Guanyu Yang

Jiacheng Shi, Yuting He, Youyong Kong et al.

An effective backbone network is important to deep learning-based Deformable Medical Image Registration (DMIR), because it extracts and matches the features between two images to discover the mutual correspondence for fine registration. However, the existing deep networks focus on single image situation and are limited in registration task which is performed on paired images. Therefore, we advance a novel backbone network, XMorpher, for the effective corresponding feature representation in DMIR. 1) It proposes a novel full transformer architecture including dual parallel feature extraction networks which exchange information through cross attention, thus discovering multi-level semantic correspondence while extracting respective features gradually for final effective registration. 2) It advances the Cross Attention Transformer (CAT) blocks to establish the attention mechanism between images which is able to find the correspondence automatically and prompts the features to fuse efficiently in the network. 3) It constrains the attention computation between base windows and searching windows with different sizes, and thus focuses on the local transformation of deformable registration and enhances the computing efficiency at the same time. Without any bells and whistles, our XMorpher gives Voxelmorph 2.8% improvement on DSC , demonstrating its effective representation of the features from the paired images in DMIR. We believe that our XMorpher has great application potential in more paired medical images. Our XMorpher is open on https://github.com/Solemoon/XMorpher

Yuting He, Guanyu Yang, Rongjun Ge et al.

Learning inter-image similarity is crucial for 3D medical images self-supervised pre-training, due to their sharing of numerous same semantic regions. However, the lack of the semantic prior in metrics and the semantic-independent variation in 3D medical images make it challenging to get a reliable measurement for the inter-image similarity, hindering the learning of consistent representation for same semantics. We investigate the challenging problem of this task, i.e., learning a consistent representation between images for a clustering effect of same semantic features. We propose a novel visual similarity learning paradigm, Geometric Visual Similarity Learning, which embeds the prior of topological invariance into the measurement of the inter-image similarity for consistent representation of semantic regions. To drive this paradigm, we further construct a novel geometric matching head, the Z-matching head, to collaboratively learn the global and local similarity of semantic regions, guiding the efficient representation learning for different scale-level inter-image semantic features. Our experiments demonstrate that the pre-training with our learning of inter-image similarity yields more powerful inner-scene, inter-scene, and global-local transferring ability on four challenging 3D medical image tasks. Our codes and pre-trained models will be publicly available on https://github.com/YutingHe-list/GVSL.

Zhangfu Dong, Yuting He, Xiaoming Qi et al.

The nature of thick-slice scanning causes severe inter-slice discontinuities of 3D medical images, and the vanilla 2D/3D convolutional neural networks (CNNs) fail to represent sparse inter-slice information and dense intra-slice information in a balanced way, leading to severe underfitting to inter-slice features (for vanilla 2D CNNs) and overfitting to noise from long-range slices (for vanilla 3D CNNs). In this work, a novel mesh network (MNet) is proposed to balance the spatial representation inter axes via learning. 1) Our MNet latently fuses plenty of representation processes by embedding multi-dimensional convolutions deeply into basic modules, making the selections of representation processes flexible, thus balancing representation for sparse inter-slice information and dense intra-slice information adaptively. 2) Our MNet latently fuses multi-dimensional features inside each basic module, simultaneously taking the advantages of 2D (high segmentation accuracy of the easily recognized regions in 2D view) and 3D (high smoothness of 3D organ contour) representations, thus obtaining more accurate modeling for target regions. Comprehensive experiments are performed on four public datasets (CT\&MR), the results consistently demonstrate the proposed MNet outperforms the other methods. The code and datasets are available at: https://github.com/zfdong-code/MNet

Zihan Ye, Guanyu Yang, Xiaobo Jin et al.

Zero-shot learning (ZSL) aims to identify unseen classes with zero samples during training. Broadly speaking, present ZSL methods usually adopt class-level semantic labels and compare them with instance-level semantic predictions to infer unseen classes. However, we find that such existing models mostly produce imbalanced semantic predictions, i.e. these models could perform precisely for some semantics, but may not for others. To address the drawback, we aim to introduce an imbalanced learning framework into ZSL. However, we find that imbalanced ZSL has two unique challenges: (1) Its imbalanced predictions are highly correlated with the value of semantic labels rather than the number of samples as typically considered in the traditional imbalanced learning; (2) Different semantics follow quite different error distributions between classes. To mitigate these issues, we first formalize ZSL as an imbalanced regression problem which offers empirical evidences to interpret how semantic labels lead to imbalanced semantic predictions. We then propose a re-weighted loss termed Re-balanced Mean-Squared Error (ReMSE), which tracks the mean and variance of error distributions, thus ensuring rebalanced learning across classes. As a major contribution, we conduct a series of analyses showing that ReMSE is theoretically well established. Extensive experiments demonstrate that the proposed method effectively alleviates the imbalance in semantic prediction and outperforms many state-of-the-art ZSL methods. Our code is available at https://github.com/FouriYe/ReZSL-TIP23.

Xiaofei Chen, Yuting He, Cheng Xue et al.

The foundation models based on pre-training technology have significantly advanced artificial intelligence from theoretical to practical applications. These models have facilitated the feasibility of computer-aided diagnosis for widespread use. Medical contrastive vision-language pre-training, which does not require human annotations, is an effective approach for guiding representation learning using description information in diagnostic reports. However, the effectiveness of pre-training is limited by the large-scale semantic overlap and shifting problems in medical field. To address these issues, we propose the Knowledge-Boosting Contrastive Vision-Language Pre-training framework (KoBo), which integrates clinical knowledge into the learning of vision-language semantic consistency. The framework uses an unbiased, open-set sample-wise knowledge representation to measure negative sample noise and supplement the correspondence between vision-language mutual information and clinical knowledge. Extensive experiments validate the effect of our framework on eight tasks including classification, segmentation, retrieval, and semantic relatedness, achieving comparable or better performance with the zero-shot or few-shot settings. Our code is open on https://github.com/ChenXiaoFei-CS/KoBo.

Kai-Ni Wang, Yuting He, Shuaishuai Zhuang et al.

Reliable automatic classification of colonoscopy images is of great significance in assessing the stage of colonic lesions and formulating appropriate treatment plans. However, it is challenging due to uneven brightness, location variability, inter-class similarity, and intra-class dissimilarity, affecting the classification accuracy. To address the above issues, we propose a Fourier-based Frequency Complex Network (FFCNet) for colon disease classification in this study. Specifically, FFCNet is a novel complex network that enables the combination of complex convolutional networks with frequency learning to overcome the loss of phase information caused by real convolution operations. Also, our Fourier transform transfers the average brightness of an image to a point in the spectrum (the DC component), alleviating the effects of uneven brightness by decoupling image content and brightness. Moreover, the image patch scrambling module in FFCNet generates random local spectral blocks, empowering the network to learn long-range and local diseasespecific features and improving the discriminative ability of hard samples. We evaluated the proposed FFCNet on an in-house dataset with 2568 colonoscopy images, showing our method achieves high performance outperforming previous state-of-the art methods with an accuracy of 86:35% and an accuracy of 4.46% higher than the backbone. The project page with code is available at https://github.com/soleilssss/FFCNet.

Yaolei Qi, Yuting He, Xiaoming Qi et al.

Accurate segmentation of topological tubular structures, such as blood vessels and roads, is crucial in various fields, ensuring accuracy and efficiency in downstream tasks. However, many factors complicate the task, including thin local structures and variable global morphologies. In this work, we note the specificity of tubular structures and use this knowledge to guide our DSCNet to simultaneously enhance perception in three stages: feature extraction, feature fusion, and loss constraint. First, we propose a dynamic snake convolution to accurately capture the features of tubular structures by adaptively focusing on slender and tortuous local structures. Subsequently, we propose a multi-view feature fusion strategy to complement the attention to features from multiple perspectives during feature fusion, ensuring the retention of important information from different global morphologies. Finally, a continuity constraint loss function, based on persistent homology, is proposed to constrain the topological continuity of the segmentation better. Experiments on 2D and 3D datasets show that our DSCNet provides better accuracy and continuity on the tubular structure segmentation task compared with several methods. Our codes will be publicly available.

Yuan Zhang, Jiahao Xia, Junzhang Huang et al.

Data scarcity in multimodal pathology motivates unified generative models that synthesize modality-specific appearance while preserving anatomically coherent structure. Although modalities differ in appearance statistics, morphological structures such as cellular topology and tissue boundaries are largely preserved across acquisition protocols. However, existing methods often model these factors within a homogeneous token stream, implicitly coupling structure with appearance and weakening structural controllability under modality shifts. To address this, we propose pathology Autorgressive modeling (PathAR), a structure-first autoregressive synthesis framework that explicitly factorizes structure and appearance for modality-label-conditioned pathology generation.PathAR employs a dual vector quantization (Dual-VQ) tokenizer to decompose samples into mask-grounded structure and appearance tokens, and an interleaved autoregressive (IAR) transformer with asymmetric attention visibility to enforce structure-to-appearance dependence. PathAR stabilizes morphology under heterogeneous modality-specific appearances and enables spatially aligned image--mask pair generation. Extensive experiments show that PathAR improves structural consistency and modality fidelity over baselines, maintains sample diversity, supports downstream segmentation in data-scarce regimes, and demonstrates extensibility to finer-grained intra-modality organ-label variation.

Yuan Zhang, Yaolei Qi, Xiaoming Qi et al.

The precise subtype classification of myeloproliferative neoplasms (MPNs) based on multimodal information, which assists clinicians in diagnosis and long-term treatment plans, is of great clinical significance. However, it remains a great challenging task due to the lack of diagnostic representativeness for local patches and the absence of diagnostic-relevant features from a single modality. In this paper, we propose a Dynamic Screening and Clinical-Enhanced Network (DSCENet) for the subtype classification of MPNs on the multimodal fusion of whole slide images (WSIs) and clinical information. (1) A dynamic screening module is proposed to flexibly adapt the feature learning of local patches, reducing the interference of irrelevant features and enhancing their diagnostic representativeness. (2) A clinical-enhanced fusion module is proposed to integrate clinical indicators to explore complementary features across modalities, providing comprehensive diagnostic information. Our approach has been validated on the real clinical data, achieving an increase of 7.91% AUC and 16.89% accuracy compared with the previous state-of-the-art (SOTA) methods. The code is available at https://github.com/yuanzhang7/DSCENet.

Tong Wang, Guanyu Yang, Qijia He et al.

Attributed graph clustering is one of the most fundamental tasks among graph learning field, the goal of which is to group nodes with similar representations into the same cluster without human annotations. Recent studies based on graph contrastive learning method have achieved remarkable results when exploit graph-structured data. However, most existing methods 1) do not directly address the clustering task, since the representation learning and clustering process are separated; 2) depend too much on data augmentation, which greatly limits the capability of contrastive learning; 3) ignore the contrastive message for clustering tasks, which adversely degenerate the clustering results. In this paper, we propose a Neighborhood Contrast Framework for Attributed Graph Clustering, namely NCAGC, seeking for conquering the aforementioned limitations. Specifically, by leveraging the Neighborhood Contrast Module, the representation of neighbor nodes will be 'push closer' and become clustering-oriented with the neighborhood contrast loss. Moreover, a Contrastive Self-Expression Module is built by minimizing the node representation before and after the self-expression layer to constraint the learning of self-expression matrix. All the modules of NCAGC are optimized in a unified framework, so the learned node representation contains clustering-oriented messages. Extensive experimental results on four attributed graph datasets demonstrate the promising performance of NCAGC compared with 16 state-of-the-art clustering methods. The code is available at https://github.com/wangtong627/NCAGC.

Zheng Zhang, Xiaolei Zhang, Yaolei Qi et al.

Coronary artery segmentation on coronary-computed tomography angiography (CCTA) images is crucial for clinical use. Due to the expertise-required and labor-intensive annotation process, there is a growing demand for the relevant label-efficient learning algorithms. To this end, we propose partial vessels annotation (PVA) based on the challenges of coronary artery segmentation and clinical diagnostic characteristics. Further, we propose a progressive weakly supervised learning framework to achieve accurate segmentation under PVA. First, our proposed framework learns the local features of vessels to propagate the knowledge to unlabeled regions. Subsequently, it learns the global structure by utilizing the propagated knowledge, and corrects the errors introduced in the propagation process. Finally, it leverages the similarity between feature embeddings and the feature prototype to enhance testing outputs. Experiments on clinical data reveals that our proposed framework outperforms the competing methods under PVA (24.29% vessels), and achieves comparable performance in trunk continuity with the baseline model using full annotation (100% vessels).

Tong Wang, Yaolei Qi, Siwen Wang et al.

Video polyp segmentation (VPS) is an important task in computer-aided colonoscopy, as it helps doctors accurately locate and track polyps during examinations. However, VPS remains challenging because polyps often look similar to surrounding mucosa, leading to weak semantic discrimination. In addition, large changes in polyp position and scale across video frames make stable and accurate segmentation difficult. To address these challenges, we propose a robust VPS framework named CMSA-Net. The proposed network introduces a Causal Multi-scale Aggregation (CMA) module to effectively gather semantic information from multiple historical frames at different scales. By using causal attention, CMA ensures that temporal feature propagation follows strict time order, which helps reduce noise and improve feature reliability. Furthermore, we design a Dynamic Multi-source Reference (DMR) strategy that adaptively selects informative and reliable reference frames based on semantic separability and prediction confidence. This strategy provides strong multi-frame guidance while keeping the model efficient for real-time inference. Extensive experiments on the SUN-SEG dataset demonstrate that CMSA-Net achieves state-of-the-art performance, offering a favorable balance between segmentation accuracy and real-time clinical applicability.

Fuzhi Wu, Jiasong Wu, Youyong Kong et al.

Deep learning and Convolutional Neural Networks (CNNs) have driven major transformations in diverse research areas. However, their limitations in handling low-frequency information present obstacles in certain tasks like interpreting global structures or managing smooth transition images. Despite the promising performance of transformer structures in numerous tasks, their intricate optimization complexities highlight the persistent need for refined CNN enhancements using limited resources. Responding to these complexities, we introduce a novel framework, the Multiscale Low-Frequency Memory (MLFM) Network, with the goal to harness the full potential of CNNs while keeping their complexity unchanged. The MLFM efficiently preserves low-frequency information, enhancing performance in targeted computer vision tasks. Central to our MLFM is the Low-Frequency Memory Unit (LFMU), which stores various low-frequency data and forms a parallel channel to the core network. A key advantage of MLFM is its seamless compatibility with various prevalent networks, requiring no alterations to their original core structure. Testing on ImageNet demonstrated substantial accuracy improvements in multiple 2D CNNs, including ResNet, MobileNet, EfficientNet, and ConvNeXt. Furthermore, we showcase MLFM's versatility beyond traditional image classification by successfully integrating it into image-to-image translation tasks, specifically in semantic segmentation networks like FCN and U-Net. In conclusion, our work signifies a pivotal stride in the journey of optimizing the efficacy and efficiency of CNNs with limited resources. This research builds upon the existing CNN foundations and paves the way for future advancements in computer vision. Our codes are available at https://github.com/AlphaWuSeu/ MLFM.

Yuan Zhang, Yaolei Qi, Xiaoming Qi et al.

Federated learning (FL) for histopathology image segmentation involving multiple medical sites plays a crucial role in advancing the field of accurate disease diagnosis and treatment. However, it is still a task of great challenges due to the sample imbalance across clients and large data heterogeneity from disparate organs, variable segmentation tasks, and diverse distribution. Thus, we propose a novel FL approach for histopathology nuclei and tissue segmentation, FedSODA, via synthetic-driven cross-assessment operation (SO) and dynamic stratified-layer aggregation (DA). Our SO constructs a cross-assessment strategy to connect clients and mitigate the representation bias under sample imbalance. Our DA utilizes layer-wise interaction and dynamic aggregation to diminish heterogeneity and enhance generalization. The effectiveness of our FedSODA has been evaluated on the most extensive histopathology image segmentation dataset from 7 independent datasets. The code is available at https://github.com/yuanzhang7/FedSODA.

Weiguang Zhao, Guanyu Yang, Rui Zhang et al.

With the explosive 3D data growth, the urgency of utilizing zero-shot learning to facilitate data labeling becomes evident. Recently, methods transferring language or language-image pre-training models like Contrastive Language-Image Pre-training (CLIP) to 3D vision have made significant progress in the 3D zero-shot classification task. These methods primarily focus on 3D object classification with an aligned pose; such a setting is, however, rather restrictive, which overlooks the recognition of 3D objects with open poses typically encountered in real-world scenarios, such as an overturned chair or a lying teddy bear. To this end, we propose a more realistic and challenging scenario named open-pose 3D zero-shot classification, focusing on the recognition of 3D objects regardless of their orientation. First, we revisit the current research on 3D zero-shot classification, and propose two benchmark datasets specifically designed for the open-pose setting. We empirically validate many of the most popular methods in the proposed open-pose benchmark. Our investigations reveal that most current 3D zero-shot classification models suffer from poor performance, indicating a substantial exploration room towards the new direction. Furthermore, we study a concise pipeline with an iterative angle refinement mechanism that automatically optimizes one ideal angle to classify these open-pose 3D objects. In particular, to make validation more compelling and not just limited to existing CLIP-based methods, we also pioneer the exploration of knowledge transfer based on Diffusion models. While the proposed solutions can serve as a new benchmark for open-pose 3D zero-shot classification, we discuss the complexities and challenges of this scenario that remain for further research development. The code is available publicly at https://github.com/weiguangzhao/Diff-OP3D.

Yuting He, Boyu Wang, Rongjun Ge et al.

Dense contrastive representation learning (DCRL) has greatly improved the learning efficiency for image-dense prediction tasks, showing its great potential to reduce the large costs of medical image collection and dense annotation. However, the properties of medical images make unreliable correspondence discovery, bringing an open problem of large-scale false positive and negative (FP&N) pairs in DCRL. In this paper, we propose GEoMetric vIsual deNse sImilarity (GEMINI) learning which embeds the homeomorphism prior to DCRL and enables a reliable correspondence discovery for effective dense contrast. We propose a deformable homeomorphism learning (DHL) which models the homeomorphism of medical images and learns to estimate a deformable mapping to predict the pixels' correspondence under topological preservation. It effectively reduces the searching space of pairing and drives an implicit and soft learning of negative pairs via a gradient. We also propose a geometric semantic similarity (GSS) which extracts semantic information in features to measure the alignment degree for the correspondence learning. It will promote the learning efficiency and performance of deformation, constructing positive pairs reliably. We implement two practical variants on two typical representation learning tasks in our experiments. Our promising results on seven datasets which outperform the existing methods show our great superiority. We will release our code on a companion link: https://github.com/YutingHe-list/GEMINI.

Tong Wang, Guanyu Yang, Nian Liu et al.

Visual Autoregressive (VAR) models have recently garnered significant attention for their innovative next-scale prediction paradigm, offering notable advantages in both inference efficiency and image quality compared to traditional multi-step autoregressive (AR) and diffusion models. However, despite their efficiency, VAR models often suffer from the diversity collapse i.e., a reduction in output variability, analogous to that observed in few-step distilled diffusion models. In this paper, we introduce DiverseVAR, a simple yet effective approach that restores the generative diversity of VAR models without requiring any additional training. Our analysis reveals the pivotal component of the feature map as a key factor governing diversity formation at early scales. By suppressing the pivotal component in the model input and amplifying it in the model output, DiverseVAR effectively unlocks the inherent generative potential of VAR models while preserving high-fidelity synthesis. Empirical results demonstrate that our approach substantially enhances generative diversity with only neglectable performance influences. Our code will be publicly released at https://github.com/wangtong627/DiverseVAR.

Yaolei Qi, Yikai Yang, Wenbo Peng et al.

Complex tubular structures are essential in medical imaging and computer-assisted diagnosis, where their integrity enhances anatomical visualization and lesion detection. However, existing segmentation algorithms struggle with structural discontinuities, particularly in severe clinical cases such as coronary artery stenosis and vessel occlusions, which leads to undesired discontinuity and compromising downstream diagnostic accuracy. Therefore, it is imperative to reconnect discontinuous structures to ensure their completeness. In this study, we explore the tubular structure completion based on point cloud for the first time and establish a Point Cloud-based Coronary Artery Completion (PC-CAC) dataset, which is derived from real clinical data. This dataset provides a novel benchmark for tubular structure completion. Additionally, we propose TSRNet, a Tubular Structure Reconnection Network that integrates a detail-preservated feature extractor, a multiple dense refinement strategy, and a global-to-local loss function to ensure accurate reconnection while maintaining structural integrity. Comprehensive experiments on our PC-CAC and two additional public datasets (PC-ImageCAS and PC-PTR) demonstrate that our method consistently outperforms state-of-the-art approaches across multiple evaluation metrics, setting a new benchmark for point cloud-based tubular structure reconstruction. Our benchmark is available at https://github.com/YaoleiQi/PCCAC.

Yutao Hu, Ying Zheng, Shumei Miao et al.

Foundation models have demonstrated remarkable potential in medical domain. However, their application to complex cardiovascular diagnostics remains underexplored. In this paper, we present Cardiac-CLIP, a multi-modal foundation model designed for 3D cardiac CT images. Cardiac-CLIP is developed through a two-stage pre-training strategy. The first stage employs a 3D masked autoencoder (MAE) to perform self-supervised representation learning from large-scale unlabeled volumetric data, enabling the visual encoder to capture rich anatomical and contextual features. In the second stage, contrastive learning is introduced to align visual and textual representations, facilitating cross-modal understanding. To support the pre-training, we collect 16641 real clinical CT scans, supplemented by 114k publicly available data. Meanwhile, we standardize free-text radiology reports into unified templates and construct the pathology vectors according to diagnostic attributes, based on which the soft-label matrix is generated to supervise the contrastive learning process. On the other hand, to comprehensively evaluate the effectiveness of Cardiac-CLIP, we collect 6,722 real-clinical data from 12 independent institutions, along with the open-source data to construct the evaluation dataset. Specifically, Cardiac-CLIP is comprehensively evaluated across multiple tasks, including cardiovascular abnormality classification, information retrieval and clinical analysis. Experimental results demonstrate that Cardiac-CLIP achieves state-of-the-art performance across various downstream tasks in both internal and external data. Particularly, Cardiac-CLIP exhibits great effectiveness in supporting complex clinical tasks such as the prospective prediction of acute coronary syndrome, which is notoriously difficult in real-world scenarios.

Xiaoming Qi, Jingyang Zhang, Huazhu Fu et al.

Federated continual learning (FCL) offers an emerging pattern to facilitate the applicability of federated learning (FL) in real-world scenarios, where tasks evolve dynamically and asynchronously across clients, especially in medical scenario. Existing server-side FCL methods in nature domain construct a continually learnable server model by client aggregation on all-involved tasks. However, they are challenged by: (1) Catastrophic forgetting for previously learned tasks, leading to error accumulation in server model, making it difficult to sustain comprehensive knowledge across all tasks. (2) Biased optimization due to asynchronous tasks handled across different clients, leading to the collision of optimization targets of different clients at the same time steps. In this work, we take the first step to propose a novel server-side FCL pattern in medical domain, Dynamic Allocation Hypernetwork with adaptive model recalibration (FedDAH). It is to facilitate collaborative learning under the distinct and dynamic task streams across clients. To alleviate the catastrophic forgetting, we propose a dynamic allocation hypernetwork (DAHyper) where a continually updated hypernetwork is designed to manage the mapping between task identities and their associated model parameters, enabling the dynamic allocation of the model across clients. For the biased optimization, we introduce a novel adaptive model recalibration (AMR) to incorporate the candidate changes of historical models into current server updates, and assign weights to identical tasks across different time steps based on the similarity for continual optimization. Extensive experiments on the AMOS dataset demonstrate the superiority of our FedDAH to other FCL methods on sites with different task streams. The code is available:https://github.com/jinlab-imvr/FedDAH.

Xiaoming Qi, Jingyang Zhang, Huazhu Fu et al.

Federated continual learning (FCL) offers an emerging pattern to facilitate the applicability of federated learning (FL) in real-world scenarios, where tasks evolve dynamically and asynchronously across clients, especially in medical scenario. Existing server-side FCL methods in nature domain construct a continually learnable server model by client aggregation on all-involved tasks. However, they are challenged by: (1) Catastrophic forgetting for previously learned tasks, leading to error accumulation in server model, making it difficult to sustain comprehensive knowledge across all tasks. (2) Biased optimization due to asynchronous tasks handled across different clients, leading to the collision of optimization targets of different clients at the same time steps. In this work, we take the first step to propose a novel server-side FCL pattern in medical domain, Dynamic Allocation Hypernetwork with adaptive model recalibration (\textbf{FedDAH}). It is to facilitate collaborative learning under the distinct and dynamic task streams across clients. To alleviate the catastrophic forgetting, we propose a dynamic allocation hypernetwork (DAHyper) where a continually updated hypernetwork is designed to manage the mapping between task identities and their associated model parameters, enabling the dynamic allocation of the model across clients. For the biased optimization, we introduce a novel adaptive model recalibration (AMR) to incorporate the candidate changes of historical models into current server updates, and assign weights to identical tasks across different time steps based on the similarity for continual optimization. Extensive experiments on the AMOS dataset demonstrate the superiority of our FedDAH to other FCL methods on sites with different task streams. The code is available:https://github.com/jinlab-imvr/FedDAH.

Jiasong Wu, Qingchun Li, Guanyu Yang et al.

In traditional speech denoising tasks, clean audio signals are often used as the training target, but absolutely clean signals are collected from expensive recording equipment or in studios with the strict environments. To overcome this drawback, we propose an end-to-end self-supervised speech denoising training scheme using only noisy audio signals, named Only-Noisy Training (ONT), without extra training conditions. The proposed ONT strategy constructs training pairs only from each single noisy audio, and it contains two modules: training audio pairs generated module and speech denoising module. The first module adopts a random audio sub-sampler on each noisy audio to generate training pairs. The sub-sampled pairs are then fed into a novel complex-valued speech denoising module. Experimental results show that the proposed method not only eliminates the high dependence on clean targets of traditional audio denoising tasks, but also achieves on-par or better performance than other training strategies. Availability-ONT is available at https://github.com/liqingchunnnn/Only-Noisy-Training

Jiasong Wu, Xuan Li, Taotao Li et al.

Previous audio-visual speech separation methods use the synchronization of the speaker's facial movement and speech in the video to supervise the speech separation in a self-supervised way. In this paper, we propose a model to solve the speech separation problem assisted by both face and sign language, which we call the extended speech separation problem. We design a general deep learning network for learning the combination of three modalities, audio, face, and sign language information, for better solving the speech separation problem. To train the model, we introduce a large-scale dataset named the Chinese Sign Language News Speech (CSLNSpeech) dataset, in which three modalities of audio, face, and sign language coexist. Experiment results show that the proposed model has better performance and robustness than the usual audio-visual system. Besides, sign language modality can also be used alone to supervise speech separation tasks, and the introduction of sign language is helpful for hearing-impaired people to learn and communicate. Last, our model is a general speech separation framework and can achieve very competitive separation performance on two open-source audio-visual datasets. The code is available at https://github.com/iveveive/SLNSpeech

Yijie Hu, Guanyu Yang, Zhaorui Tan et al.

Few-shot Class Incremental Learning (FSCIL) presents a challenging yet realistic scenario, which requires the model to continually learn new classes with limited labeled data (i.e., incremental sessions) while retaining knowledge of previously learned base classes (i.e., base sessions). Due to the limited data in incremental sessions, models are prone to overfitting new classes and suffering catastrophic forgetting of base classes. To tackle these issues, recent advancements resort to prototype-based approaches to constrain the base class distribution and learn discriminative representations of new classes. Despite the progress, the limited data issue still induces ill-divided feature space, leading the model to confuse the new class with old classes or fail to facilitate good separation among new classes. In this paper, we aim to mitigate these issues by directly constraining the span of each class distribution from a covariance perspective. In detail, we propose a simple yet effective covariance constraint loss to force the model to learn each class distribution with the same covariance matrix. In addition, we propose a perturbation approach to perturb the few-shot training samples in the feature space, which encourages the samples to be away from the weighted distribution of other classes. Regarding perturbed samples as new class data, the classifier is forced to establish explicit boundaries between each new class and the existing ones. Our approach is easy to integrate into existing FSCIL approaches to boost performance. Experiments on three benchmarks validate the effectiveness of our approach, achieving a new state-of-the-art performance of FSCIL.

Xinzhe Xia, Weiguang Zhao, Yuyao Yan et al.

3D open-world classification is a challenging yet essential task in dynamic and unstructured real-world scenarios, requiring both open-category and open-pose recognition. To address these challenges, recent wisdom often takes sophisticated 2D pre-trained models to provide enriched and stable representations. However, these methods largely rely on how 3D objects can be projected into 2D space, which is unfortunately not well solved, and thus significantly limits their performance. Unlike these present efforts, in this paper we make a pioneering exploration of 3D generative models for 3D open-world classification. Drawing on abundant prior knowledge from 3D generative models, we additionally craft a rotation-invariant feature extractor. This innovative synergy endows our pipeline with the advantages of being training-free, open-category, and pose-invariant, thus well suited to 3D open-world classification. Extensive experiments on benchmark datasets demonstrate the potential of generative models in 3D open-world classification, achieving state-of-the-art performance on ModelNet10 and McGill with 32.0% and 8.7% overall accuracy improvement, respectively.

Tong Wang, Guanyu Yang, Nian Liu et al.

Retrieving fine-grained visual content based on user intent remains a challenge in multi-modal systems. Although current Composed Image Retrieval (CIR) methods combine reference images with retrieval texts, they are constrained to image-level matching and cannot localize specific objects. To this end, we propose Composed Object Retrieval (COR), a brand-new task that goes beyond image-level retrieval to achieve object-level precision, allowing the retrieval and segmentation of target objects based on composed expressions combining reference objects and retrieval texts. COR presents significant challenges in retrieval flexibility, which requires systems to identify arbitrary objects satisfying composed expressions while avoiding semantically similar but irrelevant negative objects within the same scene. We construct COR127K, the first large-scale COR benchmark that contains 127,166 retrieval triplets with various semantic transformations in 408 categories. We also present CORE, a unified end-to-end model that integrates reference region encoding, adaptive visual-textual interaction, and region-level contrastive learning. Extensive experiments demonstrate that CORE significantly outperforms existing models in both base and novel categories, establishing a simple and effective baseline for this challenging task while opening new directions for fine-grained multi-modal retrieval research.

Yuan Zhang, Feng Chen, Yaolei Qi et al.

Pathology image segmentation across multiple centers encounters significant challenges due to diverse sources of heterogeneity including imaging modalities, organs, and scanning equipment, whose variability brings representation bias and impedes the development of generalizable segmentation models. In this paper, we propose PathFL, a novel multi-alignment Federated Learning framework for pathology image segmentation that addresses these challenges through three-level alignment strategies of image, feature, and model aggregation. Firstly, at the image level, a collaborative style enhancement module aligns and diversifies local data by facilitating style information exchange across clients. Secondly, at the feature level, an adaptive feature alignment module ensures implicit alignment in the representation space by infusing local features with global insights, promoting consistency across heterogeneous client features learning. Finally, at the model aggregation level, a stratified similarity aggregation strategy hierarchically aligns and aggregates models on the server, using layer-specific similarity to account for client discrepancies and enhance global generalization. Comprehensive evaluations on four sets of heterogeneous pathology image datasets, encompassing cross-source, cross-modality, cross-organ, and cross-scanner variations, validate the effectiveness of our PathFL in achieving better performance and robustness against data heterogeneity.

Jiahao Xia, Yutao Hu, Yaolei Qi et al.

Solving medical imaging data scarcity through semantic image generation has attracted significant attention in recent years. However, existing methods primarily focus on generating whole-organ or large-tissue structures, showing limited effectiveness for organs with fine-grained structure. Due to stringent topological consistency, fragile coronary features, and complex 3D morphological heterogeneity in cardiac imaging, accurately reconstructing fine-grained anatomical details of the heart remains a great challenge. To address this problem, in this paper, we propose the Fine-grained Cardiac image Synthesis(FCaS) framework, established on 3D template conditional diffusion model. FCaS achieves precise cardiac structure generation using Template-guided Conditional Diffusion Model (TCDM) through bidirectional mechanisms, which provides the fine-grained topological structure information of target image through the guidance of template. Meanwhile, we design a deformable Mask Generation Module (MGM) to mitigate the scarcity of high-quality and diverse reference mask in the generation process. Furthermore, to alleviate the confusion caused by imprecise synthetic images, we propose a Confidence-aware Adaptive Learning (CAL) strategy to facilitate the pre-training of downstream segmentation tasks. Specifically, we introduce the Skip-Sampling Variance (SSV) estimation to obtain confidence maps, which are subsequently employed to rectify the pre-training on downstream tasks. Experimental results demonstrate that images generated from FCaS achieves state-of-the-art performance in topological consistency and visual quality, which significantly facilitates the downstream tasks as well. Code will be released in the future.

Haochuan Jiang, Guanyu Yang, Fei Cheng et al.

Synthesizing Chinese characters with consistent style using few stylized examples is challenging. Existing models struggle to generate arbitrary style characters with limited examples. In this paper, we propose the Generalized W-Net, a novel class of W-shaped architectures that addresses this. By incorporating Adaptive Instance Normalization and introducing multi-content, our approach can synthesize Chinese characters in any desired style, even with limited examples. It handles seen and unseen styles during training and can generate new character contents. Experimental results demonstrate the effectiveness of our approach.

Haochuan Jiang, Guanyu Yang, Kaizhu Huang et al.

Due to the huge category number, the sophisticated combinations of various strokes and radicals, and the free writing or printing styles, generating Chinese characters with diverse styles is always considered as a difficult task. In this paper, an efficient and generalized deep framework, namely, the W-Net, is introduced for the one-shot arbitrary-style Chinese character generation task. Specifically, given a single character (one-shot) with a specific style (e.g., a printed font or hand-writing style), the proposed W-Net model is capable of learning and generating any arbitrary characters sharing the style similar to the given single character. Such appealing property was rarely seen in the literature. We have compared the proposed W-Net framework to many other competitive methods. Experimental results showed the proposed method is significantly superior in the one-shot setting.

Song Wang, Yuting He, Youyong Kong et al.

Renal compartment segmentation on CT images targets on extracting the 3D structure of renal compartments from abdominal CTA images and is of great significance to the diagnosis and treatment for kidney diseases. However, due to the unclear compartment boundary, thin compartment structure and large anatomy variation of 3D kidney CT images, deep-learning based renal compartment segmentation is a challenging task. We propose a novel weakly supervised learning framework, Cycle Prototype Network, for 3D renal compartment segmentation. It has three innovations: 1) A Cycle Prototype Learning (CPL) is proposed to learn consistency for generalization. It learns from pseudo labels through the forward process and learns consistency regularization through the reverse process. The two processes make the model robust to noise and label-efficient. 2) We propose a Bayes Weakly Supervised Module (BWSM) based on cross-period prior knowledge. It learns prior knowledge from cross-period unlabeled data and perform error correction automatically, thus generates accurate pseudo labels. 3) We present a Fine Decoding Feature Extractor (FDFE) for fine-grained feature extraction. It combines global morphology information and local detail information to obtain feature maps with sharp detail, so the model will achieve fine segmentation on thin structures. Our model achieves Dice of 79.1% and 78.7% with only four labeled images, achieving a significant improvement by about 20% than typical prototype model PANet.

Yuting He, Rongjun Ge, Xiaoming Qi et al.

3D complete renal structures(CRS) segmentation targets on segmenting the kidneys, tumors, renal arteries and veins in one inference. Once successful, it will provide preoperative plans and intraoperative guidance for laparoscopic partial nephrectomy(LPN), playing a key role in the renal cancer treatment. However, no success has been reported in 3D CRS segmentation due to the complex shapes of renal structures, low contrast and large anatomical variation. In this study, we utilize the adversarial ensemble learning and propose Ensemble Multi-condition GAN(EnMcGAN) for 3D CRS segmentation for the first time. Its contribution is three-fold. 1)Inspired by windowing, we propose the multi-windowing committee which divides CTA image into multiple narrow windows with different window centers and widths enhancing the contrast for salient boundaries and soft tissues. And then, it builds an ensemble segmentation model on these narrow windows to fuse the segmentation superiorities and improve whole segmentation quality. 2)We propose the multi-condition GAN which equips the segmentation model with multiple discriminators to encourage the segmented structures meeting their real shape conditions, thus improving the shape feature extraction ability. 3)We propose the adversarial weighted ensemble module which uses the trained discriminators to evaluate the quality of segmented structures, and normalizes these evaluation scores for the ensemble weights directed at the input image, thus enhancing the ensemble results. 122 patients are enrolled in this study and the mean Dice coefficient of the renal structures achieves 84.6%. Extensive experiments with promising results on renal structures reveal powerful segmentation accuracy and great clinical significance in renal cancer treatment.

Yuting He, Tiantian Li, Guanyu Yang et al.

Deep learning-based medical image registration and segmentation joint models utilize the complementarity (augmentation data or weakly supervised data from registration, region constraints from segmentation) to bring mutual improvement in complex scene and few-shot situation. However, further adoption of the joint models are hindered: 1) the diversity of augmentation data is reduced limiting the further enhancement of segmentation, 2) misaligned regions in weakly supervised data disturb the training process, 3) lack of label-based region constraints in few-shot situation limits the registration performance. We propose a novel Deep Complementary Joint Model (DeepRS) for complex scene registration and few-shot segmentation. We embed a perturbation factor in the registration to increase the activity of deformation thus maintaining the augmentation data diversity. We take a pixel-wise discriminator to extract alignment confidence maps which highlight aligned regions in weakly supervised data so the misaligned regions' disturbance will be suppressed via weighting. The outputs from segmentation model are utilized to implement deep-based region constraints thus relieving the label requirements and bringing fine registration. Extensive experiments on the CT dataset of MM-WHS 2017 Challenge show great advantages of our DeepRS that outperforms the existing state-of-the-art models.

Jiasong Wu, Jing Zhang, Fuzhi Wu et al.

Deep learning is a hot research topic in the field of machine learning methods and applications. Generative Adversarial Networks (GANs) and Variational Auto-Encoders (VAEs) provide impressive image generations from Gaussian white noise, but both of them are difficult to train since they need to train the generator (or encoder) and the discriminator (or decoder) simultaneously, which is easy to cause unstable training. In order to solve or alleviate the synchronous training difficult problems of GANs and VAEs, recently, researchers propose Generative Scattering Networks (GSNs), which use wavelet scattering networks (ScatNets) as the encoder to obtain the features (or ScatNet embeddings) and convolutional neural networks (CNNs) as the decoder to generate the image. The advantage of GSNs is the parameters of ScatNets are not needed to learn, and the disadvantage of GSNs is that the expression ability of ScatNets is slightly weaker than CNNs and the dimensional reduction method of Principal Component Analysis (PCA) is easy to lead overfitting in the training of GSNs, and therefore affect the generated quality in the testing process. In order to further improve the quality of generated images while keep the advantages of GSNs, this paper proposes Generative Fractional Scattering Networks (GFRSNs), which use more expressive fractional wavelet scattering networks (FrScatNets) instead of ScatNets as the encoder to obtain the features (or FrScatNet embeddings) and use the similar CNNs of GSNs as the decoder to generate the image. Additionally, this paper develops a new dimensional reduction method named Feature-Map Fusion (FMF) instead of PCA for better keeping the information of FrScatNets and the effect of image fusion on the quality of image generation is also discussed.

Xiahai Zhuang, Lei Li, Christian Payer et al.

Knowledge of whole heart anatomy is a prerequisite for many clinical applications. Whole heart segmentation (WHS), which delineates substructures of the heart, can be very valuable for modeling and analysis of the anatomy and functions of the heart. However, automating this segmentation can be arduous due to the large variation of the heart shape, and different image qualities of the clinical data. To achieve this goal, a set of training data is generally needed for constructing priors or for training. In addition, it is difficult to perform comparisons between different methods, largely due to differences in the datasets and evaluation metrics used. This manuscript presents the methodologies and evaluation results for the WHS algorithms selected from the submissions to the Multi-Modality Whole Heart Segmentation (MM-WHS) challenge, in conjunction with MICCAI 2017. The challenge provides 120 three-dimensional cardiac images covering the whole heart, including 60 CT and 60 MRI volumes, all acquired in clinical environments with manual delineation. Ten algorithms for CT data and eleven algorithms for MRI data, submitted from twelve groups, have been evaluated. The results show that many of the deep learning (DL) based methods achieved high accuracy, even though the number of training datasets was limited. A number of them also reported poor results in the blinded evaluation, probably due to overfitting in their training. The conventional algorithms, mainly based on multi-atlas segmentation, demonstrated robust and stable performance, even though the accuracy is not as good as the best DL method in CT segmentation. The challenge, including the provision of the annotated training data and the blinded evaluation for submitted algorithms on the test data, continues as an ongoing benchmarking resource via its homepage (\url{www.sdspeople.fudan.edu.cn/zhuangxiahai/0/mmwhs/}).

Guanyu Yang, Huazhong Shu, Christine Toumoulin et al.

Legendre orthogonal moments have been widely used in the field of image analysis. Because their computation by a direct method is very time expensive, recent efforts have been devoted to the reduction of computational complexity. Nevertheless, the existing algorithms are mainly focused on binary images. We propose here a new fast method for computing the Legendre moments, which is not only suitable for binary images but also for grey levels. We first set up the recurrence formula of one-dimensional (1D) Legendre moments by using the recursive property of Legendre polynomials. As a result, the 1D Legendre moments of order p, Lp = Lp(0), can be expressed as a linear combination of Lp-1(1) and Lp-2(0). Based on this relationship, the 1D Legendre moments Lp(0) is thus obtained from the array of L1(a) and L0(a) where a is an integer number less than p. To further decrease the computation complexity, an algorithm, in which no multiplication is required, is used to compute these quantities. The method is then extended to the calculation of the two-dimensional Legendre moments Lpq. We show that the proposed method is more efficient than the direct method.