Bernd Freisleben

Nour Neifar, Achraf Ben-Hamadou, Afef Mdhaffar et al.

Electrocardiogram (ECG) data collection during emergency situations is challenging, making ECG data generation an efficient solution for dealing with highly imbalanced ECG training datasets. In this paper, we propose a novel approach for ECG signal generation using Generative Adversarial Networks (GANs) and statistical ECG data modeling. Our approach leverages prior knowledge about ECG dynamics to synthesize realistic signals, addressing the complex dynamics of ECG signals. To validate our approach, we conducted experiments using ECG signals from the MIT-BIH arrhythmia database. Our results demonstrate that our approach, which models temporal and amplitude variations of ECG signals as 2-D shapes, generates more realistic signals compared to state-of-the-art GAN based generation baselines. Our proposed approach has significant implications for improving the quality of ECG training datasets, which can ultimately lead to better performance of ECG classification algorithms. This research contributes to the development of more efficient and accurate methods for ECG analysis, which can aid in the diagnosis and treatment of cardiac diseases.

Jan Egger, Junichi Tokuda, Laurent Chauvin et al.

We present the integration of the OpenIGTLink network protocol for image-guided therapy (IGT) with the medical prototyping platform MeVisLab. OpenIGTLink is a new, open, simple and extensible network communication protocol for IGT. The protocol provides a standardized mechanism to connect hardware and software by the transfer of coordinate transforms, images, and status messages. MeVisLab is a framework for the development of image processing algorithms and visualization and interaction methods, with a focus on medical imaging. The integration of OpenIGTLink into MeVisLab has been realized by developing a software module using the C++ programming language. As a result, researchers using MeVisLab can interface their software to hardware devices that already support the OpenIGTLink protocol, such as the NDI Aurora magnetic tracking system. In addition, the OpenIGTLink module can also be used to communicate directly with Slicer, a free, open source software package for visualization and image analysis. The integration has been tested with tracker clients available online and a real tracking system.

Jan Benedikt Ruhland, Thorsten Papenbrock, Jan-Peter Sowa et al.

Reliable detection of retinal diseases from fundus images is challenged by the variability in imaging quality, subtle early-stage manifestations, and domain shift across datasets. In this study, we systematically evaluated a Vision Transformer (ViT) classifier under multiple augmentation and enhancement strategies across several heterogeneous public datasets, as well as the AEyeDB dataset, a high-quality fundus dataset created in-house and made available for the research community. The ViT demonstrated consistently strong performance, with accuracies ranging from 0.789 to 0.843 across datasets and diseases. Diabetic retinopathy and age-related macular degeneration were detected reliably, whereas glaucoma remained the most frequently misclassified disease. Geometric and color augmentations provided the most stable improvements, while histogram equalization benefited datasets dominated by structural subtlety. Laplacian enhancement reduced performance across different settings. On the Papila dataset, the ViT with geometric augmentation achieved an AUC of 0.91, outperforming previously reported convolutional ensemble baselines (AUC of 0.87), underscoring the advantages of transformer architectures and multi-dataset training. To complement the classifier, we developed a GANomaly-based anomaly detector, achieving an AUC of 0.76 while providing inherent reconstruction-based explainability and robust generalization to unseen data. Probabilistic calibration using GUESS enabled threshold-independent decision support for future clinical implementation.

Nikolaus Korfhage, Markus Mühling, Bernd Freisleben

We present ElasticHash, a novel approach for high-quality, efficient, and large-scale semantic image similarity search. It is based on a deep hashing model to learn hash codes for fine-grained image similarity search in natural images and a two-stage method for efficiently searching binary hash codes using Elasticsearch (ES). In the first stage, a coarse search based on short hash codes is performed using multi-index hashing and ES terms lookup of neighboring hash codes. In the second stage, the list of results is re-ranked by computing the Hamming distance on long hash codes. We evaluate the retrieval performance of \textit{ElasticHash} for more than 120,000 query images on about 6.9 million database images of the OpenImages data set. The results show that our approach achieves high-quality retrieval results and low search latencies.

Lars Baumgärtner, Alexandra Dmitrienko, Bernd Freisleben et al.

Google and Apple have jointly provided an API for exposure notification in order to implement decentralized contract tracing apps using Bluetooth Low Energy, the so-called "Google/Apple Proposal", which we abbreviate by "GAP". We demonstrate that in real-world scenarios the current GAP design is vulnerable to (i) profiling and possibly de-anonymizing infected persons, and (ii) relay-based wormhole attacks that basically can generate fake contacts with the potential of affecting the accuracy of an app-based contact tracing system. For both types of attack, we have built tools that can easily be used on mobile phones or Raspberry Pis (e.g., Bluetooth sniffers). The goal of our work is to perform a reality check towards possibly providing empirical real-world evidence for these two privacy and security risks. We hope that our findings provide valuable input for developing secure and privacy-preserving digital contact tracing systems.

Lars Baumgärtner, Jonas Höchst, Patrick Lampe et al.

Currently, nearly four billion people live in urban areas. Since this trend is increasing, natural disasters or terrorist attacks in such areas affect an increasing number of people. While information and communication technology is crucial for the operation of urban infrastructures and the well-being of its inhabitants, current technology is quite vulnerable to disruptions of various kinds. In future smart cities, a more resilient urban infrastructure is imperative to handle the increasing number of hazardous situations. We present a novel resilient communication approach based on smart street lights as part of the public infrastructure. It supports people in their everyday life and adapts its functionality to the challenges of emergency situations. Our approach relies on various environmental sensors and in-situ processing for automatic situation assessment, and a range of communication mechanisms (e.g., public WiFi hotspot functionality and mesh networking) for maintaining a communication network. Furthermore, resilience is not only achieved based on infrastructure deployed by a digital city's municipality, but also based on integrating citizens through software that runs on their mobile devices (e.g., smartphones and tablets). Web-based zero-installation and platform-agnostic apps can switch to device-to-device communication to continue benefiting people even during a disaster situation. Our approach, featuring a covert channel for professional responders and the zero-installation app, is evaluated through a prototype implementation based on a commercially available street light.

Jonas Höchst, Artur Sterz, Alexander Frömmgen et al.

We present a novel data-driven approach to perform smooth Wi-Fi/cellular handovers on smartphones. Our approach relies on data provided by multiple smartphone sensors (e.g., Wi-Fi RSSI, acceleration, compass, step counter, air pressure) to predict Wi-Fi connection loss and uses Multipath TCP to dynamically switch between different connectivity modes. We train a random forest classifier and an artificial neural network on real-world sensor data collected by five smartphone users over a period of three months. The trained models are executed on smartphones to reliably predict Wi-Fi connection loss 15 seconds ahead of time, with a precision of up to 0.97 and a recall of up to 0.98. Furthermore, we present results for four DASH video streaming experiments that run on a Nexus 5 smartphone using available Wi-Fi/cellular networks. The neural network predictions for Wi-Fi connection loss are used to establish MPTCP subflows on the cellular link. The experiments show that our approach provides seamless wireless connectivity, improves quality of experience of DASH video streaming, and requires less cellular data compared to handover approaches without Wi-Fi connection loss predictions.

Kader Pustu-Iren, Markus Mühling, Nikolaus Korfhage et al.

Video indexing approaches such as visual concept classification and person recognition are essential to enable fine-grained semantic search in large-scale video archives such as the historical video collection of former German Democratic Republic (GDR) maintained by the German Broadcasting Archive (DRA). Typically, a lexicon of visual concepts has to be defined for semantic search. However, the definition of visual concepts can be more or less subjective due to individually differing judgments of annotators, which may have an impact on annotation quality and subsequently training of supervised machine learning methods. In this paper, we analyze the inter-coder agreement for historical TV data of the former GDR for visual concept classification and person recognition. The inter-coder agreement is evaluated for a group of expert as well as non-expert annotators in order to determine differences in annotation homogeneity. Furthermore, correlations between visual recognition performance and inter-annotator agreement are measured. In this context, information about image quantity and agreement are used to predict average precision for concept classification. Finally, the influence of expert vs. non-expert annotations acquired in the study are used to evaluate person recognition.

Markus Mühling, Manja Meister, Nikolaus Korfhage et al.

The German Broadcasting Archive (DRA) maintains the cultural heritage of radio and television broadcasts of the former German Democratic Republic (GDR). The uniqueness and importance of the video material stimulates a large scientific interest in the video content. In this paper, we present an automatic video analysis and retrieval system for searching in historical collections of GDR television recordings. It consists of video analysis algorithms for shot boundary detection, concept classification, person recognition, text recognition and similarity search. The performance of the system is evaluated from a technical and an archival perspective on 2,500 hours of GDR television recordings.

Jing Lu, Jan Egger, Andreas Wimmer et al.

In this paper we present an efficient algorithm for the segmentation of the inner and outer boundary of thoratic and abdominal aortic aneurysms (TAA & AAA) in computed tomography angiography (CTA) acquisitions. The aneurysm segmentation includes two steps: first, the inner boundary is segmented based on a grey level model with two thresholds; then, an adapted active contour model approach is applied to the more complicated outer boundary segmentation, with its initialization based on the available inner boundary segmentation. An opacity image, which aims at enhancing important features while reducing spurious structures, is calculated from the CTA images and employed to guide the deformation of the model. In addition, the active contour model is extended by a constraint force that prevents intersections of the inner and outer boundary and keeps the outer boundary at a distance, given by the thrombus thickness, to the inner boundary. Based upon the segmentation results, we can measure the aneurysm size at each centerline point on the centerline orthogonal multiplanar reformatting (MPR) plane. Furthermore, a 3D TAA or AAA model is reconstructed from the set of segmented contours, and the presence of endoleaks is detected and highlighted. The implemented method has been evaluated on nine clinical CTA data sets with variations in anatomy and location of the pathology and has shown promising results.

Dzenan Zukic, Jan Egger, Miriam H. A. Bauer et al.

The most common sellar lesion is the pituitary adenoma, and sellar tumors are approximately 10-15% of all intracranial neoplasms. Manual slice-by-slice segmentation takes quite some time that can be reduced by using the appropriate algorithms. In this contribution, we present a segmentation method for pituitary adenoma. The method is based on an algorithm that we have applied recently to segmenting glioblastoma multiforme. A modification of this scheme is used for adenoma segmentation that is much harder to perform, due to lack of contrast-enhanced boundaries. In our experimental evaluation, neurosurgeons performed manual slice-by-slice segmentation of ten magnetic resonance imaging (MRI) cases. The segmentations were compared to the segmentation results of the proposed method using the Dice Similarity Coefficient (DSC). The average DSC for all datasets was 75.92% +/- 7.24%. A manual segmentation took about four minutes and our algorithm required about one second.

Robert Schwarzenberg, Bernd Freisleben, Christopher Nimsky et al.

In this article, we present a graph-based method using a cubic template for volumetric segmentation of vertebrae in magnetic resonance imaging (MRI) acquisitions. The user can define the degree of deviation from a regular cube via a smoothness value Delta. The Cube-Cut algorithm generates a directed graph with two terminal nodes (s-t-network), where the nodes of the graph correspond to a cubic-shaped subset of the image's voxels. The weightings of the graph's terminal edges, which connect every node with a virtual source s or a virtual sink t, represent the affinity of a voxel to the vertebra (source) and to the background (sink). Furthermore, a set of infinite weighted and non-terminal edges implements the smoothness term. After graph construction, a minimal s-t-cut is calculated within polynomial computation time, which splits the nodes into two disjoint units. Subsequently, the segmentation result is determined out of the source-set. A quantitative evaluation of a C++ implementation of the algorithm resulted in an average Dice Similarity Coefficient (DSC) of 81.33% and a running time of less than a minute.

Miriam H. A. Bauer, Sebastiano Barbieri, Jan Klein et al.

Diffusion Tensor Imaging (DTI) is a non-invasive imaging technique that allows estimation of the location of white matter tracts in-vivo, based on the measurement of water diffusion properties. For each voxel, a second-order tensor can be calculated by using diffusion-weighted sequences (DWI) that are sensitive to the random motion of water molecules. Given at least 6 diffusion-weighted images with different gradients and one unweighted image, the coefficients of the symmetric diffusion tensor matrix can be calculated. Deriving the eigensystem of the tensor, the eigenvectors and eigenvalues can be calculated to describe the three main directions of diffusion and its magnitude. Using DTI data, fiber bundles can be determined, to gain information about eloquent brain structures. Especially in neurosurgery, information about location and dimension of eloquent structures like the corticospinal tract or the visual pathways is of major interest. Therefore, the fiber bundle boundary has to be determined. In this paper, a novel ray-based approach for boundary estimation of tubular structures is presented.

Jan Egger, Miriam H. A. Bauer, Stefan Großkopf et al.

In this contribution, a novel method for stent simulation in preoperative computed tomography angiography (CTA) acquisitions of patients is presented where the sealing zones are automatically calculated and visualized. The method is eligible for non-bifurcated and bifurcated stents (Y-stents). Results of the proposed stent simulation with an automatic calculation of the sealing zones for specific diseases (abdominal aortic aneurysms (AAA), thoracic aortic aneurysms (TAA), iliac aneurysms) are presented. The contribution is organized as follows. Section 2 presents the proposed approach. In Section 3, experimental results are discussed. Section 4 concludes the contribution and outlines areas for future work.

Jan Egger, Tina Kapur, Andriy Fedorov et al.

Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer - a free platform for biomedical research - provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 +/- 5.23% and a Hausdorff Distance of 2.32 +/- 5.23 mm.

Jan Egger, Bernd Freisleben, Christopher Nimsky et al.

We present a scale-invariant, template-based segmentation paradigm that sets up a graph and performs a graph cut to separate an object from the background. Typically graph-based schemes distribute the nodes of the graph uniformly and equidistantly on the image, and use a regularizer to bias the cut towards a particular shape. The strategy of uniform and equidistant nodes does not allow the cut to prefer more complex structures, especially when areas of the object are indistinguishable from the background. We propose a solution by introducing the concept of a "template shape" of the target object in which the nodes are sampled non-uniformly and non-equidistantly on the image. We evaluate it on 2D-images where the object's textures and backgrounds are similar, and large areas of the object have the same gray level appearance as the background. We also evaluate it in 3D on 60 brain tumor datasets for neurosurgical planning purposes.

Jan Egger, Tina Kapur, Thomas Dukatz et al.

We present a rectangle-based segmentation algorithm that sets up a graph and performs a graph cut to separate an object from the background. However, graph-based algorithms distribute the graph's nodes uniformly and equidistantly on the image. Then, a smoothness term is added to force the cut to prefer a particular shape. This strategy does not allow the cut to prefer a certain structure, especially when areas of the object are indistinguishable from the background. We solve this problem by referring to a rectangle shape of the object when sampling the graph nodes, i.e., the nodes are distributed nonuniformly and non-equidistantly on the image. This strategy can be useful, when areas of the object are indistinguishable from the background. For evaluation, we focus on vertebrae images from Magnetic Resonance Imaging (MRI) datasets to support the time consuming manual slice-by-slice segmentation performed by physicians. The ground truth of the vertebrae boundaries were manually extracted by two clinical experts (neurological surgeons) with several years of experience in spine surgery and afterwards compared with the automatic segmentation results of the proposed scheme yielding an average Dice Similarity Coefficient (DSC) of 90.97\pm62.2%.