Weisi Liu

Mayira Sharif, Guangzeng Han, Weisi Liu et al.

To support rapid AI advances and broaden access to large-scale computing resources for under-resourced institutions at the Mid-South, we established the first regional mid-scale GPU cluster at the University of Memphis (UofM), iTiger. We present and analyze efforts of infrastructure management and computational support for educators, students, and researchers across scientific and engineering disciplines, such as precision agriculture, smart transportation, and health informatics. We outline our initiatives to broaden cluster adoption on research and education, such as seed grant programs, workshop trainings, course integration, and other outreach activities. We also identify challenges and further discuss findings of GPU infrastructure adoptions among college students and multidisciplinary researchers. The insights will indicate how to effectively and broaden infrastructure adoption and integrate into research and workforce developments.

Weisi Liu, Zhe He, Xiaolei Huang

Time roots in applying language models for biomedical applications: models are trained on historical data and will be deployed for new or future data, which may vary from training data. While increasing biomedical tasks have employed state-of-the-art language models, there are very few studies have examined temporal effects on biomedical models when data usually shifts across development and deployment. This study fills the gap by statistically probing relations between language model performance and data shifts across three biomedical tasks. We deploy diverse metrics to evaluate model performance, distance methods to measure data drifts, and statistical methods to quantify temporal effects on biomedical language models. Our study shows that time matters for deploying biomedical language models, while the degree of performance degradation varies by biomedical tasks and statistical quantification approaches. We believe this study can establish a solid benchmark to evaluate and assess temporal effects on deploying biomedical language models.

Guangzeng Han, Weisi Liu, Xiaolei Huang et al.

Automatic coding patient behaviors is essential to support decision making for psychotherapists during the motivational interviewing (MI), a collaborative communication intervention approach to address psychiatric issues, such as alcohol and drug addiction. While the behavior coding task has rapidly adapted machine learning to predict patient states during the MI sessions, lacking of domain-specific knowledge and overlooking patient-therapist interactions are major challenges in developing and deploying those models in real practice. To encounter those challenges, we introduce the Chain-of-Interaction (CoI) prompting method aiming to contextualize large language models (LLMs) for psychiatric decision support by the dyadic interactions. The CoI prompting approach systematically breaks down the coding task into three key reasoning steps, extract patient engagement, learn therapist question strategies, and integrates dyadic interactions between patients and therapists. This approach enables large language models to leverage the coding scheme, patient state, and domain knowledge for patient behavioral coding. Experiments on real-world datasets can prove the effectiveness and flexibility of our prompting method with multiple state-of-the-art LLMs over existing prompting baselines. We have conducted extensive ablation analysis and demonstrate the critical role of dyadic interactions in applying LLMs for psychotherapy behavior understanding.

Weisi Liu, Guangzeng Han, Xiaolei Huang

Time introduces fundamental challenges in model development and deployment: models are usually trained on historical data while deployed on future data where semantic distributions and domain knowledge may evolve. Unfortunately, existing studies either overlook temporal shifts or hardly capture rich shifting patterns of both semantic and knowledge. We develop Knowledge-driven Augmentation and Retrieval for Integrative Temporal Adaptation (KARITA) to capture diverse temporal shifts (e.g., uncertainty and feature shift), construct and integrate rich knowledge sources (e.g., medical ontology like MeSH), and leverage shifting insights for selecting-retrieval augmented learning. We evaluate KARITA on classification tasks across multiple domains, clinical, legal, and scientific corpora, demonstrating consistent improvements across multiple domains with temporal adaptation. Our results show that knowledge integration can be more critical and effective in temporal augmentation and learning.

Guangzeng Han, Weisi Liu, Xiaolei Huang

Large Language Models (LLMs) excel at generating synthetic data, but ensuring its quality and diversity remains challenging. We propose Genetic Prompt, a novel framework that combines genetic algorithms with LLMs to augment synthetic data generation. Our approach treats semantic text attributes as gene sequences and leverages the LLM to simulate crossover and mutation operations. This genetic process enhances data quality and diversity by creating novel attribute combinations, yielding synthetic distributions closer to real-world data. To optimize parent selection, we also integrate an active learning scheme that expands the offspring search space. Our experiments on multiple NLP tasks reveal several key findings: Genetic Prompt not only significantly outperforms state-of-the-art baselines but also shows robust performance across various generator model sizes and scales. Moreover, we demonstrate that fusing our synthetic data with the original training set significantly boosts downstream model performance, particularly for class-imbalanced scenarios. Our findings validate that Genetic Prompt is an effective method for producing high-quality synthetic data for a wide range of NLP applications.

Precious Jones, Weisi Liu, I-Chan Huang et al.

Data imbalance is a fundamental challenge in applying language models to biomedical applications, particularly in ICD code prediction tasks where label and demographic distributions are uneven. While state-of-the-art language models have been increasingly adopted in biomedical tasks, few studies have systematically examined how data imbalance affects model performance and fairness across demographic groups. This study fills the gap by statistically probing the relationship between data imbalance and model performance in ICD code prediction. We analyze imbalances in a standard benchmark data across gender, age, ethnicity, and social determinants of health by state-of-the-art biomedical language models. By deploying diverse performance metrics and statistical analyses, we explore the influence of data imbalance on performance variations and demographic fairness. Our study shows that data imbalance significantly impacts model performance and fairness, but feature similarity to the majority class may be a more critical factor. We believe this study provides valuable insights for developing more equitable and robust language models in healthcare applications.

Weisi Liu, Guangzeng Han, Xiaolei Huang

Time is implicitly embedded in classification process: classifiers are usually built on existing data while to be applied on future data whose distributions (e.g., label and token) may change. However, existing state-of-the-art classification models merely consider the temporal variations and primarily focus on English corpora, which leaves temporal studies less explored, let alone under multilingual settings. In this study, we fill the gap by treating time as domains (e.g., 2024 vs. 2025), examining temporal effects, and developing a domain adaptation framework to generalize classifiers over time on multiple languages. Our framework proposes Mixture of Temporal Experts (MoTE) to leverage both semantic and data distributional shifts to learn and adapt temporal trends into classification models. Our analysis shows classification performance varies over time across different languages, and we experimentally demonstrate that MoTE can enhance classifier generalizability over temporal data shifts. Our study provides analytic insights and addresses the need for time-aware models that perform robustly in multilingual scenarios.

Hanshu Rao, Weisi Liu, Haohan Wang et al.

Synthetic data generation--mitigating data scarcity, privacy concerns, and data quality challenges in biomedical fields--has been facilitated by rapid advances of large language models (LLMs). This scoping review follows PRISMA-ScR guidelines and synthesizes 59 studies, published between 2020 and 2025 and collected from PubMed, ACM, Web of Science, and Google Scholar. The review systematically examines biomedical research and application trends in synthetic data generation, emphasizing clinical applications, methodologies, and evaluations. Our analysis identifies data modalities of unstructured texts (78.0%), tabular data (13.6%), and multimodal sources (8.4%); generation methods of prompting (72.9%), fine-tuning (22.0%) LLMs and specialized model (5.1%); and heterogeneous evaluations of intrinsic metrics (27.1%), human-in-the-loop assessments (55.9%), and LLM-based evaluations (13.6%). The analysis addresses current limitations in what, where, and how health professionals can leverage synthetic data generation for biomedical domains. Our review also highlights challenges in adaption across clinical domains, resource and model accessibility, and evaluation standardizations.