Haotian Gao

h-index5
2papers
215citations

2 Papers

6.6CLApr 5
RUQuant: Towards Refining Uniform Quantization for Large Language Models

Han Liu, Haotian Gao, Changya Li et al.

The increasing size and complexity of large language models (LLMs) have raised significant challenges in deployment efficiency, particularly under resource constraints. Post-training quantization (PTQ) has emerged as a practical solution by compressing models without requiring retraining. While existing methods focus on uniform quantization schemes for both weights and activations, they often suffer from substantial accuracy degradation due to the non-uniform nature of activation distributions. In this work, we revisit the activation quantization problem from a theoretical perspective grounded in the Lloyd-Max optimality conditions. We identify the core issue as the non-uniform distribution of activations within the quantization interval, which causes the optimal quantization point under the Lloyd-Max criterion to shift away from the midpoint of the interval. To address this issue, we propose a two-stage orthogonal transformation method, RUQuant. In the first stage, activations are divided into blocks. Each block is mapped to uniformly sampled target vectors using composite orthogonal matrices, which are constructed from Householder reflections and Givens rotations. In the second stage, a global Householder reflection is fine-tuned to further minimize quantization error using Transformer output discrepancies. Empirical results show that our method achieves near-optimal quantization performance without requiring model fine-tuning: RUQuant achieves 99.8% of full-precision accuracy with W6A6 and 97% with W4A4 quantization for a 13B LLM, within approximately one minute. A fine-tuned variant yields even higher accuracy, demonstrating the effectiveness and scalability of our approach.

4.6LGDec 3, 2024
COMET:Combined Matrix for Elucidating Targets

Haojie Wang, Zhe Zhang, Haotian Gao et al.

Identifying the interaction targets of bioactive compounds is a foundational element for deciphering their pharmacological effects. Target prediction algorithms equip researchers with an effective tool to rapidly scope and explore potential targets. Here, we introduce the COMET, a multi-technological modular target prediction tool that provides comprehensive predictive insights, including similar active compounds, three-dimensional predicted binding modes, and probability scores, all within an average processing time of less than 10 minutes per task. With meticulously curated data, the COMET database encompasses 990,944 drug-target interaction pairs and 45,035 binding pockets, enabling predictions for 2,685 targets, which span confirmed and exploratory therapeutic targets for human diseases. In comparative testing using datasets from ChEMBL and BindingDB, COMET outperformed five other well-known algorithms, offering nearly an 80% probability of accurately identifying at least one true target within the top 15 predictions for a given compound. COMET also features a user-friendly web server, accessible freely at https://www.pdbbind-plus.org.cn/comet.