Sandeep Gupta

Farhat Shaikh, Ayan Banerjee, Sandeep Gupta

We introduce EMMA, a physics-informed multimodal framework that recovers all identifiable dynamical parameters of a system directly from raw video, audio, and image-based time-series observations. Unlike prior video-only approaches that struggle with occluded states, hidden actuation inputs, or assumptions about known initial conditions and coordinate frames, EMMA performs joint inference of explicit parameters, implicit dynamical components, and calibration invariants within a unified continuous-time model. EMMA leverages a Liquid Time-Constant (LTC) network to learn latent dynamics from heterogeneous modalities while a physics-constrained loss enforces consistency with the governing differential equations. A unified feature pipeline enables consistent alignment across video trajectories, acoustic signatures, and chart-derived measurements, allowing EMMA to estimate parameters under forced, implicit, and multivariate dynamics without requiring segmentation masks, differentiable rendering, or specialized sensors. Across 100+ scenarios including five standard dynamical benchmarks (75 Delfys videos), real-world rover and quadrotor systems with hidden inputs, and simulation-chart case studies spanning biological and chaotic systems, EMMA delivers robust multi-parameter recovery and significantly outperforms existing single-modality and equation-discovery baselines. Our results establish EMMA as a general, scalable solution for physics-consistent model extraction from opportunistic multimodal data. Code and data are available at: https://github.com/ImpactLabASU/EMMA-CVPR2026

Aranyak Maity, Ayan Banerjee, Sandeep Gupta

Unknown-unknowns are operational scenarios in systems that are not accounted for in the design and test phase. In such scenarios, the operational behavior of the Human-in-loop (HIL) Human-in-Plant (HIP) systems is not guaranteed to meet requirements such as safety and efficacy. We propose a novel framework for analyzing the operational output characteristics of safety-critical HIL-HIP systems that can discover unknown-unknown scenarios and evaluate potential safety hazards. We propose dynamics-induced hybrid recurrent neural networks (DiH-RNN) to mine a physics-guided surrogate model (PGSM) that checks for deviation of the cyber-physical system (CPS) from safety-certified operational characteristics. The PGSM enables early detection of unknown-unknowns based on the physical laws governing the system. We demonstrate the detection of operational changes in an Artificial Pancreas(AP) due to unknown insulin cartridge errors.

Shubhendra Pal Singhal, Sandeep Gupta, Pierluigi Nuzzo

This paper focuses on the explanation of the architecture of profilers particularly gprof and how to profile a program according to the user defined input of execution time . Gprof is a profiler available open source in the package of binutils. Gprof records the flow of the program including the callee and caller information and their respective execution time. This information is represented in the form of a call graph. Profilers at the time of execution creates a call graph file which indicates the full flow of the program including the individual execution time as well. This paper aims at providing a better understanding of the data structure used to store the information and how is a profiler(gprof) actually using this data structure to give user a readable format. The next section of this paper solves one of the limitation of gprof i.e. edit the time of block of code without understanding the call graph. Any changes in the execution time of a particular block of code would affect the total execution time. So if we edit the gprof in such a way that its consistent and platform independent, then it can yield various results like testing execution time after parallelism, before even designing it by replacing the values with theoretical/emulated ones and see if the total execution time is getting reduced by a desired number or not? Gprof edit can help us figure out that what section of code can be parallelized or which part of code is taking the most time and which call or part can be changed to reduce the execution time. The last section of the paper walks through the application of gprof in minisat and how gprof helps in the hardware acceleration in minisat by suggesting which part to be parallelised and how does it affect the total percentage.

Midhat Urooj, Ayan Banerjee, Farhat Shaikh et al.

Accurate and interpretable image-based diagnosis remains a fundamental challenge in medical AI, particularly un- der domain shifts and rare-class conditions. Deep learning mod- els often struggle with real-world distribution changes, exhibit bias against infrequent pathologies, and lack the transparency required for deployment in safety-critical clinical environments. We introduce MedXAI (An Explainable Framework for Med- ical Imaging Classification), a unified expert knowledge based framework that integrates deep vision models with clinician- derived expert knowledge to improve generalization, reduce rare- class bias, and provide human-understandable explanations by localizing the relevant diagnostic features rather than relying on technical post-hoc methods (e.g., Saliency Maps, LIME). We evaluate MedXAI across heterogeneous modalities on two challenging tasks: (i) Seizure Onset Zone localization from resting-state fMRI, and (ii) Diabetic Retinopathy grading. Ex periments on ten multicenter datasets show consistent gains, including a 3% improvement in cross-domain generalization and a 10% improvmnet in F1 score of rare class, substantially outperforming strong deep learning baselines. Ablations confirm that the symbolic components act as effective clinical priors and regularizers, improving robustness under distribution shift. MedXAI delivers clinically aligned explanations while achieving superior in-domain and cross-domain performance, particularly for rare diseases in multimodal medical AI.

Bin Xu, Ayan Banerjee, Sandeep Gupta

Physical AI at the edge -- enabling autonomous systems to understand and predict real-world dynamics in real time -- requires hardware-efficient learning and inference. Model recovery (MR), which identifies governing equations from sensor data, is a key primitive for safe and explainable monitoring in mission-critical autonomous systems operating under strict latency, compute, and power constraints. However, state-of-the-art MR methods (e.g., EMILY and PINN+SR) rely on Neural ODE formulations that require iterative solvers and are difficult to accelerate efficiently on edge hardware. We present \textbf{MERINDA} (Model Recovery in Reconfigurable Dynamic Architecture), an FPGA-accelerated MR framework designed to make physical AI practical on resource-constrained devices. MERINDA replaces expensive Neural ODE components with a hardware-friendly formulation that combines (i) GRU-based discretized dynamics, (ii) dense inverse-ODE layers, (iii) sparsity-driven dropout, and (iv) lightweight ODE solvers. The resulting computation is structured for streaming parallelism, enabling critical kernels to be fully parallelized on the FPGA. Across four benchmark nonlinear dynamical systems, MERINDA delivers substantial gains over GPU implementations: \textbf{114$\times$ lower energy} (434~J vs.\ 49{,}375~J), \textbf{28$\times$ smaller memory footprint} (214~MB vs.\ 6{,}118~MB), and \textbf{1.68$\times$ faster training}, while matching state-of-the-art model-recovery accuracy. These results demonstrate that MERINDA can bring accurate, explainable MR to the edge for real-time monitoring of autonomous systems.

Sandeep Gupta, Roberto Passerone

This article investigates the robustness of vision systems in Connected and Autonomous Vehicles (CAVs), which is critical for developing Level-5 autonomous driving capabilities. Safe and reliable CAV navigation undeniably depends on robust vision systems that enable accurate detection of objects, lane markings, and traffic signage. We analyze the key sensors and vision components essential for CAV navigation to derive a reference architecture for CAV vision system (CAVVS). This reference architecture provides a basis for identifying potential attack surfaces of CAVVS. Subsequently, we elaborate on identified attack vectors targeting each attack surface, rigorously evaluating their implications for confidentiality, integrity, and availability (CIA). Our study provides a comprehensive understanding of attack vector dynamics in vision systems, which is crucial for formulating robust security measures that can uphold the principles of the CIA triad.

Midhat Urooj, Ayan Banerjee, Sandeep Gupta

Explainability domain generalization and rare class reliability are critical challenges in medical AI where deep models often fail under real world distribution shifts and exhibit bias against infrequent clinical conditions This paper introduces XAIMeD an explainable medical AI framework that integrates clinically accurate expert knowledge into deep learning through a unified neuro symbolic architecture XAIMeD is designed to improve robustness under distribution shift enhance rare class sensitivity and deliver transparent clinically aligned interpretations The framework encodes clinical expertise as logical connectives over atomic medical propositions transforming them into machine checkable class specific rules Their diagnostic utility is quantified through weighted feature satisfaction scores enabling a symbolic reasoning branch that complements neural predictions A confidence weighted fusion integrates symbolic and deep outputs while a Hunt inspired adaptive routing mechanism guided by Entropy Imbalance Gain EIG and Rare Class Gini mitigates class imbalance high intra class variability and uncertainty We evaluate XAIMeD across diverse modalities on four challenging tasks i Seizure Onset Zone SOZ localization from rs fMRI ii Diabetic Retinopathy grading across 6 multicenter datasets demonstrate substantial performance improvements including 6 percent gains in cross domain generalization and a 10 percent improved rare class F1 score far outperforming state of the art deep learning baselines Ablation studies confirm that the clinically grounded symbolic components act as effective regularizers ensuring robustness to distribution shifts XAIMeD thus provides a principled clinically faithful and interpretable approach to multimodal medical AI.

Ayan Banerjee, Payal Kamboj, Sandeep Gupta

Precision medicine is a promising approach for accessible disease diagnosis and personalized intervention planning in high-mortality diseases such as coronary artery disease (CAD), drug-resistant epilepsy (DRE), and chronic illnesses like Type 1 diabetes (T1D). By leveraging artificial intelligence (AI), precision medicine tailors diagnosis and treatment solutions to individual patients by explicitly modeling variance in pathophysiology. However, the adoption of AI in medical applications faces significant challenges, including poor generalizability across centers, demographics, and comorbidities, limited explainability in clinical terms, and a lack of trust in ethical decision-making. This paper proposes a framework to develop and ethically evaluate expert-guided multi-modal AI, addressing these challenges in AI integration within precision medicine. We illustrate this framework with case study on insulin management for T1D. To ensure ethical considerations and clinician engagement, we adopt a co-design approach where AI serves an assistive role, with final diagnoses or treatment plans emerging from collaboration between clinicians and AI.

Dharmendra Sharma, Peeyush Thakur, Sandeep Gupta et al.

This paper proposes a novel approach to recognizing dynamic hand gestures facilitating seamless interaction between humans and robots. Here, each robot manipulator task is assigned a specific gesture. There may be several such tasks, hence, several gestures. These gestures may be prone to several dynamic variations. All such variations for different gestures shown to the robot are accurately recognized in real-time using the proposed unsupervised model based on the Gaussian Mixture model. The accuracy during training and real-time testing prove the efficacy of this methodology.

Ayan Banerjee, Kuntal Thakur, Sandeep Gupta

Generalizing image classification across domains remains challenging in critical tasks such as fundus image-based diabetic retinopathy (DR) grading and resting-state fMRI seizure onset zone (SOZ) detection. When domains differ in unknown causal factors, achieving cross-domain generalization is difficult, and there is no established methodology to objectively assess such differences without direct metadata or protocol-level information from data collectors, which is typically inaccessible. We first introduce domain conformal bounds (DCB), a theoretical framework to evaluate whether domains diverge in unknown causal factors. Building on this, we propose GenEval, a multimodal Vision Language Models (VLM) approach that combines foundational models (e.g., MedGemma-4B) with human knowledge via Low-Rank Adaptation (LoRA) to bridge causal gaps and enhance single-source domain generalization (SDG). Across eight DR and two SOZ datasets, GenEval achieves superior SDG performance, with average accuracy of 69.2% (DR) and 81% (SOZ), outperforming the strongest baselines by 9.4% and 1.8%, respectively.

Bin Xu, Ayan Banerjee, Sandeep Gupta

Model Recovery (MR) is a core primitive for physical AI and real-time digital twins, but GPUs often execute MR inefficiently due to iterative dependencies, kernel-launch overheads, underutilized memory bandwidth, and high data-movement latency. We present MERINDA, an FPGA-accelerated MR framework that restructures computation as a streaming dataflow pipeline. MERINDA exploits on-chip locality through BRAM tiling, fixed-point kernels, and the concurrent use of LUT fabric and carry-chain adders to expose fine-grained spatial parallelism while minimizing off-chip traffic. This hardware-aware formulation removes synchronization bottlenecks and sustains high throughput across the iterative updates in MR. On representative MR workloads, MERINDA delivers up to 6.3x fewer cycles than an FPGA-based LTC baseline, enabling real-time performance for time-critical physical systems.

Midhat Urooj, Ayan Banerjee, Farhat Shaikh et al.

Domain generalization remains a critical challenge in medical imaging, where models trained on single sources often fail under real-world distribution shifts. We propose KG-DG, a neuro-symbolic framework for diabetic retinopathy (DR) classification that integrates vision transformers with expert-guided symbolic reasoning to enable robust generalization across unseen domains. Our approach leverages clinical lesion ontologies through structured, rule-based features and retinal vessel segmentation, fusing them with deep visual representations via a confidence-weighted integration strategy. The framework addresses both single-domain generalization (SDG) and multi-domain generalization (MDG) by minimizing the KL divergence between domain embeddings, thereby enforcing alignment of high-level clinical semantics. Extensive experiments across four public datasets (APTOS, EyePACS, Messidor-1, Messidor-2) demonstrate significant improvements: up to a 5.2% accuracy gain in cross-domain settings and a 6% improvement over baseline ViT models. Notably, our symbolic-only model achieves a 63.67% average accuracy in MDG, while the complete neuro-symbolic integration achieves the highest accuracy compared to existing published baselines and benchmarks in challenging SDG scenarios. Ablation studies reveal that lesion-based features (84.65% accuracy) substantially outperform purely neural approaches, confirming that symbolic components act as effective regularizers beyond merely enhancing interpretability. Our findings establish neuro-symbolic integration as a promising paradigm for building clinically robust, and domain-invariant medical AI systems.

Sandeep Gupta, Roberto Passerone

Visual Foundation Models (VFMs) are becoming ubiquitous in computer vision, powering systems for diverse tasks such as object detection, image classification, segmentation, pose estimation, and motion tracking. VFMs are capitalizing on seminal innovations in deep learning models, such as LeNet-5, AlexNet, ResNet, VGGNet, InceptionNet, DenseNet, YOLO, and ViT, to deliver superior performance across a range of critical computer vision applications. These include security-sensitive domains like biometric verification, autonomous vehicle perception, and medical image analysis, where robustness is essential to fostering trust between technology and the end-users. This article investigates network robustness requirements crucial in computer vision systems to adapt effectively to dynamic environments influenced by factors such as lighting, weather conditions, and sensor characteristics. We examine the prevalent empirical defenses and robust training employed to enhance vision network robustness against real-world challenges such as distributional shifts, noisy and spatially distorted inputs, and adversarial attacks. Subsequently, we provide a comprehensive analysis of the challenges associated with these defense mechanisms, including network properties and components to guide ablation studies and benchmarking metrics to evaluate network robustness.

Payal Kamboj, Ayan Banerjee, Bin Xu et al.

Rare events, due to their infrequent occurrences, do not have much data, and hence deep learning techniques fail in estimating the distribution for such data. Open-vocabulary models represent an innovative approach to image classification. Unlike traditional models, these models classify images into any set of categories specified with natural language prompts during inference. These prompts usually comprise manually crafted templates (e.g., 'a photo of a {}') that are filled in with the names of each category. This paper introduces a simple yet effective method for generating highly accurate and contextually descriptive prompts containing discriminative characteristics. Rare event detection, especially in medicine, is more challenging due to low inter-class and high intra-class variability. To address these, we propose a novel approach that uses domain-specific expert knowledge on rare events to generate customized and contextually relevant prompts, which are then used by large language models for image classification. Our zero-shot, privacy-preserving method enhances rare event classification without additional training, outperforming state-of-the-art techniques.