Tong Xia

Chinedu Innocent Nwoye, Deepak Alapatt, Tong Yu et al.

Context-aware decision support in the operating room can foster surgical safety and efficiency by leveraging real-time feedback from surgical workflow analysis. Most existing works recognize surgical activities at a coarse-grained level, such as phases, steps or events, leaving out fine-grained interaction details about the surgical activity; yet those are needed for more helpful AI assistance in the operating room. Recognizing surgical actions as triplets of <instrument, verb, target> combination delivers comprehensive details about the activities taking place in surgical videos. This paper presents CholecTriplet2021: an endoscopic vision challenge organized at MICCAI 2021 for the recognition of surgical action triplets in laparoscopic videos. The challenge granted private access to the large-scale CholecT50 dataset, which is annotated with action triplet information. In this paper, we present the challenge setup and assessment of the state-of-the-art deep learning methods proposed by the participants during the challenge. A total of 4 baseline methods from the challenge organizers and 19 new deep learning algorithms by competing teams are presented to recognize surgical action triplets directly from surgical videos, achieving mean average precision (mAP) ranging from 4.2% to 38.1%. This study also analyzes the significance of the results obtained by the presented approaches, performs a thorough methodological comparison between them, in-depth result analysis, and proposes a novel ensemble method for enhanced recognition. Our analysis shows that surgical workflow analysis is not yet solved, and also highlights interesting directions for future research on fine-grained surgical activity recognition which is of utmost importance for the development of AI in surgery.

Sofia Yfantidou, Dimitris Spathis, Marios Constantinides et al. · cambridge

How can we ensure that Ubiquitous Computing (UbiComp) research outcomes are both ethical and fair? While fairness in machine learning (ML) has gained traction in recent years, fairness in UbiComp remains unexplored. This workshop aims to discuss fairness in UbiComp research and its social, technical, and legal implications. From a social perspective, we will examine the relationship between fairness and UbiComp research and identify pathways to ensure that ubiquitous technologies do not cause harm or infringe on individual rights. From a technical perspective, we will initiate a discussion on data practices to develop bias mitigation approaches tailored to UbiComp research. From a legal perspective, we will examine how new policies shape our community's work and future research. We aim to foster a vibrant community centered around the topic of responsible UbiComp, while also charting a clear path for future research endeavours in this field.

Runwen You, Tong Xia, Jingzhi Wang et al.

Urban data support a wide range of applications across multiple disciplines. However, at the global scale, there is no unified platform for urban data discovery. As a result, researchers often have to manually search through websites or scientific literature to identify relevant datasets. To address this problem, we curate an open urban data discovery portal, \textit{UrbanDataMiner}, which supports dataset-level search and filtering over more than 60{,}000 urban datasets extracted from over 15{,}000 Nature-affiliated publications. \textit{UrbanDataMiner} is enabled by \textit{Paper2Data}, a novel large-scale LLM-driven pipeline that automatically identifies dataset mentions in scientific papers and structures them using a unified urban data metadata schema. Human-annotated evaluation demonstrates that \textit{Paper2Data} achieves high recall (approximately 90\%) in dataset identification and high field-level precision (above 80\%). In addition, \textit{UrbanDataMiner} can retrieve over 9\% of datasets that are not easily discoverable through general-purpose search engines such as Google. Overall, our work provides the first large-scale, literature-derived infrastructure for urban data discovery and enables more systematic and reusable data-driven research across disciplines. Our code and data are publicly available\footnote{https://github.com/Yourunwen/Paper2Data}.

Jialu Tang, Tong Xia, Yuan Lu et al.

Interpreting electrocardiograms (ECGs) and generating comprehensive reports remain challenging tasks in cardiology, often requiring specialized expertise and significant time investment. To address these critical issues, we propose ECG-ReGen, a retrieval-based approach for ECG-to-text report generation and question answering. Our method leverages a self-supervised learning for the ECG encoder, enabling efficient similarity searches and report retrieval. By combining pre-training with dynamic retrieval and Large Language Model (LLM)-based refinement, ECG-ReGen effectively analyzes ECG data and answers related queries, with the potential of improving patient care. Experiments conducted on the PTB-XL and MIMIC-IV-ECG datasets demonstrate superior performance in both in-domain and cross-domain scenarios for report generation. Furthermore, our approach exhibits competitive performance on ECG-QA dataset compared to fully supervised methods when utilizing off-the-shelf LLMs for zero-shot question answering. This approach, effectively combining self-supervised encoder and LLMs, offers a scalable and efficient solution for accurate ECG interpretation, holding significant potential to enhance clinical decision-making.

Tong Xia, Jing Han, Abhirup Ghosh et al.

Federated learning (FL) aided health diagnostic models can incorporate data from a large number of personal edge devices (e.g., mobile phones) while keeping the data local to the originating devices, largely ensuring privacy. However, such a cross-device FL approach for health diagnostics still imposes many challenges due to both local data imbalance (as extreme as local data consists of a single disease class) and global data imbalance (the disease prevalence is generally low in a population). Since the federated server has no access to data distribution information, it is not trivial to solve the imbalance issue towards an unbiased model. In this paper, we propose FedLoss, a novel cross-device FL framework for health diagnostics. Here the federated server averages the models trained on edge devices according to the predictive loss on the local data, rather than using only the number of samples as weights. As the predictive loss better quantifies the data distribution at a device, FedLoss alleviates the impact of data imbalance. Through a real-world dataset on respiratory sound and symptom-based COVID-$19$ detection task, we validate the superiority of FedLoss. It achieves competitive COVID-$19$ detection performance compared to a centralised model with an AUC-ROC of $79\%$. It also outperforms the state-of-the-art FL baselines in sensitivity and convergence speed. Our work not only demonstrates the promise of federated COVID-$19$ detection but also paves the way to a plethora of mobile health model development in a privacy-preserving fashion.

Zhenyu Han, Yanxin Xi, Tong Xia et al.

Built environment supports all the daily activities and shapes our health. Leveraging informative street view imagery, previous research has established the profound correlation between the built environment and chronic, non-communicable diseases; however, predicting the exposure risk of infectious diseases remains largely unexplored. The person-to-person contacts and interactions contribute to the complexity of infectious disease, which is inherently different from non-communicable diseases. Besides, the complex relationships between street view imagery and epidemic exposure also hinder accurate predictions. To address these problems, we construct a regional mobility graph informed by the gravity model, based on which we propose a transmission-aware graph convolutional network (GCN) to capture disease transmission patterns arising from human mobility. Experiments show that the proposed model significantly outperforms baseline models by 8.54% in weighted F1, shedding light on a low-cost, scalable approach to assess epidemic exposure risks from street view imagery.

Yu Yvonne Wu, Yuwei Zhang, Hyungjun Yoon et al.

Wearable foundation models (WFMs), trained on large volumes of data collected by affordable, always-on devices, have demonstrated strong performance on short-term, well-defined health monitoring tasks, including activity recognition, fitness tracking, and cardiovascular signal assessment. However, most existing WFMs primarily map short temporal windows to predefined labels via static encoders, emphasizing retrospective prediction rather than reasoning over evolving personal history, context, and future risk trajectories. As a result, they are poorly suited for modeling chronic, progressive, or episodic health conditions that unfold over weeks, months or years. Hence, we argue that WFMs must move beyond static encoders and be explicitly designed for longitudinal, anticipatory health reasoning. We identify three foundational shifts required to enable this transition: (1) Structurally rich data, which goes beyond isolated datasets or outcome-conditioned collection to integrated multimodal, long-term personal trajectories, and contextual metadata, ideally supported by open and interoperable data ecosystems; (2) Longitudinal-aware multimodal modeling, which prioritizes long-context inference, temporal abstraction, and personalization over cross-sectional or population-level prediction; and (3) Agentic inference systems, which move beyond static prediction to support planning, decision-making, and clinically grounded intervention under uncertainty. Together, these shifts reframe wearable health monitoring from retrospective signal interpretation toward continuous, anticipatory, and human-aligned health support.

Tong Xia, Abhirup Ghosh, Xinchi Qiu et al.

Federated Learning (FL) enables model development by leveraging data distributed across numerous edge devices without transferring local data to a central server. However, existing FL methods still face challenges when dealing with scarce and label-skewed data across devices, resulting in local model overfitting and drift, consequently hindering the performance of the global model. In response to these challenges, we propose a pioneering framework called \textit{FLea}, incorporating the following key components: \textit{i)} A global feature buffer that stores activation-target pairs shared from multiple clients to support local training. This design mitigates local model drift caused by the absence of certain classes; \textit{ii)} A feature augmentation approach based on local and global activation mix-ups for local training. This strategy enlarges the training samples, thereby reducing the risk of local overfitting; \textit{iii)} An obfuscation method to minimize the correlation between intermediate activations and the source data, enhancing the privacy of shared features. To verify the superiority of \textit{FLea}, we conduct extensive experiments using a wide range of data modalities, simulating different levels of local data scarcity and label skew. The results demonstrate that \textit{FLea} consistently outperforms state-of-the-art FL counterparts (among 13 of the experimented 18 settings, the improvement is over $5\%$) while concurrently mitigating the privacy vulnerabilities associated with shared features. Code is available at https://github.com/XTxiatong/FLea.git

Yuwei Zhang, Tong Xia, Jing Han et al.

Respiratory audio, such as coughing and breathing sounds, has predictive power for a wide range of healthcare applications, yet is currently under-explored. The main problem for those applications arises from the difficulty in collecting large labeled task-specific data for model development. Generalizable respiratory acoustic foundation models pretrained with unlabeled data would offer appealing advantages and possibly unlock this impasse. However, given the safety-critical nature of healthcare applications, it is pivotal to also ensure openness and replicability for any proposed foundation model solution. To this end, we introduce OPERA, an OPEn Respiratory Acoustic foundation model pretraining and benchmarking system, as the first approach answering this need. We curate large-scale respiratory audio datasets (~136K samples, over 400 hours), pretrain three pioneering foundation models, and build a benchmark consisting of 19 downstream respiratory health tasks for evaluation. Our pretrained models demonstrate superior performance (against existing acoustic models pretrained with general audio on 16 out of 19 tasks) and generalizability (to unseen datasets and new respiratory audio modalities). This highlights the great promise of respiratory acoustic foundation models and encourages more studies using OPERA as an open resource to accelerate research on respiratory audio for health. The system is accessible from https://github.com/evelyn0414/OPERA.

Tong Xia, Abhirup Ghosh, Xinchi Qiu et al.

Federated Learning (FL) enables model development by leveraging data distributed across numerous edge devices without transferring local data to a central server. However, existing FL methods still face challenges when dealing with scarce and label-skewed data across devices, resulting in local model overfitting and drift, consequently hindering the performance of the global model. In response to these challenges, we propose a pioneering framework called FLea, incorporating the following key components: i) A global feature buffer that stores activation-target pairs shared from multiple clients to support local training. This design mitigates local model drift caused by the absence of certain classes; ii) A feature augmentation approach based on local and global activation mix-ups for local training. This strategy enlarges the training samples, thereby reducing the risk of local overfitting; iii) An obfuscation method to minimize the correlation between intermediate activations and the source data, enhancing the privacy of shared features. To verify the superiority of FLea, we conduct extensive experiments using a wide range of data modalities, simulating different levels of local data scarcity and label skew. The results demonstrate that FLea consistently outperforms state-of-the-art FL counterparts (among 13 of the experimented 18 settings, the improvement is over 5% while concurrently mitigating the privacy vulnerabilities associated with shared features. Code is available at https://github.com/XTxiatong/FLea.git.

Erzhuo Shao, Jie Feng, Yingheng Wang et al.

Fine-grained population distribution data is of great importance for many applications, e.g., urban planning, traffic scheduling, epidemic modeling, and risk control. However, due to the limitations of data collection, including infrastructure density, user privacy, and business security, such fine-grained data is hard to collect and usually, only coarse-grained data is available. Thus, obtaining fine-grained population distribution from coarse-grained distribution becomes an important problem. To tackle this problem, existing methods mainly rely on sufficient fine-grained ground truth for training, which is not often available for the majority of cities. That limits the applications of these methods and brings the necessity to transfer knowledge between data-sufficient source cities to data-scarce target cities. In knowledge transfer scenario, we employ single reference fine-grained ground truth in target city, which is easy to obtain via remote sensing or questionnaire, as the ground truth to inform the large-scale urban structure and support the knowledge transfer in target city. By this approach, we transform the fine-grained population mapping problem into a one-shot transfer learning problem. In this paper, we propose a novel one-shot transfer learning framework PSRNet to transfer spatial-temporal knowledge across cities from the view of network structure, the view of data, and the view of optimization. Experiments on real-life datasets of 4 cities demonstrate that PSRNet has significant advantages over 8 state-of-the-art baselines by reducing RMSE and MAE by more than 25%. Our code and datasets are released in Github (https://github.com/erzhuoshao/PSRNet-CIKM).

Jiaju Chen, Jinghua Piao, Xia Xu et al.

A long-standing challenge in economics lies not in the lack of intuition, but in the difficulty of translating intuitive insights into verifiable research. To address this challenge, we introduce AgentEconomist, an end-to-end interactive system designed to translate abstract intuitions into executable computational experiments. Grounded in a domain-specific knowledge base covering over 13,000 high-quality academic papers, the system employs a modular multi-stage architecture. Specifically, the Idea Development Stage generates literature-grounded hypotheses, the Experimental Design Stage configures simulator-aligned experimental parameters and protocols, and the Experimental Execution Stage runs experiments and returns structured analyses. Together, these stages form a human-in-the-loop, iterative workflow that translates economic intuitions into executable computational experiments. Through extensive experiments involving human expert evaluation and large language models (LLMs) as judges, we show that the system generates research ideas with stronger literature grounding and higher novelty and insight than state-of-the-art generic LLMs. Overall, AgentEconomist adopts a human-AI collaboration paradigm that enables researchers to focus on high-level intuitions, while delegating the labor-intensive processes of translation and computational execution to agents.

Jialu Tang, Tong Xia, Yuan Lu et al.

Electrocardiogram (ECG) interpretation requires specialized expertise, often involving synthesizing insights from ECG signals with complex clinical queries posed in natural language. The scarcity of labeled ECG data coupled with the diverse nature of clinical inquiries presents a significant challenge for developing robust and adaptable ECG diagnostic systems. This work introduces a novel multimodal meta-learning method for few-shot ECG question answering, addressing the challenge of limited labeled data while leveraging the rich knowledge encoded within large language models (LLMs). Our LLM-agnostic approach integrates a pre-trained ECG encoder with a frozen LLM (e.g., LLaMA and Gemma) via a trainable fusion module, enabling the language model to reason about ECG data and generate clinically meaningful answers. Extensive experiments demonstrate superior generalization to unseen diagnostic tasks compared to supervised baselines, achieving notable performance even with limited ECG leads. For instance, in a 5-way 5-shot setting, our method using LLaMA-3.1-8B achieves an accuracy of 84.6%, 77.3%, and 69.6% on single verify, choose and query question types, respectively. These results highlight the potential of our method to enhance clinical ECG interpretation by combining signal processing with the nuanced language understanding capabilities of LLMs, particularly in data-constrained scenarios.

Yu Liu, Weiyao Tao, Tong Xia et al.

Survival analysis, which estimates the probability of event occurrence over time from censored data, is fundamental in numerous real-world applications, particularly in high-stakes domains such as healthcare and risk assessment. Despite advances in numerous survival models, quantifying the uncertainty of predictions from these models remains underexplored and challenging. The lack of reliable uncertainty quantification limits the interpretability and trustworthiness of survival models, hindering their adoption in clinical decision-making and other sensitive applications. To bridge this gap, in this work, we introduce SurvUnc, a novel meta-model based framework for post-hoc uncertainty quantification for survival models. SurvUnc introduces an anchor-based learning strategy that integrates concordance knowledge into meta-model optimization, leveraging pairwise ranking performance to estimate uncertainty effectively. Notably, our framework is model-agnostic, ensuring compatibility with any survival model without requiring modifications to its architecture or access to its internal parameters. Especially, we design a comprehensive evaluation pipeline tailored to this critical yet overlooked problem. Through extensive experiments on four publicly available benchmarking datasets and five representative survival models, we demonstrate the superiority of SurvUnc across multiple evaluation scenarios, including selective prediction, misprediction detection, and out-of-domain detection. Our results highlight the effectiveness of SurvUnc in enhancing model interpretability and reliability, paving the way for more trustworthy survival predictions in real-world applications.

Tong Xia, Weibin Li, Gang Liu et al.

LLM-based agents have demonstrated strong potential for autonomous machine learning, yet their applicability to health data remains limited. Existing systems often struggle to generalize across heterogeneous health data modalities, rely heavily on predefined solution templates with insufficient adaptation to task-specific objectives, and largely overlook uncertainty estimation, which is essential for reliable decision-making in healthcare. To address these challenges, we propose \textit{AutoHealth}, a novel uncertainty-aware multi-agent system that autonomously models health data and assesses model reliability. \textit{AutoHealth} employs closed-loop coordination among five specialized agents to perform data exploration, task-conditioned model construction, training, and optimization, while jointly prioritizing predictive performance and uncertainty quantification. Beyond producing ready-to-use models, the system generates comprehensive reports to support trustworthy interpretation and risk-aware decision-making. To rigorously evaluate its effectiveness, we curate a challenging real-world benchmark comprising 17 tasks across diverse data modalities and learning settings. \textit{AutoHealth} completes all tasks and outperforms state-of-the-art baselines by 29.2\% in prediction performance and 50.2\% in uncertainty estimation.

Gaia A. Bertolino, Yuwei Zhang, Tong Xia et al.

Conversational generative AI is rapidly entering healthcare, where general-purpose models must integrate heterogeneous patient signals and support diverse interaction styles while producing clinically meaningful outputs. In respiratory care, non-invasive audio, such as recordings captured via mobile microphones, enables scalable screening and longitudinal monitoring, but the heterogeneity challenge is particularly acute: recordings vary widely across devices, environments, and acquisition protocols, and questions span multiple intents and question formats. Existing biomedical audio-language QA systems are typically monolithic, without any specialization mechanisms for tackling diverse respiratory corpora and query intents. They are also only validated in limited settings, leaving it unclear how reliably they handle the shifts encountered in real-world settings. To address these limitations, we introduce RAMoEA-QA, a hierarchically routed generative model for respiratory audio question answering that unifies multiple question types and supports both discrete and continuous targets within a single multimodal system. RAMoEA-QA applies two-stage conditional specialization: an Audio Mixture-of-Experts routes each recording to a suitable pre-trained audio encoder, and a Language Mixture-of-Adapters selects a LoRA adapter on a shared frozen LLM to match the query intent and answer format. By specializing both acoustic representations and generation behaviour per example, RAMoEA-QA consistently outperforms strong baselines and routing ablations with minimal parameter overhead, improving in-domain test accuracy to 0.72 (vs. 0.61 and 0.67 for state-of-the-art baselines) and exhibiting the strongest generalization for diagnosis under domain, modality, and task shifts.

Jialu Tang, Tong Xia, Yuan Lu et al.

Accurate clinical prognosis requires synthesizing structured Electronic Health Records (EHRs) with real-time physiological signals like the Electrocardiogram (ECG). Large Language Models (LLMs) offer a powerful reasoning engine for this task but struggle to natively process these heterogeneous, non-textual data types. To address this, we propose UniPACT (Unified Prognostic Question Answering for Clinical Time-series), a unified framework for prognostic question answering that bridges this modality gap. UniPACT's core contribution is a structured prompting mechanism that converts numerical EHR data into semantically rich text. This textualized patient context is then fused with representations learned directly from raw ECG waveforms, enabling an LLM to reason over both modalities holistically. We evaluate UniPACT on the comprehensive MDS-ED benchmark, it achieves a state-of-the-art mean AUROC of 89.37% across a diverse set of prognostic tasks including diagnosis, deterioration, ICU admission, and mortality, outperforming specialized baselines. Further analysis demonstrates that our multimodal, multi-task approach is critical for performance and provides robustness in missing data scenarios.

Tong Xia, Jiankun Zhang, Ruiwen You et al.

Urban research aims to understand how cities operate and evolve as complex adaptive systems. With the rapid growth of urban data and analytical methodologies, the central challenge of the field has shifted from data availability to the integration of heterogeneous data into coherent, verifiable urban knowledge through multidisciplinary approaches. Recent advances in AI, particularly the emergence of large language models (LLMs), have enabled the development of AI scientists capable of autonomous reasoning, hypothesis generation, and data-driven experimentation, demonstrating substantial potential for autonomous urban research. However, most general-purpose AI systems remain misaligned with the domain-specific knowledge, methodological conventions, and inferential standards required in urban studies. Here, we introduce the AI Urban Scientist, a knowledge-driven multi-agent framework designed to support autonomous urban research. Grounded in hypotheses, peer-review feedback, datasets, and research methodologies distilled from large-scale prior studies, the system constructs structured domain knowledge that guides LLM-based agents to automatically generate hypotheses, identify and integrate multi-source urban datasets, conduct empirical analyses and simulations, and iteratively refine analytical methods. Through this process, the framework synthesizes new insights in urban science and accelerates the urban research lifecycle.

Ran Piao, Yuan Lu, Hareld Kemps et al.

Voice-based health assessment offers unprecedented opportunities for scalable, non-invasive disease screening, yet existing approaches typically focus on single conditions and fail to leverage the rich, multi-faceted information embedded in speech. We present MARVEL (Multi-task Acoustic Representations for Voice-based Health Analysis), a privacy-conscious multitask learning framework that simultaneously detects nine distinct neurological, respiratory, and voice disorders using only derived acoustic features, eliminating the need for raw audio transmission. Our dual-branch architecture employs specialized encoders with task-specific heads sharing a common acoustic backbone, enabling effective cross-condition knowledge transfer. Evaluated on the large-scale Bridge2AI-Voice v2.0 dataset, MARVEL achieves an overall AUROC of 0.78, with exceptional performance on neurological disorders (AUROC = 0.89), particularly for Alzheimer's disease/mild cognitive impairment (AUROC = 0.97). Our framework consistently outperforms single-modal baselines by 5-19% and surpasses state-of-the-art self-supervised models on 7 of 9 tasks, while correlation analysis reveals that the learned representations exhibit meaningful similarities with established acoustic features, indicating that the model's internal representations are consistent with clinically recognized acoustic patterns. By demonstrating that a single unified model can effectively screen for diverse conditions, this work establishes a foundation for deployable voice-based diagnostics in resource-constrained and remote healthcare settings.

Harry Coppock, Alican Akman, Christian Bergler et al.

The COVID-19 pandemic has caused massive humanitarian and economic damage. Teams of scientists from a broad range of disciplines have searched for methods to help governments and communities combat the disease. One avenue from the machine learning field which has been explored is the prospect of a digital mass test which can detect COVID-19 from infected individuals' respiratory sounds. We present a summary of the results from the INTERSPEECH 2021 Computational Paralinguistics Challenges: COVID-19 Cough, (CCS) and COVID-19 Speech, (CSS).

Ting Dang, Jing Han, Tong Xia et al.

Recent work has shown the potential of using audio data (eg, cough, breathing, and voice) in the screening for COVID-19. However, these approaches only focus on one-off detection and detect the infection given the current audio sample, but do not monitor disease progression in COVID-19. Limited exploration has been put forward to continuously monitor COVID-19 progression, especially recovery, through longitudinal audio data. Tracking disease progression characteristics could lead to more timely treatment. The primary objective of this study is to explore the potential of longitudinal audio samples over time for COVID-19 progression prediction and, especially, recovery trend prediction using sequential deep learning techniques. Crowdsourced respiratory audio data, including breathing, cough, and voice samples, from 212 individuals over 5-385 days were analyzed. We developed a deep learning-enabled tracking tool using gated recurrent units (GRUs) to detect COVID-19 progression by exploring the audio dynamics of the individuals' historical audio biomarkers. The investigation comprised 2 parts: (1) COVID-19 detection in terms of positive and negative (healthy) tests, and (2) longitudinal disease progression prediction over time in terms of probability of positive tests. The strong performance for COVID-19 detection, yielding an AUROC of 0.79, a sensitivity of 0.75, and a specificity of 0.71 supported the effectiveness of the approach compared to methods that do not leverage longitudinal dynamics. We further examined the predicted disease progression trajectory, displaying high consistency with test results with a correlation of 0.75 in the test cohort and 0.86 in a subset of the test cohort who reported recovery. Our findings suggest that monitoring COVID-19 evolution via longitudinal audio data has potential in the tracking of individuals' disease progression and recovery.

Tong Xia, Jing Han, Cecilia Mascolo

A biosignal is a signal that can be continuously measured from human bodies, such as respiratory sounds, heart activity (ECG), brain waves (EEG), etc, based on which, machine learning models have been developed with very promising performance for automatic disease detection and health status monitoring. However, dataset shift, i.e., data distribution of inference varies from the distribution of the training, is not uncommon for real biosignal-based applications. To improve the robustness, probabilistic models with uncertainty quantification are adapted to capture how reliable a prediction is. Yet, assessing the quality of the estimated uncertainty remains a challenge. In this work, we propose a framework to evaluate the capability of the estimated uncertainty in capturing different types of biosignal dataset shifts with various degrees. In particular, we use three classification tasks based on respiratory sounds and electrocardiography signals to benchmark five representative uncertainty quantification methods. Extensive experiments show that, although Ensemble and Bayesian models could provide relatively better uncertainty estimations under dataset shifts, all tested models fail to meet the promise in trustworthy prediction and model calibration. Our work paves the way for a comprehensive evaluation for any newly developed biosignal classifiers.

Martin Wagner, Beat-Peter Müller-Stich, Anna Kisilenko et al.

PURPOSE: Surgical workflow and skill analysis are key technologies for the next generation of cognitive surgical assistance systems. These systems could increase the safety of the operation through context-sensitive warnings and semi-autonomous robotic assistance or improve training of surgeons via data-driven feedback. In surgical workflow analysis up to 91% average precision has been reported for phase recognition on an open data single-center dataset. In this work we investigated the generalizability of phase recognition algorithms in a multi-center setting including more difficult recognition tasks such as surgical action and surgical skill. METHODS: To achieve this goal, a dataset with 33 laparoscopic cholecystectomy videos from three surgical centers with a total operation time of 22 hours was created. Labels included annotation of seven surgical phases with 250 phase transitions, 5514 occurences of four surgical actions, 6980 occurences of 21 surgical instruments from seven instrument categories and 495 skill classifications in five skill dimensions. The dataset was used in the 2019 Endoscopic Vision challenge, sub-challenge for surgical workflow and skill analysis. Here, 12 teams submitted their machine learning algorithms for recognition of phase, action, instrument and/or skill assessment. RESULTS: F1-scores were achieved for phase recognition between 23.9% and 67.7% (n=9 teams), for instrument presence detection between 38.5% and 63.8% (n=8 teams), but for action recognition only between 21.8% and 23.3% (n=5 teams). The average absolute error for skill assessment was 0.78 (n=1 team). CONCLUSION: Surgical workflow and skill analysis are promising technologies to support the surgical team, but are not solved yet, as shown by our comparison of algorithms. This novel benchmark can be used for comparable evaluation and validation of future work.

Zefang Zong, Jingwei Wang, Tao Feng et al.

Recent technology development brings the boom of numerous new Demand-Driven Services (DDS) into urban lives, including ridesharing, on-demand delivery, express systems and warehousing. In DDS, a service loop is an elemental structure, including its service worker, the service providers and corresponding service targets. The service workers should transport either people or parcels from the providers to the target locations. Various planning tasks within DDS can thus be classified into two individual stages: 1) Dispatching, which is to form service loops from demand/supply distributions, and 2) Routing, which is to decide specific serving orders within the constructed loops. Generating high-quality strategies in both stages is important to develop DDS but faces several challenges. Meanwhile, deep reinforcement learning (DRL) has been developed rapidly in recent years. It is a powerful tool to solve these problems since DRL can learn a parametric model without relying on too many problem-based assumptions and optimize long-term effects by learning sequential decisions. In this survey, we first define DDS, then highlight common applications and important decision/control problems within. For each problem, we comprehensively introduce the existing DRL solutions. We also introduce open simulation environments for development and evaluation of DDS applications. Finally, we analyze remaining challenges and discuss further research opportunities in DRL solutions for DDS.

Jing Han, Tong Xia, Dimitris Spathis et al.

Researchers have been battling with the question of how we can identify Coronavirus disease (COVID-19) cases efficiently, affordably and at scale. Recent work has shown how audio based approaches, which collect respiratory audio data (cough, breathing and voice) can be used for testing, however there is a lack of exploration of how biases and methodological decisions impact these tools' performance in practice. In this paper, we explore the realistic performance of audio-based digital testing of COVID-19. To investigate this, we collected a large crowdsourced respiratory audio dataset through a mobile app, alongside recent COVID-19 test result and symptoms intended as a ground truth. Within the collected dataset, we selected 5,240 samples from 2,478 participants and split them into different participant-independent sets for model development and validation. Among these, we controlled for potential confounding factors (such as demographics and language). The unbiased model takes features extracted from breathing, coughs, and voice signals as predictors and yields an AUC-ROC of 0.71 (95\% CI: 0.65$-$0.77). We further explore different unbalanced distributions to show how biases and participant splits affect performance. Finally, we discuss how the realistic model presented could be integrated in clinical practice to realize continuous, ubiquitous, sustainable and affordable testing at population scale.

Tong Xia, Jing Han, Lorena Qendro et al.

Recently, sound-based COVID-19 detection studies have shown great promise to achieve scalable and prompt digital pre-screening. However, there are still two unsolved issues hindering the practice. First, collected datasets for model training are often imbalanced, with a considerably smaller proportion of users tested positive, making it harder to learn representative and robust features. Second, deep learning models are generally overconfident in their predictions. Clinically, false predictions aggravate healthcare costs. Estimation of the uncertainty of screening would aid this. To handle these issues, we propose an ensemble framework where multiple deep learning models for sound-based COVID-19 detection are developed from different but balanced subsets from original data. As such, data are utilized more effectively compared to traditional up-sampling and down-sampling approaches: an AUC of 0.74 with a sensitivity of 0.68 and a specificity of 0.69 is achieved. Simultaneously, we estimate uncertainty from the disagreement across multiple models. It is shown that false predictions often yield higher uncertainty, enabling us to suggest the users with certainty higher than a threshold to repeat the audio test on their phones or to take clinical tests if digital diagnosis still fails. This study paves the way for a more robust sound-based COVID-19 automated screening system.

Björn W. Schuller, Anton Batliner, Christian Bergler et al.

The INTERSPEECH 2021 Computational Paralinguistics Challenge addresses four different problems for the first time in a research competition under well-defined conditions: In the COVID-19 Cough and COVID-19 Speech Sub-Challenges, a binary classification on COVID-19 infection has to be made based on coughing sounds and speech; in the Escalation SubChallenge, a three-way assessment of the level of escalation in a dialogue is featured; and in the Primates Sub-Challenge, four species vs background need to be classified. We describe the Sub-Challenges, baseline feature extraction, and classifiers based on the 'usual' COMPARE and BoAW features as well as deep unsupervised representation learning using the AuDeep toolkit, and deep feature extraction from pre-trained CNNs using the Deep Spectrum toolkit; in addition, we add deep end-to-end sequential modelling, and partially linguistic analysis.

Jing Han, Chloë Brown, Jagmohan Chauhan et al.

The development of fast and accurate screening tools, which could facilitate testing and prevent more costly clinical tests, is key to the current pandemic of COVID-19. In this context, some initial work shows promise in detecting diagnostic signals of COVID-19 from audio sounds. In this paper, we propose a voice-based framework to automatically detect individuals who have tested positive for COVID-19. We evaluate the performance of the proposed framework on a subset of data crowdsourced from our app, containing 828 samples from 343 participants. By combining voice signals and reported symptoms, an AUC of $0.79$ has been attained, with a sensitivity of $0.68$ and a specificity of $0.82$. We hope that this study opens the door to rapid, low-cost, and convenient pre-screening tools to automatically detect the disease.

Tao Feng, Sirui Song, Tong Xia et al.

The recent outbreak of COVID-19 poses a serious threat to people's lives. Epidemic control strategies have also caused damage to the economy by cutting off humans' daily commute. In this paper, we develop an Individual-based Reinforcement Learning Epidemic Control Agent (IDRLECA) to search for smart epidemic control strategies that can simultaneously minimize infections and the cost of mobility intervention. IDRLECA first hires an infection probability model to calculate the current infection probability of each individual. Then, the infection probabilities together with individuals' health status and movement information are fed to a novel GNN to estimate the spread of the virus through human contacts. The estimated risks are used to further support an RL agent to select individual-level epidemic-control actions. The training of IDRLECA is guided by a specially designed reward function considering both the cost of mobility intervention and the effectiveness of epidemic control. Moreover, we design a constraint for control-action selection that eases its difficulty and further improve exploring efficiency. Extensive experimental results demonstrate that IDRLECA can suppress infections at a very low level and retain more than 95% of human mobility.

Tong Xia, Yunhan Qi, Jie Feng et al.

A considerable amount of mobility data has been accumulated due to the proliferation of location-based service. Nevertheless, compared with mobility data from transportation systems like the GPS module in taxis, this kind of data is commonly sparse in terms of individual trajectories in the sense that users do not access mobile services and contribute their data all the time. Consequently, the sparsity inevitably weakens the practical value of the data even it has a high user penetration rate. To solve this problem, we propose a novel attentional neural network-based model, named AttnMove, to densify individual trajectories by recovering unobserved locations at a fine-grained spatial-temporal resolution. To tackle the challenges posed by sparsity, we design various intra- and inter- trajectory attention mechanisms to better model the mobility regularity of users and fully exploit the periodical pattern from long-term history. We evaluate our model on two real-world datasets, and extensive results demonstrate the performance gain compared with the state-of-the-art methods. This also shows that, by providing high-quality mobility data, our model can benefit a variety of mobility-oriented down-stream applications.

Chloë Brown, Jagmohan Chauhan, Andreas Grammenos et al.

Audio signals generated by the human body (e.g., sighs, breathing, heart, digestion, vibration sounds) have routinely been used by clinicians as indicators to diagnose disease or assess disease progression. Until recently, such signals were usually collected through manual auscultation at scheduled visits. Research has now started to use digital technology to gather bodily sounds (e.g., from digital stethoscopes) for cardiovascular or respiratory examination, which could then be used for automatic analysis. Some initial work shows promise in detecting diagnostic signals of COVID-19 from voice and coughs. In this paper we describe our data analysis over a large-scale crowdsourced dataset of respiratory sounds collected to aid diagnosis of COVID-19. We use coughs and breathing to understand how discernible COVID-19 sounds are from those in asthma or healthy controls. Our results show that even a simple binary machine learning classifier is able to classify correctly healthy and COVID-19 sounds. We also show how we distinguish a user who tested positive for COVID-19 and has a cough from a healthy user with a cough, and users who tested positive for COVID-19 and have a cough from users with asthma and a cough. Our models achieve an AUC of above 80% across all tasks. These results are preliminary and only scratch the surface of the potential of this type of data and audio-based machine learning. This work opens the door to further investigation of how automatically analysed respiratory patterns could be used as pre-screening signals to aid COVID-19 diagnosis.

Sirui Song, Tong Xia, Depeng Jin et al.

Understanding urban dynamics, i.e., how the types and intensity of urban residents' activities in the city change along with time, is of urgent demand for building an efficient and livable city. Nonetheless, this is challenging due to the expanding urban population and the complicated spatial distribution of residents. In this paper, to reveal urban dynamics, we propose a novel system UrbanRhythm to reveal the urban dynamics hidden in human mobility data. UrbanRhythm addresses three questions: 1) What mobility feature should be used to present residents' high-dimensional activities in the city? 2) What are basic components of urban dynamics? 3) What are the long-term periodicity and short-term regularity of urban dynamics? In UrbanRhythm, we extract staying, leaving, arriving three attributes of mobility and use a image processing method Saak transform to calculate the mobility distribution feature. For the second question, several city states are identified by hierarchy clustering as the basic components of urban dynamics, such as sleeping states and working states. We further characterize the urban dynamics as the transform of city states along time axis. For the third question, we directly observe the long-term periodicity of urban dynamics from visualization. Then for the short-term regularity, we design a novel motif analysis method to discovery motifs as well as their hierarchy relationships. We evaluate our proposed system on two real-life datesets and validate the results according to App usage records. This study sheds light on urban dynamics hidden in human mobility and can further pave the way for more complicated mobility behavior modeling and deeper urban understanding.