Zhaonan Sun

Gerui Xu, Boyou Chen, Huizhong Guo et al.

Traffic collision reconstruction traditionally relies on human expertise, often yielding inconsistent results when analyzing incomplete multimodal data. This study develops a multi-agent AI framework that reconstructs pre-crash scenarios and infers vehicle behaviors from fragmented collision data. We present a two-phase collaborative framework combining reconstruction and reasoning phases. The system processes 277 rear-end lead vehicle deceleration (LVD) collisions from the Crash Investigation Sampling System, integrating textual crash reports, structured tabular data, and visual scene diagrams. Phase I generates natural-language crash reconstructions from multimodal inputs. Phase II performs in-depth crash reasoning by combining these reconstructions with temporal Event Data Recorder (EDR).For validation, we applied it to all LVD cases, focusing on a subset of 39 complex crashes where multiple EDR records per collision introduced ambiguity (e.g., due to missing or conflicting data).The evaluation of the 39 LVD crash cases revealed our framework achieved perfect accuracy across all test cases, successfully identifying both the most relevant EDR event and correctly distinguishing striking versus struck vehicles, surpassing the 92% accuracy achieved by human researchers on the same challenging dataset. The system maintained robust performance even when processing incomplete data, including missing or erroneous EDR records and ambiguous scene diagrams. This study demonstrates superior AI capabilities in processing heterogeneous collision data, providing unprecedented precision in reconstructing impact dynamics and characterizing pre-crash behaviors.

Boyou Chen, Gerui Xu, Zifei Wang et al.

Vehicle crashes involve complex interactions between road users, split-second decisions, and challenging environmental conditions. Among these, two-vehicle crashes are the most prevalent, accounting for approximately 70% of roadway crashes and posing a significant challenge to traffic safety. Identifying Driver Hazardous Action (DHA) is essential for understanding crash causation, yet the reliability of DHA data in large-scale databases is limited by inconsistent and labor-intensive manual coding practices. Here, we present an innovative framework that leverages a fine-tuned large language model to automatically infer DHAs from textual crash narratives, thereby improving the validity and interpretability of DHA classifications. Using five years of two-vehicle crash data from MTCF, we fine-tuned the Llama 3.2 1B model on detailed crash narratives and benchmarked its performance against conventional machine learning classifiers, including Random Forest, XGBoost, CatBoost, and a neural network. The fine-tuned LLM achieved an overall accuracy of 80%, surpassing all baseline models and demonstrating pronounced improvements in scenarios with imbalanced data. To increase interpretability, we developed a probabilistic reasoning approach, analyzing model output shifts across original test sets and three targeted counterfactual scenarios: variations in driver distraction and age. Our analysis revealed that introducing distraction for one driver substantially increased the likelihood of "General Unsafe Driving"; distraction for both drivers maximized the probability of "Both Drivers Took Hazardous Actions"; and assigning a teen driver markedly elevated the probability of "Speed and Stopping Violations." Our framework and analytical methods provide a robust and interpretable solution for large-scale automated DHA detection, offering new opportunities for traffic safety analysis and intervention.

Bum Chul Kwon, Vibha Anand, Kristen A Severson et al.

Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models (HMMs) and its variants are a class of models that both discover these states and make inferences of health states for patients. Despite the advantages of using the algorithms for discovering interesting patterns, it still remains challenging for medical experts to interpret model outputs, understand complex modeling parameters, and clinically make sense of the patterns. To tackle these problems, we conducted a design study with clinical scientists, statisticians, and visualization experts, with the goal to investigate disease progression pathways of chronic diseases, namely type 1 diabetes (T1D), Huntington's disease, Parkinson's disease, and chronic obstructive pulmonary disease (COPD). As a result, we introduce DPVis which seamlessly integrates model parameters and outcomes of HMMs into interpretable and interactive visualizations. In this study, we demonstrate that DPVis is successful in evaluating disease progression models, visually summarizing disease states, interactively exploring disease progression patterns, and building, analyzing, and comparing clinically relevant patient subgroups.

Bin Liu, Ying Li, Soumya Ghosh et al.

Type 2 diabetes mellitus (T2DM) is a chronic disease that often results in multiple complications. Risk prediction and profiling of T2DM complications is critical for healthcare professionals to design personalized treatment plans for patients in diabetes care for improved outcomes. In this paper, we study the risk of developing complications after the initial T2DM diagnosis from longitudinal patient records. We propose a novel multi-task learning approach to simultaneously model multiple complications where each task corresponds to the risk modeling of one complication. Specifically, the proposed method strategically captures the relationships (1) between the risks of multiple T2DM complications, (2) between the different risk factors, and (3) between the risk factor selection patterns. The method uses coefficient shrinkage to identify an informative subset of risk factors from high-dimensional data, and uses a hierarchical Bayesian framework to allow domain knowledge to be incorporated as priors. The proposed method is favorable for healthcare applications because in additional to improved prediction performance, relationships among the different risks and risk factors are also identified. Extensive experimental results on a large electronic medical claims database show that the proposed method outperforms state-of-the-art models by a significant margin. Furthermore, we show that the risk associations learned and the risk factors identified lead to meaningful clinical insights.

Zhengping Che, Yu Cheng, Shuangfei Zhai et al.

The rapid growth of Electronic Health Records (EHRs), as well as the accompanied opportunities in Data-Driven Healthcare (DDH), has been attracting widespread interests and attentions. Recent progress in the design and applications of deep learning methods has shown promising results and is forcing massive changes in healthcare academia and industry, but most of these methods rely on massive labeled data. In this work, we propose a general deep learning framework which is able to boost risk prediction performance with limited EHR data. Our model takes a modified generative adversarial network namely ehrGAN, which can provide plausible labeled EHR data by mimicking real patient records, to augment the training dataset in a semi-supervised learning manner. We use this generative model together with a convolutional neural network (CNN) based prediction model to improve the onset prediction performance. Experiments on two real healthcare datasets demonstrate that our proposed framework produces realistic data samples and achieves significant improvements on classification tasks with the generated data over several stat-of-the-art baselines.

Zhengping Che, Yu Cheng, Zhaonan Sun et al.

The widespread availability of electronic health records (EHRs) promises to usher in the era of personalized medicine. However, the problem of extracting useful clinical representations from longitudinal EHR data remains challenging. In this paper, we explore deep neural network models with learned medical feature embedding to deal with the problems of high dimensionality and temporality. Specifically, we use a multi-layer convolutional neural network (CNN) to parameterize the model and is thus able to capture complex non-linear longitudinal evolution of EHRs. Our model can effectively capture local/short temporal dependency in EHRs, which is beneficial for risk prediction. To account for high dimensionality, we use the embedding medical features in the CNN model which hold the natural medical concepts. Our initial experiments produce promising results and demonstrate the effectiveness of both the medical feature embedding and the proposed convolutional neural network in risk prediction on cohorts of congestive heart failure and diabetes patients compared with several strong baselines.