Magnus Johnsson

Zahra Asghari Varzaneh, Niclas Wölner-Hanssen, Reza Khoshkangini et al.

The selection of the optimal embryo for transfer is a critical yet challenging step in in vitro fertilization (IVF), primarily due to its reliance on the manual inspection of extensive time-lapse imaging data. A key obstacle in this process is predicting blastocyst formation from the limited number of daily images available. Many clinics also lack complete time-lapse systems, so full videos are often unavailable. In this study, we aimed to predict which embryos will develop into blastocysts using limited daily images from time-lapse recordings. We propose a novel hybrid model that combines DINOv2, a transformer-based vision model, with an enhanced long short-term memory (LSTM) network featuring a multi-head attention layer. DINOv2 extracts meaningful features from embryo images, and the LSTM model then uses these features to analyze embryo development over time and generate final predictions. We tested our model on a real dataset of 704 embryo videos. The model achieved 96.4% accuracy, surpassing existing methods. It also performs well with missing frames, making it valuable for many IVF laboratories with limited imaging systems. Our approach can assist embryologists in selecting better embryos more efficiently and with greater confidence.

Zahra Asghari Varzaneh, Reza Khoshkangini, Magnus Johnsson et al.

This study introduces Blasto-Net, a multi-task deep learning model for comprehensive blastocyst analysis. The proposed model performs three tasks simultaneously in a single forward pass: segmentation of the ZP, TE, and ICM compartments, morphological grading, and implantation outcome prediction. Accurate blastocyst analysis in in vitro fertilization (IVF) is challenging. The compartments often have similar textures but very different structures. To address these challenges, Blasto-Net employs an EfficientNet-B3 encoder with a UNet-style decoder enhanced by the Convolutional Block Attention Module (CBAM) and a novel Edge-Aware Attention Module (EAAM) to effectively capture both semantic and boundary information. To handle distinct compartment topologies, the network employs specialized segmentation heads and a composite region- and boundary-based loss. Additionally, Grad-CAM++ visualizations are used to verify the anatomical consistency of the model's predictions. Evaluated on a public HMC blastocyst dataset, Blasto-Net achieves Dice scores of 94.93%, 91.60%, and 88.82% for ICM, ZP, and TE, respectively, alongside an implantation F1-score of 80.0%. These results demonstrate that Blasto-Net offers an accurate, interpretable, and efficient solution for automated blastocyst assessment, with strong potential to support clinical decision-making in IVF.

Zahra Gharaee, Peter Gärdenfors, Magnus Johnsson

Human recognition of the actions of other humans is very efficient and is based on patterns of movements. Our theoretical starting point is that the dynamics of the joint movements is important to action categorization. On the basis of this theory, we present a novel action recognition system that employs a hierarchy of Self-Organizing Maps together with a custom supervised neural network that learns to categorize actions. The system preprocesses the input from a Kinect like 3D camera to exploit the information not only about joint positions, but also their first and second order dynamics. We evaluate our system in two experiments with publicly available data sets, and compare its performance to the performance with less sophisticated preprocessing of the input. The results show that including the dynamics of the actions improves the performance. We also apply an attention mechanism that focuses on the parts of the body that are the most involved in performing the actions.