Raj Sunderraman

Yang Li, Xin Ma, Raj Sunderraman et al.

Neuroimaging-based prediction methods for intelligence and cognitive abilities have seen a rapid development in literature. Among different neuroimaging modalities, prediction based on functional connectivity (FC) has shown great promise. Most literature has focused on prediction using static FC, but there are limited investigations on the merits of such analysis compared to prediction based on dynamic FC or region level functional magnetic resonance imaging (fMRI) times series that encode temporal variability. To account for the temporal dynamics in fMRI data, we propose a deep neural network involving bi-directional long short-term memory (bi-LSTM) approach that also incorporates feature selection mechanism. The proposed pipeline is implemented via an efficient GPU computation framework and applied to predict intelligence scores based on region level fMRI time series as well as dynamic FC. We compare the prediction performance for different intelligence measures based on static FC, dynamic FC, and region level time series acquired from the Adolescent Brain Cognitive Development (ABCD) study involving close to 7000 individuals. Our detailed analysis illustrates that static FC consistently has inferior prediction performance compared to region level time series or dynamic FC for unimodal rest and task fMRI experiments, and in almost all cases using a combination of task and rest features. In addition, the proposed bi-LSTM pipeline based on region level time series identifies several shared and differential important brain regions across task and rest fMRI experiments that drive intelligence prediction. A test-retest analysis of the selected features shows strong reliability across cross-validation folds. Given the large sample size from ABCD study, our results provide strong evidence that superior prediction of intelligence can be achieved by accounting for temporal variations in fMRI.

Sepehr Salem Ghahfarokhi, M. Moein Esfahani, Raj Sunderraman et al.

Deep learning has significantly advanced automated brain tumor diagnosis, yet clinical adoption remains limited by interpretability and computational constraints. Conventional models often act as opaque ''black boxes'' and fail to quantify the complex, irregular tumor boundaries that characterize malignant growth. To address these challenges, we present XMorph, an explainable and computationally efficient framework for fine-grained classification of three prominent brain tumor types: glioma, meningioma, and pituitary tumors. We propose an Information-Weighted Boundary Normalization (IWBN) mechanism that emphasizes diagnostically relevant boundary regions alongside nonlinear chaotic and clinically validated features, enabling a richer morphological representation of tumor growth. A dual-channel explainable AI module combines GradCAM++ visual cues with LLM-generated textual rationales, translating model reasoning into clinically interpretable insights. The proposed framework achieves a classification accuracy of 96.0%, demonstrating that explainability and high performance can co-exist in AI-based medical imaging systems. The source code and materials for XMorph are all publicly available at: https://github.com/ALSER-Lab/XMorph.

Manish Dhakal, Venkat R. Dasari, Raj Sunderraman et al.

Parameter-efficient fine-tuning (PEFT) significantly reduces computational and memory costs by updating only a small subset of the model's parameters, enabling faster adaptation to new tasks with minimal loss in performance. Previous studies have introduced PEFTs tailored for point cloud data, as general approaches are suboptimal. To further reduce the number of trainable parameters, we propose a point-cloud-specific PEFT, termed Graph Features Tuning (GFT), which learns a dynamic graph from initial tokenized inputs of the transformer using a lightweight graph convolution network and passes these graph features to deeper layers via skip connections and efficient cross-attention modules. Extensive experiments on object classification and segmentation tasks show that GFT operates in the same domain, rivalling existing methods, while reducing the trainable parameters. Code is at https://github.com/manishdhakal/GFT.