Daniel Novák

Tomás Lima, Igor Varga, Eduard Bakštein et al.

Deep Brain Stimulation (DBS) is one of the most successful methods to diminish late-stage Parkinson's Disease (PD) symptoms. It is a delicate surgical procedure which requires detailed pre-surgical patient's study. High-field Magnetic Resonance Imaging (MRI) has proven its improved capacity of capturing the Subthalamic Nucleus (STN) - the main target of DBS in PD - in greater detail than lower field images. Here, we present a comparison between the performance of two different Deep Learning (DL) automatic segmentation architectures, one based in the registration to a brain template and the other performing the segmentation in in the MRI acquisition native space. The study was based on publicly available high-field 7 Tesla (T) brain MRI datasets of T1-weighted and T2-weighted sequences. nnUNet was used on the segmentation step of both architectures, while the data pre and post-processing pipelines diverged. The evaluation metrics showed that the performance of the segmentation directly in the native space yielded better results for the STN segmentation, despite not showing any advantage over the template-based method for the to other analysed structures: the Red Nucleus (RN) and the Substantia Nigra (SN).

Cheng Kang, Daniel Novak, Katerina Urbanova et al.

Large language models (LLMs) have demonstrated impressive generalization capabilities on specific tasks with human-written instruction data. However, the limited quantity, diversity, and professional expertise of such instruction data raise concerns about the performance of LLMs in psychotherapy tasks when provided with domain-specific instructions. To address this, we firstly propose Domain-Specific Assistant Instructions based on AlexanderStreet therapy, and secondly, we use an adaption fine-tuning method and retrieval augmented generation method to improve pre-trained LLMs. Through quantitative evaluation of linguistic quality using automatic and human evaluation, we observe that pre-trained LLMs on Psychotherapy Assistant Instructions outperform state-of-the-art LLMs response baselines. Our Assistant-Instruction approach offers a half-annotation method to align pre-trained LLMs with instructions and provide pre-trained LLMs with more psychotherapy knowledge.