Hugh Churchill

Xuan-Bac Nguyen, Chi Nhan Duong, Marios Savvides et al.

Promoting fairness for deep clustering models in unsupervised clustering settings to reduce demographic bias is a challenging goal. This is because of the limitation of large-scale balanced data with well-annotated labels for sensitive or protected attributes. In this paper, we first evaluate demographic bias in deep clustering models from the perspective of cluster purity, which is measured by the ratio of positive samples within a cluster to their correlation degree. This measurement is adopted as an indication of demographic bias. Then, a novel loss function is introduced to encourage a purity consistency for all clusters to maintain the fairness aspect of the learned clustering model. Moreover, we present a novel attention mechanism, Cross-attention, to measure correlations between multiple clusters, strengthening faraway positive samples and improving the purity of clusters during the learning process. Experimental results on a large-scale dataset with numerous attribute settings have demonstrated the effectiveness of the proposed approach on both clustering accuracy and fairness enhancement on several sensitive attributes.

Xuan Bac Nguyen, Apoorva Bisht, Ben Thompson et al.

In quantum machine field, detecting two-dimensional (2D) materials in Silicon chips is one of the most critical problems. Instance segmentation can be considered as a potential approach to solve this problem. However, similar to other deep learning methods, the instance segmentation requires a large scale training dataset and high quality annotation in order to achieve a considerable performance. In practice, preparing the training dataset is a challenge since annotators have to deal with a large image, e.g 2K resolution, and extremely dense objects in this problem. In this work, we present a novel method to tackle the problem of missing annotation in instance segmentation in 2D quantum material identification. We propose a new mechanism for automatically detecting false negative objects and an attention based loss strategy to reduce the negative impact of these objects contributing to the overall loss function. We experiment on the 2D material detection datasets, and the experiments show our method outperforms previous works.

Xuan Bac Nguyen, Hugh Churchill, Khoa Luu et al.

Unsupervised visual clustering has garnered significant attention in recent times, aiming to characterize distributions of unlabeled visual images through clustering based on a parameterized appearance approach. Alternatively, clustering algorithms can be viewed as assignment problems, often characterized as NP-hard, yet precisely solvable for small instances on contemporary hardware. Adiabatic quantum computing (AQC) emerges as a promising solution, poised to deliver substantial speedups for a range of NP-hard optimization problems. However, existing clustering formulations face challenges in quantum computing adoption due to scalability issues. In this study, we present the first clustering formulation tailored for resolution using Adiabatic quantum computing. An Ising model is introduced to represent the quantum mechanical system implemented on AQC. The proposed approach demonstrates high competitiveness compared to state-of-the-art optimization-based methods, even when utilizing off-the-shelf integer programming solvers. Lastly, this work showcases the solvability of the proposed clustering problem on current-generation real quantum computers for small examples and analyzes the properties of the obtained solutions

Xuan-Bac Nguyen, Hoang-Quan Nguyen, Hugh Churchill et al.

Quantum computing has emerged as a powerful tool for solving complex problems intractable for classical computers, particularly in popular fields such as cryptography, optimization, and neurocomputing. In this paper, we present a new quantum-based approach named the Hierarchical Quantum Control Gates (HQCG) method for efficient understanding of Functional Magnetic Resonance Imaging (fMRI) data. This approach includes two novel modules: the Local Quantum Control Gate (LQCG) and the Global Quantum Control Gate (GQCG), which are designed to extract local and global features of fMRI signals, respectively. Our method operates end-to-end on a quantum machine, leveraging quantum mechanics to learn patterns within extremely high-dimensional fMRI signals, such as 30,000 samples which is a challenge for classical computers. Empirical results demonstrate that our approach significantly outperforms classical methods. Additionally, we found that the proposed quantum model is more stable and less prone to overfitting than the classical methods.

Sankalp Pandey, Xuan-Bac Nguyen, Hoang-Quan Nguyen et al.

The transition from optical identification of 2D quantum materials to practical device fabrication requires dynamic reasoning beyond the detection accuracy. While recent domain-specific Multimodal Large Language Models (MLLMs) successfully ground visual features using physics-informed reasoning, their outputs are optimized for step-by-step cognitive transparency. This yields verbose candidate enumerations followed by dense reasoning that, while accurate, may induce cognitive overload and lack immediate utility for real-world interaction with researchers. To address this challenge, we introduce OpenQlaw, an agentic orchestration system for analyzing 2D materials. The architecture is built upon NanoBot, a lightweight agentic framework inspired by OpenClaw, and QuPAINT, one of the first Physics-Aware Instruction Multi-modal platforms for Quantum Material Discovery. This allows accessibility to the lab floor via a variety of messaging channels. OpenQlaw allows the core Large Language Model (LLM) agent to orchestrate a domain-expert MLLM,with QuPAINT, as a specialized node, successfully decoupling visual identification from reasoning and deterministic image rendering. By parsing spatial data from the expert, the agent can dynamically process user queries, such as performing scale-aware physical computation or generating isolated visual annotations, and answer in a naturalistic manner. Crucially, the system features a persistent memory that enables the agent to save physical scale ratios (e.g., 1 pixel = 0.25 μm) for area computations and store sample preparation methods for efficacy comparison. The application of an agentic architecture, together with the extension that uses the core agent as an orchestrator for domain-specific experts, transforms isolated inferences into a context-aware assistant capable of accelerating high-throughput device fabrication.

Xuan-Bac Nguyen, Hoang-Quan Nguyen, Sankalp Pandey et al.

Characterizing two-dimensional quantum materials from optical microscopy images is challenging due to the subtle layer-dependent contrast, limited labeled data, and significant variation across laboratories and imaging setups. Existing vision models struggle in this domain since they lack physical priors and cannot generalize to new materials or hardware conditions. This work presents a new physics-aware multimodal framework that addresses these limitations from both the data and model perspectives. We first present Synthia, a physics-based synthetic data generator that simulates realistic optical responses of quantum material flakes under thin-film interference. Synthia produces diverse and high-quality samples, helping reduce the dependence on expert manual annotation. We introduce QMat-Instruct, the first large-scale instruction dataset for quantum materials, comprising multimodal, physics-informed question-answer pairs designed to teach Multimodal Large Language Models (MLLMs) to understand the appearance and thickness of flakes. Then, we propose Physics-Aware Instruction Tuning (QuPAINT), a multimodal architecture that incorporates a Physics-Informed Attention module to fuse visual embeddings with optical priors, enabling more robust and discriminative flake representations. Finally, we establish QF-Bench, a comprehensive benchmark spanning multiple materials, substrates, and imaging settings, offering standardized protocols for fair and reproducible evaluation.

Hoang-Quan Nguyen, Xuan-Bac Nguyen, Hugh Churchill et al.

Vision-brain understanding aims to extract semantic information about brain signals from human perceptions. Existing deep learning methods for vision-brain understanding are usually introduced in a traditional learning paradigm missing the ability to learn the connectivities between brain regions. Meanwhile, the quantum computing theory offers a new paradigm for designing deep learning models. Motivated by the connectivities in the brain signals and the entanglement properties in quantum computing, we propose a novel Quantum-Brain approach, a quantum-inspired neural network, to tackle the vision-brain understanding problem. To compute the connectivity between areas in brain signals, we introduce a new Quantum-Inspired Voxel-Controlling module to learn the impact of a brain voxel on others represented in the Hilbert space. To effectively learn connectivity, a novel Phase-Shifting module is presented to calibrate the value of the brain signals. Finally, we introduce a new Measurement-like Projection module to present the connectivity information from the Hilbert space into the feature space. The proposed approach can learn to find the connectivities between fMRI voxels and enhance the semantic information obtained from human perceptions. Our experimental results on the Natural Scene Dataset benchmarks illustrate the effectiveness of the proposed method with Top-1 accuracies of 95.1% and 95.6% on image and brain retrieval tasks and an Inception score of 95.3% on fMRI-to-image reconstruction task. Our proposed quantum-inspired network brings a potential paradigm to solving the vision-brain problems via the quantum computing theory.

Sankalp Pandey, Xuan Bac Nguyen, Nicholas Borys et al.

Identifying quantum flakes is crucial for scalable quantum hardware; however, automated layer classification from optical microscopy remains challenging due to substantial appearance shifts across different materials. In this paper, we propose a new Continual-Learning Framework for Flake Layer Classification (CLIFF). To our knowledge, this is the first systematic study of continual learning in the domain of two-dimensional (2D) materials. Our method enables the model to differentiate between materials and their physical and optical properties by freezing a backbone and base head trained on a reference material. For each new material, it learns a material-specific prompt, embedding, and a delta head. A prompt pool and a cosine-similarity gate modulate features and compute material-specific corrections. Additionally, we incorporate memory replay with knowledge distillation. CLIFF achieves competitive accuracy with significantly lower forgetting than naive fine-tuning and a prompt-based baseline.

Hoang-Quan Nguyen, Xuan Bac Nguyen, Sankalp Pandey et al.

Characterizing quantum flakes is a critical step in quantum hardware engineering because the quality of these flakes directly influences qubit performance. Although computer vision methods for identifying two-dimensional quantum flakes have emerged, they still face significant challenges in estimating flake thickness. These challenges include limited data, poor generalization, sensitivity to domain shifts, and a lack of physical interpretability. In this paper, we introduce one of the first Physics-informed Adaptation Learning approaches to overcome these obstacles. We focus on two main issues, i.e., data scarcity and generalization. First, we propose a new synthetic data generation framework that produces diverse quantum flake samples across various materials and configurations, reducing the need for time-consuming manual collection. Second, we present $\varphi$-Adapt, a physics-informed adaptation method that bridges the performance gap between models trained on synthetic data and those deployed in real-world settings. Experimental results show that our approach achieves state-of-the-art performance on multiple benchmarks, outperforming existing methods. Our proposed approach advances the integration of physics-based modeling and domain adaptation. It also addresses a critical gap in leveraging synthesized data for real-world 2D material analysis, offering impactful tools for deep learning and materials science communities.

Hoang-Quan Nguyen, Xuan Bac Nguyen, Samuel Yen-Chi Chen et al.

Parameterized Quantum Circuits (PQCs) have been acknowledged as a leading strategy to utilize near-term quantum advantages in multiple problems, including machine learning and combinatorial optimization. When applied to specific tasks, the parameters in the quantum circuits are trained to minimize the target function. Although there have been comprehensive studies to improve the performance of the PQCs on practical tasks, the errors caused by the quantum noise downgrade the performance when running on real quantum computers. In particular, when the quantum state is transformed through multiple quantum circuit layers, the effect of the quantum noise happens cumulatively and becomes closer to the maximally mixed state or complete noise. This paper studies the relationship between the quantum noise and the diffusion model. Then, we propose a novel diffusion-inspired learning approach to mitigate the quantum noise in the PQCs and reduce the error for specific tasks. Through our experiments, we illustrate the efficiency of the learning strategy and achieve state-of-the-art performance on classification tasks in the quantum noise scenarios.

Aditya Dendukuri, Blake Keeling, Arash Fereidouni et al.

This work presents a novel fundamental algorithm for for defining and training Neural Networks in Quantum Information based on time evolution and the Hamiltonian. Classical Neural Network algorithms (ANN) are computationally expensive. For example, in image classification, representing an image pixel by pixel using classical information requires an enormous amount of computational memory resources. Hence, exploring methods to represent images in a different paradigm of information is important. Quantum Neural Networks (QNNs) have been explored for over 20 years. The current forefront work based on Variational Quantum Circuits is specifically defined for the Continuous Variable (CV) Model of quantum computers. In this work, a model is proposed which is defined at a more fundamental level and hence can be inherited by any variants of quantum computing models. This work also presents a quantum backpropagation algorithm to train our QNN model and validate this algorithm on the MNIST dataset on a quantum computer simulation.