Xin Hong

Mohammed A. M. Elhassan, Chenhui Yang, Chenxi Huang et al.

Modern high-performance semantic segmentation methods employ a heavy backbone and dilated convolution to extract the relevant feature. Although extracting features with both contextual and semantic information is critical for the segmentation tasks, it brings a memory footprint and high computation cost for real-time applications. This paper presents a new model to achieve a trade-off between accuracy/speed for real-time road scene semantic segmentation. Specifically, we proposed a lightweight model named Scale-aware Strip Attention Guided Feature Pyramid Network (S$^2$-FPN). Our network consists of three main modules: Attention Pyramid Fusion (APF) module, Scale-aware Strip Attention Module (SSAM), and Global Feature Upsample (GFU) module. APF adopts an attention mechanisms to learn discriminative multi-scale features and help close the semantic gap between different levels. APF uses the scale-aware attention to encode global context with vertical stripping operation and models the long-range dependencies, which helps relate pixels with similar semantic label. In addition, APF employs channel-wise reweighting block (CRB) to emphasize the channel features. Finally, the decoder of S$^2$-FPN then adopts GFU, which is used to fuse features from APF and the encoder. Extensive experiments have been conducted on two challenging semantic segmentation benchmarks, which demonstrate that our approach achieves better accuracy/speed trade-off with different model settings. The proposed models have achieved a results of 76.2\%mIoU/87.3FPS, 77.4\%mIoU/67FPS, and 77.8\%mIoU/30.5FPS on Cityscapes dataset, and 69.6\%mIoU,71.0\% mIoU, and 74.2\% mIoU on Camvid dataset. The code for this work will be made available at \url{https://github.com/mohamedac29/S2-FPN

Xin Hong, Yuan Gong, Vidhyasaharan Sethu et al.

Recent advancements in Large Language Models (LLMs) have demonstrated great success in many Natural Language Processing (NLP) tasks. In addition to their cognitive intelligence, exploring their capabilities in emotional intelligence is also crucial, as it enables more natural and empathetic conversational AI. Recent studies have shown LLMs' capability in recognizing emotions, but they often focus on single emotion labels and overlook the complex and ambiguous nature of human emotions. This study is the first to address this gap by exploring the potential of LLMs in recognizing ambiguous emotions, leveraging their strong generalization capabilities and in-context learning. We design zero-shot and few-shot prompting and incorporate past dialogue as context information for ambiguous emotion recognition. Experiments conducted using three datasets indicate significant potential for LLMs in recognizing ambiguous emotions, and highlight the substantial benefits of including context information. Furthermore, our findings indicate that LLMs demonstrate a high degree of effectiveness in recognizing less ambiguous emotions and exhibit potential for identifying more ambiguous emotions, paralleling human perceptual capabilities.

Yuanye Liu, Nannan Shi, Zhejia Zhang et al.

Despite years of methodological progress, how far AI has come in liver fibrosis staging has never been systematically evaluated under the heterogeneous, multi-center conditions that define clinical practice. To address this gap, we introduce LiFS, a large-scale dataset and benchmark derived from the MICCAI 2025 CARE-Liver challenge, comprising 610 patients across multiple centers and scanners with multi-sequence MRI. To the best of our knowledge, LiFS is the first benchmark providing complete gadoxetic acid-enhanced sequences with histopathology-confirmed annotations from diverse real-world scanners. Through systematic evaluation of 9 independently developed methods selected from 96 registered teams against in-cohort radiologist reference results, our findings address how far current AI has progressed toward clinical-level liver fibrosis staging from three complementary perspectives. First, against radiologists, the best AI methods were broadly comparable to the senior radiologist and significantly exceeded the junior radiologist in selected settings, while median AI performance generally approached junior-radiologist levels. Second, from a data perspective, cross-center heterogeneity, label imbalance, and contrast-enhanced sequence variability emerge as the dominant challenges for AI methods. Third, from a technical perspective, methodological design choices, including spatial registration, input dimensionality, multi-modal fusion strategy, and backbone architecture, appear to modulate cross-center robustness, although no single choice alone closes the gap. Overall, LiFS provides a rigorous real-world benchmark for positioning the current state of AI in liver fibrosis staging and for enabling future research on the key challenges that limit clinically reliable deployment.

Yuyan Ni, Shikun Feng, Xin Hong et al.

Deep learning methods have been considered promising for accelerating molecular screening in drug discovery and material design. Due to the limited availability of labelled data, various self-supervised molecular pre-training methods have been presented. While many existing methods utilize common pre-training tasks in computer vision (CV) and natural language processing (NLP), they often overlook the fundamental physical principles governing molecules. In contrast, applying denoising in pre-training can be interpreted as an equivalent force learning, but the limited noise distribution introduces bias into the molecular distribution. To address this issue, we introduce a molecular pre-training framework called fractional denoising (Frad), which decouples noise design from the constraints imposed by force learning equivalence. In this way, the noise becomes customizable, allowing for incorporating chemical priors to significantly improve molecular distribution modeling. Experiments demonstrate that our framework consistently outperforms existing methods, establishing state-of-the-art results across force prediction, quantum chemical properties, and binding affinity tasks. The refined noise design enhances force accuracy and sampling coverage, which contribute to the creation of physically consistent molecular representations, ultimately leading to superior predictive performance.

Xin Hong, Xinze Sun, Yinhao Li et al.

Image generation can provide physicians with an imaging diagnosis basis in the prediction of Alzheimer's Disease (AD). Recent research has shown that long-term AD predictions by image generation often face difficulties maintaining disease-related characteristics when dealing with irregular time intervals in sequential data. Considering that the time-related aspects of the distribution can reflect changes in disease-related characteristics when images are distributed unevenly, this research proposes a model to estimate the temporal parameter within the Normal Inverse Gamma Distribution (T-NIG) to assist in generating images over the long term. The T-NIG model employs brain images from two different time points to create intermediate brain images, forecast future images, and predict the disease. T-NIG is designed by identifying features using coordinate neighborhoods. It incorporates a time parameter into the normal inverse gamma distribution to understand how features change in brain imaging sequences that have varying time intervals. Additionally, T-NIG utilizes uncertainty estimation to reduce both epistemic and aleatoric uncertainties in the model, which arise from insufficient temporal data. In particular, the T-NIG model demonstrates state-of-the-art performance in both short-term and long-term prediction tasks within the dataset. Experimental results indicate that T-NIG is proficient in forecasting disease progression while maintaining disease-related characteristics, even when faced with an irregular temporal data distribution.

Xin Hong, Kaifeng Huang

Alzheimer's disease is a debilitating disorder marked by a decline in cognitive function. Timely identification of the disease is essential for the development of personalized treatment strategies that aim to mitigate its progression. The application of generated images for the prediction of Alzheimer's disease poses challenges, particularly in accurately representing the disease's characteristics when input sequences are captured at irregular time intervals. This study presents an innovative methodology for sequential image generation, guided by quantitative metrics, to maintain the essential features indicative of disease progression. Furthermore, an age-scaling factor is integrated into the process to produce age-specific MRI images, facilitating the prediction of advanced stages of the disease. The results obtained from the ablation study suggest that the inclusion of quantitative metrics significantly improves the accuracy of MRI image synthesis. Furthermore, the application of age-scaled pixel loss contributed to the enhanced iterative generation of MRI images. In terms of long-term disease prognosis, the Structural Similarity Index reached a peak value of 0.882, indicating a substantial degree of similarity in the synthesized images.

Xin Hong, Pengfei Xiong, Renhe Ji et al.

Deep image completion usually fails to harmonically blend the restored image into existing content, especially in the boundary area. This paper handles with this problem from a new perspective of creating a smooth transition and proposes a concise Deep Fusion Network (DFNet). Firstly, a fusion block is introduced to generate a flexible alpha composition map for combining known and unknown regions. The fusion block not only provides a smooth fusion between restored and existing content, but also provides an attention map to make network focus more on the unknown pixels. In this way, it builds a bridge for structural and texture information, so that information can be naturally propagated from known region into completion. Furthermore, fusion blocks are embedded into several decoder layers of the network. Accompanied by the adjustable loss constraints on each layer, more accurate structure information are achieved. We qualitatively and quantitatively compare our method with other state-of-the-art methods on Places2 and CelebA datasets. The results show the superior performance of DFNet, especially in the aspects of harmonious texture transition, texture detail and semantic structural consistency. Our source code will be avaiable at: \url{https://github.com/hughplay/DFNet}

Xin Hong, Ying Shi, Yinhao Li et al.

The uncertainty of clinical examinations frequently leads to irregular observation intervals in longitudinal imaging data, posing challenges for modeling disease progression.Most existing imaging-based disease prediction models operate in Euclidean space, which assumes a flat representation of data and fails to fully capture the intrinsic continuity and nonlinear geometric structure of irregularly sampled longitudinal images. To address the challenge of modeling Alzheimers disease (AD) progression from irregularly sampled longitudinal structural Magnetic Resonance Imaging (sMRI) data, we propose a Riemannian manifold mapping, a Time-aware manifold Neural ordinary differential equation, and an Attention-based riemannian Gated recurrent unit (R-TNAG) framework. Our approach first projects features extracted from high-dimensional sMRI into a manifold space to preserve the intrinsic geometry of disease progression. On this representation, a time-aware Neural Ordinary Differential Equation (TNODE) models the continuous evolution of latent states between observations, while an Attention-based Riemannian Gated Recurrent Unit (ARGRU) adaptively integrates historical and current information to handle irregular intervals. This joint design improves temporal consistency and yields robust AD trajectory prediction under irregular sampling.Experimental results demonstrate that the proposed method consistently outperforms state-of-the-art models in both disease status prediction and cognitive score regression. Ablation studies verify the contributions of each module, highlighting their complementary roles in enhancing predictive accuracy. Moreover, the model exhibits stable performance across varying sequence lengths and missing data rates, indicating strong temporal generalizability. Cross-dataset validation further confirms its robustness and applicability in diverse clinical settings.

Jianhui Wang, Wenyu Zhu, Bowen Gao et al.

Protein-ligand binding prediction is central to virtual screening and affinity ranking, two fundamental tasks in drug discovery. While recent retrieval-based methods embed ligands and protein pockets into Euclidean space for similarity-based search, the geometry of Euclidean embeddings often fails to capture the hierarchical structure and fine-grained affinity variations intrinsic to molecular interactions. In this work, we propose HypSeek, a hyperbolic representation learning framework that embeds ligands, protein pockets, and sequences into Lorentz-model hyperbolic space. By leveraging the exponential geometry and negative curvature of hyperbolic space, HypSeek enables expressive, affinity-sensitive embeddings that can effectively model both global activity and subtle functional differences-particularly in challenging cases such as activity cliffs, where structurally similar ligands exhibit large affinity gaps. Our mode unifies virtual screening and affinity ranking in a single framework, introducing a protein-guided three-tower architecture to enhance representational structure. HypSeek improves early enrichment in virtual screening on DUD-E from 42.63 to 51.44 (+20.7%) and affinity ranking correlation on JACS from 0.5774 to 0.7239 (+25.4%), demonstrating the benefits of hyperbolic geometry across both tasks and highlighting its potential as a powerful inductive bias for protein-ligand modeling.

Xin Hong, Longchao Da, Hua Wei

Urban flooding in arid regions poses severe risks to infrastructure and communities. Accurate, fine-scale mapping of flood extents and recovery trajectories is therefore essential for improving emergency response and resilience planning. However, arid environments often exhibit limited spectral contrast between water and adjacent surfaces, rapid hydrological dynamics, and highly heterogeneous urban land covers, which challenge traditional flood-mapping approaches. High-resolution, daily PlanetScope imagery provides the temporal and spatial detail needed. In this work, we introduce FM-LC, a hierarchical framework for Flood Mapping by Land Cover identification, for this challenging task. Through a three-stage process, it first uses an initial multi-class U-Net to segment imagery into water, vegetation, built area, and bare ground classes. We identify that this method has confusion between spectrally similar categories (e.g., water vs. vegetation). Second, by early checking, the class with the major misclassified area is flagged, and a lightweight binary expert segmentation model is trained to distinguish the flagged class from the rest. Third, a Bayesian smoothing step refines boundaries and removes spurious noise by leveraging nearby pixel information. We validate the framework on the April 2024 Dubai storm event, using pre- and post-rainfall PlanetScope composites. Experimental results demonstrate average F1-score improvements of up to 29% across all land-cover classes and notably sharper flood delineations, significantly outperforming conventional single-stage U-Net baselines.

Wanqing Cui, Xin Hong, Yanyan Lan et al.

Humans can naturally reason from superficial state differences (e.g. ground wetness) to transformations descriptions (e.g. raining) according to their life experience. In this paper, we propose a new visual reasoning task to test this transformation reasoning ability in real-world scenarios, called \textbf{V}isual \textbf{T}ransformation \textbf{T}elling (VTT). Given a series of states (i.e. images), VTT requires to describe the transformation occurring between every two adjacent states. Different from existing visual reasoning tasks that focus on surface state reasoning, the advantage of VTT is that it captures the underlying causes, e.g. actions or events, behind the differences among states. We collect a novel dataset to support the study of transformation reasoning from two existing instructional video datasets, CrossTask and COIN, comprising 13,547 samples. Each sample involves the key state images along with their transformation descriptions. Our dataset covers diverse real-world activities, providing a rich resource for training and evaluation. To construct an initial benchmark for VTT, we test several models, including traditional visual storytelling methods (CST, GLACNet, Densecap) and advanced multimodal large language models (LLaVA v1.5-7B, Qwen-VL-chat, Gemini Pro Vision, GPT-4o, and GPT-4). Experimental results reveal that even state-of-the-art models still face challenges in VTT, highlighting substantial areas for improvement.

Xin Hong, Yanyan Lan, Liang Pang et al.

Most existing visual reasoning tasks, such as CLEVR in VQA, ignore an important factor, i.e.~transformation. They are solely defined to test how well machines understand concepts and relations within static settings, like one image. Such \textbf{state driven} visual reasoning has limitations in reflecting the ability to infer the dynamics between different states, which has shown to be equally important for human cognition in Piaget's theory. To tackle this problem, we propose a novel \textbf{transformation driven} visual reasoning (TVR) task. Given both the initial and final states, the target becomes to infer the corresponding intermediate transformation. Following this definition, a new synthetic dataset namely TRANCE is first constructed on the basis of CLEVR, including three levels of settings, i.e.~Basic (single-step transformation), Event (multi-step transformation), and View (multi-step transformation with variant views). Next, we build another real dataset called TRANCO based on COIN, to cover the loss of transformation diversity on TRANCE. Inspired by human reasoning, we propose a three-staged reasoning framework called TranNet, including observing, analyzing, and concluding, to test how recent advanced techniques perform on TVR. Experimental results show that the state-of-the-art visual reasoning models perform well on Basic, but are still far from human-level intelligence on Event, View, and TRANCO. We believe the proposed new paradigm will boost the development of machine visual reasoning. More advanced methods and new problems need to be investigated in this direction. The resource of TVR is available at \url{https://hongxin2019.github.io/TVR/}.

Yuqi Huo, Manli Zhang, Guangzhen Liu et al.

Multi-modal pre-training models have been intensively explored to bridge vision and language in recent years. However, most of them explicitly model the cross-modal interaction between image-text pairs, by assuming that there exists strong semantic correlation between the text and image modalities. Since this strong assumption is often invalid in real-world scenarios, we choose to implicitly model the cross-modal correlation for large-scale multi-modal pre-training, which is the focus of the Chinese project `WenLan' led by our team. Specifically, with the weak correlation assumption over image-text pairs, we propose a two-tower pre-training model called BriVL within the cross-modal contrastive learning framework. Unlike OpenAI CLIP that adopts a simple contrastive learning method, we devise a more advanced algorithm by adapting the latest method MoCo into the cross-modal scenario. By building a large queue-based dictionary, our BriVL can incorporate more negative samples in limited GPU resources. We further construct a large Chinese multi-source image-text dataset called RUC-CAS-WenLan for pre-training our BriVL model. Extensive experiments demonstrate that the pre-trained BriVL model outperforms both UNITER and OpenAI CLIP on various downstream tasks.

Xin Hong, Yanyan Lan, Liang Pang et al.

This paper defines a new visual reasoning paradigm by introducing an important factor, i.e.~transformation. The motivation comes from the fact that most existing visual reasoning tasks, such as CLEVR in VQA, are solely defined to test how well the machine understands the concepts and relations within static settings, like one image. We argue that this kind of \textbf{state driven visual reasoning} approach has limitations in reflecting whether the machine has the ability to infer the dynamics between different states, which has been shown as important as state-level reasoning for human cognition in Piaget's theory. To tackle this problem, we propose a novel \textbf{transformation driven visual reasoning} task. Given both the initial and final states, the target is to infer the corresponding single-step or multi-step transformation, represented as a triplet (object, attribute, value) or a sequence of triplets, respectively. Following this definition, a new dataset namely TRANCE is constructed on the basis of CLEVR, including three levels of settings, i.e.~Basic (single-step transformation), Event (multi-step transformation), and View (multi-step transformation with variant views). Experimental results show that the state-of-the-art visual reasoning models perform well on Basic, but are still far from human-level intelligence on Event and View. We believe the proposed new paradigm will boost the development of machine visual reasoning. More advanced methods and real data need to be investigated in this direction. The resource of TVR is available at https://hongxin2019.github.io/TVR.

Linfang Hou, Liang Pang, Xin Hong et al.

Robust Reinforcement Learning aims to find the optimal policy with some extent of robustness to environmental dynamics. Existing learning algorithms usually enable the robustness through disturbing the current state or simulating environmental parameters in a heuristic way, which lack quantified robustness to the system dynamics (i.e. transition probability). To overcome this issue, we leverage Wasserstein distance to measure the disturbance to the reference transition kernel. With Wasserstein distance, we are able to connect transition kernel disturbance to the state disturbance, i.e. reduce an infinite-dimensional optimization problem to a finite-dimensional risk-aware problem. Through the derived risk-aware optimal Bellman equation, we show the existence of optimal robust policies, provide a sensitivity analysis for the perturbations, and then design a novel robust learning algorithm--Wasserstein Robust Advantage Actor-Critic algorithm (WRAAC). The effectiveness of the proposed algorithm is verified in the Cart-Pole environment.