Lixia Wang

Haoran Sun, Lixia Wang, Yin-Chen Hsu et al.

Geometric distortion in prostate diffusion-weighted imaging (DWI) can impair lesion localization and reduce the reliability of MRI-based clinical assessment. We propose AutoIQ, an ensemble machine learning framework for automatic quantification and classification of DWI geometric distortion severity. A total of 140 retrospective prostate biparametric MRI examinations were analyzed, including 33 scans with severe distortion requiring repeat acquisition and 107 scans with acceptable distortion based on expert radiologist assessment. AutoIQ combines two complementary distortion quantification strategies: a segmentation-based method measuring prostate boundary mismatch between T2-weighted imaging (T2WI) and DWI, and a registration-based method estimating deformation magnitude after DWI-to-T2WI alignment. The resulting distortion scores were used to train individual classifiers and a logistic-regression ensemble model. Both computational methods significantly differentiated severe from acceptable distortion cases (p < 0.001). On an independent test set, the ensemble model achieved an accuracy of 0.95, F1-score of 0.93, and AUC of 0.98, outperforming individual models. These results suggest that AutoIQ can provide automated, quantitative quality assessment for prostate DWI and may help identify scans that require repeat acquisition.

Zengtian Deng, Yimeng He, Yu Shi et al.

Radiomics and deep learning both offer powerful tools for quantitative medical imaging, but most existing fusion approaches only leverage global radiomic features and overlook the complementary value of spatially resolved radiomic parametric maps. We propose a unified framework that first selects discriminative radiomic features and then injects them into a radiomics-enhanced nnUNet at both the global and voxel levels for pancreatic ductal adenocarcinoma (PDAC) detection. On the PANORAMA dataset, our method achieved AUC = 0.96 and AP = 0.84 in cross-validation. On an external in-house cohort, it achieved AUC = 0.95 and AP = 0.78, outperforming the baseline nnUNet; it also ranked second in the PANORAMA Grand Challenge. This demonstrates that handcrafted radiomics, when injected at both global and voxel levels, provide complementary signals to deep learning models for PDAC detection. Our code can be found at https://github.com/briandzt/dl-pdac-radiomics-global-n-paramaps

Yuhua Chen, Dan Ruan, Jiayu Xiao et al.

Segmentation of multiple organs-at-risk (OARs) is essential for radiation therapy treatment planning and other clinical applications. We developed an Automated deep Learning-based Abdominal Multi-Organ segmentation (ALAMO) framework based on 2D U-net and a densely connected network structure with tailored design in data augmentation and training procedures such as deep connection, auxiliary supervision, and multi-view. The model takes in multi-slice MR images and generates the output of segmentation results. Three-Tesla T1 VIBE (Volumetric Interpolated Breath-hold Examination) images of 102 subjects were collected and used in our study. Ten OARs were studied, including the liver, spleen, pancreas, left/right kidneys, stomach, duodenum, small intestine, spinal cord, and vertebral bodies. Two radiologists manually labeled and obtained the consensus contours as the ground-truth. In the complete cohort of 102, 20 samples were held out for independent testing, and the rest were used for training and validation. The performance was measured using volume overlapping and surface distance. The ALAMO framework generated segmentation labels in good agreement with the manual results. Specifically, among the 10 OARs, 9 achieved high Dice Similarity Coefficients (DSCs) in the range of 0.87-0.96, except for the duodenum with a DSC of 0.80. The inference completes within one minute for a 3D volume of 320x288x180. Overall, the ALAMO model matches the state-of-the-art performance. The proposed ALAMO framework allows for fully automated abdominal MR segmentation with high accuracy and low memory and computation time demands.