João L. D. Comba

Noemi Maritza L. Romero, Ricco Vasconcellos, Mariana R. Mendoza et al.

The COVID-19 pandemic presented numerous challenges to healthcare systems worldwide. Given that lung infections are prevalent among COVID-19 patients, chest Computer Tomography (CT) scans have frequently been utilized as an alternative method for identifying COVID-19 conditions and various other types of pulmonary diseases. Deep learning architectures have emerged to automate the identification of pulmonary disease types by leveraging CT scan slices as inputs for classification models. This paper introduces COVID-VR, a novel approach for classifying pulmonary diseases based on volume rendering images of the lungs captured from multiple angles, thereby providing a comprehensive view of the entire lung in each image. To assess the effectiveness of our proposal, we compared it against competing strategies utilizing both private data obtained from partner hospitals and a publicly available dataset. The results demonstrate that our approach effectively identifies pulmonary lesions and performs competitively when compared to slice-based methods.

Abel Corrêa Dias, Viviane Pereira Moreira, João Luiz Dihl Comba

Objective: Scientific publications play a crucial role in uncovering insights, testing novel drugs, and shaping healthcare policies. Accessing the quality of publications requires evaluating their Risk of Bias (RoB), a process typically conducted by human reviewers. In this study, we introduce a new dataset for machine reading comprehension and RoB assessment and present RoBIn (Risk of Bias Inference), an innovative model crafted to automate such evaluation. The model employs a dual-task approach, extracting evidence from a given context and assessing the RoB based on the gathered evidence. Methods: We use data from the Cochrane Database of Systematic Reviews (CDSR) as ground truth to label open-access clinical trial publications from PubMed. This process enabled us to develop training and test datasets specifically for machine reading comprehension and RoB inference. Additionally, we created extractive (RoBInExt) and generative (RoBInGen) Transformer-based approaches to extract relevant evidence and classify the RoB effectively. Results: RoBIn is evaluated across various settings and benchmarked against state-of-the-art methods for RoB inference, including large language models in multiple scenarios. In most cases, the best-performing RoBIn variant surpasses traditional machine learning and LLM-based approaches, achieving an ROC AUC of 0.83. Conclusion: Based on the evidence extracted from clinical trial reports, RoBIn performs a binary classification to decide whether the trial is at a low RoB or a high/unclear RoB. We found that both RoBInGen and RoBInExt are robust and have the best results in many settings.

Azael M. Sousa, Fabiano Reis, Rachel Zerbini et al.

Early detection of COVID-19 is vital to control its spread. Deep learning methods have been presented to detect suggestive signs of COVID-19 from chest CT images. However, due to the novelty of the disease, annotated volumetric data are scarce. Here we propose a method that does not require either large annotated datasets or backpropagation to estimate the filters of a convolutional neural network (CNN). For a few CT images, the user draws markers at representative normal and abnormal regions. The method generates a feature extractor composed of a sequence of convolutional layers, whose kernels are specialized in enhancing regions similar to the marked ones, and the decision layer of our CNN is a support vector machine. As we have no control over the CT image acquisition, we also propose an intensity standardization approach. Our method can achieve mean accuracy and kappa values of $0.97$ and $0.93$, respectively, on a dataset with 117 CT images extracted from different sites, surpassing its counterpart in all scenarios.