Yang Zhao

Shengbo Tan, Zeyu Zhang, Ying Cai et al.

Medical imaging segmentation plays a significant role in the automatic recognition and analysis of lesions. State-of-the-art methods, particularly those utilizing transformers, have been prominently adopted in 3D semantic segmentation due to their superior performance in scalability and generalizability. However, plain vision transformers encounter challenges due to their neglect of local features and their high computational complexity. To address these challenges, we introduce three key contributions: Firstly, we proposed SegStitch, an innovative architecture that integrates transformers with denoising ODE blocks. Instead of taking whole 3D volumes as inputs, we adapt axial patches and customize patch-wise queries to ensure semantic consistency. Additionally, we conducted extensive experiments on the BTCV and ACDC datasets, achieving improvements up to 11.48% and 6.71% respectively in mDSC, compared to state-of-the-art methods. Lastly, our proposed method demonstrates outstanding efficiency, reducing the number of parameters by 36.7% and the number of FLOPS by 10.7% compared to UNETR. This advancement holds promising potential for adapting our method to real-world clinical practice. The code will be available at https://github.com/goblin327/SegStitch

Yan Xia, Zhou Zhao, Shangwei Ye et al.

In this paper, we introduce a new task, spoken video grounding (SVG), which aims to localize the desired video fragments from spoken language descriptions. Compared with using text, employing audio requires the model to directly exploit the useful phonemes and syllables related to the video from raw speech. Moreover, we randomly add environmental noises to this speech audio, further increasing the difficulty of this task and better simulating real applications. To rectify the discriminative phonemes and extract video-related information from noisy audio, we develop a novel video-guided curriculum learning (VGCL) during the audio pre-training process, which can make use of the vital visual perceptions to help understand the spoken language and suppress the external noise. Considering during inference the model can not obtain ground truth video segments, we design a curriculum strategy that gradually shifts the input video from the ground truth to the entire video content during pre-training. Finally, the model can learn how to extract critical visual information from the entire video clip to help understand the spoken language. In addition, we collect the first large-scale spoken video grounding dataset based on ActivityNet, which is named as ActivityNet Speech dataset. Extensive experiments demonstrate our proposed video-guided curriculum learning can facilitate the pre-training process to obtain a mutual audio encoder, significantly promoting the performance of spoken video grounding tasks. Moreover, we prove that in the case of noisy sound, our model outperforms the method that grounding video with ASR transcripts, further demonstrating the effectiveness of our curriculum strategy.

Shengbo Tan, Rundong Xue, Shipeng Luo et al.

Hepatic vessels in computed tomography scans often suffer from image fragmentation and noise interference, making it difficult to maintain vessel integrity and posing significant challenges for vessel segmentation. To address this issue, we propose an innovative model: SegKAN. First, we improve the conventional embedding module by adopting a novel convolutional network structure for image embedding, which smooths out image noise and prevents issues such as gradient explosion in subsequent stages. Next, we transform the spatial relationships between Patch blocks into temporal relationships to solve the problem of capturing positional relationships between Patch blocks in traditional Vision Transformer models. We conducted experiments on a Hepatic vessel dataset, and compared to the existing state-of-the-art model, the Dice score improved by 1.78%. These results demonstrate that the proposed new structure effectively enhances the segmentation performance of high-resolution extended objects. Code will be available at https://github.com/goblin327/SegKAN

Guohui Cai, Ying Cai, Zeyu Zhang et al.

Lung cancer remains one of the leading causes of morbidity and mortality worldwide, making early diagnosis critical for improving therapeutic outcomes and patient prognosis. Computer-aided diagnosis systems, which analyze computed tomography images, have proven effective in detecting and classifying pulmonary nodules, significantly enhancing the detection rate of early-stage lung cancer. Although traditional machine learning algorithms have been valuable, they exhibit limitations in handling complex sample data. The recent emergence of deep learning has revolutionized medical image analysis, driving substantial advancements in this field. This review focuses on recent progress in deep learning for pulmonary nodule detection, segmentation, and classification. Traditional machine learning methods, such as support vector machines and k-nearest neighbors, have shown limitations, paving the way for advanced approaches like Convolutional Neural Networks, Recurrent Neural Networks, and Generative Adversarial Networks. The integration of ensemble models and novel techniques is also discussed, emphasizing the latest developments in lung cancer diagnosis. Deep learning algorithms, combined with various analytical techniques, have markedly improved the accuracy and efficiency of pulmonary nodule analysis, surpassing traditional methods, particularly in nodule classification. Although challenges remain, continuous technological advancements are expected to further strengthen the role of deep learning in medical diagnostics, especially for early lung cancer detection and diagnosis. A comprehensive list of lung cancer detection models reviewed in this work is available at https://github.com/CaiGuoHui123/Awesome-Lung-Cancer-Detection.

Hongjie Zhu, Xiwei Liu, Rundong Xue et al.

In the era of information explosion, efficiently leveraging large-scale unlabeled data while minimizing the reliance on high-quality pixel-level annotations remains a critical challenge in the field of medical imaging. Semi-supervised learning (SSL) enhances the utilization of unlabeled data by facilitating knowledge transfer, significantly improving the performance of fully supervised models and emerging as a highly promising research direction in medical image analysis. Inspired by the ability of Vision Foundation Models (e.g., SAM-2) to provide rich prior knowledge, we propose SSS (Semi-Supervised SAM-2), a novel approach that leverages SAM-2's robust feature extraction capabilities to uncover latent knowledge in unlabeled medical images, thus effectively enhancing feature support for fully supervised medical image segmentation. Specifically, building upon the single-stream "weak-to-strong" consistency regularization framework, this paper introduces a Discriminative Feature Enhancement (DFE) mechanism to further explore the feature discrepancies introduced by various data augmentation strategies across multiple views. By leveraging feature similarity and dissimilarity across multi-scale augmentation techniques, the method reconstructs and models the features, thereby effectively optimizing the salient regions. Furthermore, a prompt generator is developed that integrates Physical Constraints with a Sliding Window (PCSW) mechanism to generate input prompts for unlabeled data, fulfilling SAM-2's requirement for additional prompts. Extensive experiments demonstrate the superiority of the proposed method for semi-supervised medical image segmentation on two multi-label datasets, i.e., ACDC and BHSD. Notably, SSS achieves an average Dice score of 53.15 on BHSD, surpassing the previous state-of-the-art method by +3.65 Dice. Code will be available at https://github.com/AIGeeksGroup/SSS.

Xuyin Qi, Zeyu Zhang, Huazhan Zheng et al.

Bone density prediction via CT scans to estimate T-scores is crucial, providing a more precise assessment of bone health compared to traditional methods like X-ray bone density tests, which lack spatial resolution and the ability to detect localized changes. However, CT-based prediction faces two major challenges: the high computational complexity of transformer-based architectures, which limits their deployment in portable and clinical settings, and the imbalanced, long-tailed distribution of real-world hospital data that skews predictions. To address these issues, we introduce MedConv, a convolutional model for bone density prediction that outperforms transformer models with lower computational demands. We also adapt Bal-CE loss and post-hoc logit adjustment to improve class balance. Extensive experiments on our AustinSpine dataset shows that our approach achieves up to 21% improvement in accuracy and 20% in ROC AUC over previous state-of-the-art methods.

Xiuyuan Hu, Guoqing Liu, Can Chen et al. · tsinghua

Structure-based drug design (SBDD) is a critical task in drug discovery, requiring the generation of molecular information across two distinct modalities: discrete molecular graphs and continuous 3D coordinates. However, existing SBDD methods often overlook two key challenges: (1) the multi-modal nature of this task and (2) the causal relationship between these modalities, limiting their plausibility and performance. To address both challenges, we propose TransDiffSBDD, an integrated framework combining autoregressive transformers and diffusion models for SBDD. Specifically, the autoregressive transformer models discrete molecular information, while the diffusion model samples continuous distributions, effectively resolving the first challenge. To address the second challenge, we design a hybrid-modal sequence for protein-ligand complexes that explicitly respects the causality between modalities. Experiments on the CrossDocked2020 benchmark demonstrate that TransDiffSBDD outperforms existing baselines.

Xiuyuan Hu, Guoqing Liu, Yang Zhao et al. · tsinghua

AI for drug discovery has been a research hotspot in recent years, and SMILES-based language models has been increasingly applied in drug molecular design. However, no work has explored whether and how language models understand the chemical spatial structure from 1D sequences. In this work, we pre-train a transformer model on chemical language and fine-tune it toward drug design objectives, and investigate the correspondence between high-frequency SMILES substrings and molecular fragments. The results indicate that language models can understand chemical structures from the perspective of molecular fragments, and the structural knowledge learned through fine-tuning is reflected in the high-frequency SMILES substrings generated by the model.

Dewang Hou, Yang Zhao, Yuyao Ye et al.

Scaling and lossy coding are widely used in video transmission and storage. Previous methods for enhancing the resolution of such videos often ignore the inherent interference between resolution loss and compression artifacts, which compromises perceptual video quality. To address this problem, we present a mixed-resolution coding framework, which cooperates with a reference-based DCNN. In this novel coding chain, the reference-based DCNN learns the direct mapping from low-resolution (LR) compressed video to their high-resolution (HR) clean version at the decoder side. We further improve reconstruction quality by devising an efficient deformable alignment module with receptive field block to handle various motion distances and introducing a disentangled loss that helps networks distinguish the artifact patterns from texture. Extensive experiments demonstrate the effectiveness of proposed innovations by comparing with state-of-the-art single image, video and reference-based restoration methods.

Zhu Zhang, Zhou Zhao, Yang Zhao et al.

In this paper, we consider a novel task, Spatio-Temporal Video Grounding for Multi-Form Sentences (STVG). Given an untrimmed video and a declarative/interrogative sentence depicting an object, STVG aims to localize the spatio-temporal tube of the queried object. STVG has two challenging settings: (1) We need to localize spatio-temporal object tubes from untrimmed videos, where the object may only exist in a very small segment of the video; (2) We deal with multi-form sentences, including the declarative sentences with explicit objects and interrogative sentences with unknown objects. Existing methods cannot tackle the STVG task due to the ineffective tube pre-generation and the lack of object relationship modeling. Thus, we then propose a novel Spatio-Temporal Graph Reasoning Network (STGRN) for this task. First, we build a spatio-temporal region graph to capture the region relationships with temporal object dynamics, which involves the implicit and explicit spatial subgraphs in each frame and the temporal dynamic subgraph across frames. We then incorporate textual clues into the graph and develop the multi-step cross-modal graph reasoning. Next, we introduce a spatio-temporal localizer with a dynamic selection method to directly retrieve the spatio-temporal tubes without tube pre-generation. Moreover, we contribute a large-scale video grounding dataset VidSTG based on video relation dataset VidOR. The extensive experiments demonstrate the effectiveness of our method.

Di Wu, Kun Zhang, Fei Cheng et al.

As a basic task of multi-camera surveillance system, person re-identification aims to re-identify a query pedestrian observed from non-overlapping multiple cameras or across different time with a single camera. Recently, deep learning-based person re-identification models have achieved great success in many benchmarks. However, these supervised models require a large amount of labeled image data, and the process of manual labeling spends much manpower and time. In this study, we introduce a method to automatically synthesize labeled person images and adopt them to increase the sample number per identity for person re-identification datasets. To be specific, we use block rectangles to randomly occlude pedestrian images. Then, a generative adversarial network (GAN) model is proposed to use paired occluded and original images to synthesize the de-occluded images that similar but not identical to the original image. Afterwards, we annotate the de-occluded images with the same labels of their corresponding raw images and use them to augment the number of samples per identity. Finally, we use the augmented datasets to train baseline model. The experiment results on CUHK03, Market-1501 and DukeMTMC-reID datasets show that the effectiveness of the proposed method.