Dennis P. Wall

Peter Washington, Dennis P. Wall

Autism Spectrum Disorder (autism) is a neurodevelopmental delay which affects at least 1 in 44 children. Like many neurological disorder phenotypes, the diagnostic features are observable, can be tracked over time, and can be managed or even eliminated through proper therapy and treatments. Yet, there are major bottlenecks in the diagnostic, therapeutic, and longitudinal tracking pipelines for autism and related delays, creating an opportunity for novel data science solutions to augment and transform existing workflows and provide access to services for more affected families. Several prior efforts conducted by a multitude of research labs have spawned great progress towards improved digital diagnostics and digital therapies for children with autism. We review the literature of digital health methods for autism behavior quantification using data science. We describe both case-control studies and classification systems for digital phenotyping. We then discuss digital diagnostics and therapeutics which integrate machine learning models of autism-related behaviors, including the factors which must be addressed for translational use. Finally, we describe ongoing challenges and potent opportunities for the field of autism data science. Given the heterogeneous nature of autism and the complexities of the relevant behaviors, this review contains insights which are relevant to neurological behavior analysis and digital psychiatry more broadly.

Anish Lakkapragada, Essam Sleiman, Saimourya Surabhi et al.

Multi-Task Learning (MTL) is a growing subject of interest in deep learning, due to its ability to train models more efficiently on multiple tasks compared to using a group of conventional single-task models. However, MTL can be impractical as certain tasks can dominate training and hurt performance in others, thus making some tasks perform better in a single-task model compared to a multi-task one. Such problems are broadly classified as negative transfer, and many prior approaches in the literature have been made to mitigate these issues. One such current approach to alleviate negative transfer is to weight each of the losses so that they are on the same scale. Whereas current loss balancing approaches rely on either optimization or complex numerical analysis, none directly scale the losses based on their observed magnitudes. We propose multiple techniques for loss balancing based on scaling by the exponential moving average and benchmark them against current best-performing methods on three established datasets. On these datasets, they achieve comparable, if not higher, performance compared to current best-performing methods.

Yang Qian, Ali Kargarandehkordi, Onur Cezmi Mutlu et al.

Emotions play an essential role in human communication. Developing computer vision models for automatic recognition of emotion expression can aid in a variety of domains, including robotics, digital behavioral healthcare, and media analytics. There are three types of emotional representations which are traditionally modeled in affective computing research: Action Units, Valence Arousal (VA), and Categorical Emotions. As part of an effort to move beyond these representations towards more fine-grained labels, we describe our submission to the newly introduced Emotional Reaction Intensity (ERI) Estimation challenge in the 5th competition for Affective Behavior Analysis in-the-Wild (ABAW). We developed four deep neural networks trained in the visual domain and a multimodal model trained with both visual and audio features to predict emotion reaction intensity. Our best performing model on the Hume-Reaction dataset achieved an average Pearson correlation coefficient of 0.4080 on the test set using a pre-trained ResNet50 model. This work provides a first step towards the development of production-grade models which predict emotion reaction intensities rather than discrete emotion categories.

Peter Washington, Cezmi Mutlu, Aaron Kline et al.

Some of the most severe bottlenecks preventing widespread development of machine learning models for human behavior include a dearth of labeled training data and difficulty of acquiring high quality labels. Active learning is a paradigm for using algorithms to computationally select a useful subset of data points to label using metrics for model uncertainty and data similarity. We explore active learning for naturalistic computer vision emotion data, a particularly heterogeneous and complex data space due to inherently subjective labels. Using frames collected from gameplay acquired from a therapeutic smartphone game for children with autism, we run a simulation of active learning using gameplay prompts as metadata to aid in the active learning process. We find that active learning using information generated during gameplay slightly outperforms random selection of the same number of labeled frames. We next investigate a method to conduct active learning with subjective data, such as in affective computing, and where multiple crowdsourced labels can be acquired for each image. Using the Child Affective Facial Expression (CAFE) dataset, we simulate an active learning process for crowdsourcing many labels and find that prioritizing frames using the entropy of the crowdsourced label distribution results in lower categorical cross-entropy loss compared to random frame selection. Collectively, these results demonstrate pilot evaluations of two novel active learning approaches for subjective affective data collected in noisy settings.

Marie Huynh, Aaron Kline, Saimourya Surabhi et al.

Early detection of autism, a neurodevelopmental disorder marked by social communication challenges, is crucial for timely intervention. Recent advancements have utilized naturalistic home videos captured via the mobile application GuessWhat. Through interactive games played between children and their guardians, GuessWhat has amassed over 3,000 structured videos from 382 children, both diagnosed with and without Autism Spectrum Disorder (ASD). This collection provides a robust dataset for training computer vision models to detect ASD-related phenotypic markers, including variations in emotional expression, eye contact, and head movements. We have developed a protocol to curate high-quality videos from this dataset, forming a comprehensive training set. Utilizing this set, we trained individual LSTM-based models using eye gaze, head positions, and facial landmarks as input features, achieving test AUCs of 86%, 67%, and 78%, respectively. To boost diagnostic accuracy, we applied late fusion techniques to create ensemble models, improving the overall AUC to 90%. This approach also yielded more equitable results across different genders and age groups. Our methodology offers a significant step forward in the early detection of ASD by potentially reducing the reliance on subjective assessments and making early identification more accessibly and equitable.

Onur Cezmi Mutlu, Mohammadmahdi Honarmand, Saimourya Surabhi et al.

We introduce Temporal consistency for Test-time adaptation (TempT) a novel method for test-time adaptation on videos through the use of temporal coherence of predictions across sequential frames as a self-supervision signal. TempT is an approach with broad potential applications in computer vision tasks including facial expression recognition (FER) in videos. We evaluate TempT performance on the AffWild2 dataset. Our approach focuses solely on the unimodal visual aspect of the data and utilizes a popular 2D CNN backbone in contrast to larger sequential or attention-based models used in other approaches. Our preliminary experimental results demonstrate that TempT has competitive performance compared to the previous years reported performances and its efficacy provides a compelling proof-of-concept for its use in various real-world applications.

Yang Qian, Yinan Sun, Ali Kargarandehkordi et al.

The increasing variety and quantity of tagged multimedia content on a variety of online platforms offer a unique opportunity to advance the field of human action recognition. In this study, we utilize 283,582 unique, unlabeled TikTok video clips, categorized into 386 hashtags, to train a domain-specific foundation model for action recognition. We employ VideoMAE V2, an advanced model integrating Masked Autoencoders (MAE) with Vision Transformers (ViT), pre-trained on this diverse collection of unstructured videos. Our model, fine-tuned on established action recognition benchmarks such as UCF101 and HMDB51, achieves state-of-the-art results: 99.05% on UCF101, 86.08% on HMDB51, 85.51% on Kinetics-400, and 74.27% on Something-Something V2 using the ViT-giant backbone. These results highlight the potential of using unstructured and unlabeled videos as a valuable source of diverse and dynamic content for training foundation models. Our investigation confirms that while initial increases in pre-training data volume significantly enhance model performance, the gains diminish as the dataset size continues to expand. Our findings emphasize two critical axioms in self-supervised learning for computer vision: (1) additional pre-training data can yield diminishing benefits for some datasets and (2) quality is more important than quantity in self-supervised learning, especially when building foundation models.

Aditi Jaiswal, Dennis P. Wall, Peter Washington

Autism and Attention-Deficit Hyperactivity Disorder (ADHD) are two of the most commonly observed neurodevelopmental conditions in childhood. Providing a specific computational assessment to distinguish between the two can prove difficult and time intensive. Given the high prevalence of their co-occurrence, there is a need for scalable and accessible methods for distinguishing the co-occurrence of autism and ADHD from individual diagnoses. The first step is to identify a core set of features that can serve as the basis for behavioral feature extraction. We trained machine learning models on data from the National Survey of Children's Health to identify behaviors to target as features in automated clinical decision support systems. A model trained on the binary task of distinguishing either developmental delay (autism or ADHD) vs. neither achieved sensitivity >92% and specificity >94%, while a model trained on the 4-way classification task of autism vs. ADHD vs. both vs. none demonstrated >65% sensitivity and >66% specificity. While the performance of the binary model was respectable, the relatively low performance in the differential classification of autism and ADHD highlights the challenges that persist in achieving specificity within clinical decision support tools for developmental delays. Nevertheless, this study demonstrates the potential of applying behavioral questionnaires not traditionally used for clinical purposes towards supporting digital screening assessments for pediatric developmental delays.

Mohammadmahdi Honarmand, Onur Cezmi Mutlu, Parnian Azizian et al.

Robust facial expression recognition in unconstrained, "in-the-wild" environments remains challenging due to significant domain shifts between training and testing distributions. Test-time adaptation (TTA) offers a promising solution by adapting pre-trained models during inference without requiring labeled test data. However, existing TTA approaches typically rely on manually selecting which parameters to update, potentially leading to suboptimal adaptation and high computational costs. This paper introduces a novel Fisher-driven selective adaptation framework that dynamically identifies and updates only the most critical model parameters based on their importance as quantified by Fisher information. By integrating this principled parameter selection approach with temporal consistency constraints, our method enables efficient and effective adaptation specifically tailored for video-based facial expression recognition. Experiments on the challenging AffWild2 benchmark demonstrate that our approach significantly outperforms existing TTA methods, achieving a 7.7% improvement in F1 score over the base model while adapting only 22,000 parameters-more than 20 times fewer than comparable methods. Our ablation studies further reveal that parameter importance can be effectively estimated from minimal data, with sampling just 1-3 frames sufficient for substantial performance gains. The proposed approach not only enhances recognition accuracy but also dramatically reduces computational overhead, making test-time adaptation more practical for real-world affective computing applications.

Peter Washington, Cezmi Onur Mutlu, Aaron Kline et al.

Computer Vision (CV) classifiers which distinguish and detect nonverbal social human behavior and mental state can aid digital diagnostics and therapeutics for psychiatry and the behavioral sciences. While CV classifiers for traditional and structured classification tasks can be developed with standard machine learning pipelines for supervised learning consisting of data labeling, preprocessing, and training a convolutional neural network, there are several pain points which arise when attempting this process for behavioral phenotyping. Here, we discuss the challenges and corresponding opportunities in this space, including handling heterogeneous data, avoiding biased models, labeling massive and repetitive data sets, working with ambiguous or compound class labels, managing privacy concerns, creating appropriate representations, and personalizing models. We discuss current state-of-the-art research endeavors in CV such as data curation, data augmentation, crowdsourced labeling, active learning, reinforcement learning, generative models, representation learning, federated learning, and meta-learning. We highlight at least some of the machine learning advancements needed for imaging classifiers to detect human social cues successfully and reliably.

Nathan A. Chi, Peter Washington, Aaron Kline et al.

Autism spectrum disorder (ASD) is a neurodevelopmental disorder which results in altered behavior, social development, and communication patterns. In past years, autism prevalence has tripled, with 1 in 54 children now affected. Given that traditional diagnosis is a lengthy, labor-intensive process, significant attention has been given to developing systems that automatically screen for autism. Prosody abnormalities are among the clearest signs of autism, with affected children displaying speech idiosyncrasies including echolalia, monotonous intonation, atypical pitch, and irregular linguistic stress patterns. In this work, we present a suite of machine learning approaches to detect autism in self-recorded speech audio captured from autistic and neurotypical (NT) children in home environments. We consider three methods to detect autism in child speech: first, Random Forests trained on extracted audio features (including Mel-frequency cepstral coefficients); second, convolutional neural networks (CNNs) trained on spectrograms; and third, fine-tuned wav2vec 2.0--a state-of-the-art Transformer-based ASR model. We train our classifiers on our novel dataset of cellphone-recorded child speech audio curated from Stanford's Guess What? mobile game, an app designed to crowdsource videos of autistic and neurotypical children in a natural home environment. The Random Forest classifier achieves 70% accuracy, the fine-tuned wav2vec 2.0 model achieves 77% accuracy, and the CNN achieves 79% accuracy when classifying children's audio as either ASD or NT. Our models were able to predict autism status when training on a varied selection of home audio clips with inconsistent recording quality, which may be more generalizable to real world conditions. These results demonstrate that machine learning methods offer promise in detecting autism automatically from speech without specialized equipment.

Agnik Banerjee, Peter Washington, Cezmi Mutlu et al.

Implementing automated emotion recognition on mobile devices could provide an accessible diagnostic and therapeutic tool for those who struggle to recognize emotion, including children with developmental behavioral conditions such as autism. Although recent advances have been made in building more accurate emotion classifiers, existing models are too computationally expensive to be deployed on mobile devices. In this study, we optimized and profiled various machine learning models designed for inference on edge devices and were able to match previous state of the art results for emotion recognition on children. Our best model, a MobileNet-V2 network pre-trained on ImageNet, achieved 65.11% balanced accuracy and 64.19% F1-score on CAFE, while achieving a 45-millisecond inference latency on a Motorola Moto G6 phone. This balanced accuracy is only 1.79% less than the current state of the art for CAFE, which used a model that contains 26.62x more parameters and was unable to run on the Moto G6, even when fully optimized. This work validates that with specialized design and optimization techniques, machine learning models can become lightweight enough for deployment on mobile devices and still achieve high accuracies on difficult image classification tasks.

Anish Lakkapragada, Aaron Kline, Onur Cezmi Mutlu et al.

A formal autism diagnosis can be an inefficient and lengthy process. Families may wait months or longer before receiving a diagnosis for their child despite evidence that earlier intervention leads to better treatment outcomes. Digital technologies which detect the presence of behaviors related to autism can scale access to pediatric diagnoses. This work aims to demonstrate the feasibility of deep learning technologies for detecting hand flapping from unstructured home videos as a first step towards validating whether models and digital technologies can be leveraged to aid with autism diagnoses. We used the Self-Stimulatory Behavior Dataset (SSBD), which contains 75 videos of hand flapping, head banging, and spinning exhibited by children. From all the hand flapping videos, we extracted 100 positive and control videos of hand flapping, each between 2 to 5 seconds in duration. Utilizing both landmark-driven-approaches and MobileNet V2's pretrained convolutional layers, our highest performing model achieved a testing F1 score of 84% (90% precision and 80% recall) when evaluating with 5-fold cross validation 100 times. This work provides the first step towards developing precise deep learning methods for activity detection of autism-related behaviors.

Sepideh Maleki, Donya Saless, Dennis P. Wall et al.

Many problems such as node classification and link prediction in network data can be solved using graph embeddings. However, it is difficult to use graphs to capture non-binary relations such as communities of nodes. These kinds of complex relations are expressed more naturally as hypergraphs. While hypergraphs are a generalization of graphs, state-of-the-art graph embedding techniques are not adequate for solving prediction and classification tasks on large hypergraphs accurately in reasonable time. In this paper, we introduce HyperNetVec, a novel hierarchical framework for scalable unsupervised hypergraph embedding. HyperNetVec exploits shared-memory parallelism and is capable of generating high quality embeddings for real-world hypergraphs with millions of nodes and hyperedges in only a couple of minutes while existing hypergraph systems either fail for such large hypergraphs or may take days to produce the embeddings.

Peter Washington, Aaron Kline, Onur Cezmi Mutlu et al.

Activity recognition computer vision algorithms can be used to detect the presence of autism-related behaviors, including what are termed "restricted and repetitive behaviors", or stimming, by diagnostic instruments. The limited data that exist in this domain are usually recorded with a handheld camera which can be shaky or even moving, posing a challenge for traditional feature representation approaches for activity detection which mistakenly capture the camera's motion as a feature. To address these issues, we first document the advantages and limitations of current feature representation techniques for activity recognition when applied to head banging detection. We then propose a feature representation consisting exclusively of head pose keypoints. We create a computer vision classifier for detecting head banging in home videos using a time-distributed convolutional neural network (CNN) in which a single CNN extracts features from each frame in the input sequence, and these extracted features are fed as input to a long short-term memory (LSTM) network. On the binary task of predicting head banging and no head banging within videos from the Self Stimulatory Behaviour Dataset (SSBD), we reach a mean F1-score of 90.77% using 3-fold cross validation (with individual fold F1-scores of 83.3%, 89.0%, and 100.0%) when ensuring that no child who appeared in the train set was in the test set for all folds. This work documents a successful technique for training a computer vision classifier which can detect human motion with few training examples and even when the camera recording the source clips is unstable. The general methods described here can be applied by designers and developers of interactive systems towards other human motion and pose classification problems used in mobile and ubiquitous interactive systems.

Peter Washington, Onur Cezmi Mutlu, Emilie Leblanc et al.

Emotion classifiers traditionally predict discrete emotions. However, emotion expressions are often subjective, thus requiring a method to handle subjective labels. We explore the use of crowdsourcing to acquire reliable soft-target labels and evaluate an emotion detection classifier trained with these labels. We center our study on the Child Affective Facial Expression (CAFE) dataset, a gold standard collection of images depicting pediatric facial expressions along with 100 human labels per image. To test the feasibility of crowdsourcing to generate these labels, we used Microworkers to acquire labels for 207 CAFE images. We evaluate both unfiltered workers as well as workers selected through a short crowd filtration process. We then train two versions of a classifiers on soft-target CAFE labels using the original 100 annotations provided with the dataset: (1) a classifier trained with traditional one-hot encoded labels, and (2) a classifier trained with vector labels representing the distribution of CAFE annotator responses. We compare the resulting softmax output distributions of the two classifiers with a 2-sample independent t-test of L1 distances between the classifier's output probability distribution and the distribution of human labels. While agreement with CAFE is weak for unfiltered crowd workers, the filtered crowd agree with the CAFE labels 100% of the time for many emotions. While the F1-score for a one-hot encoded classifier is much higher (94.33% vs. 78.68%) with respect to the ground truth CAFE labels, the output probability vector of the crowd-trained classifier more closely resembles the distribution of human labels (t=3.2827, p=0.0014). Reporting an emotion probability distribution that accounts for the subjectivity of human interpretation. Crowdsourcing, including a sufficient filtering mechanism, is a feasible solution for acquiring soft-target labels.

Peter Washington, Haik Kalantarian, John Kent et al.

Background: Automated emotion classification could aid those who struggle to recognize emotions, including children with developmental behavioral conditions such as autism. However, most computer vision emotion recognition models are trained on adult emotion and therefore underperform when applied to child faces. Objective: We designed a strategy to gamify the collection and labeling of child emotion-enriched images to boost the performance of automatic child emotion recognition models to a level closer to what will be needed for digital health care approaches. Methods: We leveraged our prototype therapeutic smartphone game, GuessWhat, which was designed in large part for children with developmental and behavioral conditions, to gamify the secure collection of video data of children expressing a variety of emotions prompted by the game. Independently, we created a secure web interface to gamify the human labeling effort, called HollywoodSquares, tailored for use by any qualified labeler. We gathered and labeled 2155 videos, 39,968 emotion frames, and 106,001 labels on all images. With this drastically expanded pediatric emotion-centric database (>30 times larger than existing public pediatric emotion data sets), we trained a convolutional neural network (CNN) computer vision classifier of happy, sad, surprised, fearful, angry, disgust, and neutral expressions evoked by children. Results: The classifier achieved a 66.9% balanced accuracy and 67.4% F1-score on the entirety of the Child Affective Facial Expression (CAFE) as well as a 79.1% balanced accuracy and 78% F1-score on CAFE Subset A, a subset containing at least 60% human agreement on emotions labels. This performance is at least 10% higher than all previously developed classifiers evaluated against CAFE, the best of which reached a 56% balanced accuracy even when combining "anger" and "disgust" into a single class.

Nick Haber, Catalin Voss, Jena Daniels et al.

With most recent estimates giving an incidence rate of 1 in 68 children in the United States, the autism spectrum disorder (ASD) is a growing public health crisis. Many of these children struggle to make eye contact, recognize facial expressions, and engage in social interactions. Today the standard for treatment of the core autism-related deficits focuses on a form of behavior training known as Applied Behavioral Analysis. To address perceived deficits in expression recognition, ABA approaches routinely involve the use of prompts such as flash cards for repetitive emotion recognition training via memorization. These techniques must be administered by trained practitioners and often at clinical centers that are far outnumbered by and out of reach from the many children and families in need of attention. Waitlists for access are up to 18 months long, and this wait may lead to children regressing down a path of isolation that worsens their long-term prognosis. There is an urgent need to innovate new methods of care delivery that can appropriately empower caregivers of children at risk or with a diagnosis of autism, and that capitalize on mobile tools and wearable devices for use outside of clinical settings.

Catalin Voss, Peter Washington, Nick Haber et al.

We have developed a system for automatic facial expression recognition, which runs on Google Glass and delivers real-time social cues to the wearer. We evaluate the system as a behavioral aid for children with Autism Spectrum Disorder (ASD), who can greatly benefit from real-time non-invasive emotional cues and are more sensitive to sensory input than neurotypically developing children. In addition, we present a mobile application that enables users of the wearable aid to review their videos along with auto-curated emotional information on the video playback bar. This integrates our learning aid into the context of behavioral therapy. Expanding on our previous work describing in-lab trials, this paper presents our system and application-level design decisions in depth as well as the interface learnings gathered during the use of the system by multiple children with ASD in an at-home iterative trial.

Catalin Voss, Nick Haber, Peter Washington et al.

In recent years, much focus has been put on employing technology to make novel behavioural aids for those with autism. Most of these are digital adaptations of tools used in standard behavioural therapy to enforce normative skills. These digital counterparts are often used outside of both the larger therapeutic context and the real world, in which the learned skills might apply. To address this, we are designing a system of automatic expression recognition on wearable devices that integrates directly into the families daily social interactions, to give children and their caregivers the tools and information they need to design their own holistic therapy. In order to develop a tool that will be truly useful to families, we proactively include children with autism and their families as co-designers in the development process. By providing an app and interface with interchangeable social feedback options, we aim to produce a framework for therapy that folds into their daily lives, tailored to their specific needs.

Halim Abbas, Ford Garberson, Eric Glover et al.

Existing screening tools for early detection of autism are expensive, cumbersome, time-intensive, and sometimes fall short in predictive value. In this work, we apply Machine Learning (ML) to gold standard clinical data obtained across thousands of children at risk for autism spectrum disorders to create a low-cost, quick, and easy to apply autism screening tool that performs as well or better than most widely used standardized instruments. This new tool combines two screening methods into a single assessment, one based on short, structured parent-report questionnaires and the other on tagging key behaviors from short, semi-structured home videos of children. To overcome the scarcity, sparsity, and imbalance of training data, we apply creative feature selection, feature engineering, and novel feature encoding techniques. We allow for inconclusive determination where appropriate in order to boost screening accuracy when conclusive. We demonstrate a significant accuracy improvement over standard screening tools in a clinical study sample of 162 children.