Bingsheng Huang

Hongyuan Zhang, Ching-Wei Wang, Hikam Muzakky et al.

Localization of the craniofacial landmarks from lateral cephalograms is a fundamental task in cephalometric analysis. The automation of the corresponding tasks has thus been the subject of intense research over the past decades. In this paper, we introduce the "Cephalometric Landmark Detection (CL-Detection)" dataset, which is the largest publicly available and comprehensive dataset for cephalometric landmark detection. This multi-center and multi-vendor dataset includes 600 lateral X-ray images with 38 landmarks acquired with different equipment from three medical centers. The overarching objective of this paper is to measure how far state-of-the-art deep learning methods can go for cephalometric landmark detection. Following the 2023 MICCAI CL-Detection Challenge, we report the results of the top ten research groups using deep learning methods. Results show that the best methods closely approximate the expert analysis, achieving a mean detection rate of 75.719% and a mean radial error of 1.518 mm. While there is room for improvement, these findings undeniably open the door to highly accurate and fully automatic location of craniofacial landmarks. We also identify scenarios for which deep learning methods are still failing. Both the dataset and detailed results are publicly available online, while the platform will remain open for the community to benchmark future algorithm developments at https://cl-detection2023.grand-challenge.org/.

Bin Huang, Zhong Liu, Huiying Wen et al.

Although the Segment Anything Model (SAM) has advanced medical image segmentation, its Bayesian adaptation for uncertainty-aware segmentation remains hindered by three key issues: (1) instability in Bayesian fine-tuning of large pre-trained SAMs; (2) high computation cost due to SAM's massive parameters; (3) SAM's black-box design limits interpretability. To overcome these, we propose E-BayesSAM, an efficient framework combining Token-wise Variational Bayesian Inference (T-VBI) for efficienty Bayesian adaptation and Self-Optimizing Kolmogorov-Arnold Network (SO-KAN) for improving interpretability. T-VBI innovatively reinterprets SAM's output tokens as dynamic probabilistic weights and reparameterizes them as latent variables without auxiliary training, enabling training-free VBI for uncertainty estimation. SO-KAN improves token prediction with learnable spline activations via self-supervised learning, providing insight to prune redundant tokens to boost efficiency and accuracy. Experiments on five ultrasound datasets demonstrated that E-BayesSAM achieves: (i) real-time inference (0.03s/image), (ii) superior segmentation accuracy (average DSC: Pruned E-BayesSAM's 89.0\% vs. E-BayesSAM's 88.0% vs. MedSAM's 88.3%), and (iii) identification of four critical tokens governing SAM's decisions. By unifying efficiency, reliability, and interpretability, E-BayesSAM bridges SAM's versatility with clinical needs, advancing deployment in safety-critical medical applications. The source code is available at https://github.com/mp31192/E-BayesSAM.

Yue Wang, Yuanbiao Yang, Zhuo-xu Cui et al.

Magnetic Resonance Imaging (MRI) is an inherently multi-contrast modality, where cross-contrast priors can be exploited to improve image reconstruction from undersampled data. Recently, diffusion models have shown remarkable performance in MRI reconstruction. However, they still struggle to effectively utilize such priors, mainly because existing methods rely on feature-level fusion in image or latent spaces, which lacks explicit structural correspondence and thus leads to suboptimal performance. To address this issue, we propose $\mathbf{I}^2$SB-Inversion, a multi-contrast guided reconstruction framework based on the Schrödinger Bridge (SB). The proposed method performs pixel-wise translation between paired contrasts, providing explicit structural constraints between the guidance and target images. Furthermore, an Inversion strategy is introduced to correct inter-modality misalignment, which often occurs in guided reconstruction, thereby mitigating artifacts and improving reconstruction accuracy. Experiments on paired T1- and T2-weighted datasets demonstrate that $\mathbf{I}^2$SB-Inversion achieves a high acceleration factor of up to 14.4 and consistently outperforms existing methods in both quantitative and qualitative evaluations.