Xinlin Zhang

Tao Wang, Xinlin Zhang, Yuanbo Zhou et al.

In recent years, deep learning has become a breakthrough technique in assisting medical image diagnosis. Supervised learning using convolutional neural networks (CNN) provides state-of-the-art performance and has served as a benchmark for various medical image segmentation and classification. However, supervised learning deeply relies on large-scale annotated data, which is expensive, time-consuming, and even impractical to acquire in medical imaging applications. Active Learning (AL) methods have been widely applied in natural image classification tasks to reduce annotation costs by selecting more valuable examples from the unlabeled data pool. However, their application in medical image segmentation tasks is limited, and there is currently no effective and universal AL-based method specifically designed for 3D medical image segmentation. To address this limitation, we propose an AL-based method that can be simultaneously applied to 2D medical image classification, segmentation, and 3D medical image segmentation tasks. We extensively validated our proposed active learning method on three publicly available and challenging medical image datasets, Kvasir Dataset, COVID-19 Infection Segmentation Dataset, and BraTS2019 Dataset. The experimental results demonstrate that our PCDAL can achieve significantly improved performance with fewer annotations in 2D classification and segmentation and 3D segmentation tasks. The codes of this study are available at https://github.com/ortonwang/PCDAL.

Yuanbin Chen, Tao Wang, Hui Tang et al.

While supervised learning has achieved remarkable success, obtaining large-scale labeled datasets in biomedical imaging is often impractical due to high costs and the time-consuming annotations required from radiologists. Semi-supervised learning emerges as an effective strategy to overcome this limitation by leveraging useful information from unlabeled datasets. In this paper, we present a novel semi-supervised learning method, Dual-Decoder Consistency via Pseudo-Labels Guided Data Augmentation (DCPA), for medical image segmentation. We devise a consistency regularization to promote consistent representations during the training process. Specifically, we use distinct decoders for student and teacher networks while maintain the same encoder. Moreover, to learn from unlabeled data, we create pseudo-labels generated by the teacher networks and augment the training data with the pseudo-labels. Both techniques contribute to enhancing the performance of the proposed method. The method is evaluated on three representative medical image segmentation datasets. Comprehensive comparisons with state-of-the-art semi-supervised medical image segmentation methods were conducted under typical scenarios, utilizing 10% and 20% labeled data, as well as in the extreme scenario of only 5% labeled data. The experimental results consistently demonstrate the superior performance of our method compared to other methods across the three semi-supervised settings. The source code is publicly available at https://github.com/BinYCn/DCPA.git.

Tao Wang, Yuanbin Chen, Xinlin Zhang et al.

Supervised learning algorithms based on Convolutional Neural Networks have become the benchmark for medical image segmentation tasks, but their effectiveness heavily relies on a large amount of labeled data. However, annotating medical image datasets is a laborious and time-consuming process. Inspired by semi-supervised algorithms that use both labeled and unlabeled data for training, we propose the PLGDF framework, which builds upon the mean teacher network for segmenting medical images with less annotation. We propose a novel pseudo-label utilization scheme, which combines labeled and unlabeled data to augment the dataset effectively. Additionally, we enforce the consistency between different scales in the decoder module of the segmentation network and propose a loss function suitable for evaluating the consistency. Moreover, we incorporate a sharpening operation on the predicted results, further enhancing the accuracy of the segmentation. Extensive experiments on three publicly available datasets demonstrate that the PLGDF framework can largely improve performance by incorporating the unlabeled data. Meanwhile, our framework yields superior performance compared to six state-of-the-art semi-supervised learning methods. The codes of this study are available at https://github.com/ortonwang/PLGDF.

Yuanbo Zhou, Xinlin Zhang, Wei Deng et al.

We introduce DiffSteISR, a pioneering framework for reconstructing real-world stereo images. DiffSteISR utilizes the powerful prior knowledge embedded in pre-trained text-to-image model to efficiently recover the lost texture details in low-resolution stereo images. Specifically, DiffSteISR implements a time-aware stereo cross attention with temperature adapter (TASCATA) to guide the diffusion process, ensuring that the generated left and right views exhibit high texture consistency thereby reducing disparity error between the super-resolved images and the ground truth (GT) images. Additionally, a stereo omni attention control network (SOA ControlNet) is proposed to enhance the consistency of super-resolved images with GT images in the pixel, perceptual, and distribution space. Finally, DiffSteISR incorporates a stereo semantic extractor (SSE) to capture unique viewpoint soft semantic information and shared hard tag semantic information, thereby effectively improving the semantic accuracy and consistency of the generated left and right images. Extensive experimental results demonstrate that DiffSteISR accurately reconstructs natural and precise textures from low-resolution stereo images while maintaining a high consistency of semantic and texture between the left and right views.

Yuanbo Zhou, Yuyang Xue, Wei Deng et al.

Despite advances in the paradigm of pre-training then fine-tuning in low-level vision tasks, significant challenges persist particularly regarding the increased size of pre-trained models such as memory usage and training time. Another concern often encountered is the unsatisfying results yielded when directly applying pre-trained single-image models to multi-image domain. In this paper, we propose a efficient method for transferring a pre-trained single-image super-resolution (SISR) transformer network to the domain of stereo image super-resolution (SteISR) through a parameter-efficient fine-tuning (PEFT) method. Specifically, we introduce the concept of stereo adapters and spatial adapters which are incorporated into the pre-trained SISR transformer network. Subsequently, the pre-trained SISR model is frozen, enabling us to fine-tune the adapters using stereo datasets along. By adopting this training method, we enhance the ability of the SISR model to accurately infer stereo images by 0.79dB on the Flickr1024 dataset. This method allows us to train only 4.8% of the original model parameters, achieving state-of-the-art performance on four commonly used SteISR benchmarks. Compared to the more complicated full fine-tuning approach, our method reduces training time and memory consumption by 57% and 15%, respectively.

Yuanbo Zhou, Yuyang Xue, Jiang Bi et al.

Real-world stereo image super-resolution has a significant influence on enhancing the performance of computer vision systems. Although existing methods for single-image super-resolution can be applied to improve stereo images, these methods often introduce notable modifications to the inherent disparity, resulting in a loss in the consistency of disparity between the original and the enhanced stereo images. To overcome this limitation, this paper proposes a novel approach that integrates a implicit stereo information discriminator and a hybrid degradation model. This combination ensures effective enhancement while preserving disparity consistency. The proposed method bridges the gap between the complex degradations in real-world stereo domain and the simpler degradations in real-world single-image super-resolution domain. Our results demonstrate impressive performance on synthetic and real datasets, enhancing visual perception while maintaining disparity consistency. The complete code is available at the following \href{https://github.com/fzuzyb/SCGLANet}{link}.

Tao Wang, Xinlin Zhang, Zhenxuan Zhang et al.

In clinical medicine, precise image segmentation can provide substantial support to clinicians. However, obtaining high-quality segmentation typically demands extensive pixel-level annotations, which are labor-intensive and expensive. Scribble annotations offer a more cost-effective alternative by improving labeling efficiency. Nonetheless, using such sparse supervision for training reliable medical image segmentation models remains a significant challenge. Some studies employ pseudo-labeling to enhance supervision, but these methods are susceptible to noise interference. To address these challenges, we introduce ScribbleVS, a framework designed to learn from scribble annotations. We introduce a Regional Pseudo Labels Diffusion Module to expand the scope of supervision and reduce the impact of noise present in pseudo labels. Additionally, we introduce a Dynamic Competitive Selection module for enhanced refinement in selecting pseudo labels. Experiments conducted on the ACDC, MSCMRseg, WORD, and BraTS2020 datasets demonstrate promising results, achieving segmentation precision comparable to fully supervised models. The codes of this study are available at https://github.com/ortonwang/ScribbleVS.

Tao Wang, Zhenxuan Zhang, Yuanbo Zhou et al.

The effectiveness of convolutional neural networks in medical image segmentation relies on large-scale, high-quality annotations, which are costly and time-consuming to obtain. Even expert-labeled datasets inevitably contain noise arising from subjectivity and coarse delineations, which disrupt feature learning and adversely impact model performance. To address these challenges, this study propose a Geometric-Structural Dual-Guided Network (GSD-Net), which integrates geometric and structural cues to improve robustness against noisy annotations. It incorporates a Geometric Distance-Aware module that dynamically adjusts pixel-level weights using geometric features, thereby strengthening supervision in reliable regions while suppressing noise. A Structure-Guided Label Refinement module further refines labels with structural priors, and a Knowledge Transfer module enriches supervision and improves sensitivity to local details. To comprehensively assess its effectiveness, we evaluated GSD-Net on six publicly available datasets: four containing three types of simulated label noise, and two with multi-expert annotations that reflect real-world subjectivity and labeling inconsistencies. Experimental results demonstrate that GSD-Net achieves state-of-the-art performance under noisy annotations, achieving improvements of 2.52% on Kvasir, 22.76% on Shenzhen, 8.87% on BU-SUC, and 4.59% on BraTS2020 under SR simulated noise. The codes of this study are available at https://github.com/ortonwang/GSD-Net.

Ruige Zong, Tao Wang, Chunwang Li et al.

Familial cerebral cavernous malformation (FCCM) is a hereditary disorder characterized by abnormal vascular structures within the central nervous system. The FCCM lesions are often numerous and intricate, making quantitative analysis of the lesions a labor-intensive task. Consequently, clinicians face challenges in quantitatively assessing the severity of lesions and determining whether lesions have progressed. To alleviate this problem, we propose a quantitative statistical framework for FCCM, comprising an efficient annotation module, an FCCM lesion segmentation module, and an FCCM lesion quantitative statistics module. Our framework demonstrates precise segmentation of the FCCM lesion based on efficient data annotation, achieving a Dice coefficient of 93.22\%. More importantly, we focus on quantitative statistics of lesions, which is combined with image registration to realize the quantitative comparison of lesions between different examinations of patients, and a visualization framework has been established for doctors to comprehensively compare and analyze lesions. The experimental results have demonstrated that our proposed framework not only obtains objective, accurate, and comprehensive quantitative statistical information, which provides a quantitative assessment method for disease progression and drug efficacy study, but also considerably reduces the manual measurement and statistical workload of lesions, assisting clinical decision-making for FCCM and accelerating progress in FCCM clinical research. This highlights the potential of practical application of the framework in FCCM clinical research and clinical decision-making. The codes are available at https://github.com/6zrg/Quantitative-Statistics-of-FCCM.

Tao Wang, Xinlin Zhang, Yuanbin Chen et al.

Semi-supervised learning has received considerable attention for its potential to leverage abundant unlabeled data to enhance model robustness. Pseudo labeling is a widely used strategy in semi supervised learning. However, existing methods often suffer from noise contamination, which can undermine model performance. To tackle this challenge, we introduce a novel Synergy-Guided Regional Supervision of Pseudo Labels (SGRS-Net) framework. Built upon the mean teacher network, we employ a Mix Augmentation module to enhance the unlabeled data. By evaluating the synergy before and after augmentation, we strategically partition the pseudo labels into distinct regions. Additionally, we introduce a Region Loss Evaluation module to assess the loss across each delineated area. Extensive experiments conducted on the LA dataset have demonstrated superior performance over state-of-the-art techniques, underscoring the efficiency and practicality of our framework.

Tieyuan Lu, Xinlin Zhang, Yihui Huang et al.

Magnetic resonance imaging has been widely applied in clinical diagnosis, however, is limited by its long data acquisition time. Although imaging can be accelerated by sparse sampling and parallel imaging, achieving promising reconstruction images with a fast reconstruction speed remains a challenge. Recently, deep learning approaches have attracted a lot of attention for its encouraging reconstruction results but without a proper interpretability. In this letter, to enable high-quality image reconstruction for the parallel magnetic resonance imaging, we design the network structure from the perspective of sparse iterative reconstruction and enhance it with the residual structure. The experimental results of a public knee dataset show that compared with the optimization-based method and the latest deep learning parallel imaging methods, the proposed network has less error in reconstruction and is more stable under different acceleration factors.

Xinlin Zhang, Hengfa Lu, Di Guo et al.

The boom of non-uniform sampling and compressed sensing techniques dramatically alleviates the lengthy data acquisition problem of magnetic resonance imaging. Sparse reconstruction, thanks to its fast computation and promising performance, has attracted researchers to put numerous efforts on it and has been adopted in commercial scanners. To perform sparse reconstruction, choosing a proper algorithm is essential in providing satisfying results and saving time in tuning parameters. The pFISTA, a simple and efficient algorithm for sparse reconstruction, has been successfully extended to parallel imaging. However, its convergence criterion is still an open question. And the existing convergence criterion of single-coil pFISTA cannot be applied to the parallel imaging pFISTA, which, therefore, imposes confusions and difficulties on users about determining the only parameter - step size. In this work, we provide the guaranteed convergence analysis of the parallel imaging version pFISTA to solve the two well-known parallel imaging reconstruction models, SENSE and SPIRiT. Along with the convergence analysis, we provide recommended step size values for SENSE and SPIRiT reconstructions to obtain fast and promising reconstructions. Experiments on in vivo brain images demonstrate the validity of the convergence criterion. Besides, experimental results show that compared to using backtracking and power iteration to determine the step size, our recommended step size achieves more than five times acceleration in reconstruction time in most tested cases.