Vojtěch Kulvait

Hana Haseljić, Soumick Chatterjee, Robert Frysch et al.

Model-based reconstruction employing the time separation technique (TST) was found to improve dynamic perfusion imaging of the liver using C-arm cone-beam computed tomography (CBCT). To apply TST using prior knowledge extracted from CT perfusion data, the liver should be accurately segmented from the CT scans. Reconstructions of primary and model-based CBCT data need to be segmented for proper visualisation and interpretation of perfusion maps. This research proposes Turbolift learning, which trains a modified version of the multi-scale Attention UNet on different liver segmentation tasks serially, following the order of the trainings CT, CBCT, CBCT TST - making the previous trainings act as pre-training stages for the subsequent ones - addressing the problem of limited number of datasets for training. For the final task of liver segmentation from CBCT TST, the proposed method achieved an overall Dice scores of 0.874$\pm$0.031 and 0.905$\pm$0.007 in 6-fold and 4-fold cross-validation experiments, respectively - securing statistically significant improvements over the model, which was trained only for that task. Experiments revealed that Turbolift not only improves the overall performance of the model but also makes it robust against artefacts originating from the embolisation materials and truncation artefacts. Additionally, in-depth analyses confirmed the order of the segmentation tasks. This paper shows the potential of segmenting the liver from CT, CBCT, and CBCT TST, learning from the available limited training data, which can possibly be used in the future for the visualisation and evaluation of the perfusion maps for the treatment evaluation of liver diseases.

Soumick Chatterjee, Hana Haseljić, Robert Frysch et al.

Perfusion imaging is a valuable tool for diagnosing and treatment planning for liver tumours. The time separation technique (TST) has been successfully used for modelling C-arm cone-beam computed tomography (CBCT) perfusion data. The reconstruction can be accompanied by the segmentation of the liver - for better visualisation and for generating comprehensive perfusion maps. Recently introduced Turbolift learning has been seen to perform well while working with TST reconstructions, but has not been explored for the time-resolved volumes (TRV) estimated out of TST reconstructions. The segmentation of the TRVs can be useful for tracking the movement of the liver over time. This research explores this possibility by training the multi-scale attention UNet of Turbolift learning at its third stage on the TRVs and shows the robustness of Turbolift learning since it can even work efficiently with the TRVs, resulting in a Dice score of 0.864$\pm$0.004.

Vojtěch Kulvait, Julian Moosmann, Georg Rose

We introduce a novel class of projectors for 3D cone beam tomographic reconstruction. Analytical formulas are derived to compute the relationship between the volume of a voxel projected onto a detector pixel and its contribution to the line integral of attenuation recorded by that pixel. Based on these formulas, we construct a near-exact projector and backprojector, particularly suited for algebraic reconstruction techniques and hierarchical reconstruction approaches with nonuniform voxel grids. Unlike traditional projectors, which assume a uniform grid with fixed voxel sizes, our method enables local refinement of voxels, allowing for adaptive grid resolution and improved reconstruction quality in regions of interest. We have implemented this cutting voxel projector along with a relaxed, speed-optimized version and compared them to two established projectors: a ray-tracing projector based on Siddon's algorithm and a TT footprint projector. Our results demonstrate that the cutting voxel projector achieves higher accuracy than the TT projector, especially for large cone beam angles. Furthermore, the relaxed version of the cutting voxel projector offers a significant speed advantage, while maintaining comparable accuracy. In contrast, Siddon's algorithm, tuned to achieve the same accuracy, is considerably slower than the cutting voxel projector. All algorithms are implemented in a GPU optimized open-source framework for algebraic reconstruction. GitHub repository of the project https://github.com/kulvait/KCT_cbct.

Xiaogang Yang, Dawit Hailu, Vojtěch Kulvait et al.

X-ray phase contrast imaging significantly improves the visualization of structures with weak or uniform absorption, broadening its applications across a wide range of scientific disciplines. Propagation-based phase contrast is particularly suitable for time- or dose-critical in vivo/in situ/operando (tomography) experiments because it requires only a single intensity measurement. However, the phase information of the wave field is lost during the measurement and must be recovered. Conventional algebraic and iterative methods often rely on specific approximations or boundary conditions that may not be met by many samples or experimental setups. In addition, they require manual tuning of reconstruction parameters by experts, making them less adaptable for complex or variable conditions. Here we present a self-learning approach for solving the inverse problem of phase retrieval in the near-field regime of Fresnel theory using a single intensity measurement (hologram). A physics-informed generative adversarial network is employed to reconstruct both the phase and absorbance of the unpropagated wave field in the sample plane from a single hologram. Unlike most deep learning approaches for phase retrieval, our approach does not require paired, unpaired, or simulated training data. This significantly broadens the applicability of our approach, as acquiring or generating suitable training data remains a major challenge due to the wide variability in sample types and experimental configurations. The algorithm demonstrates robust and consistent performance across diverse imaging conditions and sample types, delivering quantitative, high-quality reconstructions for both simulated data and experimental datasets acquired at beamline P05 at PETRA III (DESY, Hamburg), operated by Helmholtz-Zentrum Hereon. Furthermore, it enables the simultaneous retrieval of both phase and absorption information.