Ronan P. Killeen

Francesco Chiumento, Julia Dietlmeier, Ronan P. Killeen et al.

Detecting amyloid-$β$ (A$β$) positivity is crucial for early diagnosis of Alzheimer's disease but typically requires PET imaging, which is costly, invasive, and not widely accessible, limiting its use for population-level screening. We address this gap by proposing a PET-guided knowledge distillation framework that enables A$β$ prediction from MRI alone, without requiring non-imaging clinical covariates or PET at inference. Our approach employs a BiomedCLIP-based teacher model that learns PET-MRI alignment via cross-modal attention and triplet contrastive learning with PET-informed (Centiloid-aware) online negative sampling. An MRI-only student then mimics the teacher via feature-level and logit-level distillation. Evaluated across four MRI contrasts (T1w, T2w, FLAIR, T2*) and two independent datasets, our approach demonstrates effective knowledge transfer (best AUC: 0.74 on OASIS-3, 0.68 on ADNI) while maintaining interpretability and eliminating the need for clinical variables. Saliency analysis confirms that predictions focus on anatomically relevant cortical regions, supporting the clinical viability of PET-free A$β$ screening. Code is available at https://github.com/FrancescoChiumento/pet-guided-mri-amyloid-detection.

Misgina Tsighe Hagos, Niamh Belton, Ronan P. Killeen et al.

Alzheimer's Disease (AD) is a progressive disease preceded by Mild Cognitive Impairment (MCI). Early detection of AD is crucial for making treatment decisions. However, most of the literature on computer-assisted detection of AD focuses on classifying brain images into one of three major categories: healthy, MCI, and AD; or categorizing MCI patients into (1) progressive: those who progress from MCI to AD at a future examination time, and (2) stable: those who stay as MCI and never progress to AD. This misses the opportunity to accurately identify the trajectory of progressive MCI patients. In this paper, we revisit the brain image classification task for AD identification and re-frame it as an ordinal classification task to predict how close a patient is to the severe AD stage. To this end, we select progressive MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset and construct an ordinal dataset with a prediction target that indicates the time to progression to AD. We train a Siamese network model to predict the time to onset of AD based on MRI brain images. We also propose a Weighted variety of Siamese network and compare its performance to a baseline model. Our evaluations show that incorporating a weighting factor to Siamese networks brings considerable performance gain at predicting how close input brain MRI images are to progressing to AD. Moreover, we complement our results with an interpretation of the learned embedding space of the Siamese networks using a model explainability technique.

Siteng Ma, Honghui Du, Prateek Mathur et al.

Detecting changes in longitudinal medical imaging using deep learning requires a substantial amount of accurately labeled data. However, labeling these images is notably more costly and time-consuming than labeling other image types, as it requires labeling across various time points, where new lesions can be minor, and subtle changes are easily missed. Deep Active Learning (DAL) has shown promise in minimizing labeling costs by selectively querying the most informative samples, but existing studies have primarily focused on static tasks like classification and segmentation. Consequently, the conventional DAL approach cannot be directly applied to change detection tasks, which involve identifying subtle differences across multiple images. In this study, we propose a novel DAL framework, named Longitudinal Medical Imaging Active Learning (LMI-AL), tailored specifically for longitudinal medical imaging. By pairing and differencing all 2D slices from baseline and follow-up 3D images, LMI-AL iteratively selects the most informative pairs for labeling using DAL, training a deep learning model with minimal manual annotation. Experimental results demonstrate that, with less than 8% of the data labeled, LMI-AL can achieve performance comparable to models trained on fully labeled datasets. We also provide a detailed analysis of the method's performance, as guidance for future research. The code is publicly available at https://github.com/HelenMa9998/Longitudinal_AL.