Kai Yao

Zixian Su, Kai Yao, Xi Yang et al.

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation. Their augmented samples are usually insufficient in diversity and informativeness, thus failing to cover the possible target domain distribution. In this paper, we rethink the data augmentation strategy for SDG in medical image segmentation. Motivated by the class-level representation invariance and style mutability of medical images, we hypothesize that unseen target data can be sampled from a linear combination of $C$ (the class number) random variables, where each variable follows a location-scale distribution at the class level. Accordingly, data augmented can be readily made by sampling the random variables through a general form. On the empirical front, we implement such strategy with constrained B$\acute{\rm e}$zier transformation on both global and local (i.e. class-level) regions, which can largely increase the augmentation diversity. A Saliency-balancing Fusion mechanism is further proposed to enrich the informativeness by engaging the gradient information, guiding augmentation with proper orientation and magnitude. As an important contribution, we prove theoretically that our proposed augmentation can lead to an upper bound of the generalization risk on the unseen target domain, thus confirming our hypothesis. Combining the two strategies, our Saliency-balancing Location-scale Augmentation (SLAug) exceeds the state-of-the-art works by a large margin in two challenging SDG tasks. Code is available at https://github.com/Kaiseem/SLAug .

Matthias Eisenmann, Annika Reinke, Vivienn Weru et al. · utoronto

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Zhongyi Shui, Yunlong Zhang, Kai Yao et al.

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps requires carefully curated post-processing, which is error-prone and parameter-sensitive. Recently, the Segment Anything Model (SAM) has earned huge attention in medical image segmentation, owing to its impressive generalization ability and promptable property. Nevertheless, its potential on nucleus instance segmentation remains largely underexplored. In this paper, we present a novel prompt-driven framework that consists of a nucleus prompter and SAM for automatic nucleus instance segmentation. Specifically, the prompter learns to generate a unique point prompt for each nucleus while the SAM is fine-tuned to output the corresponding mask for the prompted nucleus. Furthermore, we propose the inclusion of adjacent nuclei as negative prompts to enhance the model's capability to identify overlapping nuclei. Without complicated post-processing, our proposed method sets a new state-of-the-art performance on three challenging benchmarks. Code is available at \url{github.com/windygoo/PromptNucSeg}

Kai Yao, Penglei Gao, Xi Yang et al.

Image outpainting, which is well studied with Convolution Neural Network (CNN) based framework, has recently drawn more attention in computer vision. However, CNNs rely on inherent inductive biases to achieve effective sample learning, which may degrade the performance ceiling. In this paper, motivated by the flexible self-attention mechanism with minimal inductive biases in transformer architecture, we reframe the generalised image outpainting problem as a patch-wise sequence-to-sequence autoregression problem, enabling query-based image outpainting. Specifically, we propose a novel hybrid vision-transformer-based encoder-decoder framework, named \textbf{Query} \textbf{O}utpainting \textbf{TR}ansformer (\textbf{QueryOTR}), for extrapolating visual context all-side around a given image. Patch-wise mode's global modeling capacity allows us to extrapolate images from the attention mechanism's query standpoint. A novel Query Expansion Module (QEM) is designed to integrate information from the predicted queries based on the encoder's output, hence accelerating the convergence of the pure transformer even with a relatively small dataset. To further enhance connectivity between each patch, the proposed Patch Smoothing Module (PSM) re-allocates and averages the overlapped regions, thus providing seamless predicted images. We experimentally show that QueryOTR could generate visually appealing results smoothly and realistically against the state-of-the-art image outpainting approaches.

Zixian Su, Kai Yao, Xi Yang et al.

Unsupervised cross-modality medical image adaptation aims to alleviate the severe domain gap between different imaging modalities without using the target domain label. A key in this campaign relies upon aligning the distributions of source and target domain. One common attempt is to enforce the global alignment between two domains, which, however, ignores the fatal local-imbalance domain gap problem, i.e., some local features with larger domain gap are harder to transfer. Recently, some methods conduct alignment focusing on local regions to improve the efficiency of model learning. While this operation may cause a deficiency of critical information from contexts. To tackle this limitation, we propose a novel strategy to alleviate the domain gap imbalance considering the characteristics of medical images, namely Global-Local Union Alignment. Specifically, a feature-disentanglement style-transfer module first synthesizes the target-like source-content images to reduce the global domain gap. Then, a local feature mask is integrated to reduce the 'inter-gap' for local features by prioritizing those discriminative features with larger domain gap. This combination of global and local alignment can precisely localize the crucial regions in segmentation target while preserving the overall semantic consistency. We conduct a series of experiments with two cross-modality adaptation tasks, i,e. cardiac substructure and abdominal multi-organ segmentation. Experimental results indicate that our method achieves state-of-the-art performance in both tasks.

Kai Yao, Marc Juarez

Model fingerprint detection has shown promise to trace the provenance of AI-generated images in forensic applications. However, despite the inherent adversarial nature of these applications, existing evaluations rarely consider adversarial settings. We present the first systematic security evaluation of these techniques, formalizing threat models that encompass both white- and black-box access and two attack goals: fingerprint removal, which erases identifying traces to evade attribution, and fingerprint forgery, which seeks to cause misattribution to a target model. We implement five attack strategies and evaluate 14 representative fingerprinting methods across RGB, frequency, and learned-feature domains on 12 state-of-the-art image generators. Our experiments reveal a pronounced gap between clean and adversarial performance. Removal attacks are highly effective, often achieving success rates above 80% in white-box settings and over 50% under black-box access. While forgery is more challenging than removal, its success varies significantly across targeted models. We also observe a utility-robustness trade-off: accurate attribution methods are often vulnerable to attacks and, although some techniques are robust in specific settings, none achieves robustness and accuracy across all evaluated threat models. These findings highlight the need for techniques that balance robustness and accuracy, and we identify the most promising approaches toward this goal. Code available at: https://github.com/kaikaiyao/SmudgedFingerprints.

Zixian Su, Jingwei Guo, Kai Yao et al.

While recent test-time adaptations exhibit efficacy by adjusting batch normalization to narrow domain disparities, their effectiveness diminishes with realistic mini-batches due to inaccurate target estimation. As previous attempts merely introduce source statistics to mitigate this issue, the fundamental problem of inaccurate target estimation still persists, leaving the intrinsic test-time domain shifts unresolved. This paper delves into the problem of mini-batch degradation. By unraveling batch normalization, we discover that the inexact target statistics largely stem from the substantially reduced class diversity in batch. Drawing upon this insight, we introduce a straightforward tool, Test-time Exponential Moving Average (TEMA), to bridge the class diversity gap between training and testing batches. Importantly, our TEMA adaptively extends the scope of typical methods beyond the current batch to incorporate a diverse set of class information, which in turn boosts an accurate target estimation. Built upon this foundation, we further design a novel layer-wise rectification strategy to consistently promote test-time performance. Our proposed method enjoys a unique advantage as it requires neither training nor tuning parameters, offering a truly hassle-free solution. It significantly enhances model robustness against shifted domains and maintains resilience in diverse real-world scenarios with various batch sizes, achieving state-of-the-art performance on several major benchmarks. Code is available at \url{https://github.com/kiwi12138/RealisticTTA}.

Penglei Gao, Kai Yao, Tiandi Ye et al.

In this paper, we tackle the recently popular topic of generating 360-degree images given the conventional narrow field of view (NFoV) images that could be taken from a single camera or cellphone. This task aims to predict the reasonable and consistent surroundings from the NFoV images. Existing methods for feature extraction and fusion, often built with transformer-based architectures, incur substantial memory usage and computational expense. They also have limitations in maintaining visual continuity across the entire 360-degree images, which could cause inconsistent texture and style generation. To solve the aforementioned issues, we propose a novel text-guided out-painting framework equipped with a State-Space Model called Mamba to utilize its long-sequence modelling and spatial continuity. Furthermore, incorporating textual information is an effective strategy for guiding image generation, enriching the process with detailed context and increasing diversity. Efficiently extracting textual features and integrating them with image attributes presents a significant challenge for 360-degree image out-painting. To address this, we develop two modules, Visual-textual Consistency Refiner (VCR) and Global-local Mamba Adapter (GMA). VCR enhances contextual richness by fusing the modified text features with the image features, while GMA provides adaptive state-selective conditions by capturing the information flow from global to local representations. Our proposed method achieves state-of-the-art performance with extensive experiments on two broadly used 360-degree image datasets, including indoor and outdoor settings.

Kai Yao, Penglei Gao, Lichun Li et al.

Parameter-Efficient Fine-Tuning (PEFT) methods have gained significant popularity for adapting pre-trained Large Language Models (LLMs) to downstream tasks, primarily due to their potential to significantly reduce memory and computational overheads. However, a common limitation in most PEFT approaches is their application of a uniform architectural design across all layers. This uniformity involves identical trainable modules and ignores the varying importance of each layer, leading to sub-optimal fine-tuning results. To overcome the above limitation and obtain better performance, we develop a novel approach, Importance-aware Sparse Tuning (IST), to fully utilize the inherent sparsity and select the most important subset of full layers with effective layer-wise importance scoring. The proposed IST is a versatile and plug-and-play technique compatible with various PEFT methods that operate on a per-layer basis. By leveraging the estimated importance scores, IST dynamically updates these selected layers in PEFT modules, leading to reduced memory demands. We further provide theoretical proof of convergence and empirical evidence of superior performance to demonstrate the advantages of IST over uniform updating strategies. Extensive experiments on a range of LLMs, PEFTs, and downstream tasks substantiate the effectiveness of our proposed method, showcasing IST's capacity to enhance existing layer-based PEFT methods. Our code is available at https://github.com/Kaiseem/IST.

Kai Yao, Zhenghan Song, Kaixin Wu et al.

Parameter-Efficient Fine-Tuning (PEFT) has become a key strategy for adapting large language models, with recent advances in sparse tuning reducing overhead by selectively updating key parameters or subsets of data. Existing approaches generally focus on two distinct paradigms: layer-selective methods aiming to fine-tune critical layers to minimize computational load, and data-selective methods aiming to select effective training subsets to boost training. However, current methods typically overlook the fact that different data points contribute varying degrees to distinct model layers, and they often discard potentially valuable information from data perceived as of low quality. To address these limitations, we propose Gradient-aligned Sparse Tuning (GAST), an innovative method that simultaneously performs selective fine-tuning at both data and layer dimensions as integral components of a unified optimization strategy. GAST specifically targets redundancy in information by employing a layer-sparse strategy that adaptively selects the most impactful data points for each layer, providing a more comprehensive and sophisticated solution than approaches restricted to a single dimension. Experiments demonstrate that GAST consistently outperforms baseline methods, establishing a promising direction for future research in PEFT strategies.

Chaolong Yang, Kai Yao, Yuyao Yan et al.

Audio-driven single-image talking portrait generation plays a crucial role in virtual reality, digital human creation, and filmmaking. Existing approaches are generally categorized into keypoint-based and image-based methods. Keypoint-based methods effectively preserve character identity but struggle to capture fine facial details due to the fixed points limitation of the 3D Morphable Model. Moreover, traditional generative networks face challenges in establishing causality between audio and keypoints on limited datasets, resulting in low pose diversity. In contrast, image-based approaches produce high-quality portraits with diverse details using the diffusion network but incur identity distortion and expensive computational costs. In this work, we propose KDTalker, the first framework to combine unsupervised implicit 3D keypoint with a spatiotemporal diffusion model. Leveraging unsupervised implicit 3D keypoints, KDTalker adapts facial information densities, allowing the diffusion process to model diverse head poses and capture fine facial details flexibly. The custom-designed spatiotemporal attention mechanism ensures accurate lip synchronization, producing temporally consistent, high-quality animations while enhancing computational efficiency. Experimental results demonstrate that KDTalker achieves state-of-the-art performance regarding lip synchronization accuracy, head pose diversity, and execution efficiency.Our codes are available at https://github.com/chaolongy/KDTalker.

Yixin Ji, Juntao Li, Yang Xiang et al.

The remarkable performance of the o1 model in complex reasoning demonstrates that test-time compute scaling can further unlock the model's potential, enabling powerful System-2 thinking. However, there is still a lack of comprehensive surveys for test-time compute scaling. We trace the concept of test-time compute back to System-1 models. In System-1 models, test-time compute addresses distribution shifts and improves robustness and generalization through parameter updating, input modification, representation editing, and output calibration. In System-2 models, it enhances the model's reasoning ability to solve complex problems through repeated sampling, self-correction, and tree search. We organize this survey according to the trend of System-1 to System-2 thinking, highlighting the key role of test-time compute in the transition from System-1 models to weak System-2 models, and then to strong System-2 models. We also point out advanced topics and future directions.

Kai Yao, Zhaorui Tan, Tiandi Ye et al.

Offsite-tuning is a privacy-preserving method for tuning large language models (LLMs) by sharing a lossy compressed emulator from the LLM owners with data owners for downstream task tuning. This approach protects the privacy of both the model and data owners. However, current offsite tuning methods often suffer from adaptation degradation, high computational costs, and limited protection strength due to uniformly dropping LLM layers or relying on expensive knowledge distillation. To address these issues, we propose ScaleOT, a novel privacy-utility-scalable offsite-tuning framework that effectively balances privacy and utility. ScaleOT introduces a novel layerwise lossy compression algorithm that uses reinforcement learning to obtain the importance of each layer. It employs lightweight networks, termed harmonizers, to replace the raw LLM layers. By combining important original LLM layers and harmonizers in different ratios, ScaleOT generates emulators tailored for optimal performance with various model scales for enhanced privacy protection. Additionally, we present a rank reduction method to further compress the original LLM layers, significantly enhancing privacy with negligible impact on utility. Comprehensive experiments show that ScaleOT can achieve nearly lossless offsite tuning performance compared with full fine-tuning while obtaining better model privacy.

Zhaorui Tan, Tan Pan, Kaizhu Huang et al.

LayerNorm is pivotal in Vision Transformers (ViTs), yet its fine-tuning dynamics under data scarcity and domain shifts remain underexplored. This paper shows that shifts in LayerNorm parameters after fine-tuning (LayerNorm shifts) are indicative of the transitions between source and target domains; its efficacy is contingent upon the degree to which the target training samples accurately represent the target domain, as quantified by our proposed Fine-tuning Shift Ratio ($FSR$). Building on this, we propose a simple yet effective rescaling mechanism using a scalar $λ$ that is negatively correlated to $FSR$ to align learned LayerNorm shifts with those ideal shifts achieved under fully representative data, combined with a cyclic framework that further enhances the LayerNorm fine-tuning. Extensive experiments across natural and pathological images, in both in-distribution (ID) and out-of-distribution (OOD) settings, and various target training sample regimes validate our framework. Notably, OOD tasks tend to yield lower $FSR$ and higher $λ$ in comparison to ID cases, especially with scarce data, indicating under-represented target training samples. Moreover, ViTFs fine-tuned on pathological data behave more like ID settings, favoring conservative LayerNorm updates. Our findings illuminate the underexplored dynamics of LayerNorm in transfer learning and provide practical strategies for LayerNorm fine-tuning.

Kai Yao, Marc Juarez

Generative models are increasingly adopted in high-stakes domains, yet current deployments offer no mechanisms to verify whether a given output truly originates from the certified model. We address this gap by extending model fingerprinting techniques beyond the traditional collaborative setting to one where the model provider itself may act adversarially, replacing the certified model with a cheaper or lower-quality substitute. To our knowledge, this is the first work to study fingerprinting for provenance attribution under such a threat model. Our approach introduces a trusted verifier that, during a certification phase, extracts hidden fingerprints from the authentic model's output space and trains a detector to recognize them. During verification, this detector can determine whether new outputs are consistent with the certified model, without requiring specialized hardware or model modifications. In extensive experiments, our methods achieve near-zero FPR@95%TPR on both GANs and diffusion models, and remain effective even against subtle architectural or training changes. Furthermore, the approach is robust to adaptive adversaries that actively manipulate outputs in an attempt to evade detection.

Kai Yao, Zhaorui Tan, Zixian Su et al.

Open compound domain adaptation (OCDA) aims to transfer knowledge from a labeled source domain to a mix of unlabeled homogeneous compound target domains while generalizing to open unseen domains. Existing OCDA methods solve the intra-domain gaps by a divide-and-conquer strategy, which divides the problem into several individual and parallel domain adaptation (DA) tasks. Such approaches often contain multiple sub-networks or stages, which may constrain the model's performance. In this work, starting from the general DA theory, we establish the generalization bound for the setting of OCDA. Built upon this, we argue that conventional OCDA approaches may substantially underestimate the inherent variance inside the compound target domains for model generalization. We subsequently present Stochastic Compound Mixing (SCMix), an augmentation strategy with the primary objective of mitigating the divergence between source and mixed target distributions. We provide theoretical analysis to substantiate the superiority of SCMix and prove that the previous methods are sub-groups of our methods. Extensive experiments show that our method attains a lower empirical risk on OCDA semantic segmentation tasks, thus supporting our theories. Combining the transformer architecture, SCMix achieves a notable performance boost compared to the SoTA results.

Kai Yao, Marc Juarez

Differential privacy has emerged as the most studied framework for privacy-preserving machine learning. However, recent studies show that enforcing differential privacy guarantees can not only significantly degrade the utility of the model, but also amplify existing disparities in its predictive performance across demographic groups. Although there is extensive research on the identification of factors that contribute to this phenomenon, we still lack a complete understanding of the mechanisms through which differential privacy exacerbates disparities. The literature on this problem is muddled by varying definitions of fairness, differential privacy mechanisms, and inconsistent experimental settings, often leading to seemingly contradictory results. This survey provides the first comprehensive overview of the factors that contribute to the disparate effect of training models with differential privacy guarantees. We discuss their impact and analyze their causal role in such a disparate effect. Our analysis is guided by a taxonomy that categorizes these factors by their position within the machine learning pipeline, allowing us to draw conclusions about their interaction and the feasibility of potential mitigation strategies. We find that factors related to the training dataset and the underlying distribution play a decisive role in the occurrence of disparate impact, highlighting the need for research on these factors to address the issue.

Zhongyi Shui, Honglin Li, Xiaozhong Ji et al.

Nucleus detection in histopathology is pivotal for a wide range of clinical applications. Existing approaches either regress nuclear proxy maps that require complex post-processing, or employ dense anchors or queries that introduce severe foreground-background imbalance. In this work, we reformulate nucleus detection as next-point prediction, wherein a multimodal large language model is developed to directly output foreground nucleus centroids from the input image. The model is trained in two stages. In the supervised learning stage, we propose spatial-aware soft supervision to relax strict centroid matching and a chain-of-visual-thought strategy to incorporate visual priors that facilitate coordinate prediction. In the reinforcement fine-tuning stage, we design distribution matching reward, low-variance group filtering, and fine-grained advantage shaping to further improve the model's detection quality. Extensive experiments on nine widely used benchmarks demonstrate the superiority of our method. Code will be released soon.

Tiandi Ye, Wenyan Liu, Kai Yao et al.

Federated learning (FL) is a privacy-preserving machine learning paradigm that enables collaborative model training across multiple distributed clients without disclosing their raw data. Personalized federated learning (pFL) has gained increasing attention for its ability to address data heterogeneity. However, most existing pFL methods assume that each client's data follows a single distribution and learn one client-level personalized model for each client. This assumption often fails in practice, where a single client may possess data from multiple sources or domains, resulting in significant intra-client heterogeneity and suboptimal performance. To tackle this challenge, we propose pFedBayesPT, a fine-grained instance-wise pFL framework based on visual prompt tuning. Specifically, we formulate instance-wise prompt generation from a Bayesian perspective and model the prompt posterior as an implicit distribution to capture diverse visual semantics. We derive a variational training objective under the semi-implicit variational inference framework. Extensive experiments on benchmark datasets demonstrate that pFedBayesPT consistently outperforms existing pFL methods under both feature and label heterogeneity settings.

Kai Yao, Zhaorui Tan, Penglei Gao et al.

The rapid growth of large language models (LLMs) with traditional centralized fine-tuning emerges as a key technique for adapting these models to domain-specific challenges, yielding privacy risks for both model and data owners. One promising solution, called offsite-tuning (OT), is proposed to address these challenges, where a weaker emulator is compressed from the original model and further fine-tuned with adapter to enhance privacy. However, the existing OT-based methods require high computational costs and lack theoretical analysis. This paper introduces a novel OT approach based on gradient-preserving compression, named GradOT. By analyzing the OT problem through the lens of optimization, we propose a method that selectively applies compression techniques such as rank compression and channel pruning, preserving the gradients of fine-tuned adapters while ensuring privacy. Extensive experiments demonstrate that our approach surpasses existing OT methods, both in terms of privacy protection and model performance. Our method provides a theoretical foundation for OT and offers a practical, training-free solution for offsite-tuning of large-scale LLMs.

Reuben Dorent, Aaron Kujawa, Marina Ivory et al.

Domain Adaptation (DA) has recently raised strong interests in the medical imaging community. While a large variety of DA techniques has been proposed for image segmentation, most of these techniques have been validated either on private datasets or on small publicly available datasets. Moreover, these datasets mostly addressed single-class problems. To tackle these limitations, the Cross-Modality Domain Adaptation (crossMoDA) challenge was organised in conjunction with the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2021). CrossMoDA is the first large and multi-class benchmark for unsupervised cross-modality DA. The challenge's goal is to segment two key brain structures involved in the follow-up and treatment planning of vestibular schwannoma (VS): the VS and the cochleas. Currently, the diagnosis and surveillance in patients with VS are performed using contrast-enhanced T1 (ceT1) MRI. However, there is growing interest in using non-contrast sequences such as high-resolution T2 (hrT2) MRI. Therefore, we created an unsupervised cross-modality segmentation benchmark. The training set provides annotated ceT1 (N=105) and unpaired non-annotated hrT2 (N=105). The aim was to automatically perform unilateral VS and bilateral cochlea segmentation on hrT2 as provided in the testing set (N=137). A total of 16 teams submitted their algorithm for the evaluation phase. The level of performance reached by the top-performing teams is strikingly high (best median Dice - VS:88.4%; Cochleas:85.7%) and close to full supervision (median Dice - VS:92.5%; Cochleas:87.7%). All top-performing methods made use of an image-to-image translation approach to transform the source-domain images into pseudo-target-domain images. A segmentation network was then trained using these generated images and the manual annotations provided for the source image.

Kai Yao, Kaizhu Huang, Jie Sun et al.

Automatic nuclei segmentation and classification play a vital role in digital pathology. However, previous works are mostly built on data with limited diversity and small sizes, making the results questionable or misleading in actual downstream tasks. In this paper, we aim to build a reliable and robust method capable of dealing with data from the 'the clinical wild'. Specifically, we study and design a new method to simultaneously detect, segment, and classify nuclei from Haematoxylin and Eosin (H&E) stained histopathology data, and evaluate our approach using the recent largest dataset: PanNuke. We address the detection and classification of each nuclei as a novel semantic keypoint estimation problem to determine the center point of each nuclei. Next, the corresponding class-agnostic masks for nuclei center points are obtained using dynamic instance segmentation. Meanwhile, we proposed a novel Joint Pyramid Fusion Module (JPFM) to model the cross-scale dependencies, thus enhancing the local feature for better nuclei detection and classification. By decoupling two simultaneous challenging tasks and taking advantage of JPFM, our method can benefit from class-aware detection and class-agnostic segmentation, thus leading to a significant performance boost. We demonstrate the superior performance of our proposed approach for nuclei segmentation and classification across 19 different tissue types, delivering new benchmark results.

Kai Yao, Kaizhu Huang, Jie Sun et al.

We consider unsupervised cell nuclei segmentation in this paper. Exploiting the recently-proposed unpaired image-to-image translation between cell nuclei images and randomly synthetic masks, existing approaches, e.g., CycleGAN, have achieved encouraging results. However, these methods usually take a two-stage pipeline and fail to learn end-to-end in cell nuclei images. More seriously, they could lead to the lossy transformation problem, i.e., the content inconsistency between the original images and the corresponding segmentation output. To address these limitations, we propose a novel end-to-end unsupervised framework called Aligned Disentangling Generative Adversarial Network (AD-GAN). Distinctively, AD-GAN introduces representation disentanglement to separate content representation (the underling spatial structure) from style representation (the rendering of the structure). With this framework, spatial structure can be preserved explicitly, enabling a significant reduction of macro-level lossy transformation. We also propose a novel training algorithm able to align the disentangled content in the latent space to reduce micro-level lossy transformation. Evaluations on real-world 2D and 3D datasets show that AD-GAN substantially outperforms the other comparison methods and the professional software both quantitatively and qualitatively. Specifically, the proposed AD-GAN leads to significant improvement over the current best unsupervised methods by an average 17.8% relatively (w.r.t. the metric DICE) on four cell nuclei datasets. As an unsupervised method, AD-GAN even performs competitive with the best supervised models, taking a further leap towards end-to-end unsupervised nuclei segmentation.

Jingxuan Li, Rui Huang, Wei Li et al.

Code completion is widely used by software developers to provide coding suggestions given a partially written code snippet. Apart from the traditional code completion methods, which only support single token completion at minimal positions, recent studies show the ability to provide longer code completion at more flexible positions. However, such frequently triggered and longer completion results reduce the overall precision as they generate more invalid results. Moreover, different studies are mostly incompatible with each other. Thus, it is vital to develop an ensemble framework that can combine results from multiple models to draw merits and offset defects of each model. This paper conducts a coding simulation to collect data from code context and different code completion models and then apply the data in two tasks. First, we introduce an acceptance model which can dynamically control whether to display completion results to the developer. It uses simulation features to predict whether correct results exist in the output of these models. Our best model reduces the percentage of false-positive completion from 55.09% to 17.44%. Second, we design a fusion ranking scheme that can automatically identify the priority of the completion results and reorder the candidates from multiple code completion models. This scheme is flexible in dealing with various models, regardless of the type or the length of their completion results. We integrate this ranking scheme with two frequency models and a GPT-2 styled language model, along with the acceptance model to yield 27.80% and 37.64% increase in TOP1 and TOP5 accuracy, respectively. In addition, we propose a new code completion evaluation metric, Benefit-Cost Ratio(BCR), taking into account the benefit of keystrokes saving and hidden cost of completion list browsing, which is closer to real coder experience scenario.

Kai Yao, Alberto Ortiz, Francisco Bonnin-Pascual

Following the success of machine vision systems for on-line automated quality control and inspection processes, an object recognition solution is presented in this work for two different specific applications, i.e., the detection of quality control items in surgery toolboxes prepared for sterilizing in a hospital, as well as the detection of defects in vessel hulls to prevent potential structural failures. The solution has two stages. First, a feature pyramid architecture based on Single Shot MultiBox Detector (SSD) is used to improve the detection performance, and a statistical analysis based on ground truth is employed to select parameters of a range of default boxes. Second, a lightweight neural network is exploited to achieve oriented detection results using a regression method. The first stage of the proposed method is capable of detecting the small targets considered in the two scenarios. In the second stage, despite the simplicity, it is efficient to detect elongated targets while maintaining high running efficiency.

Kai Yao, Alberto Ortiz, Francisco Bonnin-Pascual

It is generally accepted that one of the critical parts of current vision algorithms based on deep learning and convolutional neural networks is the annotation of a sufficient number of images to achieve competitive performance. This is particularly difficult for semantic segmentation tasks since the annotation must be ideally generated at the pixel level. Weakly-supervised semantic segmentation aims at reducing this cost by employing simpler annotations that, hence, are easier, cheaper and quicker to produce. In this paper, we propose and assess a new weakly-supervised semantic segmentation approach making use of a novel loss function whose goal is to counteract the effects of weak annotations. To this end, this loss function comprises several terms based on partial cross-entropy losses, being one of them the Centroid Loss. This term induces a clustering of the image pixels in the object classes under consideration, whose aim is to improve the training of the segmentation network by guiding the optimization. The performance of the approach is evaluated against datasets from two different industry-related case studies: while one involves the detection of instances of a number of different object classes in the context of a quality control application, the other stems from the visual inspection domain and deals with the localization of images areas whose pixels correspond to scene surface points affected by a specific sort of defect. The detection results that are reported for both cases show that, despite the differences among them and the particular challenges, the use of weak annotations do not prevent from achieving a competitive performance level for both.