Jie Bao

Si Sun, Chenyan Xiong, Yue Yu et al. · tsinghua

In this paper, we investigate the instability in the standard dense retrieval training, which iterates between model training and hard negative selection using the being-trained model. We show the catastrophic forgetting phenomena behind the training instability, where models learn and forget different negative groups during training iterations. We then propose ANCE-Tele, which accumulates momentum negatives from past iterations and approximates future iterations using lookahead negatives, as "teleportations" along the time axis to smooth the learning process. On web search and OpenQA, ANCE-Tele outperforms previous state-of-the-art systems of similar size, eliminates the dependency on sparse retrieval negatives, and is competitive among systems using significantly more (50x) parameters. Our analysis demonstrates that teleportation negatives reduce catastrophic forgetting and improve convergence speed for dense retrieval training. Our code is available at https://github.com/OpenMatch/ANCE-Tele.

Si Sun, Yida Lu, Shi Yu et al. · tsinghua

Few-shot dense retrieval (DR) aims to effectively generalize to novel search scenarios by learning a few samples. Despite its importance, there is little study on specialized datasets and standardized evaluation protocols. As a result, current methods often resort to random sampling from supervised datasets to create "few-data" setups and employ inconsistent training strategies during evaluations, which poses a challenge in accurately comparing recent progress. In this paper, we propose a customized FewDR dataset and a unified evaluation benchmark. Specifically, FewDR employs class-wise sampling to establish a standardized "few-shot" setting with finely-defined classes, reducing variability in multiple sampling rounds. Moreover, the dataset is disjointed into base and novel classes, allowing DR models to be continuously trained on ample data from base classes and a few samples in novel classes. This benchmark eliminates the risk of novel class leakage, providing a reliable estimation of the DR model's few-shot ability. Our extensive empirical results reveal that current state-of-the-art DR models still face challenges in the standard few-shot scene. Our code and data will be open-sourced at https://github.com/OpenMatch/ANCE-Tele.

Wenxuan Li, Pedro R. A. S. Bassi, Lizhou Wu et al.

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid malignancies, is often detected at a late and inoperable stage. Retrospective reviews of prediagnostic CT scans, when conducted by expert radiologists aware that the patient later developed PDAC, frequently reveal lesions that were previously overlooked. To help detecting these lesions earlier, we developed an automated system named ePAI (early Pancreatic cancer detection with Artificial Intelligence). It was trained on data from 1,598 patients from a single medical center. In the internal test involving 1,009 patients, ePAI achieved an area under the receiver operating characteristic curve (AUC) of 0.939-0.999, a sensitivity of 95.3%, and a specificity of 98.7% for detecting small PDAC less than 2 cm in diameter, precisely localizing PDAC as small as 2 mm. In an external test involving 7,158 patients across 6 centers, ePAI achieved an AUC of 0.918-0.945, a sensitivity of 91.5%, and a specificity of 88.0%, precisely localizing PDAC as small as 5 mm. Importantly, ePAI detected PDACs on prediagnostic CT scans obtained 3 to 36 months before clinical diagnosis that had originally been overlooked by radiologists. It successfully detected and localized PDACs in 75 of 159 patients, with a median lead time of 347 days before clinical diagnosis. Our multi-reader study showed that ePAI significantly outperformed 30 board-certified radiologists by 50.3% (P < 0.05) in sensitivity while maintaining a comparable specificity of 95.4% in detecting PDACs early and prediagnostic. These findings suggest its potential of ePAI as an assistive tool to improve early detection of pancreatic cancer.

Sijie Ruan, Jinyu Li, Jia Wei et al.

Spatio-temporal epidemic forecasting is critical for public health management, yet existing methods often struggle with insensitivity to weak epidemic signals, over-simplified spatial relations, and unstable parameter estimation. To address these challenges, we propose the Spatio-Temporal priOr-aware Epidemic Predictor (STOEP), a novel hybrid framework that integrates implicit spatio-temporal priors and explicit expert priors. STOEP consists of three key components: (1) Case-aware Adjacency Learning (CAL), which dynamically adjusts mobility-based regional dependencies using historical infection patterns; (2) Space-informed Parameter Estimating (SPE), which employs learnable spatial priors to amplify weak epidemic signals; and (3) Filter-based Mechanistic Forecasting (FMF), which uses an expert-guided adaptive thresholding strategy to regularize epidemic parameters. Extensive experiments on real-world COVID-19 and influenza datasets demonstrate that STOEP outperforms the best baseline by 11.1% in RMSE. The system has been deployed at one provincial CDC in China to facilitate downstream applications.

Brian R. Bartoldson, Yeping Hu, Amar Saini et al.

Data-driven modeling approaches can produce fast surrogates to study large-scale physics problems. Among them, graph neural networks (GNNs) that operate on mesh-based data are desirable because they possess inductive biases that promote physical faithfulness, but hardware limitations have precluded their application to large computational domains. We show that it is \textit{possible} to train a class of GNN surrogates on 3D meshes. We scale MeshGraphNets (MGN), a subclass of GNNs for mesh-based physics modeling, via our domain decomposition approach to facilitate training that is mathematically equivalent to training on the whole domain under certain conditions. With this, we were able to train MGN on meshes with \textit{millions} of nodes to generate computational fluid dynamics (CFD) simulations. Furthermore, we show how to enhance MGN via higher-order numerical integration, which can reduce MGN's error and training time. We validated our methods on an accompanying dataset of 3D $\text{CO}_2$-capture CFD simulations on a 3.1M-node mesh. This work presents a practical path to scaling MGN for real-world applications.

Yitao Yan, Yu Tong, Jie Bao et al.

The abundance of process operating data in modern industries, along with the rapid advancement of learning techniques, has led to a paradigm shift towards data-centric analysis and control. However, integrating machine learning with control theory for big data-driven control of nonlinear systems remains a challenging open problem. This is because the state-based, model-centric, and causal framework of classical control theory fundamentally contradicts the trajectory-based, set-theoretic, and causality-absent rationale of big data-based learning approaches. Using the behavioral framework, we show that dynamical systems possess an intrinsic state variable that encodes the system behavior in a bijective and causality-free manner, and control design can be carried out entirely within the state space. This approach not only resolves the aforementioned conflict but also complements machine learning techniques well, leading to a neural network architecture that is capable of learning the behavior representation well-suited for control design.

Yitao Yan, Shuangyu Han, Jie Bao et al.

In process operations, it is desirable to manage the sensitivity of the system output against external disturbance in the form of finite $\mathcal{L}_2$-gain stabilization. This matter is, however, nonsensical for stochastic systems because the stochastic uncertainties in the control input almost always lead to an unbounded $\mathcal{L}_2$ gain from the disturbance to the output. To address this issue, this article develops a novel concept that characterizes the $\mathcal{L}_2$ gain of stochastic systems in a probabilistic way. Combined with a large data set, we formulate a data-driven probabilistic finite $\mathcal{L}_2$-gain stabilization design using noisy trajectory measurements and the disturbance forecast that does not necessarily agree with the actual future disturbance. The design approach consists of a data-driven trajectory estimation algorithm, whose resulting estimation error covariance is nicely integrated into the feasibility conditions for controller synthesis, leading to a convex offline design in the form of linear matrix inequalities. The effectiveness of the proposed design, along with the additional insights provided by the approach, is illustrated via a numerical example.

Jie Bao, Chuangyin Dang, Rui Luo et al.

As deep learning models are increasingly deployed in high-risk applications, robust defenses against adversarial attacks and reliable performance guarantees become paramount. Moreover, accuracy alone does not provide sufficient assurance or reliable uncertainty estimates for these models. This study advances adversarial training by leveraging principles from Conformal Prediction. Specifically, we develop an adversarial attack method, termed OPSA (OPtimal Size Attack), designed to reduce the efficiency of conformal prediction at any significance level by maximizing model uncertainty without requiring coverage guarantees. Correspondingly, we introduce OPSA-AT (Adversarial Training), a defense strategy that integrates OPSA within a novel conformal training paradigm. Experimental evaluations demonstrate that our OPSA attack method induces greater uncertainty compared to baseline approaches for various defenses. Conversely, our OPSA-AT defensive model significantly enhances robustness not only against OPSA but also other adversarial attacks, and maintains reliable prediction. Our findings highlight the effectiveness of this integrated approach for developing trustworthy and resilient deep learning models for safety-critical domains. Our code is available at https://github.com/bjbbbb/Enhancing-Adversarial-Robustness-with-Conformal-Prediction.

Si Sun, Yingzhuo Qian, Zhenghao Liu et al.

The effectiveness of Neural Information Retrieval (Neu-IR) often depends on a large scale of in-domain relevance training signals, which are not always available in real-world ranking scenarios. To democratize the benefits of Neu-IR, this paper presents MetaAdaptRank, a domain adaptive learning method that generalizes Neu-IR models from label-rich source domains to few-shot target domains. Drawing on source-domain massive relevance supervision, MetaAdaptRank contrastively synthesizes a large number of weak supervision signals for target domains and meta-learns to reweight these synthetic "weak" data based on their benefits to the target-domain ranking accuracy of Neu-IR models. Experiments on three TREC benchmarks in the web, news, and biomedical domains show that MetaAdaptRank significantly improves the few-shot ranking accuracy of Neu-IR models. Further analyses indicate that MetaAdaptRank thrives from both its contrastive weak data synthesis and meta-reweighted data selection. The code and data of this paper can be obtained from https://github.com/thunlp/MetaAdaptRank.

Si Sun, Zhenghao Liu, Chenyan Xiong et al.

Open-domain KeyPhrase Extraction (KPE) aims to extract keyphrases from documents without domain or quality restrictions, e.g., web pages with variant domains and qualities. Recently, neural methods have shown promising results in many KPE tasks due to their powerful capacity for modeling contextual semantics of the given documents. However, we empirically show that most neural KPE methods prefer to extract keyphrases with good phraseness, such as short and entity-style n-grams, instead of globally informative keyphrases from open-domain documents. This paper presents JointKPE, an open-domain KPE architecture built on pre-trained language models, which can capture both local phraseness and global informativeness when extracting keyphrases. JointKPE learns to rank keyphrases by estimating their informativeness in the entire document and is jointly trained on the keyphrase chunking task to guarantee the phraseness of keyphrase candidates. Experiments on two large KPE datasets with diverse domains, OpenKP and KP20k, demonstrate the effectiveness of JointKPE on different pre-trained variants in open-domain scenarios. Further analyses reveal the significant advantages of JointKPE in predicting long and non-entity keyphrases, which are challenging for previous neural KPE methods. Our code is publicly available at https://github.com/thunlp/BERT-KPE.

Rui Luo, Jie Bao, Zhixin Zhou et al.

Adversarial attacks pose significant threats to the reliability and safety of deep learning models, especially in critical domains such as medical imaging. This paper introduces a novel framework that integrates conformal prediction with game-theoretic defensive strategies to enhance model robustness against both known and unknown adversarial perturbations. We address three primary research questions: constructing valid and efficient conformal prediction sets under known attacks (RQ1), ensuring coverage under unknown attacks through conservative thresholding (RQ2), and determining optimal defensive strategies within a zero-sum game framework (RQ3). Our methodology involves training specialized defensive models against specific attack types and employing maximum and minimum classifiers to aggregate defenses effectively. Extensive experiments conducted on the MedMNIST datasets, including PathMNIST, OrganAMNIST, and TissueMNIST, demonstrate that our approach maintains high coverage guarantees while minimizing prediction set sizes. The game-theoretic analysis reveals that the optimal defensive strategy often converges to a singular robust model, outperforming uniform and simple strategies across all evaluated datasets. This work advances the state-of-the-art in uncertainty quantification and adversarial robustness, providing a reliable mechanism for deploying deep learning models in adversarial environments.

Xiaolu Chen, Jie Bao, Haojie Wu et al.

Generative Search Engine (GSE) leverages the Retrieval-Augmented Generation (RAG) technique and the Large Language Model (LLM) to integrate multi-source information and provide users with accurate and comprehensive responses. Unlike traditional search engines that present results in ranked lists, GSE shifts users' attention from sequential browsing to content-driven subjective perception, not only driving a paradigm shift in information retrieval but also highlighting the importance of enhancing the subjective visibility of content in generative search. In this context, Generative Search Engine Optimization (G-SEO) methods have emerged as a new research focus. With the rapid advancement of Multimodal Retrieval-Augmented Generation (MRAG) techniques, GSE can now efficiently integrate text, images, audio, and video, producing richer responses that better satisfy complex information needs. Existing G-SEO methods, however, remain limited to text-based optimization and fail to fully exploit multimodal data. To address this gap, we propose Caption Injection, the first multimodal G-SEO approach, which extracts captions from images and injects them into textual content, integrating visual semantics to enhance the subjective visibility in generative search. We systematically evaluate Caption Injection on MRAMG, a benchmark for MRAG, under both unimodal and multimodal settings. Experimental results show that Caption Injection significantly outperforms text-only G-SEO baselines under the G-EVAL metric, effectively improving the subjective visibility of content perceived by users, and demonstrating the practical benefits of multimodal information in G-SEO.

Heyang Zhou, JiaJia Chen, Xiaolu Chen et al.

As Generative Engines revolutionize information retrieval by synthesizing direct answers from retrieved sources, ensuring source visibility becomes a significant challenge. Improving it through targeted content revisions is a practical strategy termed Generative Engine Optimization (GEO). However, optimizing a document for diverse queries presents a constrained optimization challenge where heterogeneous queries often impose conflicting and competing revision requirements under a limited content budget. To address this challenge, we propose IF-GEO, a "diverge-then-converge" framework comprising two phases: (i) mining distinct optimization preferences from representative latent queries; (ii) synthesizing a Global Revision Blueprint for guided editing by coordinating preferences via conflict-aware instruction fusion. To explicitly quantify IF-GEO's objective of cross-query stability, we introduce risk-aware stability metrics. Experiments on multi-query benchmarks demonstrate that IF-GEO achieves substantial performance gains while maintaining robustness across diverse retrieval scenarios.

Zheng Zhang, Jie Bao, Zhixin Zhou et al.

Graph Neural Networks (GNNs) excel at modeling relational data but face significant challenges in high-stakes domains due to unquantified uncertainty. Conformal prediction (CP) offers statistical coverage guarantees, but existing methods often produce overly conservative prediction intervals that fail to account for graph heteroscedasticity and structural biases. While residual reweighting CP variants address some of these limitations, they neglect graph topology, cluster-specific uncertainties, and risk data leakage by reusing training sets. To address these issues, we propose Residual Reweighted GNN (RR-GNN), a framework designed to generate minimal prediction sets with provable marginal coverage guarantees. RR-GNN introduces three major innovations to enhance prediction performance. First, it employs Graph-Structured Mondrian CP to partition nodes or edges into communities based on topological features, ensuring cluster-conditional coverage that reflects heterogeneity. Second, it uses Residual-Adaptive Nonconformity Scores by training a secondary GNN on a held-out calibration set to estimate task-specific residuals, dynamically adjusting prediction intervals according to node or edge uncertainty. Third, it adopts a Cross-Training Protocol, which alternates the optimization of the primary GNN and the residual predictor to prevent information leakage while maintaining graph dependencies. We validate RR-GNN on 15 real-world graphs across diverse tasks, including node classification, regression, and edge weight prediction. Compared to CP baselines, RR-GNN achieves improved efficiency over state-of-the-art methods, with no loss of coverage.

Xiaolu Chen, Haojie Wu, Jie Bao et al.

Generative Search Engines (GSEs), powered by Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG), are reshaping information retrieval. While commercial systems (e.g., BingChat, Perplexity.ai) demonstrate impressive semantic synthesis capabilities, their black-box nature fundamentally undermines established Search Engine Optimization (SEO) practices. Content creators face a critical challenge: their optimization strategies, effective in traditional search engines, are misaligned with generative retrieval contexts, resulting in diminished visibility. To bridge this gap, we propose a Role-Augmented Intent-Driven Generative Search Engine Optimization (G-SEO) method, providing a structured optimization pathway tailored for GSE scenarios. Our method models search intent through reflective refinement across diverse informational roles, enabling targeted content enhancement. To better evaluate the method under realistic settings, we address the benchmarking limitations of prior work by: (1) extending the GEO dataset with diversified query variations reflecting real-world search scenarios and (2) introducing G-Eval 2.0, a 6-level LLM-augmented evaluation rubric for fine-grained human-aligned assessment. Experimental results demonstrate that search intent serves as an effective signal for guiding content optimization, yielding significant improvements over single-aspect baseline approaches in both subjective impressions and objective content visibility within GSE responses.

Jie Bao, Zhixin Zhou, Wen Jung Li et al.

Accurate medical image segmentation is essential for effective diagnosis and treatment planning but is often challenged by domain shifts caused by variations in imaging devices, acquisition conditions, and patient-specific attributes. Traditional domain generalization methods typically require inclusion of parts of the test domain within the training set, which is not always feasible in clinical settings with limited diverse data. Additionally, although diffusion models have demonstrated strong capabilities in image generation and style transfer, they often fail to preserve the critical structural information necessary for precise medical analysis. To address these issues, we propose a novel medical image segmentation method that combines diffusion models and Structure-Preserving Network for structure-aware one-shot image stylization. Our approach effectively mitigates domain shifts by transforming images from various sources into a consistent style while maintaining the location, size, and shape of lesions. This ensures robust and accurate segmentation even when the target domain is absent from the training data. Experimental evaluations on colonoscopy polyp segmentation and skin lesion segmentation datasets show that our method enhances the robustness and accuracy of segmentation models, achieving superior performance metrics compared to baseline models without style transfer. This structure-aware stylization framework offers a practical solution for improving medical image segmentation across diverse domains, facilitating more reliable clinical diagnoses.

Si Sun, Hanqing Zhang, Zhiyuan Liu et al.

Dense Retrieval (DR) is now considered as a promising tool to enhance the memorization capacity of Large Language Models (LLM) such as GPT3 and GPT-4 by incorporating external memories. However, due to the paradigm discrepancy between text generation of LLM and DR, it is still an open challenge to integrate the retrieval and generation tasks in a shared LLM. In this paper, we propose an efficient LLM-Oriented Retrieval Tuner, namely LMORT, which decouples DR capacity from base LLM and non-invasively coordinates the optimally aligned and uniform layers of the LLM towards a unified DR space, achieving an efficient and effective DR without tuning the LLM itself. The extensive experiments on six BEIR datasets show that our approach could achieve competitive zero-shot retrieval performance compared to a range of strong DR models while maintaining the generation ability of LLM.

Brian Bartoldson, Rui Wang, Yucheng Fu et al.

The CO2 capture efficiency in solvent-based carbon capture systems (CCSs) critically depends on the gas-solvent interfacial area (IA), making maximization of IA a foundational challenge in CCS design. While the IA associated with a particular CCS design can be estimated via a computational fluid dynamics (CFD) simulation, using CFD to derive the IAs associated with numerous CCS designs is prohibitively costly. Fortunately, previous works such as Deep Fluids (DF) (Kim et al., 2019) show that large simulation speedups are achievable by replacing CFD simulators with neural network (NN) surrogates that faithfully mimic the CFD simulation process. This raises the possibility of a fast, accurate replacement for a CFD simulator and therefore efficient approximation of the IAs required by CCS design optimization. Thus, here, we build on the DF approach to develop surrogates that can successfully be applied to our complex carbon-capture CFD simulations. Our optimized DF-style surrogates produce large speedups (4000x) while obtaining IA relative errors as low as 4% on unseen CCS configurations that lie within the range of training configurations. This hints at the promise of NN surrogates for our CCS design optimization problem. Nonetheless, DF has inherent limitations with respect to CCS design (e.g., limited transferability of trained models to new CCS packings). We conclude with ideas to address these challenges.

Tianfu He, Jie Bao, Yexin Li et al.

Illegal vehicle parking is a common urban problem faced by major cities in the world, as it incurs traffic jams, which lead to air pollution and traffic accidents. The government highly relies on active human efforts to detect illegal parking events. However, such an approach is extremely ineffective to cover a large city since the police have to patrol over the entire city roads. The massive and high-quality sharing bike trajectories from Mobike offer us a unique opportunity to design a ubiquitous illegal parking detection approach, as most of the illegal parking events happen at curbsides and have significant impact on the bike users. The detection result can guide the patrol schedule, i.e. send the patrol policemen to the region with higher illegal parking risks, and further improve the patrol efficiency. Inspired by this idea, three main components are employed in the proposed framework: 1)~{\em trajectory pre-processing}, which filters outlier GPS points, performs map-matching, and builds trajectory indexes; 2)~{\em illegal parking detection}, which models the normal trajectories, extracts features from the evaluation trajectories, and utilizes a distribution test-based method to discover the illegal parking events; and 3)~{\em patrol scheduling}, which leverages the detection result as reference context, and models the scheduling task as a multi-agent reinforcement learning problem to guide the patrol police. Finally, extensive experiments are presented to validate the effectiveness of illegal parking detection, as well as the improvement of patrol efficiency.

Tianfu He, Guochun Chen, Chuishi Meng et al.

People often refer to a place of interest (POI) by an alias. In e-commerce scenarios, the POI alias problem affects the quality of the delivery address of online orders, bringing substantial challenges to intelligent logistics systems and market decision-making. Labeling the aliases of POIs involves heavy human labor, which is inefficient and expensive. Inspired by the observation that the users' GPS locations are highly related to their delivery address, we propose a ubiquitous alias discovery framework. Firstly, for each POI name in delivery addresses, the location data of its associated users, namely Mobility Profile are extracted. Then, we identify the alias relationship by modeling the similarity of mobility profiles. Comprehensive experiments on the large-scale location data and delivery address data from JD logistics validate the effectiveness.

Lai Wei, Ryan McCloy, Jie Bao

In response to the continuously changing feedstock supply and market demand for products with different specifications, the processes need to be operated at time-varying operating conditions and targets (e.g., setpoints) to improve the process economy, in contrast to traditional process operations around predetermined equilibriums. In this paper, a contraction theory-based control approach using neural networks is developed for nonlinear chemical processes to achieve time-varying reference tracking. This approach leverages the universal approximation characteristics of neural networks with discrete-time contraction analysis and control. It involves training a neural network to learn a contraction metric and differential feedback gain, that is embedded in a contraction-based controller. A second, separate neural network is also incorporated into the control-loop to perform online learning of uncertain system model parameters. The resulting control scheme is capable of achieving efficient offset-free tracking of time-varying references, with a full range of model uncertainty, without the need for controller structure redesign as the reference changes. This is a robust approach that can deal with bounded parametric uncertainties in the process model, which are commonly encountered in industrial (chemical) processes. This approach also ensures the process stability during online simultaneous learning and control. Simulation examples are provided to illustrate the above approach.

Di Weng, Chengbo Zheng, Zikun Deng et al.

Bus routes are typically updated every 3-5 years to meet constantly changing travel demands. However, identifying deficient bus routes and finding their optimal replacements remain challenging due to the difficulties in analyzing a complex bus network and the large solution space comprising alternative routes. Most of the automated approaches cannot produce satisfactory results in real-world settings without laborious inspection and evaluation of the candidates. The limitations observed in these approaches motivate us to collaborate with domain experts and propose a visual analytics solution for the performance analysis and incremental planning of bus routes based on an existing bus network. Developing such a solution involves three major challenges, namely, a) the in-depth analysis of complex bus route networks, b) the interactive generation of improved route candidates, and c) the effective evaluation of alternative bus routes. For challenge a, we employ an overview-to-detail approach by dividing the analysis of a complex bus network into three levels to facilitate the efficient identification of deficient routes. For challenge b, we improve a route generation model and interpret the performance of the generation with tailored visualizations. For challenge c, we incorporate a conflict resolution strategy in the progressive decision-making process to assist users in evaluating the alternative routes and finding the most optimal one. The proposed system is evaluated with two usage scenarios based on real-world data and received positive feedback from the experts.

Guojun Wu, Yanhua Li, Zhenming Liu et al.

Many real-world human behaviors can be characterized as a sequential decision making processes, such as urban travelers choices of transport modes and routes (Wu et al. 2017). Differing from choices controlled by machines, which in general follows perfect rationality to adopt the policy with the highest reward, studies have revealed that human agents make sub-optimal decisions under bounded rationality (Tao, Rohde, and Corcoran 2014). Such behaviors can be modeled using maximum causal entropy (MCE) principle (Ziebart 2010). In this paper, we define and investigate a general reward trans-formation problem (namely, reward advancement): Recovering the range of additional reward functions that transform the agent's policy from original policy to a predefined target policy under MCE principle. We show that given an MDP and a target policy, there are infinite many additional reward functions that can achieve the desired policy transformation. Moreover, we propose an algorithm to further extract the additional rewards with minimum "cost" to implement the policy transformation.

Yong Zhang, Yu Zhang, Zhao Zhang et al.

Traditional human activity recognition (HAR) based on time series adopts sliding window analysis method. This method faces the multi-class window problem which mistakenly labels different classes of sampling points within a window as a class. In this paper, a HAR algorithm based on U-Net is proposed to perform activity labeling and prediction at each sampling point. The activity data of the triaxial accelerometer is mapped into an image with the single pixel column and multi-channel which is input into the U-Net network for training and recognition. Our proposal can complete the pixel-level gesture recognition function. The method does not need manual feature extraction and can effectively identify short-term behaviors in long-term activity sequences. We collected the Sanitation dataset and tested the proposed scheme with four open data sets. The experimental results show that compared with Support Vector Machine (SVM), k-Nearest Neighbor (kNN), Decision Tree(DT), Quadratic Discriminant Analysis (QDA), Convolutional Neural Network (CNN) and Fully Convolutional Networks (FCN) methods, our proposal has the highest accuracy and F1-socre in each dataset, and has stable performance and high robustness. At the same time, after the U-Net has finished training, our proposal can achieve fast enough recognition speed.