acceleration and better reconstruction in magnetic resonance imaging. Nevertheless, learning the data distribution as prior knowledge and reconstructing the image from limited data remains challenging. In this work, we propose a novel Hankel-k-space generative model (HKGM), which can generate samples from a training set of as little as one k-space data. At the prior learning stage, we first construct a large Hankel matrix from k-space data, then extract multiple structured k-space patches from the large Hankel matrix to capture the internal distribution among different patches. Extracting patches from a Hankel matrix enables the generative model to be learned from redundant and low-rank data space. At the iterative reconstruction stage, it is observed that the desired solution obeys the learned prior knowledge. The intermediate reconstruction solution is updated by taking it as the input of the generative model. The updated result is then alternatively operated by imposing low-rank penalty on its Hankel matrix and data consistency con-strain on the measurement data. Experimental results confirmed that the internal statistics of patches within a single k-space data carry enough information for learning a powerful generative model and provide state-of-the-art reconstruction.

Juan Zou, Cheng Li, Sen Jia et al.

Lately, deep learning has been extensively investigated for accelerating dynamic magnetic resonance (MR) imaging, with encouraging progresses achieved. However, without fully sampled reference data for training, current approaches may have limited abilities in recovering fine details or structures. To address this challenge, this paper proposes a self-supervised collaborative learning framework (SelfCoLearn) for accurate dynamic MR image reconstruction from undersampled k-space data. The proposed framework is equipped with three important components, namely, dual-network collaborative learning, reunderampling data augmentation and a specially designed co-training loss. The framework is flexible to be integrated with both data-driven networks and model-based iterative un-rolled networks. Our method has been evaluated on in-vivo dataset and compared it to four state-of-the-art methods. Results show that our method possesses strong capabilities in capturing essential and inherent representations for direct reconstructions from the undersampled k-space data and thus enables high-quality and fast dynamic MR imaging.

Jiang Li, Tian Lan, Shanshan Wang et al.

The rapid development of large language models (LLMs) has extended text generation tasks into the literary domain. However, AI-generated literary creations has raised increasingly prominent issues of creative authenticity and ethics in literary world, making the detection of LLM-generated literary texts essential and urgent. While previous works have made significant progress in detecting AI-generated text, it has yet to address classical Chinese poetry. Due to the unique linguistic features of classical Chinese poetry, such as strict metrical regularity, a shared system of poetic imagery, and flexible syntax, distinguishing whether a poem is authored by AI presents a substantial challenge. To address these issues, we introduce ChangAn, a benchmark for detecting LLM-generated classical Chinese poetry that containing total 30,664 poems, 10,276 are human-written poems and 20,388 poems are generated by four popular LLMs. Based on ChangAn, we conducted a systematic evaluation of 12 AI detectors, investigating their performance variations across different text granularities and generation strategies. Our findings highlight the limitations of current Chinese text detectors, which fail to serve as reliable tools for detecting LLM-generated classical Chinese poetry. These results validate the effectiveness and necessity of our proposed ChangAn benchmark. Our dataset and code are available at https://github.com/VelikayaScarlet/ChangAn.

Shanshan Wang, Mamadou Diagne, Miroslav Krstić

Deep neural networks that approximate nonlinear function-to-function mappings, i.e., operators, which are called DeepONet, have been demonstrated in recent articles to be capable of encoding entire PDE control methodologies, such as backstepping, so that, for each new functional coefficient of a PDE plant, the backstepping gains are obtained through a simple function evaluation. These initial results have been limited to single PDEs from a given class, approximating the solutions of only single-PDE operators for the gain kernels. In this paper we expand this framework to the approximation of multiple (cascaded) nonlinear operators. Multiple operators arise in the control of PDE systems from distinct PDE classes, such as the system in this paper: a reaction-diffusion plant, which is a parabolic PDE, with input delay, which is a hyperbolic PDE. The DeepONet-approximated nonlinear operator is a cascade/composition of the operators defined by one hyperbolic PDE of the Goursat form and one parabolic PDE on a rectangle, both of which are bilinear in their input functions and not explicitly solvable. For the delay-compensated PDE backstepping controller, which employs the learned control operator, namely, the approximated gain kernel, we guarantee exponential stability in the $L^2$ norm of the plant state and the $H^1$ norm of the input delay state. Simulations illustrate the contributed theory.

Haoran Li, Cheng Li, Weijian Huang et al.

Brain tumor segmentation based on multi-modal magnetic resonance imaging (MRI) plays a pivotal role in assisting brain cancer diagnosis, treatment, and postoperative evaluations. Despite the achieved inspiring performance by existing automatic segmentation methods, multi-modal MRI data are still unavailable in real-world clinical applications due to quite a few uncontrollable factors (e.g. different imaging protocols, data corruption, and patient condition limitations), which lead to a large performance drop during practical applications. In this work, we propose a Deeply supervIsed knowledGE tranSfer neTwork (DIGEST), which achieves accurate brain tumor segmentation under different modality-missing scenarios. Specifically, a knowledge transfer learning frame is constructed, enabling a student model to learn modality-shared semantic information from a teacher model pretrained with the complete multi-modal MRI data. To simulate all the possible modality-missing conditions under the given multi-modal data, we generate incomplete multi-modal MRI samples based on Bernoulli sampling. Finally, a deeply supervised knowledge transfer loss is designed to ensure the consistency of the teacher-student structure at different decoding stages, which helps the extraction of inherent and effective modality representations. Experiments on the BraTS 2020 dataset demonstrate that our method achieves promising results for the incomplete multi-modal MR image segmentation task.

Yousuf Babiker M. Osman, Cheng Li, Weijian Huang et al.

Volumetric magnetic resonance (MR) image segmentation plays an important role in many clinical applications. Deep learning (DL) has recently achieved state-of-the-art or even human-level performance on various image segmentation tasks. Nevertheless, manually annotating volumetric MR images for DL model training is labor-exhaustive and time-consuming. In this work, we aim to train a semi-supervised and self-supervised collaborative learning framework for prostate 3D MR image segmentation while using extremely sparse annotations, for which the ground truth annotations are provided for just the central slice of each volumetric MR image. Specifically, semi-supervised learning and self-supervised learning methods are used to generate two independent sets of pseudo labels. These pseudo labels are then fused by Boolean operation to extract a more confident pseudo label set. The images with either manual or network self-generated labels are then employed to train a segmentation model for target volume extraction. Experimental results on a publicly available prostate MR image dataset demonstrate that, while requiring significantly less annotation effort, our framework generates very encouraging segmentation results. The proposed framework is very useful in clinical applications when training data with dense annotations are difficult to obtain.

Shanshan Wang, Zhen Zeng, Xun Yang et al.

Cognitive diagnosis is a fundamental yet critical research task in the field of intelligent education, which aims to discover the proficiency level of different students on specific knowledge concepts. Despite the effectiveness of existing efforts, previous methods always considered the mastery level on the whole students, so they still suffer from the Long Tail Effect. A large number of students who have sparse data are performed poorly in the model. To relieve the situation, we proposed a Self-supervised Cognitive Diagnosis (SCD) framework which leverages the self-supervised manner to assist the graph-based cognitive diagnosis, then the performance on those students with sparse data can be improved. Specifically, we came up with a graph confusion method that drops edges under some special rules to generate different sparse views of the graph. By maximizing the consistency of the representation on the same node under different views, the model could be more focused on long-tailed students. Additionally, we proposed an importance-based view generation rule to improve the influence of long-tailed students. Extensive experiments on real-world datasets show the effectiveness of our approach, especially on the students with sparse data.

Lei Xu, Shanshan Wang, Chenglong Xiao

High-Level Synthesis (HLS) design space exploration (DSE) seeks Pareto-optimal designs within expansive pragma configuration spaces. To accelerate HLS DSE, graph neural networks (GNNs) are commonly employed as surrogates for HLS tools to predict quality of results (QoR) metrics, while multi-objective optimization algorithms expedite the exploration. However, GNN-based prediction methods may not fully capture the rich semantic features inherent in behavioral descriptions, and conventional multi-objective optimization algorithms often do not explicitly account for the domain-specific knowledge regarding how pragma directives influence QoR. To address these limitations, this paper proposes the MPM-LLM4DSE framework, which incorporates a multimodal prediction model (MPM) that simultaneously fuses features from behavioral descriptions and control and data flow graphs. Furthermore, the framework employs a large language model (LLM) as an optimizer, accompanied by a tailored prompt engineering methodology. This methodology incorporates pragma impact analysis on QoR to guide the LLM in generating high-quality configurations (LLM4DSE). Experimental results demonstrate that our multimodal predictive model significantly outperforms state-of-the-art work ProgSG by up to 10.25$\times$. Furthermore, in DSE tasks, the proposed LLM4DSE achieves an average performance gain of 39.90\% over prior methods, validating the effectiveness of our prompting methodology. Code and models are available at https://github.com/wslcccc/MPM-LLM4DSE.

Hui Tao, Haifeng Wang, Shanshan Wang et al.

Parallel imaging is widely used in magnetic resonance imaging as an acceleration technology. Traditional linear reconstruction methods in parallel imaging often suffer from noise amplification. Recently, a non-linear robust artificial-neural-network for k-space interpolation (RAKI) exhibits superior noise resilience over other linear methods. However, RAKI performs poorly at high acceleration rates, and needs a large amount of autocalibration signals as the training samples. In order to tackle these issues, we propose a multi-weight method that implements multiple weighting matrices on the undersampled data, named as MW-RAKI. Enforcing multiple weighted matrices on the measurements can effectively reduce the influence of noise and increase the data constraints. Furthermore, we incorporate the strategy of multiple weighting matrixes into a residual version of RAKI, and form MW-rRAKI.Experimental compari-sons with the alternative methods demonstrated noticeably better reconstruction performances, particularly at high acceleration rates.

Shanshan Wang, Derek F. Wong, Jingming Yao et al.

ChatGPT has demonstrated remarkable capabilities on both poetry generation and translation, yet its ability to truly understand poetry remains unexplored. Previous poetry-related work merely analyzed experimental outcomes without addressing fundamental issues of comprehension. This paper introduces a comprehensive framework for evaluating ChatGPT's understanding of modern poetry. We collaborated with professional poets to evaluate ChatGPT's interpretation of modern Chinese poems by different poets along multiple dimensions. Evaluation results show that ChatGPT's interpretations align with the original poets' intents in over 73% of the cases. However, its understanding in certain dimensions, particularly in capturing poeticity, proved to be less satisfactory. These findings highlight the effectiveness and necessity of our proposed framework. This study not only evaluates ChatGPT's ability to understand modern poetry but also establishes a solid foundation for future research on LLMs and their application to poetry-related tasks.

Shanshan Wang, Ziying Feng, Xiaozheng Shen et al.

Source-Free Domain Adaptation (SFDA) tackles the problem of adapting a pre-trained source model to an unlabeled target domain without accessing any source data, which is quite suitable for the field of data security. Although recent advances have shown that pseudo-labeling strategies can be effective, they often fail in fine-grained scenarios due to subtle inter-class similarities. A critical but underexplored issue is the presence of asymmetric and dynamic class confusion, where visually similar classes are unequally and inconsistently misclassified by the source model. Existing methods typically ignore such confusion patterns, leading to noisy pseudo-labels and poor target discrimination. To address this, we propose CLIP-Guided Alignment(CGA), a novel framework that explicitly models and mitigates class confusion in SFDA. Generally, our method consists of three parts: (1) MCA: detects first directional confusion pairs by analyzing the predictions of the source model in the target domain; (2) MCC: leverages CLIP to construct confusion-aware textual prompts (e.g. a truck that looks like a bus), enabling more context-sensitive pseudo-labeling; and (3) FAM: builds confusion-guided feature banks for both CLIP and the source model and aligns them using contrastive learning to reduce ambiguity in the representation space. Extensive experiments on various datasets demonstrate that CGA consistently outperforms state-of-the-art SFDA methods, with especially notable gains in confusion-prone and fine-grained scenarios. Our results highlight the importance of explicitly modeling inter-class confusion for effective source-free adaptation. Our code can be find at https://github.com/soloiro/CGA

Wenxin Fan, Jian Cheng, Cheng Li et al.

Deep learning has shown great potential in accelerating diffusion tensor imaging (DTI). Nevertheless, existing methods tend to suffer from Rician noise and eddy current, leading to detail loss in reconstructing the DTI-derived parametric maps especially when sparsely sampled q-space data are used. To address this, this paper proposes a novel method, AID-DTI (\textbf{A}ccelerating h\textbf{I}gh fi\textbf{D}elity \textbf{D}iffusion \textbf{T}ensor \textbf{I}maging), to facilitate fast and accurate DTI with only six measurements. AID-DTI is equipped with a newly designed Singular Value Decomposition-based regularizer, which can effectively capture fine details while suppressing noise during network training by exploiting the correlation across DTI-derived parameters. Additionally, we introduce a Nesterov-based adaptive learning algorithm that optimizes the regularization parameter dynamically to enhance the performance. AID-DTI is an extendable framework capable of incorporating flexible network architecture. Experimental results on Human Connectome Project (HCP) data consistently demonstrate that the proposed method estimates DTI parameter maps with fine-grained details and outperforms other state-of-the-art methods both quantitatively and qualitatively.

Xue Liu, Juan Zou, Xiawu Zheng et al.

Magnetic Resonance Imaging (MRI) has become an important technique in the clinic for the visualization, detection, and diagnosis of various diseases. However, one bottleneck limitation of MRI is the relatively slow data acquisition process. Fast MRI based on k-space undersampling and high-quality image reconstruction has been widely utilized, and many deep learning-based methods have been developed in recent years. Although promising results have been achieved, most existing methods require fully-sampled reference data for training the deep learning models. Unfortunately, fully-sampled MRI data are difficult if not impossible to obtain in real-world applications. To address this issue, we propose a data refinement framework for self-supervised MR image reconstruction. Specifically, we first analyze the reason of the performance gap between self-supervised and supervised methods and identify that the bias in the training datasets between the two is one major factor. Then, we design an effective self-supervised training data refinement method to reduce this data bias. With the data refinement, an enhanced self-supervised MR image reconstruction framework is developed to prompt accurate MR imaging. We evaluate our method on an in-vivo MRI dataset. Experimental results show that without utilizing any fully sampled MRI data, our self-supervised framework possesses strong capabilities in capturing image details and structures at high acceleration factors.

Cheng Li, Yousuf Babiker M. Osman, Weijian Huang et al.

Multi-parametric magnetic resonance (MR) imaging is an indispensable tool in the clinic. Consequently, automatic volume-of-interest segmentation based on multi-parametric MR imaging is crucial for computer-aided disease diagnosis, treatment planning, and prognosis monitoring. Despite the extensive studies conducted in deep learning-based medical image analysis, further investigations are still required to effectively exploit the information provided by different imaging parameters. How to fuse the information is a key question in this field. Here, we propose an uncertainty-aware multi-parametric MR image feature fusion method to fully exploit the information for enhanced 3D image segmentation. Uncertainties in the independent predictions of individual modalities are utilized to guide the fusion of multi-modal image features. Extensive experiments on two datasets, one for brain tissue segmentation and the other for abdominal multi-organ segmentation, have been conducted, and our proposed method achieves better segmentation performance when compared to existing models.

Yeqi Wang, Weijian Huang, Cheng Li et al.

Multi-contrast magnetic resonance imaging (MRI)-based automatic auxiliary glioma diagnosis plays an important role in the clinic. Contrast-enhanced MRI sequences (e.g., contrast-enhanced T1-weighted imaging) were utilized in most of the existing relevant studies, in which remarkable diagnosis results have been reported. Nevertheless, acquiring contrast-enhanced MRI data is sometimes not feasible due to the patients physiological limitations. Furthermore, it is more time-consuming and costly to collect contrast-enhanced MRI data in the clinic. In this paper, we propose an adaptive PromptNet to address these issues. Specifically, a PromptNet for glioma grading utilizing only non-enhanced MRI data has been constructed. PromptNet receives constraints from features of contrast-enhanced MR data during training through a designed prompt loss. To further boost the performance, an adaptive strategy is designed to dynamically weight the prompt loss in a sample-based manner. As a result, PromptNet is capable of dealing with more difficult samples. The effectiveness of our method is evaluated on a widely-used BraTS2020 dataset, and competitive glioma grading performance on NE-MRI data is achieved.

Shanshan Wang, Fengying Ye, Hanjia Lyu et al.

Previous detection studies have shown that LLMs cannot be effectively used as detectors, but these studies have not addressed modern Chinese poetry. Moreover, no relevant research has explored the performance of LLMs in detecting modern Chinese poetry. This paper evaluates and enhances the performance of LLMs as detectors for modern Chinese poetry, and proposes an image-semantic guided poetry detection method. Compared with traditional detection approaches, our method innovatively incorporates images that reflect the content of the poetry. Through example-driven approaches, our method effectively integrates information such as meaning, imagery, and feeling from the image, then forms a complementary judgment with the poem text. Experimental results demonstrate that the LLM detectors based on our method outperform baseline detectors based on plain text, and even surpass the best-performing traditional detector, RoBERTa. The Gemini detector using our method achieves a Macro-F1 score of 85.65%, reaching the state-of-the-art level. The performance improvements of different LLM detectors on multiple LLMs-generated data prove the effectiveness of our method.

Wenqiang Huang, Susu Fang, Xuhang Gu et al.

Exemplified by the chemical vapor deposition growth of two-dimensional dendrites, which has potential applications in catalysis and presents a parameter-intensive, data-scarce and reaction process-complex model problem, we devise a machine intelligence-empowered framework for the full chain support of material synthesis, encompassing rapid process optimization, accurate customized synthesis, and comprehensive mechanism deciphering.First, active learning is integrated into the experimental workflow, identifying an optimal recipe for the growth of highly-branched, electrocatalytically-active ReSe2 dendrites through 60 experiments (4 iterations), which account for less than 1.3% of the numerous possible parameter combinations.Then, a prediction accuracy-guided data augmentation strategy is developed combined with a tree-based machine learning (ML) algorithm, unveiling a non-linear correlation between 5 process variables and fractal dimension (DF) of ReSe2 dendrites with only 9 experiment additions, which guides the synthesis of various user-defined DF. Finally, we construct a data-knowledge dual-driven mechanism model by integration of cross-scale characterizations, interpretable ML models, and domain knowledge in thermodynamics and kinetics, unraveling synergistic contributions of multiple process parameters to the product morphology. This work demonstrates the ML potential to transform the research paradigm and is adaptable to broader material synthesis.

Taohui Xiao, Jian Cheng, Wenxin Fan et al.

Neurite Orientation Dispersion and Density Imaging (NODDI) is an important imaging technology used to evaluate the microstructure of brain tissue, which is of great significance for the discovery and treatment of various neurological diseases. Current deep learning-based methods perform parameter estimation through diffusion magnetic resonance imaging (dMRI) with a small number of diffusion gradients. These methods speed up parameter estimation and improve accuracy. However, the diffusion directions used by most existing deep learning models during testing needs to be strictly consistent with the diffusion directions during training. This results in poor generalization and robustness of deep learning models in dMRI parameter estimation. In this work, we verify for the first time that the parameter estimation performance of current mainstream methods will significantly decrease when the testing diffusion directions and the training diffusion directions are inconsistent. A robust NODDI parameter estimation method with adaptive sampling under continuous representation (RobNODDI) is proposed. Furthermore, long short-term memory (LSTM) units and fully connected layers are selected to learn continuous representation signals. To this end, we use a total of 100 subjects to conduct experiments based on the Human Connectome Project (HCP) dataset, of which 60 are used for training, 20 are used for validation, and 20 are used for testing. The test results indicate that RobNODDI improves the generalization performance and robustness of the deep learning model, enhancing the stability and flexibility of deep learning NODDI parameter estimatimation applications.

Cheng Li, Weijian Huang, Jiarun Liu et al.

The integration of medical imaging and clinical text has enabled the emergence of generalist artificial intelligence (AI) systems for healthcare. However, pervasive biases, such as imbalanced disease prevalence, skewed anatomical region distributions, heterogeneous imaging protocols, and demographic disparities, pose significant challenges to the fairness and reliability of vision-language systems in real-world clinical settings. Here we present BiasCareVL, a bias-aware multimodal learning framework that introduces bias control directly into model design, rather than treating it as a post hoc correction. BiasCareVL incorporates adaptive uncertainty modeling with optional human-in-the-loop refinement to regulate the influence of dominant data patterns and to promote equitable reasoning under distributional imbalance. Trained on 3.44 million samples spanning over 15 imaging modalities, the framework supports diverse clinical tasks, including visual question answering, disease classification, segmentation, and report generation within a unified representation space. Across eight public benchmarks covering dermatology, oncology, radiology, and pathology, BiasCareVL consistently outperforms 20 state-of-the-art methods, with pronounced gains in clinically challenging scenarios, including over 10% accuracy improvement in multi-class skin lesion diagnosis and more than 20% Dice improvement in small tumor segmentation. Furthermore, BiasCareVL achieves diagnostic performance exceeding human accuracy with substantially reduced time requirements when evaluated with board-certified radiologists. By open-sourcing BiasCareVL, we aim to promote a transparent, reproducible, and equitable future for AI in healthcare, paving the way for general-purpose, trustworthy, and clinically reliable AI systems.

Dian Xu, Shanshan Wang, Weibing Deng et al.

The application of machine learning in the study of phase transitions has achieved remarkable success in both equilibrium and non-equilibrium systems. It is widely recognized that unsupervised learning can retrieve phase transition information through hidden variables. However, using unsupervised methods to identify the critical point of percolation models has remained an intriguing challenge. This paper suggests that, by inputting the largest cluster rather than the original configuration into the learning model, unsupervised learning can indeed predict the critical point of the percolation model. Furthermore, we observe that when the largest cluster configuration is randomly shuffled-altering the positions of occupied sites or bonds-there is no significant difference in the output compared to learning the largest cluster configuration directly. This finding suggests a more general principle: unsupervised learning primarily captures particle density, or more specifically, occupied site density. However, shuffling does impact the formation of the largest cluster, which is directly related to phase transitions. As randomness increases, we observe that the correlation length tends to decrease, providing direct evidence of this relationship. We also propose a method called Fake Finite Size Scaling (FFSS) to calculate the critical value, which improves the accuracy of fitting to a great extent.

Shahab Aslani, Mehran Azimbagirad, Daryl Cheng et al.

Background: Pleuroparenchymal fibroelastosis (PPFE) is an upper lobe predominant fibrotic lung abnormality associated with increased mortality in established interstitial lung disease. However, the clinical significance of radiologic PPFE progression in lung cancer screening populations remains unclear. We investigated whether longitudinal change in PPFE quantified on low dose CT independently associates with mortality and respiratory morbidity. Methods: We analysed longitudinal low-dose CT scans and clinical data from two lung cancer screening studies: the National Lung Screening Trial (NLST; n=7980) and the SUMMIT study (n=8561). An automated algorithm quantified PPFE volume on baseline and follow up scans. Annualised change in PPFE (dPPFE) was derived and dichotomised using a distribution based threshold to define progressive PPFE. Associations between dPPFE and mortality were evaluated using Cox proportional hazards models adjusted for demographic and clinical variables. In the SUMMIT cohort, dPPFE was also examined in relation to clinical outcomes. Findings: dPPFE independently associated with mortality in both cohorts (NLST: HR 1.25, 95% CI 1.01-1.56, p=0.042; SUMMIT: HR 3.14, 95% CI 1.66-5.97, p<0.001). Kaplan-Meier curves showed reduced survival among participants with progressive PPFE in both cohorts. In SUMMIT, dPPFE was associated with higher respiratory admissions (IRR 2.79, p<0.001), increased antibiotic and steroid use (IRR 1.55, p=0.010), and a trend towards higher mMRC scores (OR 1.40, p=0.055). Interpretation: Radiologic PPFE progression independently associates with mortality across two large lung cancer screening cohorts and with adverse clinical outcomes. Quantitative assessment of PPFE progression may provide a clinically relevant imaging biomarker for identifying individuals at increased respiratory risk within screening programmes.

Weijian Huang, Cheng Li, Hong-Yu Zhou et al.

The development of medical vision-language foundation models has attracted significant attention in the field of medicine and healthcare due to their promising prospect in various clinical applications. While previous studies have commonly focused on feature learning at a single learning scale, investigation on integrating multi-scale information is lacking, which may hinder the potential for mutual reinforcement among these features. This paper aims to bridge this gap by proposing a method that effectively exploits multi-scale information to enhance the performance of medical foundation models. The proposed method simultaneously exploits features at the local, instance, modality and global aspects, facilitating comprehensive representation learning within the models. We evaluate the effectiveness of the proposed method on six open-source datasets across different clinical tasks, demonstrating its ability to enhance the performance of medical foundation models.

Haiqin Xie, Cheng Wang, Shicheng Li et al.

In the realm of urban transportation, metro systems serve as crucial and sustainable means of public transit. However, their substantial energy consumption poses a challenge to the goal of sustainability. Disturbances such as delays and passenger flow changes can further exacerbate this issue by negatively affecting energy efficiency in metro systems. To tackle this problem, we propose a policy-based reinforcement learning approach that reschedules the metro timetable and optimizes energy efficiency in metro systems under disturbances by adjusting the dwell time and cruise speed of trains. Our experiments conducted in a simulation environment demonstrate the superiority of our method over baseline methods, achieving a traction energy consumption reduction of up to 10.9% and an increase in regenerative braking energy utilization of up to 47.9%. This study provides an effective solution to the energy-saving problem of urban rail transit.

Shanshan Wang, Chun Zhang, Ning Zhang

The Knowledge Graph-to-Text Generation task aims to convert structured knowledge graphs into coherent and human-readable natural language text. Recent efforts in this field have focused on enhancing pre-trained language models (PLMs) by incorporating graph structure information to capture the intricate structure details of knowledge graphs. However, most of these approaches tend to capture only single-granularity structure information, concentrating either on the relationships between entities within the original graph or on the relationships between words within the same entity or across different entities. This narrow focus results in a significant limitation: models that concentrate solely on entity-level structure fail to capture the nuanced semantic relationships between words, while those that focus only on word-level structure overlook the broader relationships between original entire entities. To overcome these limitations, this paper introduces the Multi-granularity Graph Structure Attention (MGSA), which is based on PLMs. The encoder of the model architecture features an entity-level structure encoding module, a word-level structure encoding module, and an aggregation module that synthesizes information from both structure. This multi-granularity structure encoding approach allows the model to simultaneously capture both entity-level and word-level structure information, providing a more comprehensive understanding of the knowledge graph's structure information, thereby significantly improving the quality of the generated text. We conducted extensive evaluations of the MGSA model using two widely recognized KG-to-Text Generation benchmark datasets, WebNLG and EventNarrative, where it consistently outperformed models that rely solely on single-granularity structure information, demonstrating the effectiveness of our approach.

Jiarun Liu, Hao Yang, Hong-Yu Zhou et al.

Accurate medical image segmentation demands the integration of multi-scale information, spanning from local features to global dependencies. However, it is challenging for existing methods to model long-range global information, where convolutional neural networks (CNNs) are constrained by their local receptive fields, and vision transformers (ViTs) suffer from high quadratic complexity of their attention mechanism. Recently, Mamba-based models have gained great attention for their impressive ability in long sequence modeling. Several studies have demonstrated that these models can outperform popular vision models in various tasks, offering higher accuracy, lower memory consumption, and less computational burden. However, existing Mamba-based models are mostly trained from scratch and do not explore the power of pretraining, which has been proven to be quite effective for data-efficient medical image analysis. This paper introduces a novel Mamba-based model, Swin-UMamba, designed specifically for medical image segmentation tasks, leveraging the advantages of ImageNet-based pretraining. Our experimental results reveal the vital role of ImageNet-based training in enhancing the performance of Mamba-based models. Swin-UMamba demonstrates superior performance with a large margin compared to CNNs, ViTs, and latest Mamba-based models. Notably, on AbdomenMRI, Encoscopy, and Microscopy datasets, Swin-UMamba outperforms its closest counterpart U-Mamba_Enc by an average score of 2.72%.

Jincai Huang, Shihao Zou, Yuchen Guo et al.

Surgical scene understanding is a cornerstone of computer-assisted intervention. While recent advances, particularly in surgical image segmentation, have driven progress, real-world clinical applications require a more holistic understanding that jointly captures procedural context, semantic reasoning, and precise visual grounding. However, existing approaches typically address these components in isolation, leading to fragmented representations and limited semantic consistency. To address this limitation, we propose SurgMLLM, a unified surgical scene understanding framework that bridges high-level reasoning and low-level visual grounding within a single model. Given surgical videos, SurgMLLM fine-tunes a multimodal large language model (MLLM) to support structured interpretability reasoning, which is used to jointly model phases, instrument-verb-target (IVT) triplets, and triplet-entity segmentation tokens. These tokens are then temporally aggregated and serve as prompts for a segmentation network, enabling accurate pixel-wise grounding of triplet instruments and targets. The entire framework is trained end-to-end with a unified objective that couples language-based reasoning supervision with visual grounding losses, promoting coherent cross-task learning and clinically consistent scene representations. To facilitate unified evaluation, we introduce CholecT45-Scene, extending CholecT45 dataset with 64,299 frames of pixel-level mask annotations for instruments and targets, aligned with existing triplet labels. Extensive experiments show that SurgMLLM significantly advances surgical scene understanding, improving the primary triplet recognition metric AP_IVT from 40.7% to 46.0% and consistently outperforming prior methods in phase recognition and segmentation. These results highlight the effectiveness of unified reasoning-and-grounding for reliable, context-aware surgical assistance.

Lei Xu, Shanshan Wang, Chenglong Xiao

High-Level Synthesis (HLS) is a pivotal electronic design automation (EDA) technology that enables the generation of hardware circuits from high-level language descriptions. A critical step in HLS is Design Space Exploration (DSE), which seeks to identify high-quality hardware architectures under given constraints. However, the enormous size of the design space makes DSE computationally prohibitive. Although numerous algorithms have been proposed to accelerate DSE, our extensive experimental studies reveal that no single algorithm consistently achieves Pareto dominance across all problem instances. Consequently, the inability of any single algorithm to dominate all benchmarks necessitates an automated selection mechanism to identify the best-performing DSE algorithm for each specific case. To address this challenge, we propose the SoberDSE framework, which recommends suitable algorithm based on benchmark characteristics. Experimental results demonstrate that our SoberDSE framework significantly outperforms state-of-the-art heuristic-based DSE algorithms by up to 5.7 $\times$ and state-of-the-art learning-based DSE methods by up to 4.2 $\times$. Furthermore, compared to conventional classification models, SoberDSE delivers superior accuracy in small-sample learning scenarios, with an average enhancement of 35.57\%. Code and models are available at https://anonymous.4open.science/r/Sober-4377.

Alou Diakite, Cheng Li, Lei Xie et al.

Recent research has shown the potential of deep learning in multi-parametric MRI-based visual pathway (VP) segmentation. However, obtaining labeled data for training is laborious and time-consuming. Therefore, it is crucial to develop effective algorithms in situations with limited labeled samples. In this work, we propose a label-efficient deep learning method with self-ensembling (LESEN). LESEN incorporates supervised and unsupervised losses, enabling the student and teacher models to mutually learn from each other, forming a self-ensembling mean teacher framework. Additionally, we introduce a reliable unlabeled sample selection (RUSS) mechanism to further enhance LESEN's effectiveness. Our experiments on the human connectome project (HCP) dataset demonstrate the superior performance of our method when compared to state-of-the-art techniques, advancing multimodal VP segmentation for comprehensive analysis in clinical and research settings. The implementation code will be available at: https://github.com/aldiak/Semi-Supervised-Multimodal-Visual-Pathway- Delineation.

Chen Hu, Cheng Li, Haifeng Wang et al.

Image reconstruction from undersampled k-space data plays an important role in accelerating the acquisition of MR data, and a lot of deep learning-based methods have been exploited recently. Despite the achieved inspiring results, the optimization of these methods commonly relies on the fully-sampled reference data, which are time-consuming and difficult to collect. To address this issue, we propose a novel self-supervised learning method. Specifically, during model optimization, two subsets are constructed by randomly selecting part of k-space data from the undersampled data and then fed into two parallel reconstruction networks to perform information recovery. Two reconstruction losses are defined on all the scanned data points to enhance the network's capability of recovering the frequency information. Meanwhile, to constrain the learned unscanned data points of the network, a difference loss is designed to enforce consistency between the two parallel networks. In this way, the reconstruction model can be properly trained with only the undersampled data. During the model evaluation, the undersampled data are treated as the inputs and either of the two trained networks is expected to reconstruct the high-quality results. The proposed method is flexible and can be employed in any existing deep learning-based method. The effectiveness of the method is evaluated on an open brain MRI dataset. Experimental results demonstrate that the proposed self-supervised method can achieve competitive reconstruction performance compared to the corresponding supervised learning method at high acceleration rates (4 and 8). The code is publicly available at \url{https://github.com/chenhu96/Self-Supervised-MRI-Reconstruction}.

Shanshan Wang, Cheng Li, Rongpin Wang et al.

Automatic medical image segmentation plays a critical role in scientific research and medical care. Existing high-performance deep learning methods typically rely on large training datasets with high-quality manual annotations, which are difficult to obtain in many clinical applications. Here, we introduce Annotation-effIcient Deep lEarning (AIDE), an open-source framework to handle imperfect training datasets. Methodological analyses and empirical evaluations are conducted, and we demonstrate that AIDE surpasses conventional fully-supervised models by presenting better performance on open datasets possessing scarce or noisy annotations. We further test AIDE in a real-life case study for breast tumor segmentation. Three datasets containing 11,852 breast images from three medical centers are employed, and AIDE, utilizing 10% training annotations, consistently produces segmentation maps comparable to those generated by fully-supervised counterparts or provided by independent radiologists. The 10-fold enhanced efficiency in utilizing expert labels has the potential to promote a wide range of biomedical applications.

Yu Gong, Hongming Shan, Yueyang Teng et al.

Due to the widespread use of positron emission tomography (PET) in clinical practice, the potential risk of PET-associated radiation dose to patients needs to be minimized. However, with the reduction in the radiation dose, the resultant images may suffer from noise and artifacts that compromise diagnostic performance. In this paper, we propose a parameter-transferred Wasserstein generative adversarial network (PT-WGAN) for low-dose PET image denoising. The contributions of this paper are twofold: i) a PT-WGAN framework is designed to denoise low-dose PET images without compromising structural details, and ii) a task-specific initialization based on transfer learning is developed to train PT-WGAN using trainable parameters transferred from a pretrained model, which significantly improves the training efficiency of PT-WGAN. The experimental results on clinical data show that the proposed network can suppress image noise more effectively while preserving better image fidelity than recently published state-of-the-art methods. We make our code available at https://github.com/90n9-yu/PT-WGAN.

Hao Yang, Weijian Huang, Kehan Qi et al.

Segmenting stroke lesions from T1-weighted MR images is of great value for large-scale stroke rehabilitation neuroimaging analyses. Nevertheless, there are great challenges with this task, such as large range of stroke lesion scales and the tissue intensity similarity. The famous encoder-decoder convolutional neural network, which although has made great achievements in medical image segmentation areas, may fail to address these challenges due to the insufficient uses of multi-scale features and context information. To address these challenges, this paper proposes a Cross-Level fusion and Context Inference Network (CLCI-Net) for the chronic stroke lesion segmentation from T1-weighted MR images. Specifically, a Cross-Level feature Fusion (CLF) strategy was developed to make full use of different scale features across different levels; Extending Atrous Spatial Pyramid Pooling (ASPP) with CLF, we have enriched multi-scale features to handle the different lesion sizes; In addition, convolutional long short-term memory (ConvLSTM) is employed to infer context information and thus capture fine structures to address the intensity similarity issue. The proposed approach was evaluated on an open-source dataset, the Anatomical Tracings of Lesions After Stroke (ATLAS) with the results showing that our network outperforms five state-of-the-art methods. We make our code and models available at https://github.com/YH0517/CLCI_Net.

Kehan Qi, Hao Yang, Cheng Li et al.

The morbidity of brain stroke increased rapidly in the past few years. To help specialists in lesion measurements and treatment planning, automatic segmentation methods are critically required for clinical practices. Recently, approaches based on deep learning and methods for contextual information extraction have served in many image segmentation tasks. However, their performances are limited due to the insufficient training of a large number of parameters, which sometimes fail in capturing long-range dependencies. To address these issues, we propose a depthwise separable convolution based X-Net that designs a nonlocal operation namely Feature Similarity Module (FSM) to capture long-range dependencies. The adopted depthwise convolution allows to reduce the network size, while the developed FSM provides a more effective, dense contextual information extraction and thus facilitates better segmentation. The effectiveness of X-Net was evaluated on an open dataset Anatomical Tracings of Lesions After Stroke (ATLAS) with superior performance achieved compared to other six state-of-the-art approaches. We make our code and models available at https://github.com/Andrewsher/X-Net.

Lei Zhang, Shanshan Wang, Guang-Bin Huang et al.

In many practical transfer learning scenarios, the feature distribution is different across the source and target domains (i.e. non-i.i.d.). Maximum mean discrepancy (MMD), as a domain discrepancy metric, has achieved promising performance in unsupervised domain adaptation (DA). We argue that MMD-based DA methods ignore the data locality structure, which, to some extent, would cause the negative transfer effect. The locality plays an important role in minimizing the nonlinear local domain discrepancy underlying the marginal distributions. For better exploiting the domain locality, a novel local generative discrepancy metric (LGDM) based intermediate domain generation learning called Manifold Criterion guided Transfer Learning (MCTL) is proposed in this paper. The merits of the proposed MCTL are four-fold: 1) the concept of manifold criterion (MC) is first proposed as a measure validating the distribution matching across domains, and domain adaptation is achieved if the MC is satisfied; 2) the proposed MC can well guide the generation of the intermediate domain sharing similar distribution with the target domain, by minimizing the local domain discrepancy; 3) a global generative discrepancy metric (GGDM) is presented, such that both the global and local discrepancy can be effectively and positively reduced; 4) a simplified version of MCTL called MCTL-S is presented under a perfect domain generation assumption for more generic learning scenario. Experiments on a number of benchmark visual transfer tasks demonstrate the superiority of the proposed manifold criterion guided generative transfer method, by comparing with other state-of-the-art methods. The source code is available in https://github.com/wangshanshanCQU/MCTL.

Mengzhu Wang, Changyuan Deng, Shanshan Wang et al.

Single Domain Generalization (SDG) for object detection aims to train a model on a single source domain that can generalize effectively to unseen target domains. While recent methods like CLIP-based semantic augmentation have shown promise, they often overlook the underlying structure of feature distributions and frequency-domain characteristics that are critical for robustness. In this paper, we propose a novel framework that enhances SDG object detection by integrating the von Mises-Fisher (vMF) distribution and Fourier transformation into a CLIP-guided pipeline. Specifically, we model the directional features of object representations using vMF to better capture domain-invariant semantic structures in the embedding space. Additionally, we introduce a Fourier-based augmentation strategy that perturbs amplitude and phase components to simulate domain shifts in the frequency domain, further improving feature robustness. Our method not only preserves the semantic alignment benefits of CLIP but also enriches feature diversity and structural consistency across domains. Extensive experiments on the diverse weather-driving benchmark demonstrate that our approach outperforms the existing state-of-the-art method.

Hanwen Shen, Ting Ying, Jiajie Lu et al.

Although debiased LLMs perform well on known bias patterns, they often fail to generalize to unfamiliar bias prompts, producing toxic outputs. We first validate that such high-bias prompts constitute a \emph{distribution shift} via OOD detection, and show static models degrade under this shift. To adapt on-the-fly, we propose \textbf{CAP-TTA}, a test-time adaptation framework that performs context-aware LoRA updates only when the bias-risk \emph{trigger} exceeds a threshold, using a precomputed diagonal \emph{preconditioner} for fast and stable updates. Across toxic-prompt settings and benchmarks, CAP-TTA reduces bias (confirmed by human evaluation) while achieving much lower update latency than AdamW/SGD; it also mitigates catastrophic forgetting by significantly improving narrative fluency over SOTA debiasing baseline while maintaining comparable debiasing effectiveness.

Shanshan Wang, Mamadou Diagne, Miroslav Krstić

Deep neural network approximation of nonlinear operators, commonly referred to as DeepONet, has proven capable of approximating PDE backstepping designs in which a single Goursat-form PDE governs a single feedback gain function. In boundary control of coupled PDEs, coupled Goursat-form PDEs govern two or more gain kernels-a PDE structure unaddressed thus far with DeepONet. In this paper, we explore the subject of approximating systems of gain kernel PDEs for hyperbolic PDE plants by considering a simple counter-convecting $2\times 2$ coupled system in whose control a $2\times 2$ kernel PDE system in Goursat form arises. Engineering applications include oil drilling, the Saint-Venant model of shallow water waves, and the Aw-Rascle-Zhang model of stop-and-go instability in congested traffic flow. We establish the continuity of the mapping from a total of five plant PDE functional coefficients to the kernel PDE solutions, prove the existence of an arbitrarily close DeepONet approximation to the kernel PDEs, and ensure that the DeepONet-approximated gains guarantee stabilization when replacing the exact backstepping gain kernels. Taking into account anti-collocated boundary actuation and sensing, our $L^2$-Globally-exponentially stabilizing (GES) approximate gain kernel-based output feedback design implies the deep learning of both the controller's and the observer's gains. Moreover, the encoding of the output-feedback law into DeepONet ensures semi-global practical exponential stability (SG-PES). The DeepONet operator speeds up the computation of the controller gains by multiple orders of magnitude. Its theoretically proven stabilizing capability is demonstrated through simulations.

Jiarun Liu, Hong-Yu Zhou, Cheng Li et al.

Existing contrastive language-image pre-training aims to learn a joint representation by matching abundant image-text pairs. However, the number of image-text pairs in medical datasets is usually orders of magnitude smaller than that in natural datasets. Besides, medical image-text pairs often involve numerous complex fine-grained correspondences. This paper aims to enhance the data efficiency by introducing multiple-to-multiple local relationship modeling to capture denser supervisions. More specifically, we propose a Medical Language-Image Pre-training (MLIP) framework, which exploits the limited image-text medical data more efficiently through patch-sentence matching. Furthermore, we introduce a masked contrastive learning strategy with semantic integrity estimation to reduce redundancy in images while preserving the underlying semantics. Our evaluation results show that MLIP outperforms previous work in zero/few-shot classification and few-shot segmentation tasks by a large margin.

Shaikat Galib, Shanshan Wang, Guanshuo Xu et al.

Smaller vision-language models (VLMs) are becoming increasingly important for privacy-focused, on-device applications due to their ability to run efficiently on consumer hardware for processing enterprise commercial documents and images. These models require strong language understanding and visual capabilities to enhance human-machine interaction. To address this need, we present H2OVL-Mississippi, a pair of small VLMs trained on 37 million image-text pairs using 240 hours of compute on 8 x H100 GPUs. H2OVL-Mississippi-0.8B is a tiny model with 0.8 billion parameters that specializes in text recognition, achieving state of the art performance on the Text Recognition portion of OCRBench and surpassing much larger models in this area. Additionally, we are releasing H2OVL-Mississippi-2B, a 2 billion parameter model for general use cases, exhibiting highly competitive metrics across various academic benchmarks. Both models build upon our prior work with H2O-Danube language models, extending their capabilities into the visual domain. We release them under the Apache 2.0 license, making VLMs accessible to everyone, democratizing document AI and visual LLMs.