Sukheon Kang, Youngkwon Kim, Jinkyu Yang et al.
Origami-inspired structures provide unprecedented opportunities for creating lightweight, deployable systems with programmable mechanical responses. However, their design remains challenging due to complex nonlinear mechanics, multistability, and the need for precise control of deployment forces. Here, we present a physics-informed neural network (PINN) framework for both forward prediction and inverse design of conical Kresling origami (CKO) without requiring pre-collected training data. By embedding mechanical equilibrium equations directly into the learning process, the model predicts complete energy landscapes with high accuracy while minimizing non-physical artifacts. The inverse design routine specifies both target stable-state heights and separating energy barriers, enabling freeform programming of the entire energy curve. This capability is extended to hierarchical CKO assemblies, where sequential layer-by-layer deployment is achieved through programmed barrier magnitudes. Finite element simulations and experiments on physical prototypes validate the designed deployment sequences and barrier ratios, confirming the robustness of the approach. This work establishes a versatile, data-free route for programming complex mechanical energy landscapes in origami-inspired metamaterials, offering broad potential for deployable aerospace systems, morphing structures, and soft robotic actuators.