Zengyi Wang

Fengyi Zhang, Xujie Zeng, Mohan Liu et al.

Medical image segmentation is more clinically valuable when it supports diagnosis rather than merely producing lesion masks. However, diagnostically relevant lesion cues are often subtle and localized, while existing models may be distracted by background tissues, acoustic artifacts, and irrelevant visual correlations. To address this problem, we propose Rad-VLSM, a two-stage cross-modal framework for semantics-assisted lesion focusing, robust segmentation, and visually grounded diagnosis. In the first stage, a BLIP-2-based vision-language alignment module identifies lesion-related candidate regions under semantic guidance and converts them into box prompts. In the second stage, these prompts are fed into a SAM-based multitask network, where a multi-candidate region aggregation strategy improves prompt stability and guides lesion segmentation. The predicted masks are then used as spatial priors for diagnosis, and a visual-radiomics fusion head integrates lesion-aware visual features with selected radiomics descriptors. By using semantic information for localization rather than direct prediction, Rad-VLSM reduces text-to-diagnosis dependence and grounds diagnosis in lesion-level evidence. Experiments on a private clinical breast ultrasound dataset and public benchmarks show that Rad-VLSM achieves strong segmentation and diagnostic performance with favorable generalization.

Xiaolei Zhu, Xiaofei Jin, Ziyang Kang et al.

Neuromorphic computing promises brain-like efficiency, yet today's multi-chip systems scale over PCBs and incur orders-of-magnitude penalties in bandwidth, latency, and energy, undermining biological algorithms and system efficiency. We present DarwinWafer, a hyperscale system-on-wafer that replaces off-chip interconnects with wafer-scale, high-density integration of 64 Darwin3 chiplets on a 300 mm silicon interposer. A GALS NoC within each chiplet and an AER-based asynchronous wafer fabric with hierarchical time-step synchronization provide low-latency, coherent operation across the wafer. Each chiplet implements 2.35 M neurons and 0.1 B synapses, yielding 0.15 B neurons and 6.4 B synapses per wafer.At 333 MHz and 0.8 V, DarwinWafer consumes ~100 W and achieves 4.9 pJ/SOP, with 64 TSOPS peak throughput (0.64 TSOPS/W). Realization is enabled by a holistic chiplet-interposer co-design flow (including an in-house interposer-bump planner with early SI/PI and electro-thermal closure) and a warpage-tolerant assembly that fans out I/O via PCBlets and compliant pogo-pin connections, enabling robust, demountable wafer-to-board integration. Measurements confirm 10 mV supply droop and a uniform thermal profile (34-36 °C) under ~100 W. Application studies demonstrate whole-brain simulations: two zebrafish brains per chiplet with high connectivity fidelity (Spearman r = 0.896) and a mouse brain mapped across 32 chiplets (r = 0.645). To our knowledge, DarwinWafer represents a pioneering demonstration of wafer-scale neuromorphic computing, establishing a viable and scalable path toward large-scale, brain-like computation on silicon by replacing PCB-level interconnects with high-density, on-wafer integration.