Yongbin Lee

Yongbin Lee, Andrew Peitzsch, Youngsun Kong et al.

Electrodermal activity (EDA) is widely used in wearable Internet of Medical Things (IoMT) systems for continuous health monitoring, including autonomic assessment. However, EDA signals are highly vulnerable to motion artifacts and environmental noise, limiting reliable deployment in harsh operating conditions such as underwater. This study proposes a robust, deployable EDA denoising framework that generalizes across multiple measurement locations and harsh environments. The framework integrates a hybrid CNN-Transformer teacher model with a lightweight depth-wise separable CNN student model via a knowledge distillation (KD) strategy. To further improve robustness, a realistic data augmentation scheme is introduced to simulate diverse motion artifacts and environmental distortions. The KD-based student model significantly reduces model size (7.87 MB to 0.51 MB) and computational cost (105.1M to 11.61M FLOPs) while maintaining denoising performance (MAE: 0.144, SNR improvement: 12.08 dB) using the public dataset validation. In real-world underwater conditions (UMAC dataset) testing, the proposed method substantially improves skin conductance response reconstruction, reducing mean absolute error from 2.809 to 0.215. Furthermore, on independent testing using the CNS-OT dataset, the denoised signals enhanced downstream CNS-OT prediction performance, achieving the highest AUROC (0.806) compared to prior denoising methods. The proposed method also improved the early prediction rate (sensitivity) from 0.550 to 0.767, enabling CNS-OT prediction up to a median of 6.9 minutes before symptom onset. These results demonstrate that the proposed framework not only improves EDA signal quality but also enhances clinically relevant prediction performance while remaining suitable for deployment in resource-constrained wearable Internet of Things systems operating in harsh environments.

Yongbin Lee, Ki H. Chon

Atrial fibrillation (AF) is the most common arrhythmia, increasing the risk of stroke, heart failure, and other cardiovascular complications. While AF detection algorithms perform well in identifying persistent AF, early-stage progression, such as paroxysmal AF (PAF), often goes undetected due to its sudden onset and short duration. However, undetected PAF can progress into sustained AF, increasing the risk of mortality and severe complications. Early prediction of AF offers an opportunity to reduce disease progression through preventive therapies, such as catecholamine-sparing agents or beta-blockers. In this study, we propose a lightweight deep learning model using only RR Intervals (RRIs), combining a Temporal Convolutional Network (TCN) for positional encoding with Mamba, a selective state space model, to enable early prediction of AF through efficient parallel sequence modeling. In subject-wise testing results, our model achieved a sensitivity of 0.908, specificity of 0.933, F1-score of 0.930, AUROC of 0.972, and AUPRC of 0.932. Additionally, our method demonstrates high computational efficiency, with only 73.5 thousand parameters and 38.3 MFLOPs, outperforming traditional Convolutional Neural Network-Recurrent Neural Network (CNN-RNN) approaches in both accuracy and model compactness. Notably, the model can predict AF up to two hours in advance using just 30 minutes of input data, providing enough lead time for preventive interventions.