Bo Wen

Carla Agurto, Guillermo Cecchi, Bo Wen et al.

Amyotrophic lateral sclerosis is a fatal disease that not only affects movement, speech, and breath but also cognition. Recent studies have focused on the use of language analysis techniques to detect ALS and infer scales for monitoring functional progression. In this paper, we focused on another important aspect, cognitive impairment, which affects 35-50% of the ALS population. In an effort to reach the ALS population, which frequently exhibits mobility limitations, we implemented the digital version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) test for the first time. This test which is designed to measure cognitive impairment was remotely performed by 56 participants from the EverythingALS Speech Study. As part of the study, participants (ALS and non-ALS) were asked to describe weekly one picture from a pool of many pictures with complex scenes displayed on their computer at home. We analyze the descriptions performed within +/- 60 days from the day the ECAS test was administered and extract different types of linguistic and acoustic features. We input those features into linear regression models to infer 5 ECAS sub-scores and the total score. Speech samples from the picture description are reliable enough to predict the ECAS subs-scores, achieving statistically significant Spearman correlation values between 0.32 and 0.51 for the model's performance using 10-fold cross-validation.

Rodrigo Ordonez-Hurtado, Bo Wen, Nicholas Barra et al.

Driving is a daily routine for many individuals across the globe. This paper presents the configuration and methodologies used to transform a vehicle into a connected ecosystem capable of assessing driver physiology. We integrated an array of commercial sensors from the automotive and digital health sectors along with driver inputs from the vehicle itself. This amalgamation of sensors allows for meticulous recording of the external conditions and driving maneuvers. These data streams are processed to extract key parameters, providing insights into driver behavior in relation to their external environment and illuminating vital physiological responses. This innovative driver evaluation system holds the potential to amplify road safety. Moreover, when paired with data from conventional health settings, it may enhance early detection of health-related complications.

Bo Wen

This paper proposes a novel framework for developing safe Artificial General Intelligence (AGI) by combining Active Inference principles with Large Language Models (LLMs). We argue that traditional approaches to AI safety, focused on post-hoc interpretability and reward engineering, have fundamental limitations. We present an architecture where safety guarantees are integrated into the system's core design through transparent belief representations and hierarchical value alignment. Our framework leverages natural language as a medium for representing and manipulating beliefs, enabling direct human oversight while maintaining computational tractability. The architecture implements a multi-agent system where agents self-organize according to Active Inference principles, with preferences and safety constraints flowing through hierarchical Markov blankets. We outline specific mechanisms for ensuring safety, including: (1) explicit separation of beliefs and preferences in natural language, (2) bounded rationality through resource-aware free energy minimization, and (3) compositional safety through modular agent structures. The paper concludes with a research agenda centered on the Abstraction and Reasoning Corpus (ARC) benchmark, proposing experiments to validate our framework's safety properties. Our approach offers a path toward AGI development that is inherently safer, rather than retrofitted with safety measures.

Bo Wen, Chen Wang, Qiwei Han et al.

The integration of voice-based AI agents in healthcare presents a transformative opportunity to bridge economic and accessibility gaps in digital health delivery. This paper explores the role of large language model (LLM)-powered voice assistants in enhancing preventive care and continuous patient monitoring, particularly in underserved populations. Drawing insights from the development and pilot study of Agent PULSE (Patient Understanding and Liaison Support Engine) -- a collaborative initiative between IBM Research, Cleveland Clinic Foundation, and Morehouse School of Medicine -- we present an economic model demonstrating how AI agents can provide cost-effective healthcare services where human intervention is economically unfeasible. Our pilot study with 33 inflammatory bowel disease patients revealed that 70\% expressed acceptance of AI-driven monitoring, with 37\% preferring it over traditional modalities. Technical challenges, including real-time conversational AI processing, integration with healthcare systems, and privacy compliance, are analyzed alongside policy considerations surrounding regulation, bias mitigation, and patient autonomy. Our findings suggest that AI-driven voice agents not only enhance healthcare scalability and efficiency but also improve patient engagement and accessibility. For healthcare executives, our cost-utility analysis demonstrates huge potential savings for routine monitoring tasks, while technologists can leverage our framework to prioritize improvements yielding the highest patient impact. By addressing current limitations and aligning AI development with ethical and regulatory frameworks, voice-based AI agents can serve as a critical entry point for equitable, sustainable digital healthcare solutions.