Fabio Caccioli

Antonio Briola, Marwin Schmidt, Fabio Caccioli et al.

High-dimensional data often exhibit dependencies among variables that violate the isotropic-noise assumption under which principal component analysis (PCA) is optimal. For cases where the noise is not independent and identically distributed across features (i.e., the covariance is not spherical) we introduce Graph Regularized PCA (GR-PCA). It is a graph-based regularization of PCA that incorporates the dependency structure of the data features by learning a sparse precision graph and biasing loadings toward the low-frequency Fourier modes of the corresponding graph Laplacian. Consequently, high-frequency signals are suppressed, while graph-coherent low-frequency ones are preserved, yielding interpretable principal components aligned with conditional relationships. We evaluate GR-PCA on synthetic data spanning diverse graph topologies, signal-to-noise ratios, and sparsity levels. Compared to mainstream alternatives, it concentrates variance on the intended support, produces loadings with lower graph-Laplacian energy, and remains competitive in out-of-sample reconstruction. When high-frequency signals are present, the graph Laplacian penalty prevents overfitting, reducing the reconstruction accuracy but improving structural fidelity. The advantage over PCA is most pronounced when high-frequency signals are graph-correlated, whereas PCA remains competitive when such signals are nearly rotationally invariant. The procedure is simple to implement, modular with respect to the precision estimator, and scalable, providing a practical route to structure-aware dimensionality reduction that improves structural fidelity without sacrificing predictive performance.

Maxime Saxena, Marco Pangallo, Fabio Caccioli et al.

As Large Language Models (LLMs) become increasingly integrated into financial systems, understanding their behavioural properties is crucial. Do LLMs conform to the rational expectations paradigm, do they exhibit human-like "animal spirits", or do they instead manifest distinct "machine spirits"? We investigate these questions with a simulated financial market, exploring the behaviour of 15 LLMs spanning a range of sizes, capabilities, and providers. Our results show that LLMs exhibit a spectrum of economic behaviours, from stable coordination on the fundamental value to human-like speculative bubbles. These behaviours are generally inconsistent with the rational expectations hypothesis. We also consider an ecology of heterogeneous agents, a more realistic setting compared to markets with identical LLM agents. These mixed markets can produce outcomes which vary substantially across repeated simulations. Even the most advanced models fail to consistently stabilise the market, with price bubbles sometimes forming despite only a minority of agents naturally forming bubbles. Instead, advanced models in mixed markets adapt their forecasting strategies to the behaviour of other agents. This adaptation can allow them to successfully exploit less sophisticated counterparts and achieve higher profits, but can also contribute to increased market volatility. These findings suggest that the introduction of AI agents into financial markets fundamentally reshapes their ecology. In particular, heterogeneous populations of LLMs can generate endogenous instability, while individual-level adaptation may amplify, rather than mitigate, market volatility.

Biobele J. Brown, Alexander A. Przybylski, Petru Manescu et al.

Plasmodium falciparum malaria still poses one of the greatest threats to human life with over 200 million cases globally leading to half-million deaths annually. Of these, 90% of cases and of the mortality occurs in sub-Saharan Africa, mostly among children. Although malaria prediction systems are central to the 2016-2030 malaria Global Technical Strategy, currently these are inadequate at capturing and estimating the burden of disease in highly endemic countries. We developed and validated a computational system that exploits the predictive power of current Machine Learning approaches on 22-years of prospective data from the high-transmission holoendemic malaria urban-densely-populated sub-Saharan West-Africa metropolis of Ibadan. Our dataset of >9x104 screened study participants attending our clinical and community services from 1996 to 2017 contains monthly prevalence, temporal, environmental and host features. Our Locality-specific Elastic-Net based Malaria Prediction System (LEMPS) achieves good generalization performance, both in magnitude and direction of the prediction, when tasked to predict monthly prevalence on previously unseen validation data (MAE<=6x10-2, MSE<=7x10-3) within a range of (+0.1 to -0.05) error-tolerance which is relevant and usable for aiding decision-support in a holoendemic setting. LEMPS is well-suited for malaria prediction, where there are multiple features which are correlated with one another, and trading-off between regularization-strength L1-norm and L2-norm allows the system to retain stability. Data-driven systems are critical for regionally-adaptable surveillance, management of control strategies and resource allocation across stretched healthcare systems.