Robert Yang

Dylan Molho, Jiayuan Ding, Zhaoheng Li et al.

Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high-dimensional, sparse, heterogeneous, and have complicated dependency structures, making analyses using conventional machine learning approaches challenging and impractical. In tackling these challenges, deep learning often demonstrates superior performance compared to traditional machine learning methods. In this work, we give a comprehensive survey on deep learning in single-cell analysis. We first introduce background on single-cell technologies and their development, as well as fundamental concepts of deep learning including the most popular deep architectures. We present an overview of the single-cell analytic pipeline pursued in research applications while noting divergences due to data sources or specific applications. We then review seven popular tasks spanning through different stages of the single-cell analysis pipeline, including multimodal integration, imputation, clustering, spatial domain identification, cell-type deconvolution, cell segmentation, and cell-type annotation. Under each task, we describe the most recent developments in classical and deep learning methods and discuss their advantages and disadvantages. Deep learning tools and benchmark datasets are also summarized for each task. Finally, we discuss the future directions and the most recent challenges. This survey will serve as a reference for biologists and computer scientists, encouraging collaborations.

Tai Vu, Robert Yang

The process of generating fully colorized drawings from sketches is a large, usually costly bottleneck in the manga and anime industry. In this study, we examine multiple models for image-to-image translation between anime characters and their sketches, including Neural Style Transfer, C-GAN, and CycleGAN. By assessing them qualitatively and quantitatively, we find that C-GAN is the most effective model that is able to produce high-quality and high-resolution images close to those created by humans.

Tai Vu, Robert Yang

Visual question answering has been an exciting challenge in the field of natural language understanding, as it requires deep learning models to exchange information from both vision and language domains. In this project, we aim to tackle a subtask of this problem, namely visual question answering on plots. To achieve this, we developed BERT-VQA, a VisualBERT-based model architecture with a pretrained ResNet 101 image encoder, along with a potential addition of joint fusion. We trained and evaluated this model against a baseline that consisted of a LSTM, a CNN, and a shallow classifier. The final outcome disproved our core hypothesis that the cross-modality module in VisualBERT is essential in aligning plot components with question phrases. Therefore, our work provided valuable insights into the difficulty of the plot question answering challenge as well as the appropriateness of different model architectures in solving this problem.

Robert Yang

Large language models display a peculiar form of inconsistency: they "know" the correct answer but fail to act on it. In human philosophy, this tension between global judgment and local impulse is called akrasia, or weakness of will. We propose akrasia as a foundational concept for analyzing inconsistency and goal drift in agentic AI systems. To operationalize it, we introduce a preliminary version of the Akrasia Benchmark, currently a structured set of prompting conditions (Baseline [B], Synonym [S], Temporal [T], and Temptation [X]) that measures when a model's local response contradicts its own prior commitments. The benchmark enables quantitative comparison of "self-control" across model families, decoding strategies, and temptation types. Beyond single-model evaluation, we outline how micro-level akrasia may compound into macro-level instability in multi-agent systems that may be interpreted as "scheming" or deliberate misalignment. By reframing inconsistency as weakness of will, this work connects agentic behavior to classical theories of agency and provides an empirical bridge between philosophy, psychology, and the emerging science of agentic AI.

Robert Yang

Bold claims about AI's role in science-from "AGI will cure all diseases" to promises of radically accelerated discovery-raise a central epistemic question: do large language models (LLMs) truly generate new knowledge, or do they merely remix memorized fragments? We propose unlearning-as-ablation as a falsifiable probe of constructive scientific discovery. The idea is to systematically remove a target result together with its forget-closure (supporting lemmas, paraphrases, and multi-hop entailments) and then evaluate whether the model can re-derive the result from only permitted axioms and tools. Success would indicate generative capability beyond recall; failure would expose current limits. Unlike prevailing motivations for unlearning-privacy, copyright, or safety-our framing repositions it as an epistemic probe for AI-for-Science. We outline a minimal pilot in mathematics and algorithms to illustrate feasibility, and sketch how the same approach could later be extended to domains such as physics or chemistry. This is a position paper: our contribution is conceptual and methodological, not empirical. We aim to stimulate discussion on how principled ablation tests could help distinguish models that reconstruct knowledge from those that merely retrieve it, and how such probes might guide the next generation of AI-for-Science benchmarks.