Yuan Xiong

Haoshen Wang, Lei Chen, Wei-Hua Zhang et al.

Cone beam computed tomography (CBCT)-guided puncture has become an established approach for diagnosing and treating early- to mid-stage thoracic tumours, yet the associated radiation exposure substantially elevates the risk of secondary malignancies. Although multiple low-dose CBCT strategies have been introduced, none have undergone validation using large-scale multicenter retrospective datasets, and prospective clinical evaluation remains lacking. Here, we propose DeepPriorCBCT - a three-stage deep learning framework that achieves diagnostic-grade reconstruction using only one-sixth of the conventional radiation dose. 4102 patients with 8675 CBCT scans from 12 centers were included to develop and validate DeepPriorCBCT. Additionally, a prospective cross-over trial (Registry number: NCT07035977) which recruited 138 patients scheduled for percutaneous thoracic puncture was conducted to assess the model's clinical applicability. Assessment by 11 physicians confirmed that reconstructed images were indistinguishable from original scans. Moreover, diagnostic performance and overall image quality were comparable to those generated by standard reconstruction algorithms. In the prospective trial, five radiologists reported no significant differences in image quality or lesion assessment between DeepPriorCBCT and the clinical standard (all P>0.05). Likewise, 25 interventionalists expressed no preference between model-based and full-sampling images for surgical guidance (Kappa<0.2). Radiation exposure with DeepPriorCBCT was reduced to approximately one-sixth of that with the conventional approach, and collectively, the findings confirm that it enables high-quality CBCT reconstruction under sparse sampling conditions while markedly decreasing intraoperative radiation risk.

Ziqi Miao, Lijun Li, Yuan Xiong et al.

Contextual priming, where earlier stimuli covertly bias later judgments, offers an unexplored attack surface for large language models (LLMs). We uncover a contextual priming vulnerability in which the previous response in the dialogue can steer its subsequent behavior toward policy-violating content. Building on this insight, we propose Response Attack, which uses an auxiliary LLM to generate a mildly harmful response to a paraphrased version of the original malicious query. They are then formatted into the dialogue and followed by a succinct trigger prompt, thereby priming the target model to generate harmful content. Across eight open-source and proprietary LLMs, RA consistently outperforms seven state-of-the-art jailbreak techniques, achieving higher attack success rates. To mitigate this threat, we construct and release a context-aware safety fine-tuning dataset, which significantly reduces the attack success rate while preserving model capabilities. The code and data are available at https://github.com/Dtc7w3PQ/Response-Attack.