Hongchao Zhou

Hongchao Zhou

Despite its great success, backpropagation has certain limitations that necessitate the investigation of new learning methods. In this study, we present a biologically plausible local learning rule that improves upon Hebb's well-known proposal and discovers unsupervised features by local competitions among neurons. This simple learning rule enables the creation of a forward learning paradigm called activation learning, in which the output activation (sum of the squared output) of the neural network estimates the likelihood of the input patterns, or "learn more, activate more" in simpler terms. For classification on a few small classical datasets, activation learning performs comparably to backpropagation using a fully connected network, and outperforms backpropagation when there are fewer training samples or unpredictable disturbances. Additionally, the same trained network can be used for a variety of tasks, including image generation and completion. Activation learning also achieves state-of-the-art performance on several real-world datasets for anomaly detection. This new learning paradigm, which has the potential to unify supervised, unsupervised, and semi-supervised learning and is reasonably more resistant to adversarial attacks, deserves in-depth investigation.

Hongchao Zhou, Shunbo Hu

Deformable medical image registration is a crucial aspect of medical image analysis. In recent years, researchers have begun leveraging auxiliary tasks (such as supervised segmentation) to provide anatomical structure information for the primary registration task, addressing complex deformation challenges in medical image registration. In this work, we propose a multi-task learning framework based on multi-scale dual attention frequency fusion (DAFF-Net), which simultaneously achieves the segmentation masks and dense deformation fields in a single-step estimation. DAFF-Net consists of a global encoder, a segmentation decoder, and a coarse-to-fine pyramid registration decoder. During the registration decoding process, we design the dual attention frequency feature fusion (DAFF) module to fuse registration and segmentation features at different scales, fully leveraging the correlation between the two tasks. The DAFF module optimizes the features through global and local weighting mechanisms. During local weighting, it incorporates both high-frequency and low-frequency information to further capture the features that are critical for the registration task. With the aid of segmentation, the registration learns more precise anatomical structure information, thereby enhancing the anatomical consistency of the warped images after registration. Additionally, due to the DAFF module's outstanding ability to extract effective feature information, we extend its application to unsupervised registration. Extensive experiments on three public 3D brain magnetic resonance imaging (MRI) datasets demonstrate that the proposed DAFF-Net and its unsupervised variant outperform state-of-the-art registration methods across several evaluation metrics, demonstrating the effectiveness of our approach in deformable medical image registration.

Hongchao Zhou, Shunbo Hu

In this work, we propose a novel deformable convolutional pyramid network for unsupervised image registration. Specifically, the proposed network enhances the traditional pyramid network by adding an additional shared auxiliary decoder for image pairs. This decoder provides multi-scale high-level feature information from unblended image pairs for the registration task. During the registration process, we also design a multi-scale feature fusion block to extract the most beneficial features for the registration task from both global and local contexts. Validation results indicate that this method can capture complex deformations while achieving higher registration accuracy and maintaining smooth and plausible deformations.

Junyu Chen, Shuwen Wei, Joel Honkamaa et al.

Medical image challenges have played a transformative role in advancing the field, catalyzing algorithmic innovation and establishing new performance standards across diverse clinical applications. Image registration, a foundational task in neuroimaging pipelines, has similarly benefited from the Learn2Reg initiative. Building on this foundation, we introduce the Large-scale Unsupervised Brain MRI Image Registration (LUMIR) challenge, a next-generation benchmark designed to assess and advance unsupervised brain MRI registration. Distinct from prior challenges that leveraged anatomical label maps for supervision, LUMIR removes this dependency by providing over 4,000 preprocessed T1-weighted brain MRIs for training without any label maps, encouraging biologically plausible deformation modeling through self-supervision. In addition to evaluating performance on 590 held-out test subjects, LUMIR introduces a rigorous suite of zero-shot generalization tasks, spanning out-of-domain imaging modalities (e.g., FLAIR, T2-weighted, T2*-weighted), disease populations (e.g., Alzheimer's disease), acquisition protocols (e.g., 9.4T MRI), and species (e.g., macaque brains). A total of 1,158 subjects and over 4,000 image pairs were included for evaluation. Performance was assessed using both segmentation-based metrics (Dice coefficient, 95th percentile Hausdorff distance) and landmark-based registration accuracy (target registration error). Across both in-domain and zero-shot tasks, deep learning-based methods consistently achieved state-of-the-art accuracy while producing anatomically plausible deformation fields. The top-performing deep learning-based models demonstrated diffeomorphic properties and inverse consistency, outperforming several leading optimization-based methods, and showing strong robustness to most domain shifts, the exception being a drop in performance on out-of-domain contrasts.

Lasse Hansen, Wiebke Heyer, Christoph Großbröhmer et al.

Medical image registration is critical for clinical applications, and fair benchmarking of different methods is essential for monitoring ongoing progress. To date, the Learn2Reg 2020-2023 challenges have released several complementary datasets and established metrics for evaluations. However, these editions did not capture all aspects of the registration problem, particularly in terms of modality diversity and task complexity. To address these limitations, the 2024 edition introduces three new tasks, including large-scale multi-modal registration and unsupervised inter-subject brain registration, as well as the first microscopy-focused benchmark within Learn2Reg. The new datasets also inspired new method developments, including invertibility constraints, pyramid features, keypoints alignment and instance optimisation.

Hongchao Zhou, Abbas El Gamal

Shannon showed that to achieve perfect secrecy in point-to-point communication, the message rate cannot exceed the shared secret key rate giving rise to the simple one-time pad encryption scheme. In this paper, we extend this work from point-to-point to networks. We consider a connected network with pairwise communication between the nodes. We assume that each node is provided with a certain amount of secret bits before communication commences. An eavesdropper with unlimited computing power has access to all communication and can hack a subset of the nodes not known to the rest of the nodes. We investigate the limits on information-theoretic secure communication for this network. We establish a tradeoff between the secure channel rate (for a node pair) and the secure network rate (sum over all node pair rates) and show that perfect secrecy can be achieved if and only if the sum rate of any subset of unhacked channels does not exceed the shared unhacked-secret-bit rate of these channels. We also propose two practical and efficient schemes that achieve a good balance of network and channel rates with perfect secrecy guarantee. This work has a wide range of potential applications for which perfect secrecy is desired, such as cyber-physical systems, distributed-control systems, and ad-hoc networks.

Hongchao Zhou, Jehoshua Bruck

We study the problem of extracting a prescribed number of random bits by reading the smallest possible number of symbols from non-ideal stochastic processes. The related interval algorithm proposed by Han and Hoshi has asymptotically optimal performance; however, it assumes that the distribution of the input stochastic process is known. The motivation for our work is the fact that, in practice, sources of randomness have inherent correlations and are affected by measurement's noise. Namely, it is hard to obtain an accurate estimation of the distribution. This challenge was addressed by the concepts of seeded and seedless extractors that can handle general random sources with unknown distributions. However, known seeded and seedless extractors provide extraction efficiencies that are substantially smaller than Shannon's entropy limit. Our main contribution is the design of extractors that have a variable input-length and a fixed output length, are efficient in the consumption of symbols from the source, are capable of generating random bits from general stochastic processes and approach the information theoretic upper bound on efficiency.

Hongchao Zhou, Jehoshua Bruck

Information-efficient approaches for extracting randomness from imperfect sources have been extensively studied, but simpler and faster ones are required in the high-speed applications of random number generation. In this paper, we focus on linear constructions, namely, applying linear transformation for randomness extraction. We show that linear transformations based on sparse random matrices are asymptotically optimal to extract randomness from independent sources and bit-fixing sources, and they are efficient (may not be optimal) to extract randomness from hidden Markov sources. Further study demonstrates the flexibility of such constructions on source models as well as their excellent information-preserving capabilities. Since linear transformations based on sparse random matrices are computationally fast and can be easy to implement using hardware like FPGAs, they are very attractive in the high-speed applications. In addition, we explore explicit constructions of transformation matrices. We show that the generator matrices of primitive BCH codes are good choices, but linear transformations based on such matrices require more computational time due to their high densities.

Hongchao Zhou, Ho-Lin Chen, Jehoshua Bruck

A stochastic flow network is a directed graph with incoming edges (inputs) and outgoing edges (outputs), tokens enter through the input edges, travel stochastically in the network, and can exit the network through the output edges. Each node in the network is a splitter, namely, a token can enter a node through an incoming edge and exit on one of the output edges according to a predefined probability distribution. Stochastic flow networks can be easily implemented by DNA-based chemical reactions, with promising applications in molecular computing and stochastic computing. In this paper, we address a fundamental synthesis question: Given a finite set of possible splitters and an arbitrary rational probability distribution, design a stochastic flow network, such that every token that enters the input edge will exit the outputs with the prescribed probability distribution. The problem of probability transformation dates back to von Neumann's 1951 work and was followed, among others, by Knuth and Yao in 1976. Most existing works have been focusing on the "simulation" of target distributions. In this paper, we design optimal-sized stochastic flow networks for "synthesizing" target distributions. It shows that when each splitter has two outgoing edges and is unbiased, an arbitrary rational probability \frac{a}{b} with a\leq b\leq 2^n can be realized by a stochastic flow network of size n that is optimal. Compared to the other stochastic systems, feedback (cycles in networks) strongly improves the expressibility of stochastic flow networks.