Lina Zhao

Weizhi Nie, Yuhe Yu, Chen Zhang et al.

In recent years, medical information technology has made it possible for electronic health record (EHR) to store fairly complete clinical data. This has brought health care into the era of "big data". However, medical data are often sparse and strongly correlated, which means that medical problems cannot be solved effectively. With the rapid development of deep learning in recent years, it has provided opportunities for the use of big data in healthcare. In this paper, we propose a temporal-saptial correlation attention network (TSCAN) to handle some clinical characteristic prediction problems, such as predicting death, predicting length of stay, detecting physiologic decline, and classifying phenotypes. Based on the design of the attention mechanism model, our approach can effectively remove irrelevant items in clinical data and irrelevant nodes in time according to different tasks, so as to obtain more accurate prediction results. Our method can also find key clinical indicators of important outcomes that can be used to improve treatment options. Our experiments use information from the Medical Information Mart for Intensive Care (MIMIC-IV) database, which is open to the public. Finally, we have achieved significant performance benefits of 2.0\% (metric) compared to other SOTA prediction methods. We achieved a staggering 90.7\% on mortality rate, 45.1\% on length of stay. The source code can be find: \url{https://github.com/yuyuheintju/TSCAN}.

Weizhi Nie, Chen Zhang, Dan Song et al.

The chest X-ray is often utilized for diagnosing common thoracic diseases. In recent years, many approaches have been proposed to handle the problem of automatic diagnosis based on chest X-rays. However, the scarcity of labeled data for related diseases still poses a huge challenge to an accurate diagnosis. In this paper, we focus on the thorax disease diagnostic problem and propose a novel deep reinforcement learning framework, which introduces prior knowledge to direct the learning of diagnostic agents and the model parameters can also be continuously updated as the data increases, like a person's learning process. Especially, 1) prior knowledge can be learned from the pre-trained model based on old data or other domains' similar data, which can effectively reduce the dependence on target domain data, and 2) the framework of reinforcement learning can make the diagnostic agent as exploratory as a human being and improve the accuracy of diagnosis through continuous exploration. The method can also effectively solve the model learning problem in the case of few-shot data and improve the generalization ability of the model. Finally, our approach's performance was demonstrated using the well-known NIH ChestX-ray 14 and CheXpert datasets, and we achieved competitive results. The source code can be found here: \url{https://github.com/NeaseZ/MARL}.

Zhengde Zhang, Yiyu Zhang, Haodong Yao et al.

Large Language Models (LLMs) are undergoing a period of rapid updates and changes, with state-of-the-art (SOTA) model frequently being replaced. When applying LLMs to a specific scientific field, it's challenging to acquire unique domain knowledge while keeping the model itself advanced. To address this challenge, a sophisticated large language model system named as Xiwu has been developed, allowing you switch between the most advanced foundation models and quickly teach the model domain knowledge. In this work, we will report on the best practices for applying LLMs in the field of high-energy physics (HEP), including: a seed fission technology is proposed and some data collection and cleaning tools are developed to quickly obtain domain AI-Ready dataset; a just-in-time learning system is implemented based on the vector store technology; an on-the-fly fine-tuning system has been developed to facilitate rapid training under a specified foundation model. The results show that Xiwu can smoothly switch between foundation models such as LLaMA, Vicuna, ChatGLM and Grok-1. The trained Xiwu model is significantly outperformed the benchmark model on the HEP knowledge question-and-answering and code generation. This strategy significantly enhances the potential for growth of our model's performance, with the hope of surpassing GPT-4 as it evolves with the development of open-source models. This work provides a customized LLM for the field of HEP, while also offering references for applying LLM to other fields, the corresponding codes are available on Github.

Lina Zhao, Zihao Bian, Qingyue Chen et al.

Focused Ultrasound Ablation Surgery (FUAS) has emerged as a promising non-invasive therapeutic modality, valued for its safety and precision. Nevertheless, its clinical implementation entails intricate tasks such as multimodal image interpretation, personalized dose planning, and real-time intraoperative decision-making processes that demand intelligent assistance to improve efficiency and reliability. We introduce FUAS-Agents, an autonomous agent system that leverages the multimodal understanding and tool-using capabilities of large language models (LLMs). The system was developed using a large-scale, multicenter, multimodal clinical dataset of over 3000 cases from three medical institutions. By integrating patient profiles and MRI data, FUAS-Agents orchestrates a suite of specialized medical AI tools, including segmentation, treatment dose prediction, and clinical guideline retrieval, to generate personalized treatment plans comprising MRI image, dose parameters, and therapeutic strategies. The system also incorporates an internal quality control and reflection mechanism, ensuring consistency and robustness of the outputs. We evaluate the system in a uterine fibroid treatment scenario. Human assessment by four senior FUAS experts indicates that 82.5\%, 82.5\%, 87.5\%, and 97.5\% of the generated plans were rated 4 or above (on a 5-point scale) in terms of completeness, accuracy, fluency, and clinical compliance, respectively. In addition, we have conducted ablation studies to systematically examine the contribution of each component to the overall performance. These results demonstrate the potential of LLM-driven agents in enhancing decision-making across complex clinical workflows, and exemplify a translational paradigm that combines general-purpose models with specialized expert systems to solve practical challenges in vertical healthcare domains.

Weizhi Nie, Chen Zhang, Dan Song et al.

The chest X-ray (CXR) is one of the most common and easy-to-get medical tests used to diagnose common diseases of the chest. Recently, many deep learning-based methods have been proposed that are capable of effectively classifying CXRs. Even though these techniques have worked quite well, it is difficult to establish whether what these algorithms actually learn is the cause-and-effect link between diseases and their causes or just how to map labels to photos.In this paper, we propose a causal approach to address the CXR classification problem, which constructs a structural causal model (SCM) and uses the backdoor adjustment to select effective visual information for CXR classification. Specially, we design different probability optimization functions to eliminate the influence of confounders on the learning of real causality. Experimental results demonstrate that our proposed method outperforms the open-source NIH ChestX-ray14 in terms of classification performance.

Shuang Liu, Lina Zhao, Tian Wang et al.

Driven by the continuous development of models such as Multi-Layer Perceptron, Convolutional Neural Network (CNN), and Transformer, deep learning has made breakthrough progress in fields such as computer vision and natural language processing, and has been successfully applied in practical scenarios such as image classification and industrial fault diagnosis. However, existing models still have certain limitations in local feature modeling and global dependency capture. Specifically, CNN is limited by local receptive fields, while Transformer has shortcomings in effectively modeling local structures, and both face challenges of high model complexity and insufficient interpretability. In response to the above issues, we proposes the following innovative work: A sparse Transformer based on Learnable Iterative Shrinkage Threshold Algorithm (LISTA-Transformer) was designed, which deeply integrates LISTA sparse encoding with visual Transformer to construct a model architecture with adaptive local and global feature collaboration mechanism. This method utilizes continuous wavelet transform to convert vibration signals into time-frequency maps and inputs them into LISTA-Transformer for more effective feature extraction. On the CWRU dataset, the fault recognition rate of our method reached 98.5%, which is 3.3% higher than traditional methods and exhibits certain superiority over existing Transformer-based approaches.

Rihao Chang, He Jiao, Weizhi Nie et al.

Recent advances in large language models (LLMs) have enabled new possibilities in simulating complex physiological systems. We introduce Organ-Agents, a multi-agent framework that simulates human physiology via LLM-driven agents. Each Simulator models a specific system (e.g., cardiovascular, renal, immune). Training consists of supervised fine-tuning on system-specific time-series data, followed by reinforcement-guided coordination using dynamic reference selection and error correction. We curated data from 7,134 sepsis patients and 7,895 controls, generating high-resolution trajectories across 9 systems and 125 variables. Organ-Agents achieved high simulation accuracy on 4,509 held-out patients, with per-system MSEs <0.16 and robustness across SOFA-based severity strata. External validation on 22,689 ICU patients from two hospitals showed moderate degradation under distribution shifts with stable simulation. Organ-Agents faithfully reproduces critical multi-system events (e.g., hypotension, hyperlactatemia, hypoxemia) with coherent timing and phase progression. Evaluation by 15 critical care physicians confirmed realism and physiological plausibility (mean Likert ratings 3.9 and 3.7). Organ-Agents also enables counterfactual simulations under alternative sepsis treatment strategies, generating trajectories and APACHE II scores aligned with matched real-world patients. In downstream early warning tasks, classifiers trained on synthetic data showed minimal AUROC drops (<0.04), indicating preserved decision-relevant patterns. These results position Organ-Agents as a credible, interpretable, and generalizable digital twin for precision diagnosis, treatment simulation, and hypothesis testing in critical care.

Lina Zhao, Eun-Jae Park, Eric Chung

In this paper we investigate staggered discontinuous Galerkin method for the Helmholtz equation with large wave number on general quadrilateral and polygonal meshes. The method is highly flexible by allowing rough grids such as the trapezoidal grids and highly distorted grids, and at the same time, is numerical flux free. Furthermore, it allows hanging nodes, which can be simply treated as additional vertices. By exploiting a modified duality argument, the stability and convergence can be proved under the condition that $κh$ is sufficiently small, where $κ$ is the wave number and $h$ is the mesh size. Error estimates for both the scalar and vector variables in $L^2$ norm are established. Several numerical experiments are tested to verify our theoretical results and to present the capability of our method for capturing singular solutions.

Lina Zhao, Eric T. Chung

In this paper we propose simple multiscale basis functions with constraint energy minimization to solve elliptic problems with high contrast medium. Our methodology is based on the recently developed non-local multicontinuum method (NLMC). The main ingredient of the method is the construction of suitable local basis functions with the capability of capturing multiscale features and non-local effects. In our method, each coarse block is decomposed into various regions according to the contrast ratio, and we require that the contrast ratio should be relatively small within each region. The basis functions are constructed by solving a local problem defined on the oversampling domains and they have mean value one on the chosen region and zero mean otherwise. Numerical analysis shows that the resulting basis functions can be localizable and have a decay property. The convergence of the multiscale solution is also proved. Finally, some numerical experiments are carried out to illustrate the performances of the proposed method. They show that the proposed method can solve problem with high contrast medium efficiently. In particular, if the oversampling size is large enough, then we can achieve the desired error.