Lifeng Zhu

Ruihui Hou, Shencheng Chen, Yongqi Fan et al.

Clinical diagnosis is critical in medical practice, typically requiring a continuous and evolving process that includes primary diagnosis, differential diagnosis, and final diagnosis. However, most existing clinical diagnostic tasks are single-step processes, which does not align with the complex multi-step diagnostic procedures found in real-world clinical settings. In this paper, we propose a Chinese clinical diagnostic benchmark, called MSDiagnosis. This benchmark consists of 2,225 cases from 12 departments, covering tasks such as primary diagnosis, differential diagnosis, and final diagnosis. Additionally, we propose a novel and effective framework. This framework combines forward inference, backward inference, reflection, and refinement, enabling the large language model to self-evaluate and adjust its diagnostic results. To this end, we test open-source models, closed-source models, and our proposed framework.The experimental results demonstrate the effectiveness of the proposed method. We also provide a comprehensive experimental analysis and suggest future research directions for this task.

Qian Da, Yijiang Chen, Min Ju et al.

Recent breakthroughs in artificial intelligence through foundation models and agents have accelerated the evolution of computational pathology. Demonstrated performance gains reported across academia in benchmarking datasets in predictive tasks such as diagnosis, prognosis, and treatment response have ignited substantial enthusiasm for clinical application. Despite this development momentum, real world adoption has lagged, as implementation faces economic, technical, and administrative challenges. Beyond existing discussions of technical architectures and comparative performance, this review considers how these emerging AI systems can be responsibly integrated into medical practice by connecting deployable clinical relevance with downstream analytical capabilities and their technical maturity, operational readiness, and economic and regulatory context. Drawing on perspectives from an international group, we provide a practical assessment of current capabilities and barriers to adoption in patient care settings.

Hongkun Zhang, Zherong Pan, Congyi Zhang et al.

The recent success of pre-trained diffusion models unlocks the possibility of the automatic generation of textures for arbitrary 3D meshes in the wild. However, these models are trained in the screen space, while converting them to a multi-view consistent texture image poses a major obstacle to the output quality. In this paper, we propose a novel method to enforce multi-view consistency. Our method is based on the observation that latent space in a pre-trained diffusion model is noised separately for each camera view, making it difficult to achieve multi-view consistency by directly manipulating the latent codes. Based on the celebrated Denoising Diffusion Implicit Models (DDIM) scheme, we propose to use an optimization-based color-fusion to enforce consistency and indirectly modify the latent codes by gradient back-propagation. Our method further relaxes the sequential dependency assumption among the camera views. By evaluating on a series of general 3D models, we find our simple approach improves consistency and overall quality of the generated textures as compared to competing state-of-the-arts. Our implementation is available at: https://github.com/Quantuman134/TexPainter

Xinkai Wang, Chenyi Wang, Yifu Xu et al.

We introduce \textbf{LaMP}, a dual-expert Vision-Language-Action framework that embeds dense 3D scene flow as a latent motion prior for robotic manipulation. Existing VLA models regress actions directly from 2D semantic visual features, forcing them to learn complex 3D physical interactions implicitly. This implicit learning strategy degrades under unfamiliar spatial dynamics. LaMP addresses this limitation by aligning a flow-matching \emph{Motion Expert} with a policy-predicting \emph{Action Expert} through gated cross-attention. Specifically, the Motion Expert generates a one-step partially denoised 3D scene flow, and its hidden states condition the Action Expert without full multi-step reconstruction. We evaluate LaMP on the LIBERO, LIBERO-Plus, and SimplerEnv-WidowX simulation benchmarks as well as real-world experiments. LaMP consistently outperforms evaluated VLA baselines across LIBERO, LIBERO-Plus, and SimplerEnv-WidowX benchmarks, achieving the highest reported average success rates under the same training budgets. On LIBERO-Plus OOD perturbations, LaMP shows improved robustness with an average 9.7% gain over the strongest prior baseline. Our project page is available at https://summerwxk.github.io/lamp-project-page/.

Xiaosong Wang, Xiaofan Zhang, Guotai Wang et al.

The emerging trend of advancing generalist artificial intelligence, such as GPTv4 and Gemini, has reshaped the landscape of research (academia and industry) in machine learning and many other research areas. However, domain-specific applications of such foundation models (e.g., in medicine) remain untouched or often at their very early stages. It will require an individual set of transfer learning and model adaptation techniques by further expanding and injecting these models with domain knowledge and data. The development of such technologies could be largely accelerated if the bundle of data, algorithms, and pre-trained foundation models were gathered together and open-sourced in an organized manner. In this work, we present OpenMEDLab, an open-source platform for multi-modality foundation models. It encapsulates not only solutions of pioneering attempts in prompting and fine-tuning large language and vision models for frontline clinical and bioinformatic applications but also building domain-specific foundation models with large-scale multi-modal medical data. Importantly, it opens access to a group of pre-trained foundation models for various medical image modalities, clinical text, protein engineering, etc. Inspiring and competitive results are also demonstrated for each collected approach and model in a variety of benchmarks for downstream tasks. We welcome researchers in the field of medical artificial intelligence to continuously contribute cutting-edge methods and models to OpenMEDLab, which can be accessed via https://github.com/openmedlab.

Kaitao Chen, Mianxin Liu, Fang Yan et al.

The advent of vision-language models fosters the interactive conversations between AI-enabled models and humans. Yet applying these models into clinics must deal with daunting challenges around large-scale training data, financial, and computational resources. Here we propose a cost-effective instruction learning framework for conversational pathology named as CLOVER. CLOVER only trains a lightweight module and uses instruction tuning while freezing the parameters of the large language model. Instead of using costly GPT-4, we propose well-designed prompts on GPT-3.5 for building generation-based instructions, emphasizing the utility of pathological knowledge derived from the Internet source. To augment the use of instructions, we construct a high-quality set of template-based instructions in the context of digital pathology. From two benchmark datasets, our findings reveal the strength of hybrid-form instructions in the visual question-answer in pathology. Extensive results show the cost-effectiveness of CLOVER in answering both open-ended and closed-ended questions, where CLOVER outperforms strong baselines that possess 37 times more training parameters and use instruction data generated from GPT-4. Through the instruction tuning, CLOVER exhibits robustness of few-shot learning in the external clinical dataset. These findings demonstrate that cost-effective modeling of CLOVER could accelerate the adoption of rapid conversational applications in the landscape of digital pathology.

Rongzhao Zhang, Zhian Bai, Ruoying Yu et al.

When delineating lesions from medical images, a human expert can always keep in mind the anatomical structure behind the voxels. However, although high-quality (though not perfect) anatomical information can be retrieved from computed tomography (CT) scans with modern deep learning algorithms, it is still an open problem how these automatically generated organ masks can assist in addressing challenging lesion segmentation tasks, such as the segmentation of colorectal cancer (CRC). In this paper, we develop a novel Anatomy-Guided segmentation framework to exploit the auto-generated organ masks to aid CRC segmentation from CT, namely AG-CRC. First, we obtain multi-organ segmentation (MOS) masks with existing MOS models (e.g., TotalSegmentor) and further derive a more robust organ of interest (OOI) mask that may cover most of the colon-rectum and CRC voxels. Then, we propose an anatomy-guided training patch sampling strategy by optimizing a heuristic gain function that considers both the proximity of important regions (e.g., the tumor or organs of interest) and sample diversity. Third, we design a novel self-supervised learning scheme inspired by the topology of tubular organs like the colon to boost the model performance further. Finally, we employ a masked loss scheme to guide the model to focus solely on the essential learning region. We extensively evaluate the proposed method on two CRC segmentation datasets, where substantial performance improvement (5% to 9% in Dice) is achieved over current state-of-the-art medical image segmentation models, and the ablation studies further evidence the efficacy of every proposed component.

Huijun Han, Congyi Zhang, Lifeng Zhu et al.

Orthognathic surgery consultation is essential to help patients understand the changes to their facial appearance after surgery. However, current visualization methods are often inefficient and inaccurate due to limited pre- and post-treatment data and the complexity of the treatment. To overcome these challenges, this study aims to develop a fully automated pipeline that generates accurate and efficient 3D previews of postsurgical facial appearances for patients with orthognathic treatment without requiring additional medical images. The study introduces novel aesthetic losses, such as mouth-convexity and asymmetry losses, to improve the accuracy of facial surgery prediction. Additionally, it proposes a specialized parametric model for 3D reconstruction of the patient, medical-related losses to guide latent code prediction network optimization, and a data augmentation scheme to address insufficient data. The study additionally employs FLAME, a parametric model, to enhance the quality of facial appearance previews by extracting facial latent codes and establishing dense correspondences between pre- and post-surgery geometries. Quantitative comparisons showed the algorithm's effectiveness, and qualitative results highlighted accurate facial contour and detail predictions. A user study confirmed that doctors and the public could not distinguish between machine learning predictions and actual postoperative results. This study aims to offer a practical, effective solution for orthognathic surgery consultations, benefiting doctors and patients.

Xinkai Wang, Yue Yang, Kehong Zhou et al. · stanford

Chinese acupuncture practitioners primarily depend on muscle memory and tactile feedback to insert needles and accurately target acupuncture points, as the current workflow lacks imaging modalities and visual aids. Consequently, new practitioners often learn through trial and error, requiring years of experience to become proficient and earn the trust of patients. Medical students face similar challenges in mastering this skill. To address these challenges, we developed an innovative system, MRUCT, that integrates ultrasonic computed tomography (UCT) with mixed reality (MR) technology to visualize acupuncture points in real-time. This system offers offline image registration and real-time guidance during needle insertion, enabling them to accurately position needles based on anatomical structures such as bones, muscles, and auto-generated reference points, with the potential for clinical implementation. In this paper, we outline the non-rigid registration methods used to reconstruct anatomical structures from UCT data, as well as the key design considerations of the MR system. We evaluated two different 3D user interface (3DUI) designs and compared the performance of our system to traditional workflows for both new practitioners and medical students. The results highlight the potential of MR to enhance therapeutic medical practices and demonstrate the effectiveness of the system we developed.

Yue Yang, Xue Xie, Xinkai Wang et al. · stanford

Optical see-through augmented reality (OST-AR) systems like Microsoft HoloLens 2 hold promise for arm's distance guidance (e.g., surgery), but depth perception of the hologram and occlusion of real instruments remain challenging. We present an evaluation of how visualizing the target object with different transparencies and visualizing a tracked tool (virtual proxy vs. real tool vs. no tool tracking) affects depth perception and system usability. Ten participants performed two experiments on HoloLens 2. In Experiment 1, we compared high-transparency vs. low-transparency target rendering in a depth matching task at arm's length. In Experiment 2, participants performed a simulated surgical pinpoint task on a frontal bone target under six visualization conditions ($2 \times 3$: two target transparencies and three tool visualization modes: virtual tool hologram, real tool, or no tool tracking). We collected data on depth matching error, target localization error, system usability, task workload, and qualitative feedback. Results show that a more opaque target yields significantly lower depth estimation error than a highly transparent target at arm's distance. Moreover, showing the real tool (occluding the virtual target) led to the highest accuracy and usability with the lowest workload, while not tracking the tool yielded the worst performance and user ratings. However, making the target highly transparent, while allowing the real tool to remain visible, slightly impaired depth cues and did not improve usability. Our findings underscore that correct occlusion cues, rendering virtual content opaque and occluding it with real tools in real time, are critical for depth perception and precision in OST-AR. Designers of arm-distance AR systems should prioritize robust tool tracking and occlusion handling; if unavailable, cautiously use transparency to balance depth perception and tool visibility.

Xinkai Wang, Shuo Zhang, Ziyi Zhao et al.

While tangible user interface has shown its power in naturally interacting with rigid or soft objects, users cannot conveniently use different types of granular materials as the interaction media. We introduce DipMe as a smart device to recognize the types of granular media in real time, which can be used to connect the granular materials in the physical world with various virtual content. Other than vision-based solutions, we propose a dip operation of our device and exploit the haptic signals to recognize different types of granular materials. With modern machine learning tools, we find the haptic signals from different granular media are distinguishable by DipMe. With the online granular object recognition, we build several tangible interactive applications, demonstrating the effects of DipMe in perceiving granular materials and its potential in developing a tangible user interface with granular objects as the new media.

Mianxin Liu, Jinru Ding, Jie Xu et al.

Ensuring the general efficacy and goodness for human beings from medical large language models (LLM) before real-world deployment is crucial. However, a widely accepted and accessible evaluation process for medical LLM, especially in the Chinese context, remains to be established. In this work, we introduce "MedBench", a comprehensive, standardized, and reliable benchmarking system for Chinese medical LLM. First, MedBench assembles the currently largest evaluation dataset (300,901 questions) to cover 43 clinical specialties and performs multi-facet evaluation on medical LLM. Second, MedBench provides a standardized and fully automatic cloud-based evaluation infrastructure, with physical separations for question and ground truth. Third, MedBench implements dynamic evaluation mechanisms to prevent shortcut learning and answer remembering. Applying MedBench to popular general and medical LLMs, we observe unbiased, reproducible evaluation results largely aligning with medical professionals' perspectives. This study establishes a significant foundation for preparing the practical applications of Chinese medical LLMs. MedBench is publicly accessible at https://medbench.opencompass.org.cn.