Ankit Singhal

Sayak Mukherjee, Ramij R. Hossain, Yuan Liu et al.

This paper presents a novel federated reinforcement learning (Fed-RL) methodology to enhance the cyber resiliency of networked microgrids. We formulate a resilient reinforcement learning (RL) training setup which (a) generates episodic trajectories injecting adversarial actions at primary control reference signals of the grid forming (GFM) inverters and (b) trains the RL agents (or controllers) to alleviate the impact of the injected adversaries. To circumvent data-sharing issues and concerns for proprietary privacy in multi-party-owned networked grids, we bring in the aspects of federated machine learning and propose a novel Fed-RL algorithm to train the RL agents. To this end, the conventional horizontal Fed-RL approaches using decoupled independent environments fail to capture the coupled dynamics in a networked microgrid, which leads us to propose a multi-agent vertically federated variation of actor-critic algorithms, namely federated soft actor-critic (FedSAC) algorithm. We created a customized simulation setup encapsulating microgrid dynamics in the GridLAB-D/HELICS co-simulation platform compatible with the OpenAI Gym interface for training RL agents. Finally, the proposed methodology is validated with numerical examples of modified IEEE 123-bus benchmark test systems consisting of three coupled microgrids.

Sayak Mukherjee, Ramij R. Hossain, Sheik M. Mohiuddin et al.

Improving system-level resiliency of networked microgrids is an important aspect with increased population of inverter-based resources (IBRs). This paper (1) presents resilient control design in presence of adversarial cyber-events, and proposes a novel federated reinforcement learning (Fed-RL) approach to tackle (a) model complexities, unknown dynamical behaviors of IBR devices, (b) privacy issues regarding data sharing in multi-party-owned networked grids, and (2) transfers learned controls from simulation to hardware-in-the-loop test-bed, thereby bridging the gap between simulation and real world. With these multi-prong objectives, first, we formulate a reinforcement learning (RL) training setup generating episodic trajectories with adversaries (attack signal) injected at the primary controllers of the grid forming (GFM) inverters where RL agents (or controllers) are being trained to mitigate the injected attacks. For networked microgrids, the horizontal Fed-RL method involving distinct independent environments is not appropriate, leading us to develop vertical variant Federated Soft Actor-Critic (FedSAC) algorithm to grasp the interconnected dynamics of networked microgrid. Next, utilizing OpenAI Gym interface, we built a custom simulation set-up in GridLAB-D/HELICS co-simulation platform, named Resilient RL Co-simulation (ResRLCoSIM), to train the RL agents with IEEE 123-bus benchmark test systems comprising 3 interconnected microgrids. Finally, the learned policies in simulation world are transferred to the real-time hardware-in-the-loop test-bed set-up developed using high-fidelity Hypersim platform. Experiments show that the simulator-trained RL controllers produce convincing results with the real-time test-bed set-up, validating the minimization of sim-to-real gap.

Ankit Singhal

Synthesis and efficient implementation mRNA strands has been shown to have wide utility, especially recently in the development of COVID vaccines. However, the intrinsic chemical stability of mRNA poses a challenge due to the presence of 2'-hydroxyl groups in ribose sugars. The -OH group in the backbone structure enables a base-catalyzed nucleophilic attack by the deprotonated hydroxyl on the adjacent phosphorous and consequent self-hydrolysis of the phosphodiester bond. As expected for in-line hydrolytic cleavage reactions, the chemical stability of mRNA strands is highly dependent on external environmental factors, e.g. pH, temperature, oxidizers, etc. Predicting this chemical instability using a computational model will reduce the number of sequences synthesized and tested through identifying the most promising candidates, aiding the development of mRNA related therapies. This paper proposes and evaluates three deep learning models (Long Short Term Memory, Gated Recurrent Unit, and Graph Convolutional Networks) as methods to predict the reactivity and risk of degradation of mRNA sequences. The Stanford Open Vaccine dataset of 6034 mRNA sequences was used in this study. The training set consisted of 3029 of these sequences (length of 107 nucleotide bases) while the testing dataset consisted of 3005 sequences (length of 130 nucleotide bases), in structured (Lowest Entropy Base Pair Probability Matrix) and unstructured (Nodes and Edges) forms. The stability of mRNA strands was accurately generated, with the Graph Convolutional Network being the best predictor of reactivity ($RMSE = 0.249$) while the Gated Recurrent Unit Network was the best at predicting risks of degradation ($RMSE = 0.266$). Combining all target variables, the GRU performed the best with 76% accuracy. Results suggest these models can be applied to understand and predict the chemical stability of mRNA in the near future.