Kaiwen Zuo

Kaiwen Zuo, Yirui Jiang, Fan Mo et al.

Integrating Large Language Models (LLMs) in healthcare diagnosis demands systematic frameworks that can handle complex medical scenarios while maintaining specialized expertise. We present KG4Diagnosis, a novel hierarchical multi-agent framework that combines LLMs with automated knowledge graph construction, encompassing 362 common diseases across medical specialties. Our framework mirrors real-world medical systems through a two-tier architecture: a general practitioner (GP) agent for initial assessment and triage, coordinating with specialized agents for in-depth diagnosis in specific domains. The core innovation lies in our end-to-end knowledge graph generation methodology, incorporating: (1) semantic-driven entity and relation extraction optimized for medical terminology, (2) multi-dimensional decision relationship reconstruction from unstructured medical texts, and (3) human-guided reasoning for knowledge expansion. KG4Diagnosis serves as an extensible foundation for specialized medical diagnosis systems, with capabilities to incorporate new diseases and medical knowledge. The framework's modular design enables seamless integration of domain-specific enhancements, making it valuable for developing targeted medical diagnosis systems. We provide architectural guidelines and protocols to facilitate adoption across medical contexts.

Kaiwen Zuo, Shuyuan Yang, Zonghe Chua

Grasp force estimation can help prevent robots from damaging delicate objects during manipulation and improve learning-based robotic control. Integrating force sensing into deformable grippers negotiates trade-offs in cost, complexity, mechanical robustness, and performance. With the growing integration of RGB-D wrist cameras into robotic systems for control purposes, camera-based techniques are a promising solution for indirect visual force estimation. Current approaches mostly utilize end-to-end deep learning, which can be brittle when generalizing to new scenarios, while existing model-based approaches are unsuited to grasping and modern grasper geometries. To address these challenges, we developed a model-based visual force sensing approach integrating an iterative contact localization with generalization to unseen objects. The system extracts structural key points from wrist camera RGB-D images of deforming fin-ray-shaped soft grippers, and uses these key points to define parameters of an inverse finite element analysis simulation in Simulation Open Framework Architecture. The iterative contact localization sub-system utilizes a deep learning-based online 3D reconstruction and pose estimation pipeline to dynamically update contact location, and is robust to visual occlusion and unseen objects. Our system demonstrated an average root mean square error of 0.23 N and normalized root mean square deviation of 2.11% during the load phase, and 0.48 N and 4.34% over the entire grasping process when interacting with different objects under various conditions, showcasing its potential for real-time model-based indirect force sensing of soft grippers.

Kaiwen Zuo, Yirui Jiang

Medical Large Language Models (MLLMs) have demonstrated potential in healthcare applications, yet their propensity for hallucinations -- generating medically implausible or inaccurate information -- presents substantial risks to patient care. This paper introduces MedHallBench, a comprehensive benchmark framework for evaluating and mitigating hallucinations in MLLMs. Our methodology integrates expert-validated medical case scenarios with established medical databases to create a robust evaluation dataset. The framework employs a sophisticated measurement system that combines automated ACHMI (Automatic Caption Hallucination Measurement in Medical Imaging) scoring with rigorous clinical expert evaluations and utilizes reinforcement learning methods to achieve automatic annotation. Through an optimized reinforcement learning from human feedback (RLHF) training pipeline specifically designed for medical applications, MedHallBench enables thorough evaluation of MLLMs across diverse clinical contexts while maintaining stringent accuracy standards. We conducted comparative experiments involving various models, utilizing the benchmark to establish a baseline for widely adopted large language models (LLMs). Our findings indicate that ACHMI provides a more nuanced understanding of the effects of hallucinations compared to traditional metrics, thereby highlighting its advantages in hallucination assessment. This research establishes a foundational framework for enhancing MLLMs' reliability in healthcare settings and presents actionable strategies for addressing the critical challenge of AI hallucinations in medical applications.

Kaiwen Zuo, Jing Tang, Hanbing Qin et al.

Recent advancements in Large Language Models (LLMs) have marked significant progress in understanding and responding to medical inquiries. However, their performance still falls short of the standards set by professional consultations. This paper introduces a novel framework for medical consultation, comprising two main modules: Terminology-Enhanced Information Retrieval (TEIR) and Emotional In-Context Learning (EICL). TEIR ensures implicit reasoning through the utilization of inductive knowledge and key terminology retrieval, overcoming the limitations of restricted domain knowledge in public databases. Additionally, this module features capabilities for processing long context. The EICL module aids in generating sentences with high attribute relevance by memorizing semantic and attribute information from unlabelled corpora and applying controlled retrieval for the required information. Furthermore, a dataset comprising 803,564 consultation records was compiled in China, significantly enhancing the model's capability for complex dialogues and proactive inquiry initiation. Comprehensive experiments demonstrate the proposed method's effectiveness in extending the context window length of existing LLMs. The experimental outcomes and extensive data validate the framework's superiority over five baseline models in terms of BLEU and ROUGE performance metrics, with substantial leads in certain capabilities. Notably, ablation studies confirm the significance of the TEIR and EICL components. In addition, our new framework has the potential to significantly improve patient satisfaction in real clinical consulting situations.

Kaiwen Zuo, Zelin Liu, Raman Dutt et al.

Large Vision-Language Models (LVLMs) augmented with Retrieval-Augmented Generation (RAG) are increasingly employed in medical AI to enhance factual grounding through external clinical image-text retrieval. However, this reliance creates a significant attack surface. We propose MedThreatRAG, a novel multimodal poisoning framework that systematically probes vulnerabilities in medical RAG systems by injecting adversarial image-text pairs. A key innovation of our approach is the construction of a simulated semi-open attack environment, mimicking real-world medical systems that permit periodic knowledge base updates via user or pipeline contributions. Within this setting, we introduce and emphasize Cross-Modal Conflict Injection (CMCI), which embeds subtle semantic contradictions between medical images and their paired reports. These mismatches degrade retrieval and generation by disrupting cross-modal alignment while remaining sufficiently plausible to evade conventional filters. While basic textual and visual attacks are included for completeness, CMCI demonstrates the most severe degradation. Evaluations on IU-Xray and MIMIC-CXR QA tasks show that MedThreatRAG reduces answer F1 scores by up to 27.66% and lowers LLaVA-Med-1.5 F1 rates to as low as 51.36%. Our findings expose fundamental security gaps in clinical RAG systems and highlight the urgent need for threat-aware design and robust multimodal consistency checks. Finally, we conclude with a concise set of guidelines to inform the safe development of future multimodal medical RAG systems.