Yating Zhou

Huihui Fang, Fei Li, Junde Wu et al.

With the rapid development of artificial intelligence (AI) in medical image processing, deep learning in color fundus photography (CFP) analysis is also evolving. Although there are some open-source, labeled datasets of CFPs in the ophthalmology community, large-scale datasets for screening only have labels of disease categories, and datasets with annotations of fundus structures are usually small in size. In addition, labeling standards are not uniform across datasets, and there is no clear information on the acquisition device. Here we release a multi-annotation, multi-quality, and multi-device color fundus image dataset for glaucoma analysis on an original challenge -- Retinal Fundus Glaucoma Challenge 2nd Edition (REFUGE2). The REFUGE2 dataset contains 2000 color fundus images with annotations of glaucoma classification, optic disc/cup segmentation, as well as fovea localization. Meanwhile, the REFUGE2 challenge sets three sub-tasks of automatic glaucoma diagnosis and fundus structure analysis and provides an online evaluation framework. Based on the characteristics of multi-device and multi-quality data, some methods with strong generalizations are provided in the challenge to make the predictions more robust. This shows that REFUGE2 brings attention to the characteristics of real-world multi-domain data, bridging the gap between scientific research and clinical application.

Haixu Liao, Yating Zhou, Songyang Zhang et al.

Contrastive learning has emerged as a powerful framework for learning generalizable representations, yet its theoretical understanding remains limited, particularly under imbalanced data distributions that are prevalent in real-world applications. Such an imbalance can degrade representation quality and induce biased model behavior, yet a rigorous characterization of these effects is lacking. In this work, we develop a theoretical framework to analyze the training dynamics of contrastive learning with Transformer-based encoders under imbalanced data. Our results reveal that neuron weights evolve through three distinct stages of training, with different dynamics for majority features, minority features, and noise. We further show that minority features reduce representational capacity, increase the need for more complex architectures, and hinder the separation of ground-truth features from noise. Inspired by these neuron-level behaviors, we show that pruning restores performance degraded by imbalance and enhances feature separation, offering both conceptual insights and practical guidance. Major theoretical findings are validated through numerical experiments.

Ruirui Li, Mingming Li, Jiacheng Li et al.

We develop a connection sensitive attention U-Net(CSAU) for accurate retinal vessel segmentation. This method improves the recent attention U-Net for semantic segmentation with four key improvements: (1) connection sensitive loss that models the structure properties to improve the accuracy of pixel-wise segmentation; (2) attention gate with novel neural network structure and concatenating DOWN-Link to effectively learn better attention weights on fine vessels; (3) integration of connection sensitive loss and attention gate to further improve the accuracy on detailed vessels by additionally concatenating attention weights to features before output; (4) metrics of connection sensitive accuracy to reflect the segmentation performance on boundaries and thin vessels. Our method can effectively improve state-of-the-art vessel segmentation methods that suffer from difficulties in presence of abnormalities, bifurcation and microvascular. This connection sensitive loss tightly integrates with the proposed attention U-Net to accurately (i) segment retinal vessels, and (ii) reserve the connectivity of thin vessels by modeling the structural properties. Our method achieves the leading position on DRIVE, STARE and HRF datasets among the state-of-the-art methods.