Gerard Calvo Bartra

Gerard Calvo Bartra, Filip Lemic, Guillem Pascual et al.

Contemporary research advances in nanotechnology and material science are rooted in the emergence of nanodevices as a versatile tool that harmonizes sensing, computing, wireless communication, data storage, and energy harvesting. These devices offer novel pathways for disease diagnostics, treatment, and monitoring within the bloodstreams. Ensuring precise localization of events of diagnostic interest, which underpins the concept of flow-guided in-body nanoscale localization, would provide an added diagnostic value to the detected events. Raw data generated by the nanodevices is pivotal for this localization and consist of an event detection indicator and the time elapsed since the last passage of a nanodevice through the heart. The energy constraints of the nanodevices lead to intermittent operation and unreliable communication, intrinsically affecting this data. This posits a need for comprehensively modelling the features of this data. These imperfections also have profound implications for the viability of existing flow-guided localization approaches, which are ill-prepared to address the intricacies of the environment. Our first contribution lies in an analytical model of raw data for flow-guided localization, dissecting how communication and energy capabilities influence the nanodevices' data output. This model acts as a vital bridge, reconciling idealized assumptions with practical challenges of flow-guided localization. Toward addressing these practical challenges, we also present an integration of Graph Neural Networks (GNNs) into the flow-guided localization paradigm. GNNs excel in capturing complex dynamic interactions inherent to the localization of events sensed by the nanodevices. Our results highlight the potential of GNNs not only to enhance localization accuracy but also extend coverage to encompass the entire bloodstream.

Pablo Galván, Filip Lemic, Gerard Calvo Bartra et al.

Flow-guided localization using in-body nanodevices in the bloodstream is expected to be beneficial for early disease detection, continuous monitoring of biological conditions, and targeted treatment. The nanodevices face size and power constraints that produce erroneous raw data for localization purposes. On-body anchors receive this data, and use it to derive the locations of diagnostic events of interest. Different Machine Learning (ML) approaches have been recently proposed for this task, yet they are currently restricted to a reference bloodstream of a resting patient. As such, they are unable to deal with the physical diversity of patients' bloodstreams and cannot provide continuous monitoring due to changes in individual patient's activities. Toward addressing these issues for the current State-of-the-Art (SotA) flow-guided localization approach based on Graph Neural Networks (GNNs), we propose a pipeline for GNN adaptation based on individual physiological indicators including height, weight, and heart rate. Our results indicate that the proposed adaptions are beneficial in reconciling the individual differences between bloodstreams and activities.

Mika Leo Hube, Filip Lemic, Ethungshan Shitiri et al.

Flow-guided Localization (FGL) enables the identification of spatial regions within the human body that contain an event of diagnostic interest. FGL does that by leveraging the passive movement of energy-constrained nanodevices circulating through the bloodstream. Existing FGL solutions rely on graph models with fixed topologies or handcrafted features, which limit their adaptability to anatomical variability and hinder scalability. In this work, we explore the use of Set Transformer architectures to address these limitations. Our formulation treats nanodevices' circulation time reports as unordered sets, enabling permutation-invariant, variable-length input processing without relying on spatial priors. To improve robustness under data scarcity and class imbalance, we integrate synthetic data generation via deep generative models, including CGAN, WGAN, WGAN-GP, and CVAE. These models are trained to replicate realistic circulation time distributions conditioned on vascular region labels, and are used to augment the training data. Our results show that the Set Transformer achieves comparable classification accuracy compared to Graph Neural Networks (GNN) baselines, while simultaneously providing by-design improved generalization to anatomical variability. The findings highlight the potential of permutation-invariant models and synthetic augmentation for robust and scalable nanoscale localization.

Filip Lemic, Gerard Calvo Bartra, Arnau Brosa López et al.

Nanodevices with Terahertz (THz)-based wireless communication capabilities are providing a primer for flow-guided localization within the human bloodstreams. Such localization is allowing for assigning the locations of sensed events with the events themselves, providing benefits along the lines of early and precise diagnostics, and reduced costs and invasiveness. Flow-guided localization is still in a rudimentary phase, with only a handful of works targeting the problem. Nonetheless, the performance assessments of the proposed solutions are already carried out in a non-standardized way, usually along a single performance metric, and ignoring various aspects that are relevant at such a scale (e.g., nanodevices' limited energy) and for such a challenging environment (e.g., extreme attenuation of in-body THz propagation). As such, these assessments feature low levels of realism and cannot be compared in an objective way. Toward addressing this issue, we account for the environmental and scale-related peculiarities of the scenario and assess the performance of two state-of-the-art flow-guided localization approaches along a set of heterogeneous performance metrics such as the accuracy and reliability of localization.