Xavier Costa Pérez

Gerard Calvo Bartra, Filip Lemic, Guillem Pascual et al.

Contemporary research advances in nanotechnology and material science are rooted in the emergence of nanodevices as a versatile tool that harmonizes sensing, computing, wireless communication, data storage, and energy harvesting. These devices offer novel pathways for disease diagnostics, treatment, and monitoring within the bloodstreams. Ensuring precise localization of events of diagnostic interest, which underpins the concept of flow-guided in-body nanoscale localization, would provide an added diagnostic value to the detected events. Raw data generated by the nanodevices is pivotal for this localization and consist of an event detection indicator and the time elapsed since the last passage of a nanodevice through the heart. The energy constraints of the nanodevices lead to intermittent operation and unreliable communication, intrinsically affecting this data. This posits a need for comprehensively modelling the features of this data. These imperfections also have profound implications for the viability of existing flow-guided localization approaches, which are ill-prepared to address the intricacies of the environment. Our first contribution lies in an analytical model of raw data for flow-guided localization, dissecting how communication and energy capabilities influence the nanodevices' data output. This model acts as a vital bridge, reconciling idealized assumptions with practical challenges of flow-guided localization. Toward addressing these practical challenges, we also present an integration of Graph Neural Networks (GNNs) into the flow-guided localization paradigm. GNNs excel in capturing complex dynamic interactions inherent to the localization of events sensed by the nanodevices. Our results highlight the potential of GNNs not only to enhance localization accuracy but also extend coverage to encompass the entire bloodstream.

Pablo Galván, Filip Lemic, Gerard Calvo Bartra et al.

Flow-guided localization using in-body nanodevices in the bloodstream is expected to be beneficial for early disease detection, continuous monitoring of biological conditions, and targeted treatment. The nanodevices face size and power constraints that produce erroneous raw data for localization purposes. On-body anchors receive this data, and use it to derive the locations of diagnostic events of interest. Different Machine Learning (ML) approaches have been recently proposed for this task, yet they are currently restricted to a reference bloodstream of a resting patient. As such, they are unable to deal with the physical diversity of patients' bloodstreams and cannot provide continuous monitoring due to changes in individual patient's activities. Toward addressing these issues for the current State-of-the-Art (SotA) flow-guided localization approach based on Graph Neural Networks (GNNs), we propose a pipeline for GNN adaptation based on individual physiological indicators including height, weight, and heart rate. Our results indicate that the proposed adaptions are beneficial in reconciling the individual differences between bloodstreams and activities.

Cyril Shih-Huan Hsu, Xi Li, Lanfranco Zanzi et al.

Recent advancements in mobile and wireless networks are unlocking the full potential of robotic autonomy, enabling robots to take advantage of ultra-low latency, high data throughput, and ubiquitous connectivity. However, for robots to navigate and operate seamlessly, efficiently and reliably, they must have an accurate understanding of both their surrounding environment and the quality of radio signals. Achieving this in highly dynamic and ever-changing environments remains a challenging and largely unsolved problem. In this paper, we introduce MapViT, a two-stage Vision Transformer (ViT)-based framework inspired by the success of pre-train and fine-tune paradigm for Large Language Models (LLMs). MapViT is designed to predict both environmental changes and expected radio signal quality. We evaluate the framework using a set of representative Machine Learning (ML) models, analyzing their respective strengths and limitations across different scenarios. Experimental results demonstrate that the proposed two-stage pipeline enables real-time prediction, with the ViT-based implementation achieving a strong balance between accuracy and computational efficiency. This makes MapViT a promising solution for energy- and resource-constrained platforms such as mobile robots. Moreover, the geometry foundation model derived from the self-supervised pre-training stage improves data efficiency and transferability, enabling effective downstream predictions even with limited labeled data. Overall, this work lays the foundation for next-generation digital twin ecosystems, and it paves the way for a new class of ML foundation models driving multi-modal intelligence in future 6G-enabled systems.

Mika Leo Hube, Filip Lemic, Ethungshan Shitiri et al.

Flow-guided Localization (FGL) enables the identification of spatial regions within the human body that contain an event of diagnostic interest. FGL does that by leveraging the passive movement of energy-constrained nanodevices circulating through the bloodstream. Existing FGL solutions rely on graph models with fixed topologies or handcrafted features, which limit their adaptability to anatomical variability and hinder scalability. In this work, we explore the use of Set Transformer architectures to address these limitations. Our formulation treats nanodevices' circulation time reports as unordered sets, enabling permutation-invariant, variable-length input processing without relying on spatial priors. To improve robustness under data scarcity and class imbalance, we integrate synthetic data generation via deep generative models, including CGAN, WGAN, WGAN-GP, and CVAE. These models are trained to replicate realistic circulation time distributions conditioned on vascular region labels, and are used to augment the training data. Our results show that the Set Transformer achieves comparable classification accuracy compared to Graph Neural Networks (GNN) baselines, while simultaneously providing by-design improved generalization to anatomical variability. The findings highlight the potential of permutation-invariant models and synthetic augmentation for robust and scalable nanoscale localization.