Xinxing Wu

Xinxing Wu, Chong Peng, Peter T. Nelson et al.

Alzheimer's disease (AD), as a progressive brain disease, affects cognition, memory, and behavior. Similarly, limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined common neurodegenerative disease that mimics the clinical symptoms of AD. At present, the risk factors implicated in LATE and those distinguishing LATE from AD are largely unknown. We leveraged an integrated feature selection-based algorithmic approach, to identify important factors differentiating subjects with LATE and/or AD from Control on significantly imbalanced data. We analyzed two datasets ROSMAP and NACC and discovered that alcohol consumption was a top lifestyle and environmental factor linked with LATE and AD and their associations were differential. In particular, we identified a specific subpopulation consisting of APOE e4 carriers. We found that, for this subpopulation, light-to-moderate alcohol intake was a protective factor against both AD and LATE, but its protective role against AD appeared stronger than LATE. The codes for our algorithms are available at https://github.com/xinxingwu-uk/PFV.

Xinxing Wu, Chong Peng, Gregory Jicha et al.

The disruption of circadian rhythm is a cardinal symptom for Alzheimer's disease (AD) patients. The full circadian rhythm orchestration of gene expression in the human brain and its inherent associations with AD remain largely unknown. We present a novel comprehensive approach, PRIME, to detect and analyze rhythmic oscillation patterns in untimed high-dimensional gene expression data across multiple datasets. To demonstrate the utility of PRIME, firstly, we validate it by a time course expression dataset from mouse liver as a cross-species and cross-organ validation. Then, we apply it to study oscillation patterns in untimed genome-wide gene expression from 19 human brain regions of controls and AD patients. Our findings reveal clear, synchronized oscillation patterns in 15 pairs of brain regions of control, while these oscillation patterns either disappear or dim for AD. It is worth noting that PRIME discovers the circadian rhythmic patterns without requiring the sample's timestamps. The codes for PRIME, along with codes to reproduce the figures in this paper, are available at https://github.com/xinxingwu-uk/PRIME.

Xinxing Wu, Chong Peng, Richard Charnigo et al.

Interpreting critical variables involved in complex biological processes related to survival time can help understand prediction from survival models, evaluate treatment efficacy, and develop new therapies for patients. Currently, the predictive results of deep learning (DL)-based models are better than or as good as standard survival methods, they are often disregarded because of their lack of transparency and little interpretability, which is crucial to their adoption in clinical applications. In this paper, we introduce a novel, easily deployable approach, called EXplainable CEnsored Learning (EXCEL), to iteratively exploit critical variables and simultaneously implement (DL) model training based on these variables. First, on a toy dataset, we illustrate the principle of EXCEL; then, we mathematically analyze our proposed method, and we derive and prove tight generalization error bounds; next, on two semi-synthetic datasets, we show that EXCEL has good anti-noise ability and stability; finally, we apply EXCEL to a variety of real-world survival datasets including clinical data and genetic data, demonstrating that EXCEL can effectively identify critical features and achieve performance on par with or better than the original models. It is worth pointing out that EXCEL is flexibly deployed in existing or emerging models for explainable survival data in the presence of right censoring.

Xinxing Wu

Slide-based teaching is widely used in higher education, yet in online, hybrid, and asynchronous contexts, slides often lose the instructor presence, narrative continuity, and expressive framing that help learners connect with content. Full lecture video can partly restore these qualities, but it is time-consuming to record, revise, and reuse. This study addresses that pedagogical and production challenge by presenting a practice-based analysis of an open-source workflow for creating talking slide avatars for slide-based teaching. The workflow integrates OpenVoice for text-to-speech generation and voice cloning with Ditto-TalkingHead for audio-driven talking-image synthesis, enabling instructors to transform a script and a static portrait into a short narrated video that can be embedded in slide decks or HTML-based lecture materials. Rather than treating this workflow merely as a technical solution, the study frames talking slide avatars as multimodal communication artifacts at the intersection of digital pedagogy, aesthetic education, and art-technology practice. Using a practice-based implementation and analytic reflection approach, the study documents the production pipeline, examines its communicative and aesthetic affordances, and proposes practical guidelines for script length, image selection, pacing, disclosure, accessibility, and ethical use. The study makes three primary contributions: it presents an educator-oriented open-source production model, reframes talking avatars as an educational communication design problem, and proposes a responsible pathway for incorporating generative synthetic media into teaching. It concludes that short, transparent, and carefully designed avatars can humanize slide-based instruction while providing a reusable communicative layer for introductions, transitions, reminders, and recaps across online, hybrid, and asynchronous learning environments.

Xinxing Wu

In practical teaching, we observe that few students thoroughly read or fully comprehend the information provided in traditional, text-based course syllabi. As a result, essential details, such as course policies and learning outcomes, are frequently overlooked. To address this challenge, in this paper, we propose a novel approach leveraging AI-generated singing and virtual avatars to present syllabi in a format that is more visually appealing, engaging, and memorable. Especially, we leveraged the open-source tool, HeyGem, to transform textual syllabi into audiovisual presentations, in which digital avatars perform the syllabus content as songs. The proposed approach aims to stimulate students' curiosity, foster emotional connection, and enhance retention of critical course information. Student feedback indicated that AI-sung syllabi significantly improved awareness and recall of key course information.

Xinxing Wu, Chaoyue Tan, Gul Deniz Cayli et al.

This study is inspired by those of Huang et al. (Soft Comput. 25, 2513--2520, 2021) and Wang et al. (Inf. Sci. 179, 3026--3040, 2009) in which some ranking techniques for interval-valued intuitionistic fuzzy numbers (IVIFNs) were introduced. In this study, we prove that the space of all IVIFNs with the relation in the method for comparing any two IVIFNs based on a score function and three types of entropy functions is a complete chain and obtain that this relation is an admissible order. Moreover, we demonstrate that IVIFNs are complete chains to the relation in the comparison method for IVIFNs on the basis of score, accuracy, membership uncertainty index, and hesitation uncertainty index functions.

Xinxing Wu, Tao Wang, Qian Liu et al.

We prove that the space of intuitionistic fuzzy values (IFVs) with a linear order based on a score function and an accuracy function has the same algebraic structure as the one induced by a linear order based on a similarity function and an accuracy function. By introducing a new operator for IFVs via the linear order based on a score function and an accuracy function, we show that such an operator is a strong negation on IFVs. Moreover, we observe that the space of IFVs is a complete lattice and a Kleene algebra with the new operator. We also demonstrate that the topological space of IFVs with the order topology induced by the above two linear orders is not separable and metrizable but compact and connected. From some new perspectives,our results partially answer three open problems posed by Atanassov [Intuitionistic Fuzzy Sets: Theory and Applications, Springer, 1999] and [On Intuitionistic Fuzzy Sets Theory, Springer, 2012]. Furthermore, we construct an isomorphism between the spaces of IFVs and q-rung orthopedic fuzzy values (q-ROFVs) under the corresponding linear orders. To this end, we introduce the concept of admissible similarity measures with particular orders for IFSs, extending the existing definition of the similarity measure for IFSs, and construct an admissible similarity measure with a linear order based on a score function and an accuracy function, which is effectively applied to a pattern recognition problem about the classification of building materials.

Xinxing Wu, Qiang Cheng

Feature selection identifies subsets of informative features and reduces dimensions in the original feature space, helping provide insights into data generation or a variety of domain problems. Existing methods mainly depend on feature scoring functions or sparse regularizations; nonetheless, they have limited ability to reconcile the representativeness and inter-correlations of features. In this paper, we introduce a novel, simple yet effective regularization approach, named top-$k$ regularization, to supervised feature selection in regression and classification tasks. Structurally, the top-$k$ regularization induces a sub-architecture on the architecture of a learning model to boost its ability to select the most informative features and model complex nonlinear relationships simultaneously. Theoretically, we derive and mathematically prove a uniform approximation error bound for using this approach to approximate high-dimensional sparse functions. Extensive experiments on a wide variety of benchmarking datasets show that the top-$k$ regularization is effective and stable for supervised feature selection.

Xinxing Wu, Qiang Cheng

Graph neural networks have been used for a variety of learning tasks, such as link prediction, node classification, and node clustering. Among them, link prediction is a relatively under-studied graph learning task, with current state-of-the-art models based on one- or two-layer of shallow graph auto-encoder (GAE) architectures. In this paper, we focus on addressing a limitation of current methods for link prediction, which can only use shallow GAEs and variational GAEs, and creating effective methods to deepen (variational) GAE architectures to achieve stable and competitive performance. Our proposed methods innovatively incorporate standard auto-encoders (AEs) into the architectures of GAEs, where standard AEs are leveraged to learn essential, low-dimensional representations via seamlessly integrating the adjacency information and node features, while GAEs further build multi-scaled low-dimensional representations via residual connections to learn a compact overall embedding for link prediction. Empirically, extensive experiments on various benchmarking datasets verify the effectiveness of our methods and demonstrate the competitive performance of our deepened graph models for link prediction. Theoretically, we prove that our deep extensions inclusively express multiple polynomial filters with different orders.

Xinxing Wu, Qiang Cheng

Feature selection reduces the dimensionality of data by identifying a subset of the most informative features. In this paper, we propose an innovative framework for unsupervised feature selection, called fractal autoencoders (FAE). It trains a neural network to pinpoint informative features for global exploring of representability and for local excavating of diversity. Architecturally, FAE extends autoencoders by adding a one-to-one scoring layer and a small sub-neural network for feature selection in an unsupervised fashion. With such a concise architecture, FAE achieves state-of-the-art performances; extensive experimental results on fourteen datasets, including very high-dimensional data, have demonstrated the superiority of FAE over existing contemporary methods for unsupervised feature selection. In particular, FAE exhibits substantial advantages on gene expression data exploration, reducing measurement cost by about $15$\% over the widely used L1000 landmark genes. Further, we show that the FAE framework is easily extensible with an application.

Xinxing Wu, Qiang Cheng

Feature selection, as a vital dimension reduction technique, reduces data dimension by identifying an essential subset of input features, which can facilitate interpretable insights into learning and inference processes. Algorithmic stability is a key characteristic of an algorithm regarding its sensitivity to perturbations of input samples. In this paper, we propose an innovative unsupervised feature selection algorithm attaining this stability with provable guarantees. The architecture of our algorithm consists of a feature scorer and a feature selector. The scorer trains a neural network (NN) to globally score all the features, and the selector adopts a dependent sub-NN to locally evaluate the representation abilities for selecting features. Further, we present algorithmic stability analysis and show that our algorithm has a performance guarantee via a generalization error bound. Extensive experimental results on real-world datasets demonstrate superior generalization performance of our proposed algorithm to strong baseline methods. Also, the properties revealed by our theoretical analysis and the stability of our algorithm-selected features are empirically confirmed.

Xinxing Wu, Junping Zhang

Concentration inequalities are indispensable tools for studying the generalization capacity of learning models. Hoeffding's and McDiarmid's inequalities are commonly used, giving bounds independent of the data distribution. Although this makes them widely applicable, a drawback is that the bounds can be too loose in some specific cases. Although efforts have been devoted to improving the bounds, we find that the bounds can be further tightened in some distribution-dependent scenarios and conditions for the inequalities can be relaxed. In particular, we propose four types of conditions for probabilistic boundedness and bounded differences, and derive several distribution-dependent extensions of Hoeffding's and McDiarmid's inequalities. These extensions provide bounds for functions not satisfying the conditions of the existing inequalities, and in some special cases, tighter bounds. Furthermore, we obtain generalization bounds for unbounded and hierarchy-bounded loss functions. Finally we discuss the potential applications of our extensions to learning theory.