Zhongchen Zhao

Nicholas Heller, Fabian Isensee, Dasha Trofimova et al.

This paper presents the challenge report for the 2021 Kidney and Kidney Tumor Segmentation Challenge (KiTS21) held in conjunction with the 2021 international conference on Medical Image Computing and Computer Assisted Interventions (MICCAI). KiTS21 is a sequel to its first edition in 2019, and it features a variety of innovations in how the challenge was designed, in addition to a larger dataset. A novel annotation method was used to collect three separate annotations for each region of interest, and these annotations were performed in a fully transparent setting using a web-based annotation tool. Further, the KiTS21 test set was collected from an outside institution, challenging participants to develop methods that generalize well to new populations. Nonetheless, the top-performing teams achieved a significant improvement over the state of the art set in 2019, and this performance is shown to inch ever closer to human-level performance. An in-depth meta-analysis is presented describing which methods were used and how they faired on the leaderboard, as well as the characteristics of which cases generally saw good performance, and which did not. Overall KiTS21 facilitated a significant advancement in the state of the art in kidney tumor segmentation, and provides useful insights that are applicable to the field of semantic segmentation as a whole.

Zhongchen Zhao, Qi Xie, Keyu Huang et al.

Rotation equivariance constitutes one of the most general and crucial structural priors for visual data, yet it remains notably absent from current Mamba-based vision architectures. Despite the success of Mamba in natural language processing and its growing adoption in computer vision, existing visual Mamba models fail to account for rotational symmetry in their design. This omission renders them inherently sensitive to image rotations, thereby constraining their robustness and cross-task generalization. To address this limitation, we propose to incorporate rotation symmetry, a universal and fundamental geometric prior in images, into Mamba-based architectures. Specifically, we introduce EQ-VMamba, the first rotation equivariant visual Mamba architecture for vision tasks. The core components of EQ-VMamba include a carefully designed rotation equivariant cross-scan strategy and group Mamba blocks. Moreover, we provide a rigorous theoretical analysis of the intrinsic equivariance error, demonstrating that the proposed architecture enforces end-to-end rotation equivariance throughout the network. Extensive experiments across multiple benchmarks - including high-level image classification task, mid-level semantic segmentation task, and low-level image super-resolution task - demonstrate that EQ-VMamba achieves superior or competitive performance compared to non-equivariant baselines, while requiring approximately 50% fewer parameters. These results indicate that embedding rotation equivariance not only effectively bolsters the robustness of visual Mamba models against rotation transformations, but also enhances overall performance with significantly improved parameter efficiency. Code is available at https://github.com/zhongchenzhao/EQ-VMamba.

Yi Lin, Zhongchen Zhao, Zhengjie ZHU et al.

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as ImageNet, to generate instance features, which can be sub-optimal due to the significant differences between natural images and histopathology images that lead to a domain shift. In this paper, we present a novel, simple yet effective method for learning domain-specific knowledge transformation from pre-trained models to histopathology images. Our approach entails using a prompt component to assist the pre-trained model in discerning differences between the pre-trained dataset and the target histopathology dataset, resulting in improved performance of MIL models. We validate our method on two publicly available datasets, Camelyon16 and TCGA-NSCLC. Extensive experimental results demonstrate the significant performance improvement of our method for different MIL models and backbones. Upon publication of this paper, we will release the source code for our method.

Yusheng Liu, Zhongchen Zhao, Lisheng Wang

Three-dimensional (3D) kidney parsing on computed tomography angiography (CTA) images is of great clinical significance. Automatic segmentation of kidney, renal tumor, renal vein and renal artery benefits a lot on surgery-based renal cancer treatment. In this paper, we propose a new nnhra-unet network, and use a multi-stage framework which is based on it to segment the multi-structure of kidney and participate in the KiPA2022 challenge.