Gouri Lakshmi S

Pritam Kar, Gouri Lakshmi S, Saptarshi Bej

Anomaly detection in medical imaging is essential for identifying rare pathological conditions, particularly when annotated abnormal samples are limited. We propose a hybrid anomaly detection framework that integrates self-supervised representation learning with manifold-based density estimation, a combination that remains largely unexplored in this domain. Medical images are first embedded into a latent feature space using pretrained, potentially domain-specific, backbones. These representations are then refined via Mean Shift Density Enhancement (MSDE), an iterative manifold-shifting procedure that moves samples toward regions of higher likelihood. Anomaly scores are subsequently computed using Gaussian density estimation in a PCA-reduced latent space, where Mahalanobis distance measures deviation from the learned normal distribution. The framework follows a one-class learning paradigm and requires only normal samples for training. Extensive experiments on seven medical imaging datasets demonstrate state-of-the-art performance. MSDE achieves the highest AUC on four datasets and the highest Average Precision on five datasets, including near-perfect performance on brain tumor detection (0.981 AUC/AP). These results underscore the potential of the proposed framework as a scalable clinical decision-support tool for early disease detection, screening in low-label settings, and robust deployment across diverse imaging modalities.

Gouri Lakshmi S, Athira Chandrasekharan, Harshit Kumar et al.

Spike-Timing-Dependent Plasticity (STDP) provides a biologically grounded learning rule for spiking neural networks (SNNs), but its reliance on precise spike timing and pairwise updates limits fast learning of weights. We introduce a supervised extension of Spike Agreement-Dependent Plasticity (SADP), which replaces pairwise spike-timing comparisons with population-level agreement metrics such as Cohen's kappa. The proposed learning rule preserves strict synaptic locality, admits linear-time complexity, and enables efficient supervised learning without backpropagation, surrogate gradients, or teacher forcing. We integrate supervised SADP within hybrid CNN-SNN architectures, where convolutional encoders provide compact feature representations that are converted into Poisson spike trains for agreement-driven learning in the SNN. Extensive experiments on MNIST, Fashion-MNIST, CIFAR-10, and biomedical image classification tasks demonstrate competitive performance and fast convergence. Additional analyses show stable performance across broad hyperparameter ranges and compatibility with device-inspired synaptic update dynamics. Together, these results establish supervised SADP as a scalable, biologically grounded, and hardware-aligned learning paradigm for spiking neural networks.