Jaume Anguera Peris

Saeed Razavikia, Jaume Anguera Peris, Jose Mairton B. da Silva et al.

Federated Edge Learning (FEEL) is a distributed machine learning technique where each device contributes to training a global inference model by independently performing local computations with their data. More recently, FEEL has been merged with over-the-air computation (OAC), where the global model is calculated over the air by leveraging the superposition of analog signals. However, when implementing FEEL with OAC, there is the challenge on how to precode the analog signals to overcome any time misalignment at the receiver. In this work, we propose a novel synchronization-free method to recover the parameters of the global model over the air without requiring any prior information about the time misalignments. For that, we construct a convex optimization based on the norm minimization problem to directly recover the global model by solving a convex semi-definite program. The performance of the proposed method is evaluated in terms of accuracy and convergence via numerical experiments. We show that our proposed algorithm is close to the ideal synchronized scenario by $10\%$, and performs $4\times$ better than the simple case where no recovering method is used.

Jaume Anguera Peris, Songtao Cheng, Hanzhao Zhang et al.

High-content screening microscopy generates large amounts of live-cell imaging data, yet its potential remains constrained by the inability to determine when and where to image most effectively. Optimally balancing acquisition time, computational capacity, and photobleaching budgets across thousands of dynamically evolving regions of interest remains an open challenge, further complicated by limited field-of-view adjustments and sensor sensitivity. Existing approaches either rely on static sampling or heuristics that neglect the dynamic evolution of biological processes, leading to inefficiencies and missed events. Here, we introduce the restless multi-process multi-armed bandit (RMPMAB), a new decision-theoretic framework in which each experimental region is modeled not as a single process but as an ensemble of Markov chains, thereby capturing the inherent heterogeneity of biological systems such as asynchronous cell cycles and heterogeneous drug responses. Building upon this foundation, we derive closed-form expressions for transient and asymptotic behaviors of aggregated processes, and design scalable Whittle index policies with sub-linear complexity in the number of imaging regions. Through both simulations and a real biological live-cell imaging dataset, we show that our approach achieves substantial improvements in throughput under resource constraints. Notably, our algorithm outperforms Thomson Sampling, Bayesian UCB, epsilon-Greedy, and Round Robin by reducing cumulative regret by more than 37% in simulations and capturing 93% more biologically relevant events in live imaging experiments, underscoring its potential for transformative smart microscopy. Beyond improving experimental efficiency, the RMPMAB framework unifies stochastic decision theory with optimal autonomous microscopy control, offering a principled approach to accelerate discovery across multidisciplinary sciences.