Edgar Rangel

Edgar Rangel, Fabio Martinez

Parkinson's Disease (PD) is associated with gait movement disorders, such as bradykinesia, stiffness, tremors and postural instability, caused by progressive dopamine deficiency. Today, some approaches have implemented learning representations to quantify kinematic patterns during locomotion, supporting clinical procedures such as diagnosis and treatment planning. These approaches assumes a large amount of stratified and labeled data to optimize discriminative representations. Nonetheless these considerations may restrict the approaches to be operable in real scenarios during clinical practice. This work introduces a self-supervised generative representation to learn gait-motion-related patterns, under the pretext of video reconstruction and an anomaly detection framework. This architecture is trained following a one-class weakly supervised learning to avoid inter-class variance and approach the multiple relationships that represent locomotion. The proposed approach was validated with 14 PD patients and 23 control subjects, and trained with the control population only, achieving an AUC of 95%, homocedasticity level of 70% and shapeness level of 70% in the classification task considering its generalization.

Santiago Gómez, Daniel Mantilla, Gustavo Garzón et al.

Stroke is the second leading cause of mortality worldwide. Immediate attention and diagnosis play a crucial role regarding patient prognosis. The key to diagnosis consists in localizing and delineating brain lesions. Standard stroke examination protocols include the initial evaluation from a non-contrast CT scan to discriminate between hemorrhage and ischemia. However, non-contrast CTs may lack sensitivity in detecting subtle ischemic changes in the acute phase. As a result, complementary diffusion-weighted MRI studies are captured to provide valuable insights, allowing to recover and quantify stroke lesions. This work introduced APIS, the first paired public dataset with NCCT and ADC studies of acute ischemic stroke patients. APIS was presented as a challenge at the 20th IEEE International Symposium on Biomedical Imaging 2023, where researchers were invited to propose new computational strategies that leverage paired data and deal with lesion segmentation over CT sequences. Despite all the teams employing specialized deep learning tools, the results suggest that the ischemic stroke segmentation task from NCCT remains challenging. The annotated dataset remains accessible to the public upon registration, inviting the scientific community to deal with stroke characterization from NCCT but guided with paired DWI information.

Edgar Rangel, Fabio Martinez

Stroke is the second leading cause of death and the third leading cause of disability worldwide. Clinical guidelines establish diffusion resonance imaging (DWI, ADC) as the standard for localizing, characterizing, and measuring infarct volume, enabling treatment support and prognosis. Nonetheless, such lesion analysis is highly variable due to different patient demographics, scanner vendors, and expert annotations. Computational support approaches have been key to helping with the localization and segmentation of lesions. However, these strategies are dedicated solutions that learn patterns from only one institution, lacking the variability to generalize geometrical lesions shape models. Even worse, many clinical centers lack sufficient labeled samples to adjust these dedicated solutions. This work developed a collaborative framework for segmenting ischemic stroke lesions in DWI sequences by sharing knowledge from deep center-independent representations. From 14 emulated healthcare centers with 2031 studies, the FedAvg model achieved a general DSC of $0.71 \pm 0.24$, AVD of $5.29 \pm 22.74$, ALD of $2.16 \pm 3.60$ and LF1 of $0.70 \pm 0.26$ over all centers, outperforming both the centralized and other federated rules. Interestingly, the model demonstrated strong generalization properties, showing uniform performance across different lesion categories and reliable performance in out-of-distribution centers (with DSC of $0.64 \pm 0.29$ and AVD of $4.44 \pm 8.74$ without any additional training).