Huy Hoang Nguyen

Huy Hoang Nguyen, Matthew B. Blaschko, Simo Saarakkala et al.

Deep neural networks are often applied to medical images to automate the problem of medical diagnosis. However, a more clinically relevant question that practitioners usually face is how to predict the future trajectory of a disease. Current methods for prognosis or disease trajectory forecasting often require domain knowledge and are complicated to apply. In this paper, we formulate the prognosis prediction problem as a one-to-many prediction problem. Inspired by a clinical decision-making process with two agents -- a radiologist and a general practitioner -- we predict prognosis with two transformer-based components that share information with each other. The first transformer in this framework aims to analyze the imaging data, and the second one leverages its internal states as inputs, also fusing them with auxiliary clinical data. The temporal nature of the problem is modeled within the transformer states, allowing us to treat the forecasting problem as a multi-task classification, for which we propose a novel loss. We show the effectiveness of our approach in predicting the development of structural knee osteoarthritis changes and forecasting Alzheimer's disease clinical status directly from raw multi-modal data. The proposed method outperforms multiple state-of-the-art baselines with respect to performance and calibration, both of which are needed for real-world applications. An open-source implementation of our method is made publicly available at \url{https://github.com/Oulu-IMEDS/CLIMATv2}.

Trung Dinh Quoc Dang, Huy Hoang Nguyen, Aleksei Tiulpin

Mamba, a State Space Model (SSM), has recently shown competitive performance to Convolutional Neural Networks (CNNs) and Transformers in Natural Language Processing and general sequence modeling. Various attempts have been made to adapt Mamba to Computer Vision tasks, including medical image segmentation (MIS). Vision Mamba (VM)-based networks are particularly attractive due to their ability to achieve global receptive fields, similar to Vision Transformers, while also maintaining linear complexity in the number of tokens. However, the existing VM models still struggle to maintain both spatially local and global dependencies of tokens in high dimensional arrays due to their sequential nature. Employing multiple and/or complicated scanning strategies is computationally costly, which hinders applications of SSMs to high-dimensional 2D and 3D images that are common in MIS problems. In this work, we propose Local-Global Vision Mamba, LoG-VMamba, that explicitly enforces spatially adjacent tokens to remain nearby on the channel axis, and retains the global context in a compressed form. Our method allows the SSMs to access the local and global contexts even before reaching the last token while requiring only a simple scanning strategy. Our segmentation models are computationally efficient and substantially outperform both CNN and Transformers-based baselines on a diverse set of 2D and 3D MIS tasks. The implementation of LoG-VMamba is available at \url{https://github.com/Oulu-IMEDS/LoG-VMamba}.

Huy Hoang Nguyen, Cuong Nhat Nguyen, Xuan Tung Dao et al.

This paper aims to conduct a comparative analysis of contemporary Variational Autoencoder (VAE) architectures employed in anomaly detection, elucidating their performance and behavioral characteristics within this specific task. The architectural configurations under consideration encompass the original VAE baseline, the VAE with a Gaussian Random Field prior (VAE-GRF), and the VAE incorporating a vision transformer (ViT-VAE). The findings reveal that ViT-VAE exhibits exemplary performance across various scenarios, whereas VAE-GRF may necessitate more intricate hyperparameter tuning to attain its optimal performance state. Additionally, to mitigate the propensity for over-reliance on results derived from the widely used MVTec dataset, this paper leverages the recently-public MiAD dataset for benchmarking. This deliberate inclusion seeks to enhance result competitiveness by alleviating the impact of domain-specific models tailored exclusively for MVTec, thereby contributing to a more robust evaluation framework. Codes is available at https://github.com/endtheme123/VAE-compare.git.

Khanh Nguyen, Huy Hoang Nguyen, Aleksei Tiulpin

This paper tackles the challenge of forensic medical image matching (FMIM) using deep neural networks (DNNs). FMIM is a particular case of content-based image retrieval (CBIR). The main challenge in FMIM compared to the general case of CBIR, is that the subject to whom a query image belongs may be affected by aging and progressive degenerative disorders, making it difficult to match data on a subject level. CBIR with DNNs is generally solved by minimizing a ranking loss, such as Triplet loss (TL), computed on image representations extracted by a DNN from the original data. TL, in particular, operates on triplets: anchor, positive (similar to anchor) and negative (dissimilar to anchor). Although TL has been shown to perform well in many CBIR tasks, it still has limitations, which we identify and analyze in this work. In this paper, we introduce (i) the AdaTriplet loss -- an extension of TL whose gradients adapt to different difficulty levels of negative samples, and (ii) the AutoMargin method -- a technique to adjust hyperparameters of margin-based losses such as TL and our proposed loss dynamically. Our results are evaluated on two large-scale benchmarks for FMIM based on the Osteoarthritis Initiative and Chest X-ray-14 datasets. The codes allowing replication of this study have been made publicly available at \url{https://github.com/Oulu-IMEDS/AdaTriplet}.

Narasimharao Kowlagi, Huy Hoang Nguyen, Terence McSweeney et al.

This paper addresses the challenge of grading visual features in lumbar spine MRI using Deep Learning. Such a method is essential for the automatic quantification of structural changes in the spine, which is valuable for understanding low back pain. Multiple recent studies investigated different architecture designs, and the most recent success has been attributed to the use of transformer architectures. In this work, we argue that with a well-tuned three-stage pipeline comprising semantic segmentation, localization, and classification, convolutional networks outperform the state-of-the-art approaches. We conducted an ablation study of the existing methods in a population cohort, and report performance generalization across various subgroups. Our code is publicly available to advance research on disc degeneration and low back pain.

Thanh Duc Hoang, Do Viet Tung, Duy-Hung Nguyen et al.

We address catastrophic forgetting issues in graph learning as incoming data transits from one to another graph distribution. Whereas prior studies primarily tackle one setting of graph continual learning such as incremental node classification, we focus on a universal approach wherein each data point in a task can be a node or a graph, and the task varies from node to graph classification. We propose a novel method that enables graph neural networks to excel in this universal setting. Our approach perseveres knowledge about past tasks through a rehearsal mechanism that maintains local and global structure consistency across the graphs. We benchmark our method against various continual learning baselines in real-world graph datasets and achieve significant improvement in average performance and forgetting across tasks.

Huy Hoang Nguyen, An Vuong, Anh Nguyen et al.

Grasp detection is a fundamental robotic task critical to the success of many industrial applications. However, current language-driven models for this task often struggle with cluttered images, lengthy textual descriptions, or slow inference speed. We introduce GraspMamba, a new language-driven grasp detection method that employs hierarchical feature fusion with Mamba vision to tackle these challenges. By leveraging rich visual features of the Mamba-based backbone alongside textual information, our approach effectively enhances the fusion of multimodal features. GraspMamba represents the first Mamba-based grasp detection model to extract vision and language features at multiple scales, delivering robust performance and rapid inference time. Intensive experiments show that GraspMamba outperforms recent methods by a clear margin. We validate our approach through real-world robotic experiments, highlighting its fast inference speed.

Khanh Nguyen, Huy Hoang Nguyen, Egor Panfilov et al.

Osteoarthritis (OA) is the most common musculoskeletal disease, with knee OA (KOA) being one of the leading causes of disability and a significant economic burden. Predicting KOA progression is crucial for improving patient outcomes, optimizing healthcare resources, studying the disease, and developing new treatments. The latter application particularly requires one to understand the disease progression in order to collect the most informative data at the right time. Existing methods, however, are limited by their static nature and their focus on individual joints, leading to suboptimal predictive performance and downstream utility. Our study proposes a new method that allows to dynamically monitor patients rather than individual joints with KOA using a novel Active Sensing (AS) approach powered by Reinforcement Learning (RL). Our key idea is to directly optimize for the downstream task by training an agent that maximizes informative data collection while minimizing overall costs. Our RL-based method leverages a specially designed reward function to monitor disease progression across multiple body parts, employs multimodal deep learning, and requires no human input during testing. Extensive numerical experiments demonstrate that our approach outperforms current state-of-the-art models, paving the way for the next generation of KOA trials.

Huy Hoang Nguyen, Simo Saarakkala, Matthew B. Blaschko et al.

In medical applications, deep learning methods are built to automate diagnostic tasks. However, a clinically relevant question that practitioners usually face, is how to predict the future trajectory of a disease (prognosis). Current methods for such a problem often require domain knowledge, and are complicated to apply. In this paper, we formulate the prognosis prediction problem as a one-to-many forecasting problem from multimodal data. Inspired by a clinical decision-making process with two agents -- a radiologist and a general practitioner, we model a prognosis prediction problem with two transformer-based components that share information between each other. The first block in this model aims to analyze the imaging data, and the second block leverages the internal representations of the first one as inputs, also fusing them with auxiliary patient data. We show the effectiveness of our method in predicting the development of structural knee osteoarthritis changes over time. Our results show that the proposed method outperforms the state-of-the-art baselines in terms of various performance metrics. In addition, we empirically show that the existence of the multi-agent transformers with depths of 2 is sufficient to achieve good performances. Our code is publicly available at \url{https://github.com/MIPT-Oulu/CLIMAT}.

Huy Hoang Nguyen, Cédric Jung, Shirin Salehi et al.

Foundation models for vision have transformed visual recognition with powerful pretrained representations and strong zero-shot capabilities, yet their potential for data-efficient learning remains largely untapped. Active Learning (AL) aims to minimize annotation costs by strategically selecting the most informative samples for labeling, but existing methods largely overlook the rich multimodal knowledge embedded in modern vision-language models (VLMs). We introduce Conformal Cross-Modal Acquisition (CCMA), a novel AL framework that bridges vision and language modalities through a teacher-student architecture. CCMA employs a pretrained VLM as a teacher to provide semantically grounded uncertainty estimates, conformally calibrated to guide sample selection for a vision-only student model. By integrating multimodal conformal scoring with diversity-aware selection strategies, CCMA achieves superior data efficiency across multiple benchmarks. Our approach consistently outperforms state-of-the-art AL baselines, demonstrating clear advantages over methods relying solely on uncertainty or diversity metrics.

Huy Hoang Nguyen, Johannes Huemer, Markus Murschitz et al.

The logistics and construction industries face persistent challenges in automating pallet handling, especially in outdoor environments with variable payloads, inconsistencies in pallet quality and dimensions, and unstructured surroundings. In this paper, we tackle automation of a critical step in pallet transport: the pallet pick-up operation. Our work is motivated by labor shortages, safety concerns, and inefficiencies in manually locating and retrieving pallets under such conditions. We present Lang2Lift, a framework that leverages foundation models for natural language-guided pallet detection and 6D pose estimation, enabling operators to specify targets through intuitive commands such as "pick up the steel beam pallet near the crane." The perception pipeline integrates Florence-2 and SAM-2 for language-grounded segmentation with FoundationPose for robust pose estimation in cluttered, multi-pallet outdoor scenes under variable lighting. The resulting poses feed into a motion planning module for fully autonomous forklift operation. We validate Lang2Lift on the ADAPT autonomous forklift platform, achieving 0.76 mIoU pallet segmentation accuracy on a real-world test dataset. Timing and error analysis demonstrate the system's robustness and confirm its feasibility for deployment in operational logistics and construction environments. Video demonstrations are available at https://eric-nguyen1402.github.io/lang2lift.github.io/

Huy Hoang Nguyen, Han Zhou, Matthew B. Blaschko et al.

Bayesian optimization with Gaussian processes (GP) is commonly used to optimize black-box functions. The Matérn and the Radial Basis Function (RBF) covariance functions are used frequently, but they do not make any assumptions about the domain of the function, which may limit their applicability in bounded domains. To address the limitation, we introduce the Beta kernel, a non-stationary kernel induced by a product of Beta distribution density functions. Such a formulation allows our kernel to naturally model functions on bounded domains. We present statistical evidence supporting the hypothesis that the kernel exhibits an exponential eigendecay rate, based on empirical analyses of its spectral properties across different settings. Our experimental results demonstrate the robustness of the Beta kernel in modeling functions with optima located near the faces or vertices of the unit hypercube. The experiments show that our kernel consistently outperforms a wide range of kernels, including the well-known Matérn and RBF, in different problems, including synthetic function optimization and the compression of vision and language models.

Huy Hoang Nguyen, Simo Saarakkala, Matthew Blaschko et al.

Knee osteoarthritis (OA) is one of the highest disability factors in the world. This musculoskeletal disorder is assessed from clinical symptoms, and typically confirmed via radiographic assessment. This visual assessment done by a radiologist requires experience, and suffers from moderate to high inter-observer variability. The recent literature has shown that deep learning methods can reliably perform the OA severity assessment according to the gold standard Kellgren-Lawrence (KL) grading system. However, these methods require large amounts of labeled data, which are costly to obtain. In this study, we propose the Semixup algorithm, a semi-supervised learning (SSL) approach to leverage unlabeled data. Semixup relies on consistency regularization using in- and out-of-manifold samples, together with interpolated consistency. On an independent test set, our method significantly outperformed other state-of-the-art SSL methods in most cases. Finally, when compared to a well-tuned fully supervised baseline that yielded a balanced accuracy (BA) of $70.9\pm0.8%$ on the test set, Semixup had comparable performance -- BA of $71\pm0.8%$ $(p=0.368)$ while requiring $6$ times less labeled data. These results show that our proposed SSL method allows building fully automatic OA severity assessment tools with datasets that are available outside research settings.