Xiaoyan Wang

Rachael Fleurence, Jiang Bian, Xiaoyan Wang et al.

This review introduces the transformative potential of generative Artificial Intelligence (AI) and foundation models, including large language models (LLMs), for health technology assessment (HTA). We explore their applications in four critical areas, evidence synthesis, evidence generation, clinical trials and economic modeling: (1) Evidence synthesis: Generative AI has the potential to assist in automating literature reviews and meta-analyses by proposing search terms, screening abstracts, and extracting data with notable accuracy; (2) Evidence generation: These models can potentially facilitate automating the process and analyze the increasingly available large collections of real-world data (RWD), including unstructured clinical notes and imaging, enhancing the speed and quality of real-world evidence (RWE) generation; (3) Clinical trials: Generative AI can be used to optimize trial design, improve patient matching, and manage trial data more efficiently; and (4) Economic modeling: Generative AI can also aid in the development of health economic models, from conceptualization to validation, thus streamlining the overall HTA process. Despite their promise, these technologies, while rapidly improving, are still nascent and continued careful evaluation in their applications to HTA is required. To ensure their responsible use and implementation, both developers and users of research incorporating these tools, should familiarize themselves with their current limitations, including the issues related to scientific validity, risk of bias, and consider equity and ethical implications. We also surveyed the current policy landscape and provide suggestions for HTA agencies on responsibly integrating generative AI into their workflows, emphasizing the importance of human oversight and the fast-evolving nature of these tools.

James Mitchell-White, Reza Omdivar, Benjamin Partridge et al.

This paper introduces Llettuce, an open-source tool designed to address the complexities of converting medical terms into OMOP standard concepts. Unlike existing solutions such as the Athena database search and Usagi, which struggle with semantic nuances and require substantial manual input, Llettuce leverages advanced natural language processing, including large language models and fuzzy matching, to automate and enhance the mapping process. Developed with a focus on GDPR compliance, Llettuce can be deployed locally, ensuring data protection while maintaining high performance in converting informal medical terms to standardised concepts.

Zeju Li, Chao Zhang, Xiaoyan Wang et al.

The remarkable potential of multi-modal large language models (MLLMs) in comprehending both vision and language information has been widely acknowledged. However, the scarcity of 3D scenes-language pairs in comparison to their 2D counterparts, coupled with the inadequacy of existing approaches in understanding of 3D scenes by LLMs, poses a significant challenge. In response, we collect and construct an extensive dataset comprising 75K instruction-response pairs tailored for 3D scenes. This dataset addresses tasks related to 3D VQA, 3D grounding, and 3D conversation. To further enhance the integration of 3D spatial information into LLMs, we introduce a novel and efficient prompt tuning paradigm, 3DMIT. This paradigm eliminates the alignment stage between 3D scenes and language and extends the instruction prompt with the 3D modality information including the entire scene and segmented objects. We evaluate the effectiveness of our method across diverse tasks in the 3D scene domain and find that our approach serves as a strategic means to enrich LLMs' comprehension of the 3D world. Our code is available at https://github.com/staymylove/3DMIT.

Feihong He, Gang Li, Fuhui Sun et al.

The rapid development of generative diffusion models has significantly advanced the field of style transfer. However, most current style transfer methods based on diffusion models typically involve a slow iterative optimization process, e.g., model fine-tuning and textual inversion of style concept. In this paper, we introduce FreeStyle, an innovative style transfer method built upon a pre-trained large diffusion model, requiring no further optimization. Besides, our method enables style transfer only through a text description of the desired style, eliminating the necessity of style images. Specifically, we propose a dual-stream encoder and single-stream decoder architecture, replacing the conventional U-Net in diffusion models. In the dual-stream encoder, two distinct branches take the content image and style text prompt as inputs, achieving content and style decoupling. In the decoder, we further modulate features from the dual streams based on a given content image and the corresponding style text prompt for precise style transfer. Our experimental results demonstrate high-quality synthesis and fidelity of our method across various content images and style text prompts. Compared with state-of-the-art methods that require training, our FreeStyle approach notably reduces the computational burden by thousands of iterations, while achieving comparable or superior performance across multiple evaluation metrics including CLIP Aesthetic Score, CLIP Score, and Preference. We have released the code at: https://github.com/FreeStyleFreeLunch/FreeStyle.

Yibing Liu, Chong Zhang, Zhongyi Han et al.

We address the problem of runtime trajectory anomaly detection, a critical capability for enabling trustworthy LLM agents. Current safety measures predominantly focus on static input/output filtering. However, we argue that ensuring LLM agents reliability requires auditing the intermediate execution process. In this work, we formulate the task of Trajectory Anomaly Detection. The goal is not merely detection, but precise error localization. This capability is essential for enabling efficient rollback-and-retry. To achieve this, we construct TrajBench, a dataset synthesized via a perturb-and-complete strategy to cover diverse procedural anomalies. Using this benchmark, we investigate the capability of models in process supervision. We observe that general-purpose LLMs, even with zero-shot prompting, struggle to identify and localize these anomalies. This reveals that generalized capabilities do not automatically translate to process reliability. To address this, we propose TrajAD, a specialized verifier trained with fine-grained process supervision. Our approach outperforms baselines, demonstrating that specialized supervision is essential for building trustworthy agents.

Xiaoyan Wang, Zeju Li, Yifan Xu et al. · pku

New era has unlocked exciting possibilities for extending Large Language Models (LLMs) to tackle 3D vision-language tasks. However, most existing 3D multimodal LLMs (MLLMs) rely on compressing holistic 3D scene information or segmenting independent objects to perform these tasks, which limits their spatial awareness due to insufficient representation of the richness inherent in 3D scenes. To overcome these limitations, we propose Spatial 3D-LLM, a 3D MLLM specifically designed to enhance spatial awareness for 3D vision-language tasks by enriching the spatial embeddings of 3D scenes. Spatial 3D-LLM integrates an LLM backbone with a progressive spatial awareness scheme that progressively captures spatial information as the perception field expands, generating location-enriched 3D scene embeddings to serve as visual prompts. Furthermore, we introduce two novel tasks: 3D object distance measurement and 3D layout editing, and construct a 3D instruction dataset, MODEL, to evaluate the model's spatial awareness capabilities. Experimental results demonstrate that Spatial 3D-LLM achieves state-of-the-art performance across a wide range of 3D vision-language tasks, revealing the improvements stemmed from our progressive spatial awareness scheme of mining more profound spatial information. Our code is available at https://github.com/bjshuyuan/Spatial-3D-LLM.

McCoy R. Becker, Alexander K. Lew, Xiaoyan Wang et al.

Compared to the wide array of advanced Monte Carlo methods supported by modern probabilistic programming languages (PPLs), PPL support for variational inference (VI) is less developed: users are typically limited to a predefined selection of variational objectives and gradient estimators, which are implemented monolithically (and without formal correctness arguments) in PPL backends. In this paper, we propose a more modular approach to supporting variational inference in PPLs, based on compositional program transformation. In our approach, variational objectives are expressed as programs, that may employ first-class constructs for computing densities of and expected values under user-defined models and variational families. We then transform these programs systematically into unbiased gradient estimators for optimizing the objectives they define. Our design enables modular reasoning about many interacting concerns, including automatic differentiation, density accumulation, tracing, and the application of unbiased gradient estimation strategies. Additionally, relative to existing support for VI in PPLs, our design increases expressiveness along three axes: (1) it supports an open-ended set of user-defined variational objectives, rather than a fixed menu of options; (2) it supports a combinatorial space of gradient estimation strategies, many not automated by today's PPLs; and (3) it supports a broader class of models and variational families, because it supports constructs for approximate marginalization and normalization (previously introduced only for Monte Carlo inference). We implement our approach in an extension to the Gen probabilistic programming system (genjax.vi, implemented in JAX), and evaluate on several deep generative modeling tasks, showing minimal performance overhead vs. hand-coded implementations and performance competitive with well-established open-source PPLs.

Zhixing Zhang, Bichen Wu, Xiaoyan Wang et al.

Recent advances in diffusion models have successfully enabled text-guided image inpainting. While it seems straightforward to extend such editing capability into the video domain, there have been fewer works regarding text-guided video inpainting. Given a video, a masked region at its initial frame, and an editing prompt, it requires a model to do infilling at each frame following the editing guidance while keeping the out-of-mask region intact. There are three main challenges in text-guided video inpainting: ($i$) temporal consistency of the edited video, ($ii$) supporting different inpainting types at different structural fidelity levels, and ($iii$) dealing with variable video length. To address these challenges, we introduce Any-Length Video Inpainting with Diffusion Model, dubbed as AVID. At its core, our model is equipped with effective motion modules and adjustable structure guidance, for fixed-length video inpainting. Building on top of that, we propose a novel Temporal MultiDiffusion sampling pipeline with a middle-frame attention guidance mechanism, facilitating the generation of videos with any desired duration. Our comprehensive experiments show our model can robustly deal with various inpainting types at different video duration ranges, with high quality. More visualization results are made publicly available at https://zhang-zx.github.io/AVID/ .

Bichen Wu, Ching-Yao Chuang, Xiaoyan Wang et al.

In this paper, we introduce Fairy, a minimalist yet robust adaptation of image-editing diffusion models, enhancing them for video editing applications. Our approach centers on the concept of anchor-based cross-frame attention, a mechanism that implicitly propagates diffusion features across frames, ensuring superior temporal coherence and high-fidelity synthesis. Fairy not only addresses limitations of previous models, including memory and processing speed. It also improves temporal consistency through a unique data augmentation strategy. This strategy renders the model equivariant to affine transformations in both source and target images. Remarkably efficient, Fairy generates 120-frame 512x384 videos (4-second duration at 30 FPS) in just 14 seconds, outpacing prior works by at least 44x. A comprehensive user study, involving 1000 generated samples, confirms that our approach delivers superior quality, decisively outperforming established methods.

Rachael Fleurence, Xiaoyan Wang, Jiang Bian et al.

Objective: This article offers a taxonomy of generative artificial intelligence (AI) for health economics and outcomes research (HEOR), explores its emerging applications, and outlines methods to enhance the accuracy and reliability of AI-generated outputs. Methods: The review defines foundational generative AI concepts and highlights current HEOR applications, including systematic literature reviews, health economic modeling, real-world evidence generation, and dossier development. Approaches such as prompt engineering (zero-shot, few-shot, chain-of-thought, persona pattern prompting), retrieval-augmented generation, model fine-tuning, and the use of domain-specific models are introduced to improve AI accuracy and reliability. Results: Generative AI shows significant potential in HEOR, enhancing efficiency, productivity, and offering novel solutions to complex challenges. Foundation models are promising in automating complex tasks, though challenges remain in scientific reliability, bias, interpretability, and workflow integration. The article discusses strategies to improve the accuracy of these AI tools. Conclusion: Generative AI could transform HEOR by increasing efficiency and accuracy across various applications. However, its full potential can only be realized by building HEOR expertise and addressing the limitations of current AI technologies. As AI evolves, ongoing research and innovation will shape its future role in the field.

Rachael L. Fleurence, Dalia Dawoud, Jiang Bian et al.

Introduction: Generative artificial intelligence (AI), particularly large language models (LLMs), holds significant promise for Health Economics and Outcomes Research (HEOR). However, standardized reporting guidance for LLM-assisted research is lacking. This article introduces the ELEVATE GenAI framework and checklist - reporting guidelines specifically designed for HEOR studies involving LLMs. Methods: The framework was developed through a targeted literature review of existing reporting guidelines, AI evaluation frameworks, and expert input from the ISPOR Working Group on Generative AI. It comprises ten domains, including model characteristics, accuracy, reproducibility, and fairness and bias. The accompanying checklist translates the framework into actionable reporting items. To illustrate its use, the framework was applied to two published HEOR studies: one focused on systematic literature review tasks and the other on economic modeling. Results: The ELEVATE GenAI framework offers a comprehensive structure for reporting LLM-assisted HEOR research, while the checklist facilitates practical implementation. Its application to the two case studies demonstrates its relevance and usability across different HEOR contexts. Limitations: Although the framework provides robust reporting guidance, further empirical testing is needed to assess its validity, completeness, usability, as well as its generalizability across diverse HEOR use cases. Conclusion: The ELEVATE GenAI framework and checklist address a critical gap by offering structured guidance for transparent, accurate, and reproducible reporting of LLM-assisted HEOR research. Future work will focus on extensive testing and validation to support broader adoption and refinement.

Yifan Xu, Chao Zhang, Hanqi Jiang et al.

Advancements in foundation models have made it possible to conduct applications in various downstream tasks. Especially, the new era has witnessed a remarkable capability to extend Large Language Models (LLMs) for tackling tasks of 3D scene understanding. Current methods rely heavily on 3D point clouds, but the 3D point cloud reconstruction of an indoor scene often results in information loss. Some textureless planes or repetitive patterns are prone to omission and manifest as voids within the reconstructed 3D point clouds. Besides, objects with complex structures tend to introduce distortion of details caused by misalignments between the captured images and the dense reconstructed point clouds. 2D multi-view images present visual consistency with 3D point clouds and provide more detailed representations of scene components, which can naturally compensate for these deficiencies. Based on these insights, we propose Argus, a novel 3D multimodal framework that leverages multi-view images for enhanced 3D scene understanding with LLMs. In general, Argus can be treated as a 3D Large Multimodal Foundation Model (3D-LMM) since it takes various modalities as input(text instructions, 2D multi-view images, and 3D point clouds) and expands the capability of LLMs to tackle 3D tasks. Argus involves fusing and integrating multi-view images and camera poses into view-as-scene features, which interact with the 3D features to create comprehensive and detailed 3D-aware scene embeddings. Our approach compensates for the information loss while reconstructing 3D point clouds and helps LLMs better understand the 3D world. Extensive experiments demonstrate that our method outperforms existing 3D-LMMs in various downstream tasks.

Juan He, Xiaoyan Wang, Long Chen et al.

Wound healing is a complex process involving changes in collagen fibers. Accurate monitoring of these changes is crucial for assessing the progress of wound healing and has significant implications for guiding clinical treatment strategies and drug screening. However, traditional quantitative analysis methods focus on spatial characteristics such as collagen fiber alignment and variance, lacking threshold standards to differentiate between different stages of wound healing. To address this issue, we propose an innovative approach based on deep learning to predict the progression of wound healing by analyzing collagen fiber features in histological images of wound tissue. Leveraging the unique learning capabilities of deep learning models, our approach captures the feature variations of collagen fibers in histological images from different categories and classifies them into various stages of wound healing. To overcome the limited availability of histological image data, we employ a transfer learning strategy. Specifically, we fine-tune a VGG16 model pretrained on the ImageNet dataset to adapt it to the classification task of histological images of wounds. Through this process, our model achieves 82% accuracy in classifying six stages of wound healing. Furthermore, to enhance the interpretability of the model, we employ a class activation mapping technique called LayerCAM. LayerCAM reveals the image regions on which the model relies when making predictions, providing transparency to the model's decision-making process. This visualization not only helps us understand how the model identifies and evaluates collagen fiber features but also enhances trust in the model's prediction results. To the best of our knowledge, our proposed model is the first deep learning-based classification model used for predicting wound healing stages.

Guanyu Xu, Zhiwei Hao, Li Shen et al.

The impressive performance of transformer models has sparked the deployment of intelligent applications on resource-constrained edge devices. However, ensuring high-quality service for real-time edge systems is a significant challenge due to the considerable computational demands and resource requirements of these models. Existing strategies typically either offload transformer computations to other devices or directly deploy compressed models on individual edge devices. These strategies, however, result in either considerable communication overhead or suboptimal trade-offs between accuracy and efficiency. To tackle these challenges, we propose a collaborative inference system for general transformer models, termed CoFormer. The central idea behind CoFormer is to exploit the divisibility and integrability of transformer. An off-the-shelf large transformer can be decomposed into multiple smaller models for distributed inference, and their intermediate results are aggregated to generate the final output. We formulate an optimization problem to minimize both inference latency and accuracy degradation under heterogeneous hardware constraints. DeBo algorithm is proposed to first solve the optimization problem to derive the decomposition policy, and then progressively calibrate decomposed models to restore performance. We demonstrate the capability to support a wide range of transformer models on heterogeneous edge devices, achieving up to 3.1$\times$ inference speedup with large transformer models. Notably, CoFormer enables the efficient inference of GPT2-XL with 1.6 billion parameters on edge devices, reducing memory requirements by 76.3\%. CoFormer can also reduce energy consumption by approximately 40\% while maintaining satisfactory inference performance.

Matthew T. Dearing, Xiaoyan Wang

Many interesting datasets ubiquitous in machine learning and deep learning can be described via graphs. As the scale and complexity of graph-structured datasets increase, such as in expansive social networks, protein folding, chemical interaction networks, and material phase transitions, improving the efficiency of the machine learning techniques applied to these is crucial. In this study, we focus on Graph Neural Networks (GNN) that have found great success in tasks such as node or edge classification and link prediction. However, standard GNN models have scaling limits due to necessary recursive calculations performed through dense graph relationships that lead to memory and runtime bottlenecks. While new approaches for processing larger networks are needed to advance graph techniques, and several have been proposed, we study how GNNs could be parallelized using existing tools and frameworks that are known to be successful in the deep learning community. In particular, we investigate applying pipeline parallelism to GNN models with GPipe, introduced by Google in 2018.

Sourabh Kulkarni, Kinjal Divesh Shah, Nimar Arora et al.

We introduce PPL Bench, a new benchmark for evaluating Probabilistic Programming Languages (PPLs) on a variety of statistical models. The benchmark includes data generation and evaluation code for a number of models as well as implementations in some common PPLs. All of the benchmark code and PPL implementations are available on Github. We welcome contributions of new models and PPLs and as well as improvements in existing PPL implementations. The purpose of the benchmark is two-fold. First, we want researchers as well as conference reviewers to be able to evaluate improvements in PPLs in a standardized setting. Second, we want end users to be able to pick the PPL that is most suited for their modeling application. In particular, we are interested in evaluating the accuracy and speed of convergence of the inferred posterior. Each PPL only needs to provide posterior samples given a model and observation data. The framework automatically computes and plots growth in predictive log-likelihood on held out data in addition to reporting other common metrics such as effective sample size and $\hat{r}$.

Nuo Xu, Pinghui Wang, Long Chen et al.

Legal Judgment Prediction (LJP) is the task of automatically predicting a law case's judgment results given a text describing its facts, which has excellent prospects in judicial assistance systems and convenient services for the public. In practice, confusing charges are frequent, because law cases applicable to similar law articles are easily misjudged. For addressing this issue, the existing method relies heavily on domain experts, which hinders its application in different law systems. In this paper, we present an end-to-end model, LADAN, to solve the task of LJP. To distinguish confusing charges, we propose a novel graph neural network to automatically learn subtle differences between confusing law articles and design a novel attention mechanism that fully exploits the learned differences to extract compelling discriminative features from fact descriptions attentively. Experiments conducted on real-world datasets demonstrate the superiority of our LADAN.

Yunan Zhang, Xiang Cheng, Yufeng Zhang et al.

Answering complex questions involving multiple entities and relations is a challenging task. Logically, the answer to a complex question should be derived by decomposing the complex question into multiple simple sub-questions and then answering those sub-questions. Existing work has followed this strategy but has not attempted to optimize the order of how those sub-questions are answered. As a result, the sub-questions are answered in an arbitrary order, leading to larger search space and a higher risk of missing an answer. In this paper, we propose a novel reinforcement learning(RL) approach to answering complex questions that can learn a policy to dynamically decide which sub-question should be answered at each stage of reasoning. We lever-age the expected value-variance criterion to enable the learned policy to balance between the risk and utility of answering a sub-question. Experiment results show that the RL approach can substantially improve the optimality of ordering the sub-questions, leading to improved accuracy of question answering. The proposed method for learning to order sub-questions is general and can thus be potentially combined with many existing ideas for answering complex questions to enhance their performance.

Yu Gu, Yantong Wang, Tao Liu et al.

Emotion is well-recognized as a distinguished symbol of human beings, and it plays a crucial role in our daily lives. Existing vision-based or sensor-based solutions are either obstructive to use or rely on specialized hardware, hindering their applicability. This paper introduces EmoSense, a first-of-its-kind wireless emotion sensing system driven by computational intelligence. The basic methodology is to explore the physical expression of emotions from wireless channel response via data mining. The design and implementation of EmoSense {face} two major challenges: extracting physical expression from wireless channel data and recovering emotion from the corresponding physical expression. For the former, we present a Fresnel zone based theoretical model depicting the fingerprint of the physical expression on channel response. For the latter, we design an efficient computational intelligence driven mechanism to recognize emotion from the corresponding fingerprints. We prototyped EmoSense on the commodity WiFi infrastructure and compared it with main-stream sensor-based and vision-based approaches in the real-world scenario. The numerical study over $3360$ cases confirms that EmoSense achieves a comparable performance to the vision-based and sensor-based rivals under different scenarios. EmoSense only leverages the low-cost and prevalent WiFi infrastructures and thus constitutes a tempting solution for emotion sensing.

Xiaoyan Wang, Ran Li, Bowei Yan et al.

We propose a framework for constructing and analyzing multiclass and multioutput classification metrics, i.e., involving multiple, possibly correlated multiclass labels. Our analysis reveals novel insights on the geometry of feasible confusion tensors -- including necessary and sufficient conditions for the equivalence between optimizing an arbitrary non-decomposable metric and learning a weighted classifier. Further, we analyze averaging methodologies commonly used to compute multioutput metrics and characterize the corresponding Bayes optimal classifiers. We show that the plug-in estimator based on this characterization is consistent and is easily implemented as a post-processing rule. Empirical results on synthetic and benchmark datasets support the theoretical findings.

Ryan Musa, Xiaoyan Wang, Achille Fokoue et al.

Open-domain question answering (QA) is an important problem in AI and NLP that is emerging as a bellwether for progress on the generalizability of AI methods and techniques. Much of the progress in open-domain QA systems has been realized through advances in information retrieval methods and corpus construction. In this paper, we focus on the recently introduced ARC Challenge dataset, which contains 2,590 multiple choice questions authored for grade-school science exams. These questions are selected to be the most challenging for current QA systems, and current state of the art performance is only slightly better than random chance. We present a system that rewrites a given question into queries that are used to retrieve supporting text from a large corpus of science-related text. Our rewriter is able to incorporate background knowledge from ConceptNet and -- in tandem with a generic textual entailment system trained on SciTail that identifies support in the retrieved results -- outperforms several strong baselines on the end-to-end QA task despite only being trained to identify essential terms in the original source question. We use a generalizable decision methodology over the retrieved evidence and answer candidates to select the best answer. By combining query rewriting, background knowledge, and textual entailment our system is able to outperform several strong baselines on the ARC dataset.

Xiaoyan Wang, Pavan Kapanipathi, Ryan Musa et al.

Natural Language Inference (NLI) is fundamental to many Natural Language Processing (NLP) applications including semantic search and question answering. The NLI problem has gained significant attention thanks to the release of large scale, challenging datasets. Present approaches to the problem largely focus on learning-based methods that use only textual information in order to classify whether a given premise entails, contradicts, or is neutral with respect to a given hypothesis. Surprisingly, the use of methods based on structured knowledge -- a central topic in artificial intelligence -- has not received much attention vis-a-vis the NLI problem. While there are many open knowledge bases that contain various types of reasoning information, their use for NLI has not been well explored. To address this, we present a combination of techniques that harness knowledge graphs to improve performance on the NLI problem in the science questions domain. We present the results of applying our techniques on text, graph, and text-to-graph based models, and discuss implications for the use of external knowledge in solving the NLI problem. Our model achieves the new state-of-the-art performance on the NLI problem over the SciTail science questions dataset.