Jun Tan

Jun Tan, Qing Guo, Zicheng Xu et al.

Counterfactual explanations (CEs) are essential for actionable recourse, yet their reliability is often compromised in low-density regions, where classifiers exhibit high variance. Unlike existing methods that rely on expensive ensemble intersections to define stability, we propose \textit{DensityFlow}, a generative framework that constructs robust CEs by adhering to the high-confidence data manifold. Specifically, we model the counterfactual generation as continuous-time dynamics parameterized by Neural ODE, guided by a differentiable density score to actively avoid uncertain, low-density areas. This density score is learned via Noise Contrastive Estimation, effectively leveraging a $(K{+}1)$-way discriminator to estimate density ratios. For black-box settings, we introduce a local proxy distillation mechanism that aligns a lightweight surrogate with the target model strictly within the trajectory of CE generation, enabling efficient gradient-based optimization with minimal queries. Experiments demonstrate that \textit{DensityFlow} achieves superior validity under model multiplicity while significantly reducing query costs compared to ensemble-based baselines. Our implementation is available at https://github.com/G-AILab/DensityFlow.

Jinglin Li, Jun Tan, QI Fang et al.

Effectively modeling non-stationary dynamics in probabilistic multivariate time series(MTS) forecasting requires balancing expressiveness with robustness. Existing parametric approaches benefit from strong inductive biases but lack flexibility, whereas deep generative models struggle to capture complex temporal dependencies without extensive data and computation. We introduce Parametric Prior Mapping (PPM), a framework that injects parametric structural priors into a generative modeling process. Specifically, PPM utilizes a parametric estimator to derive a dynamic, adaptive prior that guides the learning of a complex predictive distribution via a learnable mapping. This design allows the model to retain the efficiency of parametric methods while exploiting the expressive power of generative models. Trained with a hybrid objective, PPM yields precise forecasts with well-calibrated uncertainty estimates. Empirical results show that PPM outperforms existing baselines in handling non-stationary data, offering a superior trade-off between accuracy and computational efficiency. The code is available at https://github.com/ljl8336/PPM.

Daijiafan Mao, Jun Tan, Guangyi Liu et al.

Under the ambition of boosting Plug-in Electric Vehicle (PEV) charging speed to a level comparable to the traditional refueling, Fast Charging Station (FCS) has been integrated into power distribution system. The location planning of FCS must allow for satisfactory charging service for PEV users as well as mitigate the detrimental effects on power grid caused by uncertainty and impulsiveness of charging demand. This paper proposed a location planning model for FCS, taking into account its impacts on the critical power grid assets. The multi-objective planning model simultaneously considered the role of FCS in the electricity and transportation sectors. This planning model is solved by the cross-entropy (CE) method. The validity and effectiveness of the CE approach have been demonstrated on a synthetic coupled network.

Zijie Fang, Yihan Liu, Yifeng Wang et al.

Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported. To overcome these challenges, we propose an interpretable deep learning pipeline, a Multi-Biomarker Histomorphology Discoverer (Multi-Beholder) model based on the multiple instance learning (MIL) framework, to predict the status of five biomarkers in LGG using only hematoxylin and eosin-stained whole slide images and slide-level biomarker status labels. Specifically, by incorporating the one-class classification into the MIL framework, accurate instance pseudo-labeling is realized for instance-level supervision, which greatly complements the slide-level labels and improves the biomarker prediction performance. Multi-Beholder demonstrates superior prediction performance and generalizability for five LGG biomarkers (AUROC=0.6469-0.9735) in two cohorts (n=607) with diverse races and scanning protocols. Moreover, the excellent interpretability of Multi-Beholder allows for discovering the quantitative and qualitative correlations between biomarker status and histomorphology characteristics. Our pipeline not only provides a novel approach for biomarker prediction, enhancing the applicability of molecular treatments for LGG patients but also facilitates the discovery of new mechanisms in molecular functionality and LGG progression.

Simin Ma, Shujian Liu, Jun Tan et al. · microsoft-research

Diverse instruction data is vital for effective instruction tuning of large language models, as it enables the model to generalize across different types of inputs . Building such diversified instruction dataset is an essential step in this process. Existing approaches often leverage large language models to automatically explore and generate diverse instructions, ensuring both data diversity and quality. However, they tend to overlook an important factor in real-world applications: on-task relevance. In practice, only a few real-world applications require a truly general-purpose model; most benefit from task-specific knowledge tailored to their particular use case. Therefore, it is vital to develop instruction augmentation methods that not only maintain diversity but are also optimized for specific, real-world scenarios. We thus introduce Task Centric Instruction Augmentation (TCIA), a framework that systematically expands instructions while preserving both diversity and task alignment. By representing instructions in a discrete query-constraints space, TCIA creates a rich set of task-relevant instructions and enables models to generalize to these task-specific instructions without sacrificing overall performance. Experiments show that TCIA improves open-source LLMs' performance by an average of 8.7% across four real-world, task-specific applications, and in some cases outperforming leading closed-source models. These improvements do not compromise general instruction-following ability, making TCIA a scalable and efficient solution for adapting LLMs to real-world, task-focused applications.

Ti Bai, Anjali Balagopal, Michael Dohopolski et al.

Automatic segmentation of anatomical structures is critical for many medical applications. However, the results are not always clinically acceptable and require tedious manual revision. Here, we present a novel concept called artificial intelligence assisted contour revision (AIACR) and demonstrate its feasibility. The proposed clinical workflow of AIACR is as follows given an initial contour that requires a clinicians revision, the clinician indicates where a large revision is needed, and a trained deep learning (DL) model takes this input to update the contour. This process repeats until a clinically acceptable contour is achieved. The DL model is designed to minimize the clinicians input at each iteration and to minimize the number of iterations needed to reach acceptance. In this proof-of-concept study, we demonstrated the concept on 2D axial images of three head-and-neck cancer datasets, with the clinicians input at each iteration being one mouse click on the desired location of the contour segment. The performance of the model is quantified with Dice Similarity Coefficient (DSC) and 95th percentile of Hausdorff Distance (HD95). The average DSC/HD95 (mm) of the auto-generated initial contours were 0.82/4.3, 0.73/5.6 and 0.67/11.4 for three datasets, which were improved to 0.91/2.1, 0.86/2.4 and 0.86/4.7 with three mouse clicks, respectively. Each DL-based contour update requires around 20 ms. We proposed a novel AIACR concept that uses DL models to assist clinicians in revising contours in an efficient and effective way, and we demonstrated its feasibility by using 2D axial CT images from three head-and-neck cancer datasets.

Dan Nguyen, Fernando Kay, Jun Tan et al.

Since the outbreak of the COVID-19 pandemic, worldwide research efforts have focused on using artificial intelligence (AI) technologies on various medical data of COVID-19-positive patients in order to identify or classify various aspects of the disease, with promising reported results. However, concerns have been raised over their generalizability, given the heterogeneous factors in training datasets. This study aims to examine the severity of this problem by evaluating deep learning (DL) classification models trained to identify COVID-19-positive patients on 3D computed tomography (CT) datasets from different countries. We collected one dataset at UT Southwestern (UTSW), and three external datasets from different countries: CC-CCII Dataset (China), COVID-CTset (Iran), and MosMedData (Russia). We divided the data into 2 classes: COVID-19-positive and COVID-19-negative patients. We trained nine identical DL-based classification models by using combinations of the datasets with a 72% train, 8% validation, and 20% test data split. The models trained on a single dataset achieved accuracy/area under the receiver operating characteristics curve (AUC) values of 0.87/0.826 (UTSW), 0.97/0.988 (CC-CCCI), and 0.86/0.873 (COVID-CTset) when evaluated on their own dataset. The models trained on multiple datasets and evaluated on a test set from one of the datasets used for training performed better. However, the performance dropped close to an AUC of 0.5 (random guess) for all models when evaluated on a different dataset outside of its training datasets. Including the MosMedData, which only contained positive labels, into the training did not necessarily help the performance on the other datasets. Multiple factors likely contribute to these results, such as patient demographics and differences in image acquisition or reconstruction, causing a data shift among different study cohorts.