Hongbin Han

Zhengyong Huang, Xingwen Sun, Xuting Chang et al.

Deformable image registration is a critical technology in medical image analysis, with broad applications in clinical practice such as disease diagnosis, multi-modal fusion, and surgical navigation. Traditional methods often rely on iterative optimization, which is computationally intensive and lacks generalizability. Recent advances in deep learning have introduced attention-based mechanisms that improve feature alignment, yet accurately registering regions with high anatomical variability remains challenging. In this study, we proposed a novel unsupervised deformable image registration framework, LGANet++, which employs a novel local-global attention mechanism integrated with a unique technique for feature interaction and fusion to enhance registration accuracy, robustness, and generalizability. We evaluated our approach using five publicly available datasets, representing three distinct registration scenarios: cross-patient, cross-time, and cross-modal CT-MR registration. The results demonstrated that our approach consistently outperforms several state-of-the-art registration methods, improving registration accuracy by 1.39% in cross-patient registration, 0.71% in cross-time registration, and 6.12% in cross-modal CT-MR registration tasks. These results underscore the potential of LGANet++ to support clinical workflows requiring reliable and efficient image registration. The source code is available at https://github.com/huangzyong/LGANet-Registration.

Yuchen Yang, Shuangyang Zhong, Haijun Yu et al.

Background: Deep learning has demonstrated significant potential for automated brain metastases (BM) segmentation; however, models trained at a singular institution often exhibit suboptimal performance at various sites due to disparities in scanner hardware, imaging protocols, and patient demographics. The goal of this work is to create a domain adaptation framework that will allow for BM segmentation to be used across multiple institutions. Methods: We propose a VAE-MMD preprocessing pipeline that combines variational autoencoders (VAE) with maximum mean discrepancy (MMD) loss, incorporating skip connections and self-attention mechanisms alongside nnU-Net segmentation. The method was tested on 740 patients from four public databases: Stanford, UCSF, UCLM, and PKG, evaluated by domain classifier's accuracy, sensitivity, precision, F1/F2 scores, surface Dice (sDice), and 95th percentile Hausdorff distance (HD95). Results: VAE-MMD reduced domain classifier accuracy from 0.91 to 0.50, indicating successful feature alignment across institutions. Reconstructed volumes attained a PSNR greater than 36 dB, maintaining anatomical accuracy. The combined method raised the mean F1 by 11.1% (0.700 to 0.778), the mean sDice by 7.93% (0.7121 to 0.7686), and reduced the mean HD95 by 65.5% (11.33 to 3.91 mm) across all four centers compared to the baseline nnU-Net. Conclusions: VAE-MMD effectively diminishes cross-institutional data heterogeneity and enhances BM segmentation generalization across volumetric, detection, and boundary-level metrics without necessitating target-domain labels, thereby overcoming a significant obstacle to the clinical implementation of AI-assisted segmentation.

Jiayi Xie, Hongfeng Li, Jin Cheng et al.

The brain extracellular space (ECS), an irregular, extremely tortuous nanoscale space located between cells or between cells and blood vessels, is crucial for nerve cell survival. It plays a pivotal role in high-level brain functions such as memory, emotion, and sensation. However, the specific form of molecular transport within the ECS remain elusive. To address this challenge, this paper proposes a novel approach to quantitatively analyze the molecular transport within the ECS by solving an inverse problem derived from the advection-diffusion equation (ADE) using a physics-informed neural network (PINN). PINN provides a streamlined solution to the ADE without the need for intricate mathematical formulations or grid settings. Additionally, the optimization of PINN facilitates the automatic computation of the diffusion coefficient governing long-term molecule transport and the velocity of molecules driven by advection. Consequently, the proposed method allows for the quantitative analysis and identification of the specific pattern of molecular transport within the ECS through the calculation of the Peclet number. Experimental validation on two datasets of magnetic resonance images (MRIs) captured at different time points showcases the effectiveness of the proposed method. Notably, our simulations reveal identical molecular transport patterns between datasets representing rats with tracer injected into the same brain region. These findings highlight the potential of PINN as a promising tool for comprehensively exploring molecular transport within the ECS.

Zhenhao Li, Long Yang, Xiaojie Yin et al.

Computed tomography (CT) is a cornerstone imaging modality for non-invasive, high-resolution visualization of internal anatomical structures. However, when the scanned object exceeds the scanner's field of view (FOV), projection data are truncated, resulting in incomplete reconstructions and pronounced artifacts near FOV boundaries. Conventional reconstruction algorithms struggle to recover accurate anatomy from such data, limiting clinical reliability. Deep learning approaches have been explored for FOV extension, with diffusion generative models representing the latest advances in image synthesis. Yet, conventional diffusion models are computationally demanding and slow at inference due to their iterative sampling process. To address these limitations, we propose an efficient CT FOV extension framework based on the image-to-image Schrödinger Bridge (I$^2$SB) diffusion model. Unlike traditional diffusion models that synthesize images from pure Gaussian noise, I$^2$SB learns a direct stochastic mapping between paired limited-FOV and extended-FOV images. This direct correspondence yields a more interpretable and traceable generative process, enhancing anatomical consistency and structural fidelity in reconstructions. I$^2$SB achieves superior quantitative performance, with root-mean-square error (RMSE) values of 49.8\,HU on simulated noisy data and 152.0HU on real data, outperforming state-of-the-art diffusion models such as conditional denoising diffusion probabilistic models (cDDPM) and patch-based diffusion methods. Moreover, its one-step inference enables reconstruction in just 0.19s per 2D slice, representing over a 700-fold speedup compared to cDDPM (135s) and surpassing diffusionGAN (0.58s), the second fastest. This combination of accuracy and efficiency makes I$^2$SB highly suitable for real-time or clinical deployment.

Yixin Chen, Lin Gao, Yajuan Gao et al.

The integration of deep learning in medical imaging has shown great promise for enhancing diagnostic, therapeutic, and research outcomes. However, applying universal models across multiple modalities remains challenging due to the inherent variability in data characteristics. This study aims to introduce and evaluate a Modality Projection Universal Model (MPUM). MPUM employs a novel modality-projection strategy, which allows the model to dynamically adjust its parameters to optimize performance across different imaging modalities. The MPUM demonstrated superior accuracy in identifying anatomical structures, enabling precise quantification for improved clinical decision-making. It also identifies metabolic associations within the brain-body axis, advancing research on brain-body physiological correlations. Furthermore, MPUM's unique controller-based convolution layer enables visualization of saliency maps across all network layers, significantly enhancing the model's interpretability.