Jiacheng Xie

Yifan Zuo, Jiacheng Xie, Yuming Fang et al.

A mainstream type of the state of the arts (SOTAs) based on convolutional neural network (CNN) for real image denoising contains two sub-problems, i.e., noise estimation and non-blind denoising. This paper considers real noise approximated by heteroscedastic Gaussian/Poisson Gaussian distributions with in-camera signal processing pipelines. The related works always exploit the estimated noise prior via channel-wise concatenation followed by a convolutional layer with spatially sharing kernels. Due to the variable modes of noise strength and frequency details of all feature positions, this design cannot adaptively tune the corresponding denoising patterns. To address this problem, we propose a novel conditional filter in which the optimal kernels for different feature positions can be adaptively inferred by local features from the image and the noise map. Also, we bring the thought that alternatively performs noise estimation and non-blind denoising into CNN structure, which continuously updates noise prior to guide the iterative feature denoising. In addition, according to the property of heteroscedastic Gaussian distribution, a novel affine transform block is designed to predict the stationary noise component and the signal-dependent noise component. Compared with SOTAs, extensive experiments are conducted on five synthetic datasets and three real datasets, which shows the improvement of the proposed CFNet.

Jiacheng Xie, Ziyang Zhang, Biplab Poudel et al.

Tongue imaging serves as a valuable diagnostic tool, particularly in Traditional Chinese Medicine (TCM). The quality of tongue surface segmentation significantly affects the accuracy of tongue image classification and subsequent diagnosis in intelligent tongue diagnosis systems. However, existing research on tongue image segmentation faces notable limitations, and there is a lack of robust and user-friendly segmentation tools. This paper proposes a tongue image segmentation model (TOM) based on multi-teacher knowledge distillation. By incorporating a novel diffusion-based data augmentation method, we enhanced the generalization ability of the segmentation model while reducing its parameter size. Notably, after reducing the parameter count by 96.6% compared to the teacher models, the student model still achieves an impressive segmentation performance of 95.22% mIoU. Furthermore, we packaged and deployed the trained model as both an online and offline segmentation tool (available at https://itongue.cn/), allowing TCM practitioners and researchers to use it without any programming experience. We also present a case study on TCM constitution classification using segmented tongue patches. Experimental results demonstrate that training with tongue patches yields higher classification performance and better interpretability than original tongue images. To our knowledge, this is the first open-source and freely available tongue image segmentation tool.

Xi Xiao, Zhengji Li, Wentao Wang et al.

Object detection has witnessed remarkable advancements over the past decade, largely driven by breakthroughs in deep learning and the proliferation of large scale datasets. However, the domain of road damage detection remains relatively under explored, despite its critical significance for applications such as infrastructure maintenance and road safety. This paper addresses this gap by introducing a novel top down benchmark that offers a complementary perspective to existing datasets, specifically tailored for road damage detection. Our proposed Top Down Road Damage Detection Dataset (TDRD) includes three primary categories of road damage cracks, potholes, and patches captured from a top down viewpoint. The dataset consists of 7,088 high resolution images, encompassing 12,882 annotated instances of road damage. Additionally, we present a novel real time object detection framework, TDYOLOV10, designed to handle the unique challenges posed by the TDRD dataset. Comparative studies with state of the art models demonstrate competitive baseline results. By releasing TDRD, we aim to accelerate research in this crucial area. A sample of the dataset will be made publicly available upon the paper's acceptance.

Jiacheng Xie, Yang Yu, Yibo Chen et al.

Traditional Chinese Medicine (TCM), with a history spanning over two millennia, plays a role in global healthcare. However, applying large language models (LLMs) to TCM remains challenging due to its reliance on holistic reasoning, implicit logic, and multimodal diagnostic cues. Existing TCM-domain LLMs have made progress in text-based understanding but lack multimodal integration, interpretability, and clinical applicability. To address these limitations, we developed BenCao, a ChatGPT-based multimodal assistant for TCM, integrating structured knowledge bases, diagnostic data, and expert feedback refinement. BenCao was trained through natural language instruction tuning rather than parameter retraining, aligning with expert-level reasoning and ethical norms specific to TCM. The system incorporates a comprehensive knowledge base of over 1,000 classical and modern texts, a scenario-based instruction framework for diverse interactions, a chain-of-thought simulation mechanism for interpretable reasoning, and a feedback refinement process involving licensed TCM practitioners. BenCao connects to external APIs for tongue-image classification and multimodal database retrieval, enabling dynamic access to diagnostic resources. In evaluations across single-choice question benchmarks and multimodal classification tasks, BenCao achieved superior accuracy to general-domain and TCM-domain models, particularly in diagnostics, herb recognition, and constitution classification. The model was deployed as an interactive application on the OpenAI GPTs Store, accessed by nearly 1,000 users globally as of October 2025. This study demonstrates the feasibility of developing a TCM-domain LLM through natural language-based instruction tuning and multimodal integration, offering a practical framework for aligning generative AI with traditional medical reasoning and a scalable pathway for real-world deployment.

Jiacheng Xie, Shuai Zeng, Yang Yu et al.

Traditional Chinese Medicine (TCM) presents a rich and structurally unique knowledge system that challenges conventional applications of large language models (LLMs). Although previous TCM-specific LLMs have shown progress through supervised fine-tuning, they often face limitations in alignment, data quality, and evaluation consistency. In this study, we introduce Ladder-base, the first TCM-focused LLM trained with Group Relative Policy Optimization (GRPO), a reinforcement learning method that improves reasoning and factual consistency by optimizing response selection based on intra-group comparisons. Ladder-base is built upon the Qwen2.5-7B-Instruct foundation model and trained exclusively on the textual subset of the TCM-Ladder benchmark, using 80 percent of the data for training and the remaining 20 percent split evenly between validation and test sets. Through standardized evaluation, Ladder-base demonstrates superior performance across multiple reasoning metrics when compared to both state-of-the-art general-purpose LLMs such as GPT-4, Gemini 2.5, Claude 3, and Qwen3 and domain-specific TCM models including BenTsao, HuatuoGPT2, and Zhongjing. These findings suggest that GRPO provides an effective and efficient strategy for aligning LLMs with expert-level reasoning in traditional medical domains and supports the development of trustworthy and clinically grounded TCM artificial intelligence systems.

Jiacheng Xie, Yingrui Ji, Linghuan Zeng et al.

Accurate prediction of CB2 receptor ligand activity is pivotal for advancing drug discovery targeting this receptor, which is implicated in inflammation, pain management, and neurodegenerative conditions. Although conventional machine learning and deep learning techniques have shown promise, their limited interpretability remains a significant barrier to rational drug design. In this work, we introduce CB2former, a framework that combines a Graph Convolutional Network with a Transformer architecture to predict CB2 receptor ligand activity. By leveraging the Transformer's self attention mechanism alongside the GCN's structural learning capability, CB2former not only enhances predictive performance but also offers insights into the molecular features underlying receptor activity. We benchmark CB2former against diverse baseline models including Random Forest, Support Vector Machine, K Nearest Neighbors, Gradient Boosting, Extreme Gradient Boosting, Multilayer Perceptron, Convolutional Neural Network, and Recurrent Neural Network and demonstrate its superior performance with an R squared of 0.685, an RMSE of 0.675, and an AUC of 0.940. Moreover, attention weight analysis reveals key molecular substructures influencing CB2 receptor activity, underscoring the model's potential as an interpretable AI tool for drug discovery. This ability to pinpoint critical molecular motifs can streamline virtual screening, guide lead optimization, and expedite therapeutic development. Overall, our results showcase the transformative potential of advanced AI approaches exemplified by CB2former in delivering both accurate predictions and actionable molecular insights, thus fostering interdisciplinary collaboration and innovation in drug discovery.

Xi Xiao, Wentao Wang, Jiacheng Xie et al.

Drug target binding affinity (DTA) is a key criterion for drug screening. Existing experimental methods are time-consuming and rely on limited structural and domain information. While learning-based methods can model sequence and structural information, they struggle to integrate contextual data and often lack comprehensive modeling of drug-target interactions. In this study, we propose a novel DTA prediction method, termed HGTDP-DTA, which utilizes dynamic prompts within a hybrid Graph-Transformer framework. Our method generates context-specific prompts for each drug-target pair, enhancing the model's ability to capture unique interactions. The introduction of prompt tuning further optimizes the prediction process by filtering out irrelevant noise and emphasizing task-relevant information, dynamically adjusting the input features of the molecular graph. The proposed hybrid Graph-Transformer architecture combines structural information from Graph Convolutional Networks (GCNs) with sequence information captured by Transformers, facilitating the interaction between global and local information. Additionally, we adopted the multi-view feature fusion method to project molecular graph views and affinity subgraph views into a common feature space, effectively combining structural and contextual information. Experiments on two widely used public datasets, Davis and KIBA, show that HGTDP-DTA outperforms state-of-the-art DTA prediction methods in both prediction performance and generalization ability.